28 research outputs found
Session 2 : Pratiquer la donnée
No full text- Aliou Badji (GÉRIICO, Université de Lille) : La donnée, une aide à l’élaboration de stratégies de communication ?
- Dany Baillargeon, Loic-Alexandre Rousseau (Université de Sherbrooke) : Créativité et IA, intégration des robots conversationnels et autres IA dans les pratiques professionnelles - Pudens Malibabo Lavu, (Observatoire de Recherche sur les Médias, Université catholique de Louvain) : Enjeux de l’évaluation et de l’amélioration de la qualité des données. État de l’art et quelques pistes de recherches et d’actions en matière des données énergétiques
- Marie-Ève Carignan, Olivier Champagne-Poirier, Marc D. David, Carol-Ann Rouillard (Université de Sherbrooke) : Les données publiques et en libre accès pour penser la communication en temps de crise : perspectives professionnelles et de recherch
Loss of α5β1-mediated adhesion of monocytic cells to fibronectin by interferons β and γ is associated with changes in actin and paxillin cytoskeleton
No full textSortir de la Grande Noirceur grâce aux documents d’archives
No full textL’objectif de ce texte est de montrer l’importance de l’acquisition, de la conservation et du classement des documents d’archives pour cerner notre histoire et éviter que le récit historique devienne une construction mythique sans fondement véritable. Les bibliothécaires et les archivistes sont en quelque sorte les gardiens de la mémoire d’une société. Il appartient aux historiens de consulter ces documents pour comprendre et interpréter le passé. Malheureusement, ce n’est pas ce cheminement qui s’est imposé dans la représentation de l’histoire du Québec contemporain qui domine encore notre mémoire collective, selon laquelle le Québec francophone d’avant 1960 est une société monolithique et ultraconservatrice, qui serait entrée de plain-pied dans la modernité à l’occasion de la Révolution tranquille. Cette vision du passé, portée par des intellectuels impatients d’en finir avec le régime de Maurice Duplessis et influencée par une lecture de l’histoire du Québec mise de l’avant par plusieurs sociologues, repose sur une recherche historique très sommaire. Elle est remise en question à partir des années 1970 par des historiens intéressés à l’histoire du Québec récent, dont la formation et la méthodologie les portent à accorder une importance primordiale à la consultation de fonds d’archives. Leurs travaux apportent un nouvel éclairage sur l’histoire du Québec depuis la Confédération. Loin d’être une société figée où règne l’unanimité sociale, il apparaît que le pouvoir clérical est contrebalancé par d’autres forces venant des milieux politiques et syndicaux. Il en ressort l’image d’une société, sans doute distincte, mais aussi diversifiée. C’est ce que l’auteur montre à partir de travaux qu’il a réalisés depuis plus de quarante ans portant sur divers aspects de l’histoire du Québec. La représentation misérabiliste du passé sous le signe de la Grande Noirceur et de l’impuissance est un mythe qui affecte la psychologie collective des Québécois et Québécoises, les porte à rejeter une large portion de leur passé et contribue à ternir leur sens d’identité.The objective of this text is to show the importance of the acquisition, preservation and arrangement of archival documents in contributing to an understanding our history and in avoiding the situation where historical accounts are mythic constructs without real foundation. Librarians and archivists are in a way the guardians of the memory of society. It is the job of historians to consult the documentary record to understand and interpret the past. Unfortunately, this has not been the practice in presenting the history of Quebec which now dominates our collective memory; according to contemporary Quebec history, Francophone Quebec before 1960 was a monolithic, ultraconservative society, which plunged into modernity at the time of the Quiet Revolution. This vision of the past, held by intellectuals impatient to get over the Maurice Duplessis regime, and influenced by a reading of the history of Quebec that was put forward by a number of sociologists, is based on minimal historical research. It has been questioned since the 1970s by historians who are interested in the recent history of Quebec and whose formation and methodology have led them to believe that consulting archival fonds is of basic importance in their work. Their studies are shedding new light on the post-Confederation history of Quebec. Far from being a hidebound society in which social unanimity ruled, it appears that the power of the clergy was checked by other forces from the political and union milieux. An image is emerging of a society, distinct, but also diversified. The author shows this from work that he has done over more than forty years on various aspects of the history of Quebec. The “miserabilist” representation of the past under the sign of the Great Darkness and of impotence is being shown to be a myth that affects the collective psychology of the people of the Québécois and Québécoises, influencing them to reject a large swath of their past and tarnishing their sense of identity
The pag gene product, a physiological inhibitor of c-abl tyrosine kinase, is overexpressed in cells entering S phase and by contact with agents inducing oxidative stress
No full textAbstractThe human pag gene product is an inhibitor of the c-abl tyrosine kinase and belongs to a new family of proteins. We show here that higher levels of pag gene expression are observed following induction of proliferation and contact with compounds inducing oxidative stress such as diethyl maleate and sodium arsenate. A weaker overexpression is seen in a macrophage cell line using hydrogen peroxide or menadione as inducers. Pag gene expression increases in synchronized cells entering the S phase. This raises the possibility that elevated levels of pag counteract the cytostatic activity of abl. Treatment of growth arrested cells with diethyl maleate and sodium arsenate induces pag gene overexpression, independently of cell proliferation. Thus, enhanced pag gene expression occurs in two cellular events: proliferation and response to oxidative stress
Synergistic effect of prolactin on IFN-γ-mediated growth arrest in human monoblastic cells: correlation with the up-regulation of IFN-γ receptor gene expression
No full textγ-Glutamyl transpeptidase expression in Ewing's sarcoma cells:up-regulation by interferons
No full textLament for a Nation (The Defeat of Canadian Nationalism) by George P. Grant
No full textA few years back, I had decided that I would not write a traditional "mémoire" for my Master's degree; instead, I would translate a book, a special kind of book. Translating a work of the creative imagination (e.g. a novel) did not particularly interest me at that time, but I was dravn to writings of philosophical exposition. That is why the suggestion that I translate George Grant's Lament for a Nation vas very welcome. I must admit that neither the title nor the author were then known to me. On inquiring about them, I soon found out that only an "élite" seemed to have had the opportunity of reading George Grant's writing. These persons all agreed that Lament for a Nation was an excellent work which deserved a better fate than the status of minor Canadian classic, revered but largely unread. Lament for a Nation instantly appealed to me. I accordingly decided to explore why it did so. To my surprise, the book reminded me of those small classics we had had to read during our college years, weighty in thought, terse in expression. The dark, sometimes gnarled style repelled me at first, but as I read along, I eventually achieved a kind of complicity and deep interest in Grant's meditation. I have never been a politically involved person. But to live in Québec these last few years has meant being almost incessantly bombarded by propaganda of a nationalist or federalist tinge. This has forced Quebeckers to take sides, or at least to become aware and informed. Conveniently, Grant's work crossed my path at a time when I needed a kind of refresher course in Canadian history, more specifically its political component. I also wanted a rough sketch of Canada's continental and international situation. Both of these things are discussed in Lament for a Nation, and some readers must have been more interested in simply getting at the information than in being told what Grant specifically thought about Canada's plight
Lament for a Nation (The Defeat of Canadian Nationalism) by George P. Grant
No full textA few years back, I had decided that I would not write a traditional "mémoire" for my Master's degree; instead, I would translate a book, a special kind of book. Translating a work of the creative imagination (e.g. a novel) did not particularly interest me at that time, but I was dravn to writings of philosophical exposition. That is why the suggestion that I translate George Grant's Lament for a Nation vas very welcome. I must admit that neither the title nor the author were then known to me. On inquiring about them, I soon found out that only an "élite" seemed to have had the opportunity of reading George Grant's writing. These persons all agreed that Lament for a Nation was an excellent work which deserved a better fate than the status of minor Canadian classic, revered but largely unread. Lament for a Nation instantly appealed to me. I accordingly decided to explore why it did so. To my surprise, the book reminded me of those small classics we had had to read during our college years, weighty in thought, terse in expression. The dark, sometimes gnarled style repelled me at first, but as I read along, I eventually achieved a kind of complicity and deep interest in Grant's meditation. I have never been a politically involved person. But to live in Québec these last few years has meant being almost incessantly bombarded by propaganda of a nationalist or federalist tinge. This has forced Quebeckers to take sides, or at least to become aware and informed. Conveniently, Grant's work crossed my path at a time when I needed a kind of refresher course in Canadian history, more specifically its political component. I also wanted a rough sketch of Canada's continental and international situation. Both of these things are discussed in Lament for a Nation, and some readers must have been more interested in simply getting at the information than in being told what Grant specifically thought about Canada's plight
Treatment of multiple sclerosis patients with interferon-beta primes monocyte-derived macrophages for apoptotic cell death
No full textAlthough interferon (IFN)-b has shown
a significant clinical benefit in multiple sclerosis
(MS), its mechanism of action remains unclear. We
found that IFN-b treatment of patients with MS
resulted in a significant increase in apoptotic cell
death (measured by annexin V staining and nuclear
fragmentation) of monocyte-derived macrophages,
as compared with cells derived from patients before
treatment. Stimulation of the cells with IFN-b
in vitro resulted in an even further increase of
annexin V binding, as well as increased Fas (CD 95,
APO-1) expression. However, no increased Fas
expression, apoptotic monocytes, or monocytopenia
were observed upon in vivo treatment. This
indicates that IFN-b does not deliver a death signal
to monocytes but rather primes for subsequent macrophage
apoptosis upon activation or differentiatio
