1,721,208 research outputs found
A Performance Analysis of J2ME Web Services Extension
No full textWeb Services (WS) technologies have considerably matured in the last years and are considered one of the most promising way to overcome interoperability problems among distributed systems. Their main success factor is the adoption of technologies like Simple Object Access Protocol (SOAP) and Web Service Description Language (WSDL) based on widely known standards like HTTP and XML. Originally their field of applications was business to business (b2b) interaction, but recently several projects identified this combination of technologies as an interesting communication mechanism for grid- and meta- computing too. The scenario where WS have had the most recent adoption is, however, mobile computing. In fact, the first client-side WS API implementation for Java 2 Micro Edition (J2ME) has been provided in 2004 by Sun. In this paper we evaluate the J2ME WS extension and we compare it with a Java 2 Standard Edition (J2SE) implementation like the Apache Axis client API. Our interest comes out from the consideration that in a mobile system the WS standards implementation has to be optimized because of the limited computational resources offered by a mobile device. The main contribution of our work is a neutral comparison between the standard approach and the mobile approach made with a software configuration able to run directly the J2ME code on a standard PC architecture without an emulation layer
La funzione di barriera della cute e i suoi difetti nella dermatite atopica
No full textLa Dermatire Atopica (DA) è una malattia infiammatoria pruriginosa della cute a carattere cronicorecidivante, in cui la xerosi rappresenta uno degli elementi distintivi. Ed è proprio dallo studio della xerosi cutanea (tramite corneometria, che valuta il contenuto d’acqua dello strato corneo, e Tewametria, che quantifica la perdita transepidermica di acqua) che l’attenzione degli studiosi si è rivolta sempre più verso alterazioni della barriera cutanea come momento eziopatogenetico importante della DA e che possono essere sia secondarie alla flogosi cronica locale che di natura genetica. Tali alterazioni cutanee del contenuto e della perdita di acqua sono state infatti riscontrate non solo in corrispondenza delle lesioni attive ma anche nella restante cute integra del soggetto affetto da DA. Ciò è a supporto dell’ipotesi che un primitivo difetto di barriera, generalizzato all’intera superficie cutanea, possa costituire un fattore determinante nella genesi della DA. Questa è dunque da inquadrare come il prodotto di una complessa interazione tra alterazioni immunologiche e difetto di funzione della barriera cutanea, che solo comprendendo a fondo consentirà lo sviluppo di strategie terapeutiche sempre più efficaci
Covariance Analysis Applied to the MESSENGER and BepiColombo Relativity Experiments
No full textMESSENGER (MErcury Surface, Space ENvironment, GEochemistry, and Ranging) and BepiColombo are joint NASA and ESA/JAXA missions devoted to the exploration of Mercury. MESSENGER operated between 2008 and 2015, while BepiColombo will be launched in October 2018 and will orbit around Mercury for at least one year starting from March 2026. Both missions have the aim to study characteristics of Mercury in terms of its geology, magnetosphere, exosphere, etc. BepiColombo will improve some of the MESSENGER results regarding the rotation state and gravity field of Mercury and it will perform important tests of the General Relativity. In this work we investigate the benefits of the joint dataset of the two missions for the Relativity experiment. The very large baseline (about 19 years) together with BepiColombo's high precision measurements will be a key factor for the improvement of the accuracies. To this aim, we developed a semi-analytical model for a covariance analysis to estimate the formal uncertainties of the parameters of our interest: post-Newtonian parameters, Nordtvedt parameter, the Sun's GM, its rate of change and the Sun's gravitational oblateness. Non-gravitational forces have also been modeled. Finally, particular attention has been paid to the repercussions on the Relativity experiment due to the uncertainties on the GMs and ephemerides of planets and minor bodies of the Solar System
How could patient reported outcomes improve patient management in chronic myeloid leukemia?
Full text linkIntroduction: Patients reported outcome (PRO) are still under-used in patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs), though data on the correlation between quality of life (QoL) and therapeutic efficacy are increasingly known. Chronic low-grade toxicities can reduce patient's QoL and negatively impact on adherence.Areas covered: This review will focus on the role of QoL questionnaires in patients with CML, receiving imatinib or newer TKIs (dasatinib, nilotinib, bosutinib, ponatinib). Physicians tend to underestimate the impact of TKI-related symptoms, in particular fatigue, that negatively affect QoL and can be a reason of poor adherence to therapy, with detrimental effect on long-term response. Few studies pointed out the role of PRO in CML, and there is paucity of questionnaires specifically designed for CML patients.Expert commentary: We recommend a wider use of PRO to join the pursuit of a rapid and deep responses with an optimization of QoL
Zeolin is a recombinant storage protein with different solubility and stability properties according to its localization in the endoplasmic reticulum or in the chloroplast.
No full textFrequency-dependent Ganymede's tidal Love number k2 detection by JUICE's 3GM experiment and implications for the subsurface ocean thickness
No full textGanymede will be the first icy satellite in the Solar System orbited by a spacecraft, ESA's JUpiter ICy moons Explorer (JUICE). JUICE launch is scheduled for April 2023 and the arrival at Ganymede is foreseen in 2035. Thanks to the advanced Ka-band radio tracking system, the Geodesy and Geophysics of Jupiter and Galilean Moons (3GM) experiment aboard the mission will provide range and range-rate measurements that will be used to infer the static (up to degree 35-45) and time-varying gravity field and the internal structure of the moon. Ganymede is subject to tidal deformation, which periodically modifies its gravity field. The larger contribution to the time-varying gravity is due to the tidal interaction with Jupiter, modulated by the eccentricity and the inclination of the moon's orbit. In addition, Ganymede also experiences a lower amplitude time-varying tidal interaction with Io, Europa and Callisto. To a good approximation, the corresponding gravitational signals are periodic and they contain several harmonics of the fundamental synodic frequencies. The elastic response of Ganymede is expected to be frequency-dependent as well. In this work we describe a procedure to estimate the Ganymede's tidal Love number k2 at different frequencies in the orbit determination process of the 3GM experiment, supported by numerical simulations. Finally, we show that 3GM measurements can be used to characterize the interior structure of Ganymede, providing a tight constraint on the subsurface ocean thickness. The ocean density can be also constrained, but with a lower precision
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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