1,721,812 research outputs found
D. Russo, Studii şi critice
No full textBardou L. D. Russo, Studii şi critice. In: Échos d'Orient, tome 14, n°89, 1911. p. 246
D. Russo, Studii si critice. 1910
No full textRoques Mario. D. Russo, Studii si critice. 1910. In: Romania, tome 40 n°157, 1911. pp. 143-144
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Utilizzo di scores multiparametrici nella caratterizzazione del rischio stimato di malignità di noduli tiroidei sottoposti a citologia per ago sottile
Full text linkScopo
Le società scientifiche hanno adottato sistemi per la classificazione ecografica dei noduli tiroidei, con l’obiettivo di ridurre gli agoaspirati senza perdere neoplasie clinicamente rilevanti. L’obiettivo del progetto è stato la validazione prospettica dell’accuratezza diagnostica di tali sistemi e la loro potenziale integrazione con i dati citologici tradizionali e di biologia molecolare.
Metodi
Sono stati prospetticamente valutati noduli sottoposti ad agoaspirato ecoguidato. Le caratteristiche ultrasonografiche sono state registrate ed utilizzate per classificare ciascun nodulo secondo le linee guida American Association of Clinical Endocrinologists (AACE/ACE/AME), American College of Radiologists (ACR), American Thyroid Association (ATA), EU-TIRADS e K-TIRADS. Lo standard di riferimento è l’istologia definitiva se disponibile, oppure una citologia benigna con successivo follow-up. Sono stati escluse citologie non diagnostiche o indeterminate. E’stato raccolto materiale residuo in soluzione conservante gli acidi nucleici, per studi di Next Generation Sequencing su pannello custom per carcinoma tiroideo.
Risultati
Sono stati campionati 917 noduli, di cui 82 sono stati esclusi per dimensioni <1 cm e 282 per assenza di diagnosi conclusiva. L’applicazione dei sistemi di classificazione permetterebbe di evitare da 92 (16.6%) a 287 (51.9%) agoaspirati (sistema K-TIRADS e ACR TIRADS, rispettivamente [p<0.001], con un false-negative rate di 3.3% e 2.8%). Il tasso di malignità nelle varie categorie risulta congruente con il rischio stimato.
Conclusioni
La stratificazione ecografica permette una migliore selezione dei noduli candidati a citologia ed eventuale analisi molecolare, attraverso la stima del rischio di malignità pre-test, ottimizzando i valori predittivi risultanti. I vari sistemi presentano differenze significative nel numero di prelievi evitabili
Nuove frontiere nel carcinoma midollare della tiroide: identificazione di nuovi biomarkers diagnostici
Full text linkBackground: medullary thyroid carcinoma (MTC) is rare thyroid cancer. The difficulty in management and the unfavorable outcome are mainly due to the absence of tools for early diagnosis. Recent studies have demonstrated the deregulation of microRNAs (miRNAs) in tumor samples from MTC patients. Extracellular plasma vesicles (pEVs) containing miRNA represent an emerging source of tumor biomarkers. There are no data from the circulating pEV-miRNAs in patients with MTC.
Aim: to identify new circulating diagnostic biomarkers in MTC.
Study design: multicenter, prospective, observational study enrolling adult patients with stage I-IV MTC (Group 1, n=23), compared to healthy subjects (Group 2, n=22). For Group 1 patients we collected: blood sample at the time of surgery and tumor tissue from the primary tumor. Step 1: pre-operative plasma from MTC patients (Group 1a) was compared to plasma from healthy subjects (Group 2). Step 2: pre-operative plasma from each MTC patients (Group 1a) was compared to tumor tissue of the same patient (Group 1b). Step 3: data from Step 1 and Step 2 were combined.
Methods: the expression analysis of circulating (pEV) and tissue miRNAs was performed by RT-qPCR with TLDA technology analyzing 754 miRNAs. Results were considered statistically significant when P-values were <0.05
Results: 555 miRNAs are considered to be informative comparing Group 1a and Group 2, 44 of them differentially expressed between two groups. 603 miRNAs are considered to be informative, comparing Group 1a vs Group 1b, 209 of them differentially expressed and 394 equally expressed between two groups, respectively. Combining Step 1 and Step 2 results, 24 miRNAs were identified.
Conclusions: a specific pattern of pEV-miRNAs was observed in MTC patients, which in part reflects tissue miRNAs arrangement. The 24 miRNAs identified represent potential diagnostic biomarkers in MTC, that could play an active role in the modulation of cellular pathways in targeted cells
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Computer-aided analysis of patents and search for TRIZ contradictions
No full textTRIZ, the Soviet-initiated Theory of Inventive Problem Solving, is gaining acknowledgement both as a systematic methodology for innovation and a powerful tool for technology forecasting. Nevertheless, the analysis of patents necessary for gathering the data to be used for the previsional activity is very cumbersome and sometimes unworthy due to the intrinsic low reliability of forecasting tasks. With this perspective it is necessary to speed up the identification of the technical/physical conflict(s) overcome by an invention, according to its textual description. Although text-mining tools have reached relevant capabilities for extracting useful information from huge sets of documents, no specific means are available to support the analysis of patents with the aim of identifying the contradiction underlying a given technical system. This paper proposes a computer-aided approach for accomplishing such a task: the algorithm is described and validated by means of practical examples
Ogden’s Basic English and its roots in the Early Modern English search for language simplicity
No full textThe idea of English as a lingua franca was anticipated in the early 1920s by Charles Kay Ogden, who conceived his Basic English as a form of controlled language that could be widely understood and used with proficiency by both native and non-native speakers. Basic English arguably represents a crucial moment in the development of the ideas of language simplicity and it remains a milestone which has influenced later controlled versions of English (e.g. Simplified Technical English, Special English, Simple English Wikipedia). In Ogden’s codification of simplified language (which was deeply influenced by his previous semiotic studies) a few simplification criteria can be distinguished: controlled vocabulary, lexical isomorphism, standardisation (intended as establishing a discrete number of shared rules for the use of language), morphosyntax as an outgrowth of lexicon, the superiority of analytic structures over synthetic structures, and universality of a shared language as a key factor in the resolution of human conflicts. Language simplicity is therefore essential for better communication and improved social interactions. This essay argues that Ogden’s idea of language simplicity is deeply rooted in the history of the English language and can be tracked back to the Reformation period, in which “plain speech” was seen as a source of truth and virtue as opposed to the ambiguity of a language rich in figures of speech and rhetorical artifice, and to the 17th century, in which we can distinguish a supposedly scientific approach in language simplification
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