171,932 research outputs found
Characterizing the firing properties of an adaptive analog VLSI neuron
No full textBen Dayan Rubin D, Chicca E, Indiveri G. Characterizing the firing properties of an adaptive analog VLSI neuron. Biologically Inspired Approaches to Advanced Information Technology. 2004;3141:189-200.We describe the response properties of a compact, low power, analog circuit that implements a model of a leaky-Integrate & Fire (I&F) neuron, with spike-frequency adaptation, refractory period and voltage threshold modulation properties. We investigate the statistics of the circuit's output response by modulating its operating parameters, like refractory period and adaptation level and by changing the statistics of the input current. The results show a clear match with theoretical prediction and neurophysiological data in a given range of the parameter space. This analysis defines the chip's parameter working range and predicts its behavior in case of integration into large massively parallel very-large-scale-integration (VLSI) networks
Emerging technologies in face and body contouring/ [edited by] Spero J. Theodorou, Christopher T. Chia, Erez Dayan.
No full textIncludes bibliographical references and index."Emerging Technologies in Face and Body Contouring by internationally acclaimed experts Spero Theodorou, Christopher Chia, Erez Dayan and esteemed contributors, details emerging state-of-the-art technologies in minimally-invasive body contouring. This resource fills a void in the literature, providing plastic, aesthetic, and dermatologic surgeons with clinical insights on the latest proven techniques in nonsurgical fat reduction and skin tightening. The book begins with chapters on 3D imaging for emerging body contouring technologies, clinically applicable concepts of fat metabolism, and discussion of laser and ultrasound. Procedural chapters cover a diverse array of cutting-edge noninvasive body contouring and VASER techniques, including water-assisted and power-assisted liposuction. Chapters dedicated to the face and neck detail scarless face lifting, injection lipolysis, and radiofrequency skin tightening. Body-specific chapters focus on the neck, arms, abdomen, flanks and hips, gluteal region, thighs and calves, ankles and knees"--Three-dimensional Imaging for Emerging Technologies in Body Contouring / Isabel Robinson and Pierre Saadeh -- Clinically Applicable Concepts of Fat Metabolism / Rachel L. Goldstein, William G. Austen Jr., and Erez Dayan -- Noninvasive Laser Body Contouring / John W. Decorato -- Ultrasound in Noninvasive Body Shaping / Jennifer Croix and Anne Chapas -- Three-dimensional Cryolipolysis Body Contouring / Villy Rodopoulou -- Noninvasive Radiofrequency Fat Destruction for Body Contouring / Alix O'Brien and Sherrell J. Aston -- The Role of Stem Cells in Body Contouring / Aris Sterodimas -- Ethnic Considerations in Liposuction / William Lao -- Laser-Assisted Liposuction Under Local Anesthesia : Office-Based Surgery / Christopher Chia -- Radiofrequency-Assisted Liposuction for Body Contouring / Spero J. Theodorou, Christopher T. Chia, and Erez Dayan -- VASER Technology for Body Contouring / Alfredo Hoyos and Mauricio Perez -- Water-Assisted Liposuction / Pei-Hsuan Lu and Hsiang-Ya Wang -- Power-Assisted Liposuction Cannula Types and Technique / Briar L. Dent and B. Aviva Preminger -- Scarless Face Lifting with Bipolar Radiofrequency Assistance / Diane Irvine Duncan -- Injection Lipolysis-Neck / Sachin M. Shridharani -- Neck : Radiofrequency Liposuction / Keramidas Evangelos -- Neck Liposuction : The Classic Technique / Steven M. Levine -- Radiofrequency-Assisted Liposuction for Arm Contouring / Spero J. Theodorou, Christopher T. Chia, and Stelios C. Wilson -- FaceTite : Procedure Technique / P. Paolo Rovatti -- Male Gynecomastia Treatment / Alfredo Hoyos and David Guarin -- High Definition Body Contouring of the Abdomen / Alfredo Hoyos and David Guarin -- Flanks and Hips / Spero J. Theodorou -- Gluteal Augmentation with Implants / Douglas Senderoff -- Technology-Based Contouring of the Thighs / W. Jason Martin -- Calf, Ankle, and Knee Contouring / Christopher, Chia Stelios C. Wilson, and Gerald H. Pitman.1 online resourc
Liking
No full textBerridge and Dayan outline the psychological and neural basis of the hedonic concept of 'liking', and its relationship with close, but not always consonant, motivational cousin, 'wanting'
Gene ontology defines pre‐post‐hatch energy dynamics in the complexus muscle of broiler chickens
No full textBackground. Chicken embryos emerge from their shell by the piercing movement of the hatching muscle. Although considered a key player during hatching, with activity that imposes a substantial metabolic demand, data are still limited. The study provides a bioenergetic and transcriptomic analyses during the pre-post-hatching period.
Methods. Weight and morphology alongside content determination of creatine and glycogen were analysed. Transcriptome identified differentially expressed genes and enriched biological processes associated with hatching muscle development, catabolism, and energy provision. Using gene set enrichment, we followed the dynamics
of gene-sets involved in energy pathways of oxidative phosphorylation, protein catabolism, glycolysis/gluconeogenesis,
and glycogen metabolism.
Results. Results show several significant findings: (A) Creatine plays a crucial role in the energy metabolism of the hatching muscle, with its concentration remaining stable while glycogen concentration is depleted at hatch and placement. (B) The hatching muscle has the capacity for de-novo creatine synthesis, as indicated by the expression of related genes (AGAT, GAMT). (C) Transcriptome provided insights into genes related to energy pathways under conditions of pre-hatch oxygen and post-hatch glucose limitations (oxidative phosphorylation: NDUF, MT-ND, SDH, UQCR, COX, MT-CO, ATP5, MT-ATP; glycolysis/gluconeogenesis: FBP,G6PC, PFKM; glycogen metabolism: PPP1, PYGL, GYG1). (D) The post-hatch upregulation of protein catabolic processes genes (PSMA, RNF, UBE, FBX), which align
with the muscle’s weight dynamics, indicates a functional shift from movement during hatching to lifting the head during feeding.
Conclusions. There is a dynamic metabolic switch in the hatching muscle during embryo-to-hatchling transition. When glycogen concentration depletes, energy supply is maintained by creatine and its de-novo synthesis. Understanding the hatching muscle’s energy dynamics is crucial, for reducing hatching failures in endangered avian species, and in domesticated chickens
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mosu dayan Lin & Li, 2013, new species
No full textMosu dayan new species Figs 1 –6, 26 Type material: Holotype: male (IZCAS), Dayan Cave (25 ° 34.263´N, 110 ° 36.594´E; altitude 355 m), Dayan Village, Hucheng Town, Xing’an County, Guangxi, China, 12 July 2009, Z.Y. Yao and C.X. Wang. Paratypes: 1 male and 3 females, same data as holotype (IZCAS). Etymology. The species epithet is a noun in apposition taken from the Dayan Cave, the locality of the collected types. Diagnosis. The female of Mosu dayan n. sp. is similar to M. huogou Miller, Griswold & Yin, 2009, but can be distinguished by the presence of a rounded copulatory basal stem, the presence of dorsal plate in posterior to the spermathecae, and the wide, sclerotized copulatory atrium (Figs 3 B, 6 B). The male can be distinguished by the presence of a long tibial apophysis and a large, long cymbial process (Figs 2 A–C, 5 A–C). Description. Male: holotype (Figs 1 A–C), total length 0.84. Prosoma 0.46 long, 0.46 wide, 0.30 high. Carapace of prosoma rounded, brown. Thoracic pars smooth, cephalic pars raised. Ocular area at apex, black, covered with few setae. Eight eyes in two rows. AME black, others white. AME, ALE and PLE round, PME ovate. In dorsal view, AER slightly recurved, PER straight, AER as wide as PER; ALE and PLE contiguous. All eyes surrounded by black rings. Clypeus 0.18 high, 5.2 x AME diameter; ALE separated by about 3.2 x its diameter from anterolateral edge of carapace. Chelicerae brown, slightly shorter than endites. Labium brown, fused to sternum, endites with serrula. Sternum 0.30 long, 0.29 wide, heart-shaped, dark brown, with a light vertical stripe in midline. Legs yellow brown, each segment lightest proximally. Leg formula: I-II-IV-III. Leg measurements: I 1.96 (0.63, 0.21, 0.45, 0.34, 0.34); II 1.66 (0.50, 0.20, 0.36, 0.27, 0.34); III 1.07 (0.34, 0.13, 0.20, 0.18, 0.23); IV 1.34 (0.43, 0.14, 0.29, 0.23, 0.25). Leg I with a ventral sclerotized spot on femur subdistally, a row of setae on tibia prolaterally, and a bent clasping spine on prolateral metatarsus (Fig. 4 C). Patellae I–IV with a dorsally distal seta; tibiae I–IV with a dorsal proximal seta. Tibiae I–III with 3 trichobothria; tibia IV with 4 trichobothria. Opisthosoma 0.52 long, 0.48 wide, 0.68 high, round dorsally, dark brown, with a pair of white spots on abdominal dorsum. Pedipalp large (Figs 2 A–C; 5 A–C). Femur without modification. Patella short, with a few setae. Tibia swollen, askew cup-shaped, covered with long setae, tibial brim extending to form a long retro-dorsal apophysis. Cymbium membranous, translucent, with a sclerotized long process and a cluster of long setae on cymbial fold. Subtegulum smooth, distinctly sclerotized. Tegulum membranous, rugose. Spermatic duct visible through wrinkled tegulum. Embolus long, coiling into two loops under tegulum and reaching to distal cymbium. Female: Total length 1.09 (one of paratypes) (Figs 1 D–F). Prosoma 0.52 long, 0.48 wide, 0.23 high. Coloration and shape same as in male but cephalic pars lower. Clypeus 0.11 high, distinctly lower than in male. Sternum 0.32 long, 0.30 wide. Leg formula: I-II-IV-III. Leg measurements: I 2.13 (0.71, 0.21, 0.50, 0.36, 0.34); II 1.73 (0.55, 0.20, 0.39, 0.29, 0.30); III 1.23 (0.38, 0.16, 0.23, 0.21, 0.25); IV 1.55 (0.52, 0.16, 0.34, 0.27, 0.27). Femora I and II with a ventral sclerotized spot distally. Setae and trichobothria of each leg as in male except for lacking a row of tibial setae and a metatarsal clasping spine on prolateral leg I. Opisthosoma as in male, 0.71 long, 0.71 wide, 0.89 high. Epigynum rugose (Figs 3 A–B, 4 A–B, 6 A–B), covered with long setae, margin posteriorly protruded. Internally with complex dorsal plates posterior to spermathecae. Spermathecae egg-shaped, strongly sclerotized. Fertilization ducts short, deriving from inner side of spermathecae. Copulatory ducts intricate, with looped and coiled trajectory, arising from lateral spermathecae, forming a membranous sac on dorsal spermathecae, extending to ventral spermathecae. Sclerotised copulatory ducts connected with atrium, attaching to a rounded copulatory basal stem. Copulatory opening situated at posterior margin of epigynum. Variation. The total length ranges from 0.82 to 0.84 in males (n = 2) and from 1.04 to 1.11 in females (n = 3). Distribution. Known only from the type locality (Fig. 26).Published as part of Lin, Yucheng & Li, Shuqiang, 2013, Five new minute orb-weaving spiders of the family Mysmenidae from China (Araneae), pp. 449-481 in Zootaxa 3670 (4) on pages 450-457, DOI: 10.11646/zootaxa.3670.4.3, http://zenodo.org/record/24921
sj-docx-1-pss-10.1177_0956797621996660 – Supplemental material for Search for the Unknown: Guidance of Visual Search in the Absence of an Active Template
No full textSupplemental material, sj-docx-1-pss-10.1177_0956797621996660 for Search for the Unknown: Guidance of Visual Search in the Absence of an Active Template by Oryah C. Lancry-Dayan, Matthias Gamer and Yoni Pertzov in Psychological Science</p
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Evolution of resistance to phytoene desaturase and protoporphyrinogen oxidase inhibitors - state of knowledge
No full textAbstract not availableFranck E Dayan, Daniel K Owens, Patrick J Tranel, Christopher Preston and Stephen O Duk
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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