1,237 research outputs found
Bland-Altman methods for comparing methods of measurement and response to criticisms
No full textIntroduced in 1983, Bland-Altman methods is now considered the standard approach for assessment of agreement between two methods of measurement. The method is widely used by researchers in various disciplines so that the Bland-Altman 1986 Lancet paper has been named as the 29th mostly highly cited paper ever, over all fields. However, two papers by Hopkins (2004) and Krouwer (2007) questioned the validity of the Bland-Altman analysis. We review the points of critical papers and provide responses to them. The discussions in the critical papers of the Bland-Altman method are scientifically delusive. Hopkins misused the Bland-Altman methodology for research question of model validation and also incorrectly used least-square regression when there is measurement error in the predictor. The problem with Krouwers' paper is making sweeping generalisation of a very narrow and somewhat unrealistic situation. The method proposed by Bland and Altman should be used when the research question is method comparison. © 202
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No Apparent Reason
No full textThis paper discusses five works the author created and the thought process that went into the creation of these works. Helen Altman discusses the fascination with temporary or process pieces and the use of commonplace materials to depict a message
Patients' & Healthcare Professionals' Values Regarding True- & False-Positive Diagnosis when Colorectal Cancer Screening by CT Colonography: Discrete Choice Experiment.
No full textTo establish the relative weighting given by patients and healthcare professionals to gains in diagnostic sensitivity versus loss of specificity when using CT colonography (CTC) for colorectal cancer screening
Family history and outcome of young patients with breast cancer in the UK (POSH study)
No full textBACKGROUND: Young patients presenting to surgical clinics with breast cancer are usually aware of their family history and frequently believe that a positive family history may adversely affect their prognosis. Tumour pathology and outcomes were compared in young British patients with breast cancer with and without a family history of breast cancer.METHODS: Prospective Outcomes in Sporadic versus Hereditary breast cancer (POSH) is a large prospective cohort study of women aged less than 41 years with breast cancer diagnosed and treated in the UK using modern oncological management. Personal characteristics,?tumour pathology, treatment and family history of breast/ovarian cancer were recorded. Follow-up data were collected annually.RESULTS: Family history data were available for 2850 patients. No family history was reported by 65·9 per cent, and 34·1 per cent reported breast/ovarian cancer in at least one first- or second-degree relative. Patients with a family history were more likely to have grade 3 tumours (63·3 versus 58·9 per cent) and less likely to have human epidermal growth factor receptor 2-positive tumours (24·7 versus 28·8 per cent) than those with no family history. In multivariable analyses,?there were no significant differences in distant disease-free intervals for patients with versus those without a family history, either for the whole cohort (hazard ratio (HR) 0·89, 95 per cent c.i. 0·76 to 1·03; P = 0·120) or when stratified by oestrogen receptor (ER) status (ER-negative: HR 0·80, 0·62 to 1·04, P = 0·101; ER-positive: HR 0·95, 0·78 to 1·15, P = 0·589).CONCLUSION: Young British patients presenting to breast surgical clinics with a positive family history can be reassured that this is not a significant independent risk factor for breast cancer outcome<br/
Enzyme Kinetics Systematic Generation of Valid King-Altman Patterns
No full textOne of the most generally applicable algorithms for the derivation of steady-state rate equations for complex enzyme reaction mechanisms is that of King and Altman. Several modifications of this algorithm have been suggested; however, each requires the generation of numerous valid and invalid patterns and the subsequent elimination of those that are invalid. A method is presented, employing topological theory of linear graphs, for the systematic generation of only those patterns which are valid. This method is readily adaptable to use on a digital computer. An independent method for the calculation of the number of valid patterns is also presented. This calculation can be used to substantiate the accuracy of the patterns obtained. This calculation is also adaptable to computerization. Examples are included to demonstrate both the generation of patterns and the calculation of their number for specific enzyme mechanisms
Good Reporting Practices And The Consort
No full text[No abstract available]75285Simera, I., Moher, D., Hirst, A., Hoey, J., Schulz, K.F., Altman, D.G., Transparent and accurate reporting increases reliability, utility, and impact of your research: reporting guidelines and the EQUATOR Network (2010) BMC Med., 8, p. 24Jüni, P., Altman, D.G., Egger, M., Systematic reviews in health care: assessing the quality of controlled clinical trials (2001) BMJ., 323 (7303), pp. 42-46Chan, A.W., Altman, D.G., Epidemiology and reporting of randomised trials published in PubMed journals (2005) Lancet, 365 (9465), pp. 1159-1162Glasziou, P., Meats, E., Heneghan, C., Shepperd, S., What is missing from descriptions of treatment in trials and reviews? (2008) BMJ., 336 (7659), pp. 1472-1474Moher, D., Hopewell, S., Schulz, K.F., Montori, V., Gotzsche, P.C., Devereaux, P.J., Elbourne, D., Submitted for publication: April 11, 2012 Accepted for publication: April 11, 2012Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., PRISMA Group. Preferred reporting items for systematic reviews and meta-analysis: the PRISMA statement (2009) BMJ, 339, pp. b2535-b2540von Elm, E., Altman, D.G., Egger, M., Pocock, S.J., Gøtzsche, P.C., Vandenbroucke, J.P., STROBE Initiative Strengthening the reporting of observational studies in epidemio logy (STROBE) statement: guidelines for reporting observational studies (2007) BMJ., 335 (7624), pp. 806-808. , Comment in: BMJ. 2007;335(7624):783-4. Arch Dermatol. 2008144(9):1200-4. BMJ. 2007335(7626):90
The world of Robert Altman : Auteur, Innovator and Iconoclast
No full textFilmmaker Ron Mann’s recent documentary Altman (2014), features interviews with various notable filmmakers and actors who worked with Robert Altman over the years. Mann said that people who come to see his documentary “just to see Bob’s films” then he has done his job. Mann also more poignantly said that
“Altman was America’s greatest filmmaker and that his work matters more than ever now because it stands in contrast to all the sequels that Hollywood makes to sell lunch boxes”. (Gilbey, 2015)1
This quote encapsulates what Robert Altman stood for as a film director in that it illustrates his innovative approaches to filmmaking, his maverick tendencies and individuality. His vision, creativity and independence are a testament to his influential legacy which continues to inspire film makers today. Author keywords: Altman, film noir, satire, anti-western, ensemble, mystery, Hollywood and Studio Syste
Posthumous Queer: Hemingway Among Others
No full textChallenges the common assumption that posthumous texts introducing unconventional sexual themes like The Garden of Eden have more authority than previously published works by the same author. Altman concludes that it is a mistake to use the novel’s manuscript to debunk earlier Hemingway scholarship regarding gender and sexuality
Beyond closing the gap: valuing diversity in Indigenous Australia
No full textIn his Apology speech the Prime Minister attempted to balance the symbolic with the practical while emphasising that ‘business as usual’ is not working. Ultimately though, the \u27Closing the Gap\u27 approach is business as usual that fails to value Indigenous difference and fails to accommodate Indigenous aspirations in all their diversity. Unless we get beyond CTG, the next phase in Indigenous policy making and program investments is as ‘destined to fail’ as previous approaches. This paper advocates for the pendulum to swing back, to accommodate and value diversity and difference rather than just statistical equality. In doing so, the author provides some reflexive comment as an academic on these policy swings. In 2005, Tim Rowse and Jon Altman wrote a piece on Indigenous policy that contrasted the contending approaches of economics and anthropology to Indigenous affairs policy: the first emphasising equality of socioeconomic outcomes, the second the facilitation of choice and self-determination. The former implies integration, the latter adherence to different and diverse life worlds. Over time, the author has used economics and official statistics to highlight socioeconomic disadvantage and neglect, while at the same time using anthropology to critique any approach that uses mainstream social indicators that only reflect the dominant society’s social norms. This paper will continue in the same vein using a dual disciplinary approach. However, without being over-reflexive, as an anthropologist of development he is clearly uncomfortable with the current dominance of the \u27Closing the Gap\u27 framework. This paper was presented at the Centre for Public Policy\u27s \u27Values & Public Policy\u27 conference in February 2009. Jon Altman is Professor and the inaugural Director of the Centre for Aboriginal Economic Policy Research established in 1990. He is currently researching Indigenous development and economic hybridity as ARC Australian Professorial Fellow. 
Preferred reporting items for systematic reviews and meta-analyses : the PRISMA statement
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