1,721,025 research outputs found
DUPLICE ENUCLEORESEZIONE RENALE ROBOTICA CON ACCESSO RETROPERITONEALE IN PAZIENTE CON PREGRESSA CHIRURGIA ADDOMINALE, TROMBOCITOPENIA CRONICA E CIRROSI EPATICA
No full textSURVIVAL AND FUNCTIONAL OUTCOMES AFTER RADICAL PROSTATECTOMY: BIFECTA ACHIEVEMENT IN PATIENTS AGED ≥ 75 YEARS
No full textIMPATTO ECONOMICO DELLA TERAPIA CHIRURGICA A CIELO APERTO ED ENDOSCOPICA PER L’IPERTROFIA PROSTATICA BENIGNA: ANALISI E CONFRONTO DEI COSTI SOSTENUTI NEL 2015 DA UN CENTRO DI TERZO LIVELLO
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PREDICTING CANCER- SPECIFIC AND OTHER-CAUSE MORTALITY IN ELDERLY PATIENTS UNDERGOING RADICAL PROSTATECTOMY FOR PROSTATE CANCER: A COMPETING RISK ANALYSIS
No full textAdverse Features and Competing Risk Mortality in Patients With High-Risk Prostate Cancer
No full textPURPOSE:
To assess survival and competing causes of mortality in prostate cancer (PCa) patients referred to radical prostatectomy through a combination of unfavorable characteristics.
PATIENTS AND METHODS:
We evaluated 615 PCa patients referred to radical prostatectomy and pelvic lymph node dissection at single tertiary-care center with at least one adverse feature (AF): preoperative prostate-specific antigen ≥ 20 ng/mL, pathologic Gleason score 8 to 10, and no organ-confined disease at final pathology (seminal vesicle involvement, positive surgical margins, and/or lymph node invasion). Kaplan-Meier analyses were used to assess cancer-specific mortality (CSM)-free survival rates by stratifying patients into 3 risk categories according to the number of AFs (namely, 1, 2, and 3 AFs). Multivariable competing risk Cox regression analyses were used to assess CSM and other cause of mortality.
RESULTS:
Significant differences were found in terms of preoperative and pathologic tumor characteristics, adjuvant therapies, and biochemical recurrence (BCR). Men with 1 AF had higher CSM-free survival estimates compared to those with 2 and 3 AFs (92.8% vs. 84.2% vs. 27.7% at 10 years' follow-up, P < .001). Moreover, the presence of 3 AFs (hazard ratio [HR], 2.96), postoperative adjuvant treatment status (HR, 2.44), and time to BCR (HR, 0.96) were all independent predictors of CSM (P ≤ .04). Age at surgery and time to BCR were the only independent predictors of other causes of mortality (P ≤ .0009).
CONCLUSION:
The risk group stratification according to the number of AFs could help physicians to accurately predict oncologic outcomes and to select PCa patients for the most appropriate postoperative strategies
Small Renal Masses Managed With Active Surveillance: Predictors of Tumor Growth Rate After Long-Term Follow-Up.
No full textBackground The purpose of the study was to evaluate the relationships between the patients' clinical characteristics and the growth pattern of SRMs, and to investigate the predictive factors of tumor growth rates in patients initially managed with AS. Materials and Methods We retrospectively reviewed data from our prospectively collected database of 70 patients diagnosed with 72 SRMs between 1996 and 2013. Clinical and demographic data, and linear and volumetric growth rates were recorded for each patient. A Pearson correlation test was used to evaluate initial tumor size and linear or volumetric growth rate. Logistic regression models were used to evaluate the predictive factors affecting tumor growth kinetics. Results The mean age was 76 ± 6.8 years, and 47 (67.1%) of patients were male. The mean (± SD) and the median (interquartile range [IQR]) tumor size at presentation were 2.1 ± 1.3 and 2.7 (1.8-3.7) cm, respectively. The mean (± SD) and the median (IQR) linear growth rate were 0.5 ± 0.3 and 0.6 (0.4-1.5) cm per year, respectively. Patients treated with delayed surgery experienced a significantly greater mean linear growth rate (1.4 vs. 0.3 cm per year) than those observed in the AS group (P <.001). Male sex (HR, 1.70; P =.04) and symptomatic presentation (HR, 1.85; P =.02) were found to be significant predictors of tumor growth rates during AS. Conversely, age, Charlson Comorbidity Index, and initial tumor size failed to predict growth kinetics. Conclusion Male sex and symptomatic presentation are associated with faster growth rates in patients managed with AS after long-term follow-up
THE IMPACT OF PATHOLOGIC FEATURES ON CANCER SPECIFIC SURVIVAL OF PATIENTS WITH CLINICALLY HIGH-RISK PROSTATE CANCER
No full textRIPARAZIONE DI LESIONE DEL RETTO IN CORSO DI PROSTATECTOMIA RADICALE ROBOTICA UTILIZZANDO UN INNESTO PERITONEALE
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