6 research outputs found
Testes de inspeção visual e colpocitologia: validade e aplicabilidade no programa de prevenção e detecção precoce do câncer de colo uterino
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2013.Introdução: Nos países em desenvolvimento que ainda concentram seus programas de rastreamento primário do câncer cervical apenas na colpocitologia (CO) como por exemplo, o Brasil, as taxas da doença têm diminuído ligeiramente ou permanecendo estáveis ao longo das duas últimas décadas. Portanto, há necessidade de testes adjuvantes à CO devido à sua baixa sensibilidade e alta taxa de falso negativo (TFN), e também para evitar os múltiplos estágios e a demora que vão desde o diagnóstico até o tratamento. Como metodologia alternativa, os testes de inspeção visual (TIV) têm sido considerados uma possível opção à CO no rastreamento primário do câncer cervical em locais com poucos recursos. Objetivo: Verificar o desempenho diagnóstico da colpocitologia oncótica e dos testes de inspeção visual (TIV) no Programa de Rastreamento e Detecção Precoce do Câncer de Colo Uterino em uma população de baixo risco. Desenho do estudo: Estudo transversal prospectivo de validação diagnóstica da CO e dos TIV do colo uterino quando empregados separadamente e em paralelo tendo como padrão ouro os resultados da colposcopia e histopatologia para os casos negativos e positivos, respectivamente. Métodos: A amostra foi composta por 919 mulheres atendidas na Rede Feminina de Combate ao Câncer de Florianópolis (RFCCF) durante o período de junho de 2010 a junho de 2012. Foi verificada a sensibilidade, a especificidade, os valores preditivos positivo e negativo, as taxas de falsos negativos e de falsos positivos. Utilizou-se estatística descritiva e analítica considerando-se como significativo os intervalos de confiança de 95% (IC 95%) e o valor de pAbstract : Introduction: In developing countries such as Brazil, where the focus for the primary screening programs for cervical cancer has been only on Papanicolaou smear test (CO), the disease rates have declined slightly or remained stable over the past two decades. It follows, then, that other tests aimed at improving the CO use as for the tracking of cancer due to its low sensitivity and high false negative rate (FNR), and also to avoid the delay and multiple stages ranging from diagnosis to treatment, are necessary. As an alternative methodology, visual inspection tests (VIT) have been considered as a possible option for CO in primary cervical cancer screening in resources-lacking settings. Objective: To investigate the diagnostic performance of both CO and VIT in the Tracking and Early Detection of Cervical Cancer Program based in a low-risk population. Study Design: This is a prospective cross-sectional study of diagnostic validation of CO and VIT cervix tests when used separately and in parallel, having as the gold standard parameter the results of CO and histopathology tests for negative and positive cases, respectively. Methods: The sample consisted of 919 women being treated at the Rede Feminina de Combate ao Câncer de Florianópolis (RFCCF), from June 2010 to June 2012. The variables investigated were the sensitivity, the specificity, the positive (PPV) and negative predictive values (NPV) and the rates of false negatives (FNR) and false positives (FPR). We used descriptive and analytical statistics considering as significant the 95% confidence intervals (95% CI) and the value of p<0.05. Results: We analyzed 882 women who showed abnormalities in 4,9% of CO and 13,8% of VIT of which approximately 10% of each modality (VIA, VIAM, VILI and VILIM), separately, presented value alterations. Comparing the parallel implementation of CO under broad criteria (= ASC-US) to the VIT isolated-application test, it can be said that there was a gain in sensitivity of 33,3% and of 13,3%, respectively, and similar values were observed in relation to the decrease in FNR. There was also a statistically significant reduction of approximately 5,5% specificity and a significant increase in FPR of 5,9%. The PPV results have remained nearly half of broad CO (33,3% to 16,9%) and increased 1,5% compared to VIT results. The PNV remained virtually the same almost reaching the perfect status (99,9%) when the application was conducted in parallel. Conclusion: The present data showed that the CO possesses reasonable diagnostic performance for tracking cancer of the uterine cervix and its precursor lesions among women treated at RFCCF. However, the VIT, applied either alone or in parallel with the CO, has proved to be a good option for primary screening of these diseases, with reasonable sensitivity, stable good specificity, high NPV, and low FPR and FNR
Efecto de la suplementación con Ácidos Grasos Poliinsaturados Omega-3 (PUFA) como tratamiento alternativo para la depresión postparto (DPP): revisión sistemática
No full textIlustracionesspa:La Depresión Postparto (DPP) afecta a una proporción considerable de mujeres (10% - 20%) y puede tener graves repercusiones en la salud mental y emocional de la madre y el bebé. Aunque el uso de medicamentos como los inhibidores selectivos de la recaptación de serotonina plantea preocupaciones sobre la seguridad fetal, se ha observado un potencial prometedor en el tratamiento de la DPP mediante la suplementación con omega-3. El objetivo de esta revisión sistemática fue evaluar la calidad de la evidencia científica en cuanto al efecto de la suplementación con omega-3 (PUFA) como opción de tratamiento alternativo para mujeres con DPP. Se realizaron búsquedas exhaustivas de ensayos clínicos aleatorizados en bases de datos como Pubmed, Science Direct y Web of Science. El riesgo de sesgo en estos ensayos se evaluó utilizando la herramienta de detección de sesgos de Cochrane, y la calidad metodológica se analizó mediante la escala de Jadad. Inicialmente, se identificaron 1335 manuscritos, pero después de aplicar los criterios de selección, se incluyeron dos estudios en el análisis. Los estudios sobre la suplementación con omega-3 en mujeres con DPP arrojaron resultados diversos en términos de eficacia. Ambos estudios fueron ensayos controlados aleatorizados, proporcionando un nivel apropiado de evidencia científica. Sin embargo, se encontraron diferencias significativas en la escala de depresión BDI en el estudio de Llorente et al., mientras que el estudio de Freeman et al. mostró una reducción significativa en las puntuaciones de depresión en ambas escalas utilizadas (EPDS y HRSD), sin diferencias notables entre los grupos de dosis. Además, se identificaron diferencias en las características de las poblaciones de estudio, las dosis de omega-3 y la duración del tratamiento, lo que afecta la consistencia y generalización de los resultados. Los estudios sobre la eficacia de la suplementación con omega-3 en mujeres con DPP han mostrado resultados dispares; mientras algunos mostraron diferencias significativas en ciertas escalas de depresión, otros reflejaron reducciones notables en varios índices. A pesar de estos hallazgos, es vital tener en cuenta las limitaciones de estas investigaciones, ya que pueden influir en la interpretación y generalización de los resultados. Por ello, es esencial llevar a cabo más investigaciones con diseños sólidos, muestras amplias y enfoques específicos para la DPP, evaluando además otros factores asociados a la condición. Además, la incorporación de la medición de biomarcadores en los estudios de intervención con omega-3 en DPP podría ser esencial. La evaluación de biomarcadores, como la allopregnanolona (ALLO) y la oxitocina, podría permitir identificar a las mujeres en riesgo, facilitando intervenciones tempranas y tratamientos personalizados, y potenciando estrategias preventivas más efectivas. Esto facilitará un diseño de investigación más óptimo sobre la DPP con omega-3, proporcionando una comprensión más profunda de los efectos de esta suplementación durante el período postnatal en mujeres afectadas por DPP. Este avance no solo beneficiará la salud mental y física de las mujeres, sino que también repercutirá positivamente en el bienestar de su familia.eng:Postpartum Depression (PPD) affects a significant proportion of women (10% - 20%) and can have severe repercussions on the mental and emotional health of both the mother and baby. Although the use of medications such as selective serotonin reuptake inhibitors raises concerns about fetal safety, promising potential has been observed in treating PPD with omega-3 supplementation. The aim of this systematic review was to assess the quality of scientific evidence regarding the effect of omega-3 (PUFA) supplementation as an alternative treatment option for women with PPD. Comprehensive searches for randomized clinical trials were conducted in databases like Pubmed, Science Direct, and Web of Science. The risk of bias in these trials was assessed using the Cochrane bias detection tool, and the methodological quality was analyzed using the Jadad scale. Initially, 1335 manuscripts were identified, but after applying selection criteria, two studies were included in the analysis. The studies on omega-3 supplementation in women with PPD yielded diverse results in terms of efficacy. Both studies were randomized controlled trials, providing an appropriate level of scientific evidence. However, significant differences in the BDI depression scale were found in the Llorente et al. study, while the Freeman et al. study showed a significant reduction in depression scores on both scales used (EPDS and HRSD), with no notable differences between dose groups. Moreover, differences in study population characteristics, omega-3 dosages, and treatment duration were identified, affecting the consistency and generalization of results. Studies on the efficacy of omega-3 supplementation in women with PPD have shown varied outcomes; while some revealed significant differences on certain depression scales, others reflected notable reductions in various indices. Despite these findings, it's crucial to consider the limitations of these studies as they can influence the interpretation and generalization of results. Therefore, more research with robust designs, larger samples, and specific focuses on PPD is essential, also evaluating other factors associated with the condition. Furthermore, the incorporation of biomarker measurement in omega-3 intervention studies in PPD might be crucial. Evaluating biomarkers, such as allopregnanolone (ALLO) and oxytocin, could help identify at-risk women, facilitating early interventions and personalized treatments, and enhancing more effective preventive strategies. This will pave the way for a more optimal research design on PPD with omega-3, providing a deeper understanding of the effects of this supplementation during the postnatal period in women affected by PPD. This progress will not only benefit the mental and physical health of women but will also positively impact the well-being of their families.Lista de tablas / Lista de Figuras / RESUMEN / 1.INTRODUCCIÓN / PROBLEMA DE INVESTIGACIÓN / JUSTIFICACIÓN DE LA INVESTIGACIÓN / 2. MARCO CONCEPTUAL / 2.1. Revisión sistemática / 2.1.1 ¿Qué es una revisión sistemática y para qué sirve? / 2.1.2 Metodología de una revisión sistemática / 2.1.3 Calidad de una revisión sistemática vs calidad metodológica del estudio / 2.2. Introducción a la depresión y su impacto en la salud mental / 2.3. DPP: una variante particular de la depresión / 2.4. Epidemiología y factores de riesgo de la DPP / 2.5 Consecuencias a largo plazo de la DPP en la salud materna, paterna e infantil / 2.6. Fisiopatología de la DPP / 2.7 Diagnóstico y tratamiento convencional de la DPP / 2.8 Avances en el tratamiento de la DPP / 2.9 Omega-3 como alternativa en el tratamiento de la DPP / 3. OBJETIVOS / 3.1 OBJETIVOS GENERAL / 3.2 OBJETIVOS ESPECÍFICOS / 4.METODOLOGÍA / 4.1 Definición de conceptos / 4.2 Definición de caso / 4.3 La pregunta PICO para esta investigación es / 4.4 Diseño del estudio / 4.5 Estrategia de búsqueda / 4.6 Criterios de inclusión y exclusión / 4.7 Selección y extracción de datos / 4.8 Evaluación del Riesgo de Sesgo / 4.9 Consideraciones Éticas / 5.RESULTADOS / 5.1 Características de los estudios incluidos / 5.2 Hallazgos en los estudios / 5.3 Riesgo de sesgo / 6. DISCUSIÓN / 7. CONCLUSIONES / BIBLIOGRAFÍAEspecializaciónEspecialista en Epidemiologí
Participação dos receptores glutamatérgicos e dos receptores de potencial transitório na ação antinociceptiva do (-)-Linalol
No full textTese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Farmacologia, Florianópolis, 2010O objetivo do presente trabalho foi o de estender e confirmar a ação antinociceptiva do (-)-linalol, bem como do envolvimento do sistema glutamatérgico e dos receptores de potencial transitório (TRP) no seu mecanismo de ação antinociceptivo em camundongos. O (-)-linalol administrado via sistêmica (intraperitoneal ou oral), central (intratecal) ou periférica (intraplantar) inibiu, de maneira dependente da dose, a nocicepção induzida pelo glutamato. Além disso, o (-)-linalol foi capaz de reduzir a nocicepção causada pela injeção intratecal de agonistas iGluRs (NMDA, AMPA e cainato), citocinas pró-inflamatórias (IL-1? e TNF-?) e SP. Entretanto, não preveniu a nocicepção induzida pelo trans-ACPD, agonista mGluR. Por outro lado, o (-)-linalol também inibiu a nocicepção induzida pelo cinamaldeido (CA, agonista TRPA1) e somente uma dose alta de (-)-linalol (200 mg/kg) foi capaz de inibir a nocicepção induzida pela capsaicina (agonista TRPV1). Além disso, o (-)-linalol inibiu a hipernocicepção mecânica, mas não a hipernocicepção térmica (quente), induzida pelo CA (i.pl.). A injeção i.pl. de glutamato induziu nocicepção em animais com deleção gênica TRPA1-/- de maneira equivalente àquela observada em camundongos selvagens, sendo que a nocicepção induzida pelo glutamato em animais TRPA1-/- foi também reduzida pelo (-)-linalol. O MK801 (antagonista de receptores NMDA) foi capaz de inibir a nocicepção induzida pelo CA e, interessantemente, a co-administração de doses sub-efetivas de (-)-linalol e de MK801 promoveram redução significativa da nocicepção induzida pelo CA. Usando a técnica de imagens de Ca+2, observou-se que o (-)-linalol inibiu o aumento da [Ca+2]i induzido pelo agonista TRPA1 (alil isotiocianato) em células CHO transfectadas com TRPA1. Porém, apenas a maior dose inibiu o aumento da [Ca+2]i induzido pela capsaicina em cultura de células CHO transfectadas com TRPV1. Em cultura de neurônios do GRD, a adição de (-)-linalol (500 µM) ao sistema causou um aumento na [Ca+2]i tanto em neurônios sensíveis quanto insensíveis aos agonistas TRPs (mentol, alil isotiocianato e capsaicina). Entretanto, doses menores de (-)-linalol (100 e 250 µM) foram capazes de reduzir o aumento da [Ca+2]i em neurônios do GRD induzido pelo AITC, sendo que esta resposta não foi bloqueada pela infusão de MK801. O (-)-linalol (500 µM) também foi capaz de reduzir o aumento da [Ca+2]i induzido pelo glutamato em cultura de neurônios do corno dorsal da medula espinhal. É importante mencionar que o (-)-linalol foi também efetivo em modelos de dor crônica. Assim, o (-)-linalol foi capaz de reduzir a hipersensibilidade mecânica e térmica (frio), bem como o edema de pata, induzida pelo CFA. Contudo, o (-)-linalol não foi capaz de reduzir a hipersensibilidade mecânica induzida pelo CFA em animais TRPA1-/-, sugerindo que o efeito do (-)-linalol na hipersensibilidade mecânica parece envolver os canais TRPA1. Na neuropatia induzida pela ligação parcial do nervo ciático, o (-)-linalol também foi eficiente em atenuar a hipersensibilidade mecânica. Portanto, o presente trabalho estende os dados descritos na literatura e demonstra que o (-)-linalol é eficaz em vários modelos de dor aguda e crônica, sendo, então, uma molécula interessante para o desenvolvimento de fármacos terapêuticamente úteis no controle de estados de dor, principalmente estados de dor crônica.The objective of the present work was to extend and confirm the antinociceptive action of (-)-linalool, as well the involvement of glutamatergic system and transient receptor potential (TRP) channels in the mechanism (s) underlying the antinociceptive action of (-)-linalool. (-)-Linalool administered by systemic, central or peripheral routes inhibited, dose-dependent, the nociception induced by glutamate and the nociception induced by intrathecal injection of iGluRs agonists (NMDA, AMPA and kainate), pro-inflammatory cytokines (IL-1? e TNF-?) and SP. This compound also inhibited the nociception induced by cinnamaldehyde (CA, TRPA1 agonist) and only the highest dose of (-)-linalool (200 mg/kg) was able to inhibit the nociception induced by capsaicin (TRPV1 agonist). Moreover, (-)-linalool inhibited the mechanical hypersensitivity, but it did not reduce the thermal hypersensitivity, induced by CA (i.pl.). MK801 (NMDA antagonist) was able to inhibit the nociception induced by CA and, interestingly, sub-effectives doses of (-)-linalool co-administered with MK801 promoted significant reduction of CA-induced nociception. We observed that (-)-linalool inhibited the [Ca+2]i increase induced by TRPA1 agonist (AITC, allyl isothiocyanate) in CHO cells. In DRG neurons, (-)-linalool inhibited the [Ca+2]i increase by AITC, not being blocked by MK801. Also, (-)-linalool was able to reduces [Ca+2]i increased induced by glutamate in cultured dorsal horn neurons. It is important to mention that (-)-linalool was effective in pain chronic models. Therefore, (-)-linalool was able to reduce mechanical and thermal (cold) hypersensitivity induced by both CFA and nerve injury, but did not reduce the mechanical hypersensitivity induced by CFA in TRPA1-/-. So, this study adds information about the antinociceptive action of (-)-linalool and indicates that (-)-linalool might be potentially interesting in the development of new clinically relevant drugs for the management of persistent pain
The effects of early developmental stress and exercise intervention on neurodegeneration in a rat model of Parkinson's disease
No full textIncludes bibliographical references (p. 224-253).Early developmental stress has been shown to produce numerous deleterious effects, e.g. the later development of affective disorders, and this has been related to chronic enhanced hypothalamic-pituitary-adrenal axis activity. Animal studies have shown that maternally separated rats exhibit increased anxiety- and depression-like behaviour in adulthood, although other evidence shows hyperactivity and impulsivity in such cases. Given that stress has these behavioural effects, it is of interest to determine whether early developmental stress might enhance the toxicity of a later unrelated neural insult. The 6-hydroxydopamine (6-OHDA) model of Parkinson's disease involves the selective unilateral lesion of nigrostriatal dopamine neurons. In this group of studies it was hypothesized that maternal separation might enhance the toxic effects of 6-OHDA
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Fowk-r's "Ten yi-.trs in Wall strt'et."
Do s-omoii ■-;" :■!.■.' Thi
'piusHon is rt-nilily utit-wered in thi- nf-
lirumtiTe. Jloru th:.n •-}». they an
not only fro'pieiit, hnt lUring Apeoala*
tow. - Thoy encounter risks tlitat wo-jUI
trtpnl th.* stbntsat Wull strvt-t vett-rtui,
mui rush Ik-MIv into pli-ci-:* that even it
VimJt-rliiIt -.voiiU four to trt-*uh Th.*
H.trl. in. ami six or »*ipht weeis from ; Kecnrltiei* nru sent tj the Uniteil Stntt*
thnt rime they rtTeivi<Unotnh.Het-tIohi, j to Im H.ild. and theiprucyi-tla of thsse
but iv ci.ll for mnro mar-in. for Barlem I Kales, in g rid, is ren>itt(t! to Eiiglauil,
hutl sold down* to 75, aud iiii,.,! nf diminitthiiij* in this jirtr-KirtioD, the
ninking 2_,000. Fortunately. | Gold hnd risen to 180, ami rumors of
all of those young ludies belonged to comniereial distretb* iu Lontlon were
tho hemic moult!, and iiiatead of f-uing j alrwidy foriwaruiug the bears of their
iuto hysterica, or sitting down and hav- j tlungerous positiou, frtim- which they
ing n. good cry, Ihey \wut -aniifiilly, or i ww only one montis of .relief, viz: lho
rather wtinmuful-y, to work nnd raised sate* tf </ '-i by the UoveAnr.nt. These
money, funiinhed the liecettwiry margin \ aales in a tt-w tlnys ran up to SJ,0J0 froui Iheir broker's nrrivnl of tho ttieniu »hip Culm brought
broker* ofalie, propnre.1 ti» buy nt tlu-
lowcHl prices, and when sto-.*ka go np
she itlwayH t.i ml*, want lo her bioker to
sell out. Her prolUs from these investments have s»:iH-tiniesri*M*u to more
than t»ne hundred thousand dollars per
iiiiiiu*ii.
Tin* tno-st rt markable enso of nil, in
ftm-ile t-hitracU-r is, in ninny reKp«cts;| Umt of a lady wh-*m we uill cnll Hi«
he
Ono of Ihe iiotnble-L'umleRpecnhttot-s ! which biul ever oefcurred iu Kngland.
in Wall street is n mtiideu lady, who Tlie Goveruiiu-ut tttoopM Helliiig, sad
touuU her'property by the uulli.iu. I gold jumptd lo 40. Erie cei.ilkales
She la na vs. moh there, however, ex- J tuitl Gov. nuueut bonds enmo ptiuriu^-
cept when stocks are falliug, uud prol*- [ in by t-verj* stenuirr, apd every oul-
iibly l-yloiii^ to tho 'j-Qiiic-bmU before ttofaag steamer carried millions of gt»ld.
d<r-—-.ibed. ,In Iheso seasons she muy \Xk six weeks, more th;m'$10,000,000
bo seen in herl " cuslcm iry suit o^ j bud Wen sent oui of the eoni-try.
s Mfir.ii black," trij-ping down to hor
be n broker? Could, or would, ot t*hoult3
f'she hnc her dehtate throat with hell
tiu-tul, put diiuble bras-; njxru her face,
change her tender heurt into atone,
cnisb out her hnnmii arinpathit's with
the pnfortunate and the distressed, and
see men \ retlnced from iiill lence t. he^-
gan*. and protit by it as « broker?
Thi* *jn)fe*i_ion ns it stock-broker
would seem to lie almost the last oue
tlmt woman woull rvsptro to fill, and
yet already two ambitious Indies have
eutered Ihe ranks of that profestdou
R-ithin the hn-t few months. We d'.s-
■**l;iini here, mui uow h tinctly, nny iu-
'entiou to niU'ertise .irokers, but we
','i.unot refrain from giving theso. tw.i
lulies mimes in fall, viz: Mrs. Victoria
WckKlhull mid Mrs. Tiiuiie C. Claf-
h-_ compose the new firm of
ojdhull, Cl-ifilin -t Co., doing busi-
C. Wtxal
fflin.' wh
NVojdhul
TITE ROOTS;
BT tOOTt BI*L_*CS03.
the news of the grefiti-*-t fimtuciul panie tie-w at No. 51 B4o.nl street. Let ns
with that their con rage may win success iu this unwonted .i-1.1 of feminine
taUrprue.
, JACX STRATMAN \\D SIR. FISH.
! A. good story is tvil.l in nigard to the
i'lterview at W.ishiugton, some w. i-fc.
-since, U*tw_.u M ij n* J.u'k Stratinan,
On the Oth of J line the price stood i *of S*»a Fraueisco, nud Um. llamil-
trt 169. One of tho largest holders of hoa -ti-1'- B««rrts**y of SUte. and
({old tit ISO was the Aim of M—- A X>—, fa We 1»-*T- not seen a st..;-tn ■>.-.: con-
nnd this house was si most ihe oury j-ceruing the - eibtbitiu-i, in print, we
proiutent ono which bulled gold very j?-**5"-* th-* liberty of pm.lucin^ the same.
heavily. Tiieir profits iftcr the arrival vJuck w.u enga^etl in earnestly pressing
suited to a life of s^ei-ulatt.m. Siieeu- | *\|-
f the Cuba could! bo t-ouuted by tie
million. *-1
Many a shrewd inerchant nnd oper-
n.or found himself dtiring tho rise
-iMrvss, MA-TF1ET.-*! ENTERPRnE, Fr-m-.nl Townslilp om-ers,
May-x-M. Ssnt- Cl-r- Co. W-Wt H -a -, :t Justice of the TV-rs-
Caliromift 'C TjiPitrit O--***- td»
- r-dO^s-sroxvL cvrt)^.
W. It. CMPPERTON,
Attorney «r,:l Csanaellnr St LlW,
- E-*rr-:a**RT,*- Om^. . M'Tnn.n.
■V-** W.-J_rSB HE-NDEI-SOX,
Juatloe or tho I * < ■;»< • • ■
OTI**, *_».aJs Bir.Ll.ii.:. Miln street. My-
n>ld. sir-«
"TV r**-—1-ilar. •<" i l,..-i_:_ tn-,.'* b- n.
***'•' Itj o-i tbe f r-t M-m t* v of !**-« nit*- r. T' e
Rt*i|--te In iT*r:i*i — il of rorty. er*d tin- Art* ml Iy
of •-f--li-v nn-tnl. nt. T*-nu*of Senaf. r*. four
ve-w: As-v-iiiMvnH-n. Iwi y™rs O-mp. n-
a-t»tn. %"• *>r d"*f dttr.-j*t the Rrsslen. rnd'
ttik**-*-, rt tb" l-'o of twjaly ***rnts p- r mil.-
T»-- Ri*t-> .l.t
*a't*'f*i-*ad*y of Sept- mis r. IS'l. • nd t-T, ry two
rrrn* th-r« Iter. Tht-1< rm of nfQre ot ereh of
Iheft'-te of*r>->r«*ia f->nr *-»rr* ei-mnirnr'n-*
v, jib the rrv* Tuund- f In Ih-ccnibtr (Dt-ctmlxr
?. lSTT) titer Iht-iltctluti.
1-Jtion is founded ou h.-pe, mid women
nr** generally remarkalily prone to h ■;*<•.
S**eeiila'.iu!i rtquiri-:* ftirtittuU* nnd pn-
Sl,elsl-,nx»t„the chat of lima bsntl and root. J. M. T—
sti'».lit;-!iiili,l.'.l „Ues. Her fare U tlmt
of a (-oaliawt, an.1 Ihe white tlort
vehieh she vaeiirs Dpon her JtickeJ h..t
ii. n... -vhlch are, ur ..it ■ .11 be, Ixilh i seems eoiist.mlly in the aet of swoup-
ao.-naul)' virtum. S;»calitij.l lltrlraS j ing pluvfully dot— ejpoa the leaa iiii*.
ils foyvl from excil*—ant, iin,l women ' ,l,le liir.l Is nei.th. In her vi.»-s on
oficli fvt-.l uiwa . Aiileimnl. S|n.ouL.- , Unnnciiil q,u-sli.,lis she Ins ■1-MTI laltatl
ii ,u laimes from fane)-, nml women are j u^\, ulnni! gnrnniK ,lise,iiiiit,n.i,iiii;
muih uiveu lo fancy. M'oaicu of s eejv. _(.t-nnits o raise ihe price of gulil.
tuia ly,.e tuc oatnrJly. or Oy e.l.icatioi,, Dnriiix Iter tin yenrs eljverience she
lucliDed lo sirreolalc in stock*, Per- ■_, ,„„,,. nI1,| )o j, „ r,ir,mw nch y,,aT
haia thoy m .y uiteh the iulectioli from j l„ ,l,, sr(-t rise of lSe^ sh* stotsl one
tti.ir bro.hein, or uuiles, wh., all lalk t |,.,n,lr«l tad thirty t]iai*anil ilo'.hirs
stot-ks vvhilo U,:tinjj thoir m.uls in I better than she ili.l in ISD3. Then,
baste, sq lh.it they star bjy a Ltil. | w.nn m-ii'-.e, hi-r h^;its rose to tho nm-
m ,ro C'.Wral or cover to.ir sho. t fjf. 11. bilio ia height ,,r liaffa million, whirl,
W-Uhy Li I m, who ure lileir o.vn mis- | „. 01„s („ l^ |llr. rs,:,| whieh most snecu-
-rejaet, au.l ha.-eltlenly oflelttuu lilu,, LalorS proriae-lo th, rna-lrn. Tint,
In. .-; .: :i . 1 .. .. .1 ■'. 11-hil b-.i..-.',:l
Senator Colt to snch an extent that
his him bottom ou the b.wk of his
coul h i.l miule two holes in the Sella-
jtor's jvarlor sofa. At last tho irrepres-
-t-reatstreeilhitor was-ran, lit a-oriP-**- M*jt>r WAS rvfemd to iL. **Uh,
wh.,, it is well kn.iw-ti, is a very i ...1-
„. .UheJ git-ttan-O, p., vsessed of yrs.il rt-
olrtilnal then Ixotj-ht tsrgsrr, snd w,l,l |iinr~e«l. ai.a. athar pr, i.„ and ili.,-oi.
*70O,0lJ0 of hia pnrchava to Ih, not,sl [*"-** m U,i ■»***-*■ '."» H'jor (jamed
nrcn-htiut, 11. B. q jatlRi. AsfirS'"- •■>■«***»- ».•" I'« Ba»_et*rr, hi.
tho smaller tribe of opentors-, the li, Id f *al* *'hUo bil* l**i-*iug u:'ii- *t an.;lo of
w.wf.,irly strown.with.lhiir financial j •■'«>■-'-*» **&**] 'Iro'.ing his hog,
corpses,
l^is
notetl, arose purely from cominercial
M VYFIKLT) A!)Vi:i.TISr:MEXTS.
J. J. M.'XI-l.Tl,
Attorney nt Lnw,
Axnoc-, CirsTS* Costa Co.
oa.-**,' S-i *. H-rd-s Itslldltui.
SPAULD'NG HOUSE,
>rn>*llc*ltl. f*.nii!rt C'lnra Co.
J. S. SPAULDING. Proprietor.
.... l"T I** STTCATKn OS THE tOT.STT.^
air* II . ot M.-ln sn.l l.'nr. lit rwl.. a,hr' a,]
Dr. at. S. ALVA1EZ,
r*li>-«U-lina oiatl Sur-eoit.
Omcst At hta r—lietrre oa Llncolo alrrst.
MAVFlIll.!,. aril
J. C. 111. 1 IK,
Attorney at J_.*tav,
SAX JOKE. CAL.
Orncr. tn Kaoa n»IMlns. Room Sa. It,
11j t ■ t-. s. it. v. i.ii. or,. . i.
!^_
^. V. sQAl/VUfc-AV, M. ii.,
8ur--.eon. Etc.
AT OITiee and rtttld. n<v. wxt door lo !!■ n
e ■ -i k lasturup'* Ltv, ry SUble, UCUWUOD
CITVa
nil. BA'1-ON,
♦tur-j-ftiu and Ptiysirlsn,
M.H'Miv Vutw CAL
Offl".* in Dru.'St.-n. Pir-JcripUonsrsii fully
prtpsn d. "j. an
A. T. Mi ..
8 Ki-an-.y str- t. m ■■ r Mur.i t.
HAN FR\NCISCO.
Offi.-H. sr*.. -toll A. M : 1 io3
A* T. IIl.KKM VNN,
Surveyor, Clvir Engineer nrtf
Draurht-iman.
* On-it-E-Knoi Dnlldlug, No. S.Res It*se.
S**" bpt-rU,! atttutlon tu r»m-h *unar*.
fA\ \K D. STRONG:
Teacher of
t-1 Mio-Forte and O-V*-11*
sAVFir.i.n, .
ilMin.v fr- m llie de-vtt of the P- u Fr.n i___i
cl-c'Oi-'d R-.I1 J- IS Hrflni' d
The ltuura* la lx.rgo. aud trr-nsed for the
Comfort and Convenience
. of the guests.
IT CONTAINS
-i*-**ro Parlors. « l> r«e Itml Rmr 11 Pin ing Room,
l\ ny Dcd nooms.
Also. Itothis for lh« Bi-ri*rrimr*«l"llonof frm!
lit-*. Who il' *'rr I rival.- i 1'..rll;i. lit.-, ; 11 (-.i-
Illt-Ilttl tlUll-llv t.'.
Also, Etlrchetl to the Ifuui*- Is s
I. \ lit-.: B\R ROOM.
,t there vrlio rro loud of the g* me. I *-.*uld
. Ih_t ."..r tb.tr pl.aaun-1 bt vti*ttintl.v put
THE VtANl>B
will aatlsly tbe moat faslldlouscpleurt*.
For prMifulrrs.csIl on the prcprit trr rnd
■it « tla..*t.llK>tl. •
tur 12 3. R RPATLIHSO.
MAYFIELD BREWERY.
Comer of Mala end Grand sins la.
MAvnrxo.'
A, .ai'MH Proprietor
*.aore— le and
rrlail dralrr in
The Oiolce.t IVItiea, Liquor* »n,l
riser*.
S^B. FLETCHER.
aSor.tr—otor uti.l It,,11.1, r.
MEXI.0 -»ARK. CAL.
ar*l
PHItlP OEYER,
U..U-1-. —Inn .V <•,,,:,,,,,.,,till
Pele.er, K.latenaIn.. Bte,. Etr.
Srrtdrnre. Main Siriat. Mrrft, 1,1.
DS*. J. A. BAtta,TO*t,
l*IUr**l*»lan and *tur>a*c-ranyk
O—rr*. at 1-ranrU A l-mthrr'a rvm. t
aai ■
Alsa. the laraoaa JlajCId LA0FJ1 ttlir.n.
OCCIDENTAL SALCON,
J. D. mi.*-. Prep'r,
tniCOl-t rTlKIXT l-ATniOP
Tttn ro-WODdM nrxTs on hand the
sxty
C-|a>tc*e*t IJqsrrors ami Clj-sra
toWfcuadinicwn.
ini^ht be e_;H-eted, its ih.-y t-it enibit*id,
Hug golden becri uii.l ti.UUr.liiB to.
bhitk velvet, to have tlivir thought.-.
turned ii-k-u sto-k-Jyent, snd to dr-Jhui
.if new e-4tiii>a,.e*', jewvla an.1 silks W011
ont of HttH-kstir gold. From wh iteve
.ttise it in.iy aritwi, there nre uo iuom
•tiger un.I veiiturv-Honit- gitml-Ier-i n
il.tue.i ll.nh n, in Gerinu.iy, then wo
:inn, uud there nre Ui> in in- AgCt :inA
veiitui*e*Tunie a'H.-cuhitors in stpolts ttulii
wotuen.
On nlnioHt nuy hriglit dty, when
stock* tire liMin^, n doMafvr more very
■diuwy c-irriageji way be men dt.*wu n*
iu front tif the offlce.*! of pro-niiiwn
brokeruge honsas, w titiug for the goi-
;eoUrt tl.iun *. who j i.V- in tliem to torn,
utit, when tlu-y have tiantu-tid tlu i;
biutiut-ut with their broltiru. Mist i
.hire Hpecuhilive ludies mo djw.igei**a
iviih Lu..1 baiuk HOOiaUits. for whiel,
V IVbrn 1. \i )y wt.m: n st.x>p* to .oily.
And i i ■!- tt... Ulr tb-t i.-.tn L- U tn.y."
And b.-.i'.ii r.t bt**gal-o] She awolse from
her dream «f fortnno on the 18th o*
April 18*" I. when pmiie Wtm raging.
with the ret-due of her fortune, about
..■■''. fast locked up in tho baada of
'nr broker, who had failetl. nnd was
u:i:ible even to niy her (hit- tunall b.,1-
■-.nre.
Hut broken nre the most clastic of
mortal.*-, iM-iiintivially Bpciking: their
f.iilureH tire gener.illy only tcioparai-v.
:ind in th'ee weeks our heroine re-
.vivtil from her Ruppn-ed ins.>lvent
t-^ent, 82,000 of her bali-sco. With
thi*t she comment-id to operate on the
■li'irt aide, f»r h T lo«es in the panic
had, as in u-m.il in such USOS converted
bar luto ti b.ar — a she-bear, now
uionming for her whflps; nnd on the
:W of April, 1Q05, -tha hid rveovered
•?I0.IKH) of her k»r«ea. \Vh,t iim,. biirl
ihty, ]■:'■■■■■■■■. thank tluir .!■ j .n.
ht.sl-.i.iiK, or fathew, or'unthti, and | -*(-w whttpered hiVr e*ir, "buyErie,"
whitih they are now using a* margins in | cannot Ik* told, but k'.io bought it ul 4".,
stock M-H-trulmioiiK, riluiort ulways for n ****** B*» nV wil1* « <° *)-1. li-tt-* n witch
riw-, for it seeais to (heiiiairiuwmp-*t*-|'^n**1* of n broomWiek. rOnco more
hen**ibla* thing that any money can be j M--** ■• >(« u-"-t »:■ *'er ferttum. but *he
inaili Ity a Mil in atueU, Like so luwiy I ***** -1"1 ********* >• m** of the jnws of th-
M -gl.d, n i. they roll (In ir line eyes »„| j marki t. nlwiys open aul ravenous.
.epeiiiunlly, but uvuriiiously apSTLrda, i Thr? vi-iim of n miUion -dill haunted
lowatds Iho lowering lights of It-vl. I,,oT; sl*° -•'■"ressVd several of her «t»»ck
NUind or New York Central. a*h«MU*.Tori-**>** Ivdf*'-»*\% Old Soiith.-rn.
ilny ho-K) to make their prsilts. j mftiti WayTJ'*', etc.. alt of which conduct
liisides Ihesc middle .aged inutrous. ' ooni •--••" da_X. II r margin was rapidly
• here are not a lewitt*is--es in Iheir teens, \ ditnintshin-. In M iy. 1S5H, she teased
whose faces nro turne.i Wall streetward*-.
Iniiipue these sylph-like creatures
o-U-tg the ehphanliite bulk of 1 .■■ as
it paces up with ilijuit.e.1 -':.'.. o;
easting sheep's eyes at Tiitsbur^h as it
tlaiue-i on Ihe light-rope held by the
bauds ol u ell pie.
One fair yo.ing creature, with wealth
of blonde hail, lean* Mr—sirely o« he.
hand, nn.l indulges in I'liasant tho.i^hts
ot lle_d.nx, or in lnr sleep b.u* k-it.
drtnms of old Boat—Urn. Auother
tpiiek brunette opens with palpitalin,
to buy stocks, and commenced to-operate for n fall.
Odd hid ilroppr-1 ti 126. Every
'must*u-h.-, su.1 reiiuviu^ '..- ■ l.irhe-vl of
'apirt" in gold, it should Ik ' I**-**** ^ ™*** oi a h»W» «*-
; 1. i.i.! UTiiii l' I. i.-d 'iv.l with bright bine
w-it-ii IM.. li ..i .i..i..*s,".l him: " Well.
How fared it witb onr heroine mean- * -***"- J1UU loU *ou haw *-• of great
wh0i
She *■ f-it li!*c p.iiienee on n monument" of sh.i.-t gold. When it touched
L"*0 idle desi't-ndi>l from her *H*ds*al,i
and gazing with tCnrhtts eyo njH>*i had
... *.. ■;. (-^sjO.000,) then proee-fthd qniU-
eo.dy to gatlur np the wreck undn-con*
alrnct Ihe ttliflee.
Whi» will r-ay, after hearing the atory
of Miss M——, that women cannot
s-H-eul.ite'r
A htpge numbed of tl*e stock acconnLs
stAiidiug in the nntne of w mien on'Ihe
booka tif brokers, repfem-nt the wives
of the stoik opmtqra, who have had
settled upon them by tluir i.i.* ■ ■ ■'
Lifter some lucky hit u large sum —gains).
ihe Wet nnd dark day. which is ;......*-.;
into to come in the career j»f a s*m*ci*_
lator. As idnudy noteih lha wife oj"
lluthenvy utoek 0]**enUor is quite certain to Ih* providtd for, aud whin —is
huslt-ind l.trtcs liii* nil, \ie can fall baofl
.m his wife's mtmey »m| rt-new his fo:'
tune. M»st of the -wOnitu who spectr*-
late in Btttt-ks, coudm-t thi ir spet-ala-
ttons in tho nmnt-s of in ile friends ixn)l
relative-*. Henije it conies that th-v
very often make inouey. for what hi-tSkir
w uid bo m uo'lllmt (.ml all b.Mkei-i
ftre gallant to the f.iir twx) as to ia*t« V
lady to Um mouty in lii-t ofil.e. Sonyi
times tho broker or operator Injriwas.
bauds these iicco.mts; stands, pu>( hir. ■ ^^ ^.^
shoulder under the loid when a psnlo ,
o-.-1-urs, uud siivei- his lady customer ui J
all hazards. Sometimes ho iutroduees i
gol-ieu " M.'iu-ii-is,
liervjee to our good e.iu-e in t-aUfui*t*iis
tbiriug the 1... ■. .li.i.-.d csmprign."
Tae Major, throwiiig himself back iu
that gra>-*eful po-uiiou pec.ili.u- to him-
.s. If, aud i-i ti !-i_: both thumbs in the
arm -holes of hi-t Te.tt, . v -i..: s 1, " Oh,
nn! lyutss not! lis lite tunn around
the eoriaer i-i the y**ootry."' Mr. Fish,
*iomewh.it daunted by the attitude struck
