2,865 research outputs found
C. Caprino, A. M. Colini, G. Gatti, M. Pallottino, P. Romanelli, La colonna di Marco Aurelio
No full textD. S. G. M. C. Caprino, A. M. Colini, G. Gatti, M. Pallottino, P. Romanelli, La colonna di Marco Aurelio. In: Bulletin de l'Association Guillaume Budé, n°2, juin 1957. pp. 99-100
Proceedings of the International Minicourse-Workshop "Interplay between ()-semigroups and PDEs: theory and applications", Bari, 22-26 Settembre 2003
No full textDynamic and generalized Wentzell node conditions for network equations
No full textMotivated by a neurobiological problem, we discuss a class of diffusion problems on a network. The celebrated Rail lumped soma model for the spread of electrical potential in a dendritical tree prescribes that the common cable equation must be coupled with particular dynamic conditions in some nodes (the cell bodies, or somata). We discuss the extension of this model to the case of a whole network of neurons, where the ramification nodes can be either active (with excitatory time-dependent boundary conditions) or passive (where no dynamics take place, i.e. only Kirchhoff laws are imposed). While well-posedness of the system has already been obtained in previous works, using abstract tools based on variational methods and semigroup theory we are able to prove several qualitative properties, including asymptotic behaviour, regularity of solutions, and monotonicity of the semigroups in dependence on the physical coefficients.
Parole chiave cable equations on networks, ultracontractive semigroups of operators, Wentzell and dynamic boundary conditions
Dirichlet forms for general Wentzell boundary conditions, analytic semigroups, and cosine operator functions
No full textThe aim of this paper is to study uniformly elliptic operators with general Wentzell boundary conditions in suitable -spaces by using the approach of sesquilinear forms. We use different tools to re-prove analiticity and related results concerning the semigroups generated by the above operators. In addition, we make some complementary observations on, among other things, compactness issues and characterization of domains
The wolf from Grotta Romanelli (Apulia, Italy) and its implications in the evolutionary history of Canis lupus in the Late Pleistocene of Southern Italy
No full textCanis lupus dispersed into Europe in the late Middle Pleistocene. The phylogenetic origin of C. lupus from Canis mosbachensis is widely accepted in the literature although their relationships and taxonomy are debated. In this paper, canid remains coming from the so-called "terre rosse", Level G at Grotta Romanelli (Apulia, Southern Italy) are described. The Level G was dated between 69,000 and 40,000 ± 3250 years using the 230Th/238U method. Despite the great archeological importance of the site, some of the vertebrate fossil remains have been never described in detail. Among these are cranial remains of a canid that different authors referred to Canis aureus, C. lupus, C. mosbachensis, Canis aff. mosbachensis, or Canis sp. The skull remains from Grotta Romanelli Level G were analyzed using Computed Tomography and 3D virtual modeling to provide a detailed reconstruction of the specimens and investigate inner structures. In addition, the Grotta Romanelli material was compared with (1) fossil wolves from other Middle-Late Pleistocene sites of Apulia (Melpignano/San Sidero, Ingarano and Grotta Paglicci) and France, (2) C. mosbachensis remains from various Early-Middle Pleistocene European sites, (3) a large sample of the extant Italian subspecies C. lupus italicus.The Late Pleistocene wolves from Apulia can be included in a single group, morphologically and morphometrically homogeneous. Although the wolf from Grotta Romanelli shares some similarities with the Early-Middle Pleistocene C. mosbachensis, its overall morphology and proportions fall into the wide variability of the extant C. lupus. Moreover, this determination is much more parsimonious than the taxonomic attribution of the "Apulian wolves" (including the Romanelli specimens) to C. mosbachensis, a typical late Early-Middle Pleistocene species, whose survival in Apulia during the Late Pleistocene is not adequately supported
Seismic waves in 3-D: from mantle asymmetries to reliable seismic hazard assessment.
No full textA global cross-section of the Earth parallel to the tectonic equator (TE) path, the great circle representing the equator of net lithosphere rotation, shows a difference in shear wave velocities between the western and eastern flanks of the three major oceanic rift basins. The low-velocity layer in the upper asthenosphere, at a depth range of 120 to 200 km, is assumed to represent the decoupling between the lithosphere and the underlying mantle. Along the TE-perturbed (TE-pert) path, a ubiquitous LVZ, about 1,000-km-wide and 100-km-thick, occurs in the astheno-sphere. The existence of the TE-pert is a necessary pre-requisite for the existence of a continuous global flow within the Earth. Ground-shaking scenarios were con-structed using a scenario-based method for seismic hazard analysis (NDSHA), using realistic and duly validated synthetic time series, and generating a data bank of several thousands of seismograms that account for source, propa-gation, and site effects. Accordingly, with basic self-organized criticality concepts, NDSHA permits the inte-gration of available information provided by the most updated seismological, geological, geophysical, and geo-technical databases for the site of interest, as well as advanced physical modeling techniques, to provide a reli-able and robust background for the development of a design basis for cultural heritage and civil infrastructures. Estimates of seismic hazard obtained using the NDSHA and standard probabilistic approaches are compared for the Italian territory, and a case-study is discussed. In order to enable a reliable estimation of the ground motion response to an earthquake, three-dimensional velocity models have to be considered, resulting in a new, very efficient, ana-lytical procedure for computing the broadband seismic wave-field in a 3-D anelastic Earth model
New human fossil from the latest Pleistocene levels of Grotta Romanelli (Apulia, southern Italy)
No full textGrotta Romanelli can be counted among the most interesting sites for the late Upper Palaeolithic of the Mediterranean area, since returned a consistent record of lithic artefacts, faunal remains, mobiliary and parietal art, and human fossils which represent the least-known materials from the context. The resumption of the investigations in 2015, after 40 years of inactivity in the cave, provided relevant results. During the 2019 campaign, a distal phalanx of the hand was recovered in the so-called terre brune levels, providing for the first time a clear stratigraphic and chronological reference for the human fossils record of Grotta Romanelli. In addition to morphological description and age estimation, the new finding is here analyzed using 3D Micro-CT scans. The new human fossil confirms the exceptional richness of the paleoanthropological record of Grotta Romanelli, opening new avenues of investigation and posing crucial questions on the use of the cave and cultural practices at the Late Pleistocene-Holocene boundary
Spotlight on dupilumab in the treatment of atopic dermatitis: design, development, and potential place in therapy
No full textAngelo Massimiliano D’Erme,1,2 Marco Romanelli,2 Andrea Chiricozzi2 1Dermatology Unit, Livorno Hospital, Livorno, 2Dermatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy Abstract: Atopic dermatitis (AD) is among the most common inflammatory skin diseases in children and adults in industrialized countries. Up to one-third of adults (probably a smaller proportion in childhood) suffer from moderate-to-severe AD, whose recommended treatment is usually based on systemic therapies. The currently available therapeutics are limited, and AD management becomes challenging in most cases. Over the last few years, new advances in the understanding of AD pathogenic mechanisms and inflammatory pathways have led to the identification of specific therapeutic targets and new molecules have been tested. Dupilumab is a fully human monoclonal antibody directed against the IL-4 receptor α subunit that is able to block the signaling of both IL-4 and IL-13 and achieve rapid and significant improvements in adults with moderate-to-severe AD. Dupilumab is ready to inaugurate a long and promising biological target treatment option for Th2 cell-mediated atopic immune response that characterizes AD. Keywords: dupilumab, atopic dermatitis, eczema, IL-4, IL-13, biologic
A General Empirically Based Micro-Instability Transport Model
No full textA mixed Bohm--gyro-Bohm, shear-dependent thermal diffusion coefficient to model the anomalous thermal transport in tokamaks is proposed. It is derived on the basis of recent findings on the radial correlation length of turbulent processes generated by small scale, collisionless, electrostatic microinstabilities (ROMANELLI, F., ZONCA, F., Phys. Fluids B, 5 (1993) 4081). The model has been used to describe standard L and H-mode discharges of the JET, DIII-D and TFTR devices and JET PEP and hot ion mode discharges successfully. 1 Introduction The energy and particle transport in tokamaks is determined by turbulent processes. At present no definitive transport model (that is, a closed expression for energy and particle fluxes in terms of plasma parameters) which fully accounts for all the features of turbulence is available, in spite of the effort produced in recent years in order to determine the anomalous fluxes from first-principle plasma models [1, 2, 3, 4, 5]. Nevertheless, there is ..
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