3,716 research outputs found
Feo con f de foca
No full textNo te quieren ni un poquito, ni un poquitico. Feo con f de foca, el intento de la mala hora por abordar nociones apariencia:belleza, fealdad,bueno,malo,alma y desastre
Vernacular architecture of the Amalfi coast: a medieval domus in Villa Rufolo in Ravello (Italy)
Get PDF[EN] The oldest medieval domus in Ravello date back to the twelfth century, as an evolution of the original house with barrel vaults, a primitive stone construction with walls of dry masonry of limestone and almost always connected to an olive grove or a vineyard, widespread on the Campania coasts between the island of Capri, the coast of Sorrento and that of Amalfi. Vertical and horizontal aggregations of this module have constituted, over time, the evolution of the building typology, while retaining some of the pre-existing architectural elements and the peculiar construction characteristics, including the strong link of this architecture with the particular orography of the territory. The private building complexes are the result of this ongoing process, consisting of various rooms connected to each other and arranged on several levels, in which the members of a single family lived with their servants. The entire structure was surrounded by walls and defended by towers. The interiors consisted of rooms heated by fireplaces, kitchens, furnaces, Arab baths, cisterns, wells, cellars, warehouses, stables, rooms for winemaking, gardens and cultivated terraces. The paper analyzes the history and construction features of one of the few medieval domus still existing and which has not undergone substantial transformations, also because it was brought to light only in the last decade of the twentieth century, currently located in the boundaries of Villa Rufolo in Ravello. Its original conformation is hypothesized, thanks also to a description made of it in the archive documents. The paper also reports the work carried out on the case study in order to undertake a cataloguing of a heritage in continuous discovery.De Feo, E. (2022). Vernacular architecture of the Amalfi coast: a medieval domus in Villa Rufolo in Ravello (Italy). En Proceedings HERITAGE 2022 - International Conference on Vernacular Heritage: Culture, People and Sustainability. Editorial Universitat Politècnica de València. 87-93. https://doi.org/10.4995/HERITAGE2022.2022.15171OCS879
n. 32 Ritratto di Johann Baptist Franz Leopold de Bosizio-Thurnberg
No full textFranz Eybl (?), Ritratto di Johann Baptist Franz Leopold de Bosizio-Thurnber
Guerriero, S. Barba, E. De Feo, F. Fiorillo, A. Manco, Multidisciplinary analysis: the Early Christian complex in Cimitile (Italy)
No full textEssential oils from Salvia spp. (Lamiaceae). II. Chemical composition of the essential oil from Salvia pratensis L. subsp. haemathodes (L.) Briq. inflorescences.
No full text
Trabajo final de carrera Agrimensura: análisis de los cambios en la cuenca media y baja del río Luján
Get PDFEl presente ha sido un Trabajo Final de grado con el que se graduaron con la máxima calificación, los hoy Ing. Agrimensores Franco Feo y Esteban Hernández, quienes se encuentran actualmente ejerciendo la profesión en Mar del Plata y Gral. Belgrano (Prov. Bs.As.) respectivamente El mismo propuso aplicar la experiencia académica de estudiantes de Agrimensura tanto en la investigación como en la práctica para desarrollar un trabajo que se piensa, puede servir a la comunidad. Como director del trabajo y contando con el aval de los ejecutores, se presenta el análisis multitemporal realizado sobre una zona con propensión a la instalación de proyectos urbanísticos, y que sufre regularmente de inundaciones afectando áreas urbanas. Los resultados podrían señalar algunas fallas en la aplicación de la planificación en el uso del suelo o de los organismos de aplicación de las normas, y contribuir a explicar los problemas que se padecen en épocas de excesos de precipitaciones.Ponencia realizada sobre la base del Trabajo Final de Carrera de los alumnos F. Feo y E. Hernández, dirigido por el Dr. J. Sisti y co-dirigido por la Lic. V. Villamayor.Facultad de Ingenierí
Exosome mediated communication in cancer: melanoma and sarcoma models
Get PDFExosomes (EXOs) are nanovesicles of diameter ranging between 50 to 140 nm, distinguished from other cell-derived vesicles by their origin, size, morphology and composition. Their stimulatory or inhibitory signaling activities are mediated by their content (mRNAs, microRNAs and proteins) that can be transferred from the cells of origin to recipient cells, influencing the surrounding microenvironment besides cell behavior. In this study we investigated EXO-mediated communications in two cancer models, melanoma and Ewing’s sarcoma.
In view of our previous results demonstrating miR-221&222 as key factors for melanoma development and dissemination, we demonstrated that the EXO-mediated horizontal transfer of miR-222 was competent to deliver miR-222-associated properties increasing tumor malignancy.
Melanoma-purified vesicles were characterized and investigated for the functionality of miR-222 in EXO-mediated tumorigenesis. Our data showed that EXOs secreted by miR-222-overexpressing cells induced a protumorigenic program in target cells, mainly through the upmodulation of the PI3K/AKT pathway. The reverse effects were obtained with EXOs recovered after inhibition of endogenous miR-221 and miR-222 by antagomir transfections. The possible differential significance of PI3K/AKT blockade in miR-222-transduced vs control cells was assessed by using BKM120, a pan inhibitor of PI3K. Results showed the capability of miR-222 overexpression to overcome BKM120-dependent effects.
We then demonstrated the role of Ewing’s sarcoma-derived EXOs as mediators of signals involved in cancer growth, metastases and differentiation. Ewing’s sarcoma (EWS) is an aggressive childhood bone tumor characterized in the majority of cases by the presence of the fusion oncoprotein EWS-FLI1 and by high expression of the membrane glycoprotein CD99. These features, which are the necessary conditions for the pathogenesis of EWS, mediate tumor progression and maintain the cells in a dedifferentiated state. We evaluated the ability of EXOs, expressing or not CD99, to modulate the phenotype of EWS cells. We observed that the delivery of EXOs devoid of CD99 was sufficient to induce neural differentiation in EWS recipient cells through the inhibition of Notch-NF-kB signaling mediated by miR-34a overexpression.
All together these observations would provide a significant step toward new biomarker discovery and innovative therapeutic options. These data on one side support miR-222 responsibility in the exosome-associated melanoma properties, on the other the role of CD99-shRNA/miR-34a-derived EXOs to induce differentiation in EWS, thus further indicating microRNAs as potential diagnostic, prognostic and eventually therapeutic biomarkers
Dubet, F. e Duru-Bellat, M. (2020), L'école peut-elle sauver la démocratie?, Paris, Seuil
No full textHealth and sustainability: New gender perspectives
No full textAbstract: - European health systems face important challenges related to the sustainability of health care, both
from an economic point of view and in relation to the quality of health services provided in terms of continuous
improvement of effectiveness, safety, clinical and organisational appropriateness. The ability of EU Member
States to continue to provide high quality care to all, whatever their biological and socio-cultural characteristics,
depends on their health systems becoming more sustainable. Therefore, there is a need to strengthen health
promotion and disease prevention, to invest in primary care systems, to move health care out of the hospital and
into more accessible ambulatory and domestic care, and to develop integrated care practices.
Starting from these premises, the aim of this paper is to present a narrative overview of the main aspects related
to Gender Medicine and its evolution over time. Our critical overview is, therefore, aimed at providing a general
picture of what has been developed by health systems on Gender Medicine, with a particular focus on the
relationship between social sustainability and Gender Medicine.
To achieve our goal, we carry out a systematic literature review in order to understand what has been developed
so far in the area and to highlight the possible evolution of studies in the field and to strengthen the awareness of
the importance of encouraging prevention, training and information programs shared with hospitals, institutions,
health professionals and patient associations.
To the best of the authors' knowledge, this is among the first studies that investigate through a systematic literature
review the phenomenon of gender medicine, especially with reference to the sustainability of the health care
system. Although our analysis needs further investigation, due to the fact that the topic is not yet fully mature,
our initial and preliminary results underline the importance of further investigating gender diversity and assessing
the possibility of promoting a clinical pathway to personalised treatment. In fact, only through a “gender
medicine” approach it is possible to guarantee a real right to health and an effective personalisation of treatments,
thus reinforcing the concept of patient focussed care and contributing to the sustainability of the whole health
system
- …
