44 research outputs found
Management of Oral Hydroxyurea-Related Ulcers: A Cases Series
No full textHydroxyurea (HU) is an anti-cancer agent commonly used in myeloproliferative Philadelphia negative disorders as polycythemia vera (PV), essential thrombocitosis (ET) and myelofibrosis (MF). [...
Report of the use of topical ozone together with professional oral hygiene procedures in patient with gingival mucous membrane pemphigoid
No full textDiagnosis of Oral Pemphigus Vulgaris: from histological studies to new serological methods
No full textChanging epidemiology of HCV infection in patient with oral lichen planus in North-West Italy
No full textoral lichen planus (OLP) is a chronic inflammatory condition, affecting roughly 1.5-2% of the total population, women almost more than twice as men; patients of all ages could be interested, more frequently in the fifth to sixth decades of life (Arduino, 2017). This article is protected by copyright. All rights reserved
A report on the clinical-pathological correlations of 788 gingival lesion
No full textThe diagnosis and treatment of a variety of non-plaque related gingival diseases have become an integrated aspect of everyday dentistry. The aim of this study was to analyse the relationship between clinical appearance and histopathological features of gingival lesions in a large Northern Italian population. A retrospective study of 788 cases of gingival and alveolar mucosal biopsies was set up. Statistical analysis was performed by calculating the odds ratio and 95% confidence interval (C.I.), in order to assess the degree of association between the clinical parameters considered (primary lesions) and the single pathologies, statistically evaluated by Mantel-Haenszel tests. The correlation between clinical and histological diagnosis was classified as follow: 1) expected data (ED): provisional clinical diagnosis; 2) real data (RD): final histopathology diagnosis; 3) concordant data (CD): correspondence between the expected data and real data. The correlation was calculated as follow: CC (complete concordance) = CD x 100 / ED, this expressing the percentage in which the clinical and the histological diagnosis overlapped. The most frequently observed and biopsied primary lesions resulted to be exophytic, followed by mucosal colour changes and finally by losses of substance. The statistically significant association between primary lesion and their manifestation in gingival pathologies was reported. Volume increases, for instance, were positively correlated to plasma cell epulis, pyogenic granuloma, fibrous reactive hyperplasia and hemangioma. Verrucous-papillary lesions were most often seen in verrucous carcinoma, verrucous leukoplakia and mild dysplasia. White lesion resulted to be related to leukoplakia or oral lichen planus. Red lesions resulted to be related only oral lichen planus. Erosive vesicle-bullous lesions were linked to disimmune pathologies. Ulcerative lesions were positively associated to oral squamous cell cancer. Finally, potentially malignant disorders have the most percentage high concordance. Among the malignant lesions, the correlation increased up to the squamous cell carcinoma and leukaemia. This article presented the frequency and the clinico-pathological concordance of all primary lesions and the histopathological diagnosis of gingival lesions. For every primary lesion, it is possible to correlate a specific histopathological diagnosis in a statistical manner. This can be a valuable aid for not specialist clinicians who daily observe mucosae and have the opportunity to intercept major diseases
Plexin-B3 is a functional receptor for semaphorin 5A
No full textSemaphorins are a large family of molecular cues implicated in neural development and in a variety of functions outside the nervous system. Semaphorin 5A (Sema5A) is a transmembrane semaphorin, containing seven thrombospondin type-1 repeats, which was recently found to control axon guidance. Here we show that plexin-B3 is a high-affinity receptor specific for Sema5A. We further demonstrate that plexin-B3 activation by Sema5A mediates functional responses in plexin-B3-expressing cells (either fibroblasts, epithelial and primary endothelial cells). in addition, Sema5A can trigger the intracellular signalling of the hepatocyte growth factor/scatter factor receptor, Met, associated in a complex with plexin-B3. We thus conclude that Sema5A is able to elicit multiple functional responses through its receptor plexin-B3
The prompt use of rituximab could decrease adverse effects in patient with pemphigus vulgaris: a preliminary evaluation
No full textBackground: The systemic use of corticosteroid is the treatment of choice for pa-
tients with pemphigus vulgaris (PV), but adverse effects are frequent. To date, the
use of rituximab (RTX) for PV patients is usually indicated when they failed first-line
immunosuppressive therapies. The early use of RTX could theoretically lessen ad-
verse effects.
Methods: We performed a single-center study on patients with predominantly oral
PV, treated with systemic corticosteroid and the prompt use of 1000 mg of intra-
venous RTX two weeks apart. We evaluated the clinical response and the reported
adverse effect during a period of 24 months, comparing those with a previously pub-
lished series.
Results: The study group comprised 11 patients, while the control group com-
prised 98 patients. The average time to achieve complete clinical remission was
3.2 ± 2.72 months. Study group took steroids for a mean time of 11.09 ± 2.02 months,
and they are all actually disease-free with no medication. Only three patients (27.3%)
developed plain side effects. The effect of the length of the corticosteroid therapy
on the side effects (also adjusted by sex, age, and clinical oral involvement) was sta-
tistically different in the two groups: the prompt use of RTX reduced of 94% the
chance to have adverse effects (P = .001).
Conclusions: This is the first report of the use of RTX as first line of therapy for
PV patients with predominantly oral involvement. With the proposed regimen, the
adverse effects have been minimized compared with classic systemic corticosteroid-
centered therapy. Multi-center randomized controlled trail is however necessary
testo atlante di patologia gengivale non placca correlata, Valutazioni cliniche e protocolli terapeutici- seconda edizione
No full textA Randomized Controlled Trial on Efficacy of Surgical Excision of non-dysplastic Leukoplakia to Prevent Oral Cancer
No full textThe aim of this study was to evaluate the effectiveness of surgical excision to prevent cancer in patients with nondysplastic oral leukoplakia (OL). This study was the first randomized controlled clinical trial comparing surgical treatment with standard care in this group of patients. Patients were divided into two groups. The first group underwent standard care, that is smoking counseling, follow-up visits every 6 months, and control biopsy when indicated. The second group underwent surgical excision, together with standard care. Oral cancer onset was the primary outcome; secondary outcomes included healing, recurrence after surgery, onset of new lesions, and worsening of the primary lesions. The differences in distribution of the patients' and lesions' characteristics were investigated through nonparametrical tests (Wilcoxon rank-sum and Fisher exact). Univariate and multivariate logistic regressions have been performed to estimate the odds ratio of the treatment on the recurrence or worsening of the lesions. A total of 260 patients took part in the study of which 132 were women (50.8%); during the follow-up period, two subjects developed oral cancer, one for each arm. Surgical treatment, when compared with standard care, was associated with a lower probability of the treated zone to remain healed during the follow up period (OR = 7.43; 95% confidence interval, 2.96-22.66). In conclusion, it is possible to assumed that regular clinical follow-up could be considered a reliable standard of care among patients with nondysplastic OLs. PREVENTION RELEVANCE: Oral white patches can transform into cancer and none has provided clinical guidelines to prevent it. For the first time ever, we have showed that the clinical follow up of non dysplastic lesions was able to provide benefits if compared with surgical excision
Clinical features and histological description of tongue lesions in a large Northern Italian population
No full textOnly few studies on tongue lesions considered sizable populations, and contemporary literature does not provide a valid report regarding the epidemiology of tongue lesions within the Italian population. In this report, the histopathological and clinical appearance of 1.106 tongue lesions from northern Italians are described and discussed
