1,721,067 research outputs found
D. Valentini (éd.), L'ecclesiologia contemporanea, 1994
No full textRoland Minnerath. D. Valentini (éd.), L'ecclesiologia contemporanea, 1994. In: Revue des Sciences Religieuses, tome 71, fascicule 1, 1997. p. 132
D. Valentini (éd.), L'ecclesiologia contemporanea, 1994
No full textRoland Minnerath. D. Valentini (éd.), L'ecclesiologia contemporanea, 1994. In: Revue des Sciences Religieuses, tome 71, fascicule 1, 1997. p. 132
Dysregulation of stress response in Down Syndrome
Full text linkSeveral studies support the implication of oxidative stress (OS) in phenotypical alterations of Down Syndrome (DS) individuals; however, the mechanisms through which OS damage leads to DS pathological phenotypes need to be clarified. OS seems to be a chronic condition in DS brain and it represents a strong risk factor for neurodegeneration. The mapping of HSA21 showed the involvement of several genes, such as SOD-1, BACH-1, APP, CBR and S100B, in the over-production of ROS in DS individuals and animal models. In my thesis I focused on two main projects on the dysregulation of stress response in Down Syndrome. Project 1. To highlight novel mechanisms leading to neurodegeneration in DS phenotype we investigated the role of BACH-1 in the brain and its implication in the failure of antioxidant response. A number of studies demonstrated the importance of the nuclear balance between BACH-1 and Nrf-2 to finely tune the antioxidant response. In this scenario, using different DS models, (a) neurons and astrocytes isolated from cortex and hippocampus of Ts2cje mice, an animal model of DS; (b) hippocampus from Ts2cje mice at 3 months of age; and (c) human DS lymphoblastoid cell lines (LCLs), we demonstrated that BACH-1 triplication alters BACH-1/Nrf-2 ratio and in turn downregulate the antioxidant responses. In light of these findings, we tested the antioxidant properties of two polyphenols, Caffeic Acid Phenethyl Ester and VP961, already proved to act as inducers of Nrf-2. Our results showed the ability of these compounds to modulate BACH-1/Nrf-2 pathway in neuroblastoma cell line and in DS LCLs, proposing their targeting as a powerful strategy to reduce OS conditions in DS. Project 2. To search for biomarkers for the early detection and exploration of the disease mechanisms, we investigated the protein expression signature of peripheral blood mononuclear cells (PBMCs) from DS children compared with healthy donors (HD) by using an in-depth label-free shotgun proteomics approach. Identified proteins were found associated with metabolic pathways, cellular trafficking, DNA structure, stress response, cytoskeleton network, and signaling pathways. The results showed that a well-defined number of dysregulated pathways retain a prominent role in mediating DS pathological features. Further, proteomics results were consistent with published study in DS and provide evidence that increased oxidative stress and the increased induction of stress related response, are contributors to DS pathology. In addition, the expression levels of few key proteins have been validated by Western blot analysis while protein carbonylation, as marker of protein oxidation, was investigated. The results of this study propose that PBMCs from DS children might be in an activated state where endoplasmic reticulum stress and increased production of radical species are one of the primary events contributing to multiple DS pathological features
Gestire le informazioni e la pianificazione nel facility management: nuove opportunità e sviluppi
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dissertatio Academica, De Sagis, Sive Foeminis, commercium cum Malo Spiritu habentibus / E Christiana Pneumatologia desumpta, & Sub Praesidio ... Dn. D. Valentini Alberti ... Publicae proposita ventilationi Ad diem 6. Decembr. A.O.R. M.DC.XC. Ab Autore Christiano Stridtbeckh/ Augustano, Phil. Baccal. & Mag. Cand.
No full textDISSERTATIO ACADEMICA, DE SAGIS, SIVE FOEMINIS, COMMERCIUM CUM MALO SPIRITU HABENTIBUS / E CHRISTIANA PNEUMATOLOGIA DESUMPTA, & SUB PRAESIDIO ... DN. D. VALENTINI ALBERTI ... PUBLICAE PROPOSITA VENTILATIONI AD DIEM 6. DECEMBR. A.O.R. M.DC.XC. AB AUTORE CHRISTIANO STRIDTBECKH/ AUGUSTANO, PHIL. BACCAL. & MAG. CAND.
Dissertatio Academica, De Sagis, Sive Foeminis, commercium cum Malo Spiritu habentibus / E Christiana Pneumatologia desumpta, & Sub Praesidio ... Dn. D. Valentini Alberti ... Publicae proposita ventilationi Ad diem 6. Decembr. A.O.R. M.DC.XC. Ab Autore Christiano Stridtbeckh/ Augustano, Phil. Baccal. & Mag. Cand. (1)
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Caput. I. Onomatologicum (5)
Caput. II. Pragmatologicum (12)
Caput. III. Porismaticum (43)
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Carolus Stengelius in Commentario Rerum Augustanarum ... (49)
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Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
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