1,720,983 research outputs found
Impact of Surgery on Functional and Patient-reported Outcomes in Patients With Early-stage Non-small Cell Lung Cancer
No full textRationale In patients with early-stage non-small cell lung cancer (NSCLC), the treatment of choice is surgical resection, with or without (neo)adjuvant chemotherapy. As a result of the disease and its treatment, patients have an increased risk for poor functional performances, decreased quality of life and high symptom burden. Current knowledge is mainly based on cross-sectional evaluations after treatment; longitudinal changes have been poorly characterized. Therefore, we aimed to investigate functional and patient-reported outcomes in patients with early-stage NSCLC before treatment and 12 weeks after treatment. Methods Patients with early-stage NSCLC (stage I-IIIB) were assessed before surgery and 12 weeks after treatment initiation. Functional outcome measures were a six-minute walk distance (6MWD), 1-minute sit-to-stand test (1-MSTST), quadriceps muscle strength (QMS; microFET), and handgrip strength (HGS; Jamar). Patient-reported outcome measures were the European Organization for the Research and Treatment of Cancer Questionnaire and lung cancer module (EORTC QLQ-C30-LC13), multidimensional fatigue inventory (MFI-20), and San Diego shortness of breath questionnaire (SOBQ). Analyses were performed using JMP PRO 14.2.0. Paired t-tests and Wilcoxon Signed rank tests were used to compare differences between both timepoints. Results Fifteen patients were included (10 males; age 65±9yrs; 5 with COPD). Patients had NSCLC stage IA (n=10), IB (n=1), IIB (n=2) or IIIA (n=2) and were treated via VATS only (n=11) or VATS and adjuvant chemotherapy (n=4). Results are presented in Figure 1. Twelve weeks after treatment, a significant worsening was found for 1-MSTST (27reps vs. 23reps, p=0.008), HGS (36kg vs. 31kg, p=0.036), and SOBQ score (11 vs. 21, p=0.010). No significant differences were found for the other outcomes. Conclusion In early-stage NSCLC, the treatment mainly affected the performance on the 1-MSTST, peripheral muscle strength, and shortness of breath. In contrast to previous findings, we did not observe a significant decrease in 6MWD, quality of life, and fatigue levels
Impact of Surgery on Functional and Patient-reported Outcomes in Patients With Early-stage Non-small Cell Lung Cancer
No full textRationale In patients with early-stage non-small cell lung cancer (NSCLC), the treatment of choice is surgical resection, with or without (neo)adjuvant chemotherapy. As a result of the disease and its treatment, patients have an increased risk for poor functional performances, decreased quality of life and high symptom burden. Current knowledge is mainly based on cross-sectional evaluations after treatment; longitudinal changes have been poorly characterized. Therefore, we aimed to investigate functional and patient-reported outcomes in patients with early-stage NSCLC before treatment and 12 weeks after treatment. Methods Patients with early-stage NSCLC (stage I-IIIB) were assessed before surgery and 12 weeks after treatment initiation. Functional outcome measures were a six-minute walk distance (6MWD), 1-minute sit-to-stand test (1-MSTST), quadriceps muscle strength (QMS; microFET), and handgrip strength (HGS; Jamar). Patient-reported outcome measures were the European Organization for the Research and Treatment of Cancer Questionnaire and lung cancer module (EORTC QLQ-C30-LC13), multidimensional fatigue inventory (MFI-20), and San Diego shortness of breath questionnaire (SOBQ). Analyses were performed using JMP PRO 14.2.0. Paired t-tests and Wilcoxon Signed rank tests were used to compare differences between both timepoints. Results Fifteen patients were included (10 males; age 65±9yrs; 5 with COPD). Patients had NSCLC stage IA (n=10), IB (n=1), IIB (n=2) or IIIA (n=2) and were treated via VATS only (n=11) or VATS and adjuvant chemotherapy (n=4). Results are presented in Figure 1. Twelve weeks after treatment, a significant worsening was found for 1-MSTST (27reps vs. 23reps, p=0.008), HGS (36kg vs. 31kg, p=0.036), and SOBQ score (11 vs. 21, p=0.010). No significant differences were found for the other outcomes. Conclusion In early-stage NSCLC, the treatment mainly affected the performance on the 1-MSTST, peripheral muscle strength, and shortness of breath. In contrast to previous findings, we did not observe a significant decrease in 6MWD, quality of life, and fatigue levels
Functional and Patient-reported Outcomes at Diagnosis of Non-small Cell Lung Cancer
No full textRationale Poor functional performance and high symptom burden are frequently observed in patients undergoing treatment for non-small cell lung cancer (NSCLC). Little is known about their health status initiation therapy. We investigated functional and patient-reported outcomes at diagnosis in patients with early-and advanced-stage NSCLC, and compared them to age-matched healthy individuals. Methods A cross-sectional study was conducted in newly diagnosed patients with early-stage (stage IA-IIIA) and advanced-stage (stage IIIB-IVB) NSCLC-before starting treatment-and healthy individuals. Functional outcome measures were maximal inspiratory pressure (MIP; MicroRPM), quadriceps muscle strength (QMS; microFET), handgrip strength (HGS; Jamar), short physical performance battery (SPPB), one-minute sit-to-stand test (1-MSTST), and six-minute walk distance (6MWD). Patient-reported outcome measures were modified Baecke questionnaire, physical activity scale for the elderly questionnaire (PASE), multidimensional fatigue inventory (MFI-20), modified Medical Research Council dyspnea questionnaire (mMRC), San Diego shortness of breath questionnaire (SOBQ), hospital anxiety and depression scale (HADS), short-form health survey (SF-12), EuroQoL 5-dimensions (EQ-5D), and instrumental activities of daily living scale (IADLs). One-way ANOVAs and Kruskal-Wallis tests, followed by Tukey-Kramer or Steel-Dwass pairwise comparisons, were performed in JMP PRO 14.2.0 to explore differences between the three groups. Results We recruited 24 patients with early-stage NSCLC (70% male; age 66±9yrs; 33% COPD), 17 patients with advanced-stage NSCLC (65% male; age 64±7yrs; 6% COPD) and 18 healthy individuals (44% male; age 67±10yrs; 0% COPD). Patients with early-and advanced-stage NSCLC presented significant lower 1-MSTST (72%pred vs. 74%pred vs. 89%pred, p=0.010), 6MWD (97%pred vs. 106%pred vs. 128%pred, p<0.0001) and SF-12 mental component score (45 vs. 42 vs. 53, p=0.046) in comparison to healthy individuals. PASE and MFI-20 scores were significantly worse in patients with advanced-stage NSCLC than in healthy controls (56 vs. 108, p=0.005; 58 vs. 42, p=0.027). Compared to patients with early-stage NSCLC, patients with advanced-stage NSCLC had a significantly lower PASE score (88 vs. 56, p=0.049). Detailed results are presented in Table 1. Conclusion Patients with NSCLC scored lower on the 1-MSTST and SF-12 mental score at diagnosis compared to healthy individuals. Patients with advanced-stage NSCLC reported higher fatigue symptoms than healthy individuals, and lower self-reported physical activity levels than patients with early-stage NSCLC and healthy individuals. Although patients with NSCLC scored worse compared to healthy individuals, clinically relevant impairments were not found at diagnosis. To prevent a further decrease, it is important to implement individually tailored interventions to maintain their health status during and after treatment
Functional and Patient-reported Outcomes at Diagnosis of Non-small Cell Lung Cancer
No full textRationale Poor functional performance and high symptom burden are frequently observed in patients undergoing treatment for non-small cell lung cancer (NSCLC). Little is known about their health status initiation therapy. We investigated functional and patient-reported outcomes at diagnosis in patients with early-and advanced-stage NSCLC, and compared them to age-matched healthy individuals. Methods A cross-sectional study was conducted in newly diagnosed patients with early-stage (stage IA-IIIA) and advanced-stage (stage IIIB-IVB) NSCLC-before starting treatment-and healthy individuals. Functional outcome measures were maximal inspiratory pressure (MIP; MicroRPM), quadriceps muscle strength (QMS; microFET), handgrip strength (HGS; Jamar), short physical performance battery (SPPB), one-minute sit-to-stand test (1-MSTST), and six-minute walk distance (6MWD). Patient-reported outcome measures were modified Baecke questionnaire, physical activity scale for the elderly questionnaire (PASE), multidimensional fatigue inventory (MFI-20), modified Medical Research Council dyspnea questionnaire (mMRC), San Diego shortness of breath questionnaire (SOBQ), hospital anxiety and depression scale (HADS), short-form health survey (SF-12), EuroQoL 5-dimensions (EQ-5D), and instrumental activities of daily living scale (IADLs). One-way ANOVAs and Kruskal-Wallis tests, followed by Tukey-Kramer or Steel-Dwass pairwise comparisons, were performed in JMP PRO 14.2.0 to explore differences between the three groups. Results We recruited 24 patients with early-stage NSCLC (70% male; age 66±9yrs; 33% COPD), 17 patients with advanced-stage NSCLC (65% male; age 64±7yrs; 6% COPD) and 18 healthy individuals (44% male; age 67±10yrs; 0% COPD). Patients with early-and advanced-stage NSCLC presented significant lower 1-MSTST (72%pred vs. 74%pred vs. 89%pred, p=0.010), 6MWD (97%pred vs. 106%pred vs. 128%pred, p<0.0001) and SF-12 mental component score (45 vs. 42 vs. 53, p=0.046) in comparison to healthy individuals. PASE and MFI-20 scores were significantly worse in patients with advanced-stage NSCLC than in healthy controls (56 vs. 108, p=0.005; 58 vs. 42, p=0.027). Compared to patients with early-stage NSCLC, patients with advanced-stage NSCLC had a significantly lower PASE score (88 vs. 56, p=0.049). Detailed results are presented in Table 1. Conclusion Patients with NSCLC scored lower on the 1-MSTST and SF-12 mental score at diagnosis compared to healthy individuals. Patients with advanced-stage NSCLC reported higher fatigue symptoms than healthy individuals, and lower self-reported physical activity levels than patients with early-stage NSCLC and healthy individuals. Although patients with NSCLC scored worse compared to healthy individuals, clinically relevant impairments were not found at diagnosis. To prevent a further decrease, it is important to implement individually tailored interventions to maintain their health status during and after treatment
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Fever and an abnormal chest X-ray during the COVID-19 pandemic
No full textDuring the COVID-19 pandemic, a 56-year-old man presented at our emergency department with fever and shortness of breath; Diffuse pulmonary nodular vascular spread lesions were found. Detailed history taking showed a four-week history of fever and night sweats. The man had been under treatment for 2 years with Adalimumab, a tumor-necrosis-factor (TNF) inhibitor, for ulcerative colitis. Before start, screening by tuberculin skin test was negative. Cultures en PCR on BAL and urine were positive for mycobacterium tuberculosis also ocular findings were present. The diagnosis of military tuberculosis was made.status: Publishe
Prognostic value of the 1-minute sit-to-stand test on postoperative complications in people with lung cancer elected for lung surgery
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