1,721,386 research outputs found
SYMPATHETIC AND HYPERTHERMIC REACTIONS BY OREXIN A: ROLE OF CEREBRAL CATECHOLAMINERGIC NEURONS
No full textSympathetic and hyperthermic reactions by orexin A: role of cerebral catecholaminergic neurons.
Monda M, Viggiano A, Viggiano A, Viggiano E, Messina G, Tafuri D, De Luca V.
SourceDepartment of Experimental Medicine, Section of Human Physiology, Second University of Naples, via Costantinopoli 16, 80138 Naples, Italy. [email protected]
Abstract
This experiment tested the effect of a lesion of cerebral catecholaminergic neurons on the sympathetic and thermogenic effects induced by an intracerebroventicular (icv) injection of orexin A. The firing rates of the sympathetic nerves to the interscapular brown adipose tissue (IBAT), along with IBAT, colonic temperatures and heart rate were monitored in urethane-anesthetized male Sprague-Dawley rats before an injection of orexin A (1.5 nmol) into the lateral cerebral ventricle and over a period of 150 min after the injection. Three days before the experiment, the rats were pre-treated with an icv injection of 6-hydroxydopamine (6-OHDA) or 6-OHDA plus desipramine or saline. The results show that orexin A increases the sympathetic firing rate, IBAT, colonic temperatures and heart rate in the rats pre-treated with saline. This increase is blocked by the pre-treatment with 6-OHDA alone or 6-OHDA plus desipramine. These findings indicate that cerebral catecholaminergic neurons (particularly the dopaminergic pathway) play a fundamental role in the complex reactions related to activation of the orexinergic system
Tidal deformability of dressed black holes and tests of ultralight bosons in extended mass ranges
No full textThe deformability of a compact object under the presence of a tidal perturbation is encoded in the tidal Love numbers (TLNs), which vanish for isolated black holes in vacuum. We show that the TLNs of black holes surrounded by matter fields do not vanish and can be used to probe the environment around binary black holes. In particular, we compute the TLNs for the case of a black hole surrounded by a scalar condensate under the presence of scalar and vector tidal perturbations, finding a strong power-law behavior of the TLN in terms of the mass of the scalar field. Using this result as a proxy for gravitational tidal perturbations, we show that future gravitational-wave detectors like the Einstein Telescope and LISA can impose stringent constraints on the mass of ultralight bosons that condensate around black holes due to accretion or superradiance. Interestingly, LISA could measure the tidal deformability of dressed black holes across the range from stellar-mass (≈ 102M ) to supermassive (≈ 107M ) objects, providing a measurement of the mass of ultralight bosons in the range (10-17 - 10-13) eV with less than 10% accuracy, thus filling the gap between other superradiance-driven constraints coming from terrestrial and space interferometers. Altogether, LISA and Einstein Telescope can probe tidal effects from dressed black holes in the combined mass range (10-17 - 10-11) eV
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Comparing self-reported ethnicity and structure-determined ethnicity: analysis of antipsychotic-induced weight gain
No full textResponse to: Kaufman JS, Hamra G. In Chan et al. the difference between p < 0.05 and p < 0.05 is p > 0.05. Pharmacogenomics14(16), 1941-1942 (2013)
Injection of muscimol into the posterior hypothalamus reduces sympathetic and thermogenic activation induced by hippocampal neostigmine injection
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