14 research outputs found
[Biological and clinical significance of glycocorticoid receptors in acute lymphatic leukemia].
No full text¿Puede la enseñanza de la historia cambiar las representaciones sociales de los chicos y las chicas?. Estudio de caso en jóvenes de Alicante
No full text1 recurso en línea (páginas 19-50).This article presents the results of a research project carried out in Benidorm (Alicante, Spain) during the period 2015-2016. It explores the social representations of young people between 16 and 18 years of age, in the face of the current political and economic situation: the causes, the solutions, and those responsible for the economic crisis. The adolescents that took part in this study are in secondary school, attend the same educational institution and come from similar socio-economic contexts. They were divided into two groups. One of the groups receives Contemporary History classes (Group A) and the other does not (Group B). The data was collected from a questionnaire with questions about the crisis, regarding images from the current socio-economic crisis and commentaries from historical sources about the crises of 1873, 1929 and 2008. The results show that the group that receives History classes is more critical when analyzing the current societal problems, as well as establishing analogies with the past to explain the situations of the present, whereas the other group reproduces the opinions of the media.Dans cet article nous présentons les résultats d’une enquête menée à Benidorm (Alicante, Espagne) pendant l’année scolaire 2015-2016. Le but était de connaître les représentations sociales des garçons et des illes entre 16 et 18 ans face à la réalité politique et économique actuelle : les causes, les responsables et les solutions de la crise économique. Les adolescent.e.s en question poursuivent leurs études dans le secondaire et appartiennent à deux classes de la même institution, partageant en outre un contexte socio-économique similaire. Cependant, alors que l’une des classes suit des cours d’Histoire Contemporaine (Groupe A), l’autre ne le fait pas (Groupe B). Pour mener l’enquête un questionnaire a été constitué autour de la crise, des images de l’actualité socio-économique et des commentaires de sources historiques à propos des crises de 1873, 1929 et 2008. Les résultats indiquent que le groupe suivant les cours d’histoire est plus critique lorsqu’il s’agit d’analyser les problèmes actuels de la société, établissant en plus des analogies avec le passé pour expliquer les situations du présent, tandis que l’autre groupe reproduit les opinions véhiculées par les médias.En este artículo se indaga sobre las representaciones sociales de chicos y chicas de 16 a 18 años ante la realidad política y económica actual: las causas, los culpables y soluciones a la crisis económica. Los y las adolescentes cursan estudios de Bachillerato en dos grupos del mismo centro educativo y provienen de contextos socioeconómicos similares, sin embargo, uno de los dos recibe las clases de Historia Contemporánea (Grupo A) y el otro no cursa la asignatura (Grupo B). Se recopila la información a partir de un cuestionario de preguntas sobre la crisis, en torno a imágenes de la actualidad socioeconómica y comentarios de fuentes históricas sobre las crisis de 1873, 1929 y 2008. Los resultados muestran que el grupo que recibe las clases de Historia es más crítico a la hora de analizar los problemas actuales de la sociedad, además de establecer analogías con el pasado para explicar las situaciones del presente, mientras que el otro grupo reproduce las opiniones de los medios de comunicación.Bibliografía y webgrafía: páginas 47-50.Artículo de Investigación e Innovación
Problematizando o aleitamento materno :: visando uma prática consciente /
No full textDissertação (Mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde
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Consumer purchasing behaviour towards fish and seafood products: patterns and insights from a sample of international studies
No full textThe present systematic review was performed to assess consumer purchasing behaviour towards fish and seafood products in the wide context of developed countries. Web of Science, Scopus, ScienceDirect and Google Scholar engines were used to search the existing literature and a total of 49 studies were identified for inclusion. These studies investigated consumer purchasing behaviour towards a variety of fish and seafood products, in different countries and by means of different methodological approaches. In particular, the review identifies and discusses the main drivers and barriers of fish consumption as well as consumers’ preferences about the most relevant attributes of fish and seafood products providing useful insights for both practitioners and policy makers. Finally, main gaps of the existing literature and possible trajectories for future research are also discussed
EBV DNA increase in COVID-19 patients with impaired lymphocyte subpopulation count
No full textObjectives: The immunologic profile and opportunistic viral DNA increase were monitored in Italian patients with COVID-19 in order to identify markers of disease severity.Methods: A total of 104 patients infected with SARS-CoV-2 were evaluated in the study. Of them, 42/104 (40.4%) were hospitalized in an intensive care unit (ICU) and 62/104(59.6%) in a sub-intensive care unit (SICU). Human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV), Parvovirus B19 and Human Herpesvirus 6 virus reactivations were determined by real-time PCR, and lymphocyte subpopulation counts were determined by flow cytometry.Results: Among opportunistic viruses, only EBV was consistently detected. EBV DNA was observed in 40/42 (95.2%) of the ICU patients and in 51/61 (83.6%) of the SICU patients. Comparing the two groups of patients, the EBV DNA median level among ICU patients was significantly higher than that observed in SICU patients. In parallel, a significant reduction of CD8 T cell and NK count in ICU patients as compared with SICU patients was observed (p < 0.05). In contrast, B cell count was significantly increased in ICU patients (p = 0.0172).Conclusions: A correlation between reduced CD8(+) T cells and NK counts, EBV DNA levels and COVID-19 severity was observed. Other opportunistic viral infections were not observed. The relationship between EBV load and COVID-19 severity should be further evaluated in longitudinal studies. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases
Severe acute respiratory syndrome coronavirus 2 RNA contamination of inanimate surfaces and virus viability in a health care emergency unit
No full textObjectives: To detect possible severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA contamination of inanimate surfaces in areas at high risk of aerosol formation by patients with coronavirus disease 2019 (COVID-19). Methods: Sampling was performed in the emergency unit and the sub-intensive care ward. SARS-CoV-2 RNA was extracted from swabbed surfaces and objects and subjected to real-time RT-PCR targeting RNA-dependent RNA polymerase and E genes. Virus isolation from positive samples was attempted in vitro on Vero E6 cells. Results: Twenty-six samples were collected and only two were positive for low-level SARS-CoV-2 RNA, both collected on the external surface of continuous positive airway pressure helmets. All transport media were inoculated onto susceptible cells, but none induced a cytopathic effect on day 7 of culture. Conclusions: Even though daily contact with inanimate surfaces and patient fomites in contaminated areas may be a medium of infection, our data obtained in real-life conditions suggest that it might be less extensive than hitherto recognized
EBV DNA increase in COVID-19 patients with impaired lymphocyte subpopulation count
No full textObjectives: The immunologic profile and opportunistic viral DNA increase were monitored in Italian patients with COVID-19 in order to identify markers of disease severity. Methods: A total of 104 patients infected with SARS-CoV-2 were evaluated in the study. Of them, 42/104 (40.4%) were hospitalized in an intensive care unit (ICU) and 62/104(59.6%) in a sub-intensive care unit (SICU). Human cytomegalovirus (HCMV) and Epstein-Barr virus (EBV), Parvovirus B19 and Human Herpesvirus 6 virus reactivations were determined by real-time PCR, and lymphocyte subpopulation counts were determined by flow cytometry. Results: Among opportunistic viruses, only EBV was consistently detected. EBV DNA was observed in 40/42 (95.2%) of the ICU patients and in 51/61 (83.6%) of the SICU patients. Comparing the two groups of patients, the EBV DNA median level among ICU patients was significantly higher than that observed in SICU patients. In parallel, a significant reduction of CD8 T cell and NK count in ICU patients as compared with SICU patients was observed (p < 0.05). In contrast, B cell count was significantly increased in ICU patients (p = 0.0172). Conclusions: A correlation between reduced CD8+ T cells and NK counts, EBV DNA levels and COVID-19 severity was observed. Other opportunistic viral infections were not observed. The relationship between EBV load and COVID-19 severity should be further evaluated in longitudinal studies
Tocilizumab for treatment of severe covid-19 patients: Preliminary results from smatteo covid19 registry (smacore)
No full textObjective: This study aimed to assess the role of Tocilizumab therapy (TCZ) in terms of ICU admission and mortality rate of critically ill patients with severe COVID-19 pneumonia. Design: Patients with COVID-19 pneumonia were prospectively enrolled in SMAtteo COvid19 REgistry (SMACORE). A retrospective analysis of patients treated with TCZ matched using propensity score to patients treated with Standard Of Care (SOC) was conducted. Setting: The study was conducted at IRCCS Policlinico San Matteo Hospital, Pavia, Italy, from March 14, 2020 to March 27, 2020. Participants: Patients with a confirmed diagnosis of COVID-19 hospitalized in our institution at the time of TCZ availability. Interventions: TCZ was administered to 21 patients. The first administration was 8 mg/kg (up to a maximum 800 mg per dose) of Tocilizumab intravenously, repeated after 12 h if no side effects were reported after the first dose. Main Outcomes and Measures: ICU admission and 7-day mortality rate. Secondary outcomes included clinical and laboratory data. Results: There were 112 patients evaluated (82 were male and 30 were female, with a median age of 63.55 years). Using propensity scores, the 21 patients who received TCZ were matched to 21 patients who received SOC (a combination of hydroxychloroquine, azithromycin and prophylactic dose of low weight heparin). No adverse event was detected following TCZ administration. This study found that treatment with TCZ did not significantly affect ICU admission (OR 0.11; 95% CI between 0.00 and 3.38; p = 0.22) or 7-day mortality rate (OR 0.78; 95% CI between 0.06 and 9.34; p = 0.84) when compared with SOC. Analysis of laboratory measures showed significant interactions between time and treatment regarding C-Reactive Protein (CRP), alanine aminotransferase (ALT), platelets and international normalized ratio (INR) levels. Variation in lymphocytes count was observed over time, irrespective of treatment. Conclusions: TCZ administration did not reduce ICU admission or mortality rate in a cohort of 21 patients. Additional data are needed to understand the effect(s) of TCZ in treating patients diagnosed with COVID-19
Severe acute respiratory syndrome coronavirus 2 RNA contamination of inanimate surfaces and virus viability in a health care emergency unit
No full textObjectives: To detect possible severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA contamination of inanimate surfaces in areas at high risk of aerosol formation by patients with coronavirus disease 2019 (COVID-19).Methods: Sampling was performed in the emergency unit and the sub-intensive care ward. SARS-CoV-2 RNA was extracted from swabbed surfaces and objects and subjected to real-time RT-PCR targeting RNAdependent RNA polymerase and E genes. Virus isolation from positive samples was attempted in vitro on Vero E6 cells.Results: Twenty-six samples were collected and only two were positive for low-level SARS-CoV-2 RNA, both collected on the external surface of continuous positive airway pressure helmets. All transport media were inoculated onto susceptible cells, but none induced a cytopathic effect on day 7 of culture.Conclusions: Even though daily contact with inanimate surfaces and patient fomites in contaminated areas may be a medium of infection, our data obtained in real-life conditions suggest that it might be less extensive than hitherto recognized. (C) 2020 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved
