1,721,035 research outputs found
Organizzazione sanitaria attuale dei servizi per la diagnosi e la cura dei disturbi climaterici: Friuli-Venezia Giulia.
No full textInterleukin-8 (IL-8) response impairment in a subgroup of women with bacterial vaginosis
No full textDietary soy supplementation and phytoestrogen levels
No full textOBJECTIVE: To investigate the relationship between levels of phytoestrogens in blood and urine and symptom control in postmenopausal women whose diets were supplemented with soy containing high levels of phytoestrogen.
METHODS: Phytoestrogen levels in blood and urine were correlated with the number of hot flushes and vaginal maturation indices in 104 postmenopausal women whose diets were supplemented with 60 g of soy powder daily for 3 months in a double-masked, parallel, placebo-controlled trial. The effect of soy supplementation on menopausal symptoms in this study population was reported previously.
RESULTS: Serum levels of genistin, daidzin, and equol were significantly higher in women after soy diet supplementation (+756%, +593%, +1008%, and 57% respectively). The concentration of enterolactone in the soy group was increased by 57% compared with baseline, but the difference with placebo was not statistically significant. The increase in phytoestrogen levels in the soy group in blood or urine did not correlate with fewer hot flushes. Vaginal maturation indices did not change in the soy group.
CONCLUSION: Phytoestrogen levels increased in women who consumed soy supplement, but that does not fully explain climacteric symptom reduction. It is possible that other types of yet unknown phytoestrogens or components in soy other than phytoestrogen influence hot flushe
Interrelationships of interleukin-8 with interleukin-1beta and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women
No full textThe effect of dietary soy supplementation on hot flushes
No full textOBJECTIVE: To assess the effect of daily dietary supplementation of soy protein isolate powder on hot flushes in postmenopausal women.
METHODS: We carried out a double-blind, parallel, multicenter, randomized placebo-controlled trial of 104 postmenopausal women. Fifty-one patients (age range 48-61 years) took 60 g of products containing 40 g of isolated soy protein [corrected] daily and 53 patients (age range 45-62 years) took 60 g of placebo (casein) daily. The study lasted 12 weeks. Using analysis of covariance, we analyzed changes from baseline in mean number of moderate to severe hot flushes (including night sweats) during treatment.
RESULTS: Soy was significantly superior to placebo (P < .01 in reducing the mean number of hot flushes per 24 hours after 4, 8, and 12 weeks of treatment. In particular, women taking soy had a 26% reduction in the mean number of hot flushes by week 3 and a 33% reduction by week 4 (P < .001 by the Wilcoxon exact test). By the end of the 12th week, patients taking soy had a 45% reduction in their daily hot flushes versus a 30% reduction obtained with the placebo (P < .01). The overall rates of adverse effects were similar for soy and casein-placebo. Twenty-five patients dropped out of the study: 11 in the soy group and 14 in the placebo group. Gastrointestinal side effects were the most common cause of premature withdrawal from the study (seven patients in each group).
CONCLUSION: Soy protein isolate added daily to the diet substantially reduced the frequency of hot flushes in climacteric wome
Neutral effect of prolonged transdermal hormone therapy on liver function in postmenopausal women with chronic active hepatitis
No full textObjective: To test whether transdermal hormone therapy can be safely administered to postmenopausal
women with chronic viral hepatitis B and/or C.
Design: Eighty-one postmenopausal women with chronic viral hepatitis B and/or C and with
severe vasomotor symptoms were treated for 5 years with transdermal estradiol (50 mg/day) continuously
and with transdermal norethisterone (250 mg/day) for 14 days of every 28-day cycle.
Another 95 women with viral chronic hepatitis but without climacteric symptoms were used
as controls. Liver enzymes (glutamic-oxalacetic transaminase, glutamic-pyruvic transaminase,
g-glutamine-transferase, and alkaline phosphatase) were measured every year.
Results: At baseline, liver enzymes were similar in the two groups, with the exception of g-GT,
which was slightly higher in untreated women (P , 0.01). Liver enzymes did not significantly vary
with time in hormone-treated and untreated women. No significant difference was observed between
the two groups.
Conclusions: Transdermal estradiol and norethisterone can be safely administered for a prolonged
period to postmenopausal women with chronic viral B and/or C hepatitis
Interrelationships of interleukin-8 with interleukin-1beta and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women
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