20,167 research outputs found
TARDis Project Final Report
No full textThe TARDis Project Final Report outlines the background, methodology and implementation of e-Prints Soton. It identifies outcomes of the project and its evolution to a centrally funded University research repository, embedded within the research landscape of the organization
Unprecedented staining of polar lipids by a luminescent rhenium complex revealed by FTIR microspectroscopy in adipocytes
No full textData source: Supplementary information, http://www.rsc.org/suppdata/c6/mb/c6mb00242k/c6mb00242k1.pdfFourier transform infrared (FTIR) microspectroscopy and confocal imaging have been used to demonstrate that the neutral rhenium(i) tricarbonyl 1,10-phenanthroline complex bound to 4-cyanophenyltetrazolate as the ancillary ligand is able to localise in regions with high concentrations of polar lipids such as phosphatidylethanolamine (PE), sphingomyelin, sphingosphine and lysophosphatidic acid (LPA) in mammalian adipocytes.C. A. Bader, E. A. Carter, A. Safitri, P. V. Simpson, P. Wright, S. Stagni, M. Massi, P. A. Lay, D. A. Brooksa and S. E. Plus
Opening the can of worms: molecular analysis of schistosome populations
No full textThe Schistosomatidae are dioecious digenean parasites of the blood vascular system of vertebrates. Of the 13 genera within the family, only Sehistosoma is associated with humans and, of the mammalian blood flukes, this genus has achieved the greatest geographical distribution and diversification in terms of recognized species and definitive hosts parasitized. In this review, Dave Johnston, Emmanuel Dias Neto, Andy Simpson and David Rollinson consider some recent molecular research that either sheds light on the micro-evolutionary changes occurring within schistosome populations or provides insights into broader, macro-evolutionary questions.</p
A clinical and molecular investigation of two families with Simpson-Golabi-Behmel syndrome
No full textIncludes abstract (p. 30-32).
Includes bibliographical references
Positron beam study of annealed silicon nitride films
No full textPositron annihilation spectroscopy has been used to study silicon nitride films grown by plasma-enhanced chemical vapor deposition and annealed at different temperatures. For both silicon-rich and nitrogen-rich films, the positron line shape (S) parameter increases after annealing for 15 min at temperatures up to 700-800 degrees C. This is understood in terms of the fact that removal of the hydrogen by annealing leads to the presence of unpassivated silicon dangling bond sites and vacancy complexes. Annealing at higher temperatures leads to a reduction in the S parameter, consistent with further hydrogen removal producing unpassivated N- sites. (C) 1996 American Institute of Physics.PT: J; CR: ASOKAKUMAR P, 1994, J APPL PHYS, V76, P4935 GOLDBERG RD, 1995, APPL SURF SCI, V85, P287 GOSSMANN HJ, 1992, APPL PHYS LETT, V61, P540 HABRAKEN FHP, 1991, LPCVD SILICON NITRID, P118 HAKVOORT RA, 1991, APPL PHYS LETT, V59, P1687 HAKVOORT RA, 1993, THESIS DELFT U TECHN HEYNS M, 1991, LPCVD SILICON NITRID, P82 LANDFORD WA, 1978, J APPL PHYS, V49, P2473 LANDFORD WA, 1992, NUCL INSTRUM METH B, V66, P65 LANDHEER D, 1995, J APPL PHYS, V78, P2568 LU Z, 1995, J VAC SCI TECHNOL 1, V13, P607 LYNN KG, 1989, CAN J PHYS, V67, P618 MITCHELL LV, 1990, AIP C P, V218, P121 PEROVIC DD, 1991, PHYS REV B, V43, P14257 RUBLOFF GW, 1990, VACUUM, V41, P790 SCHULTZ PJ, 1988, NUCL INSTRUM METH B, V30, P94 SCHULTZ PJ, 1988, PHYS REV LETT, V61, P187 SCHULTZ PJ, 1988, REV MOD PHYS, V60, P701 SIMPSON PJ, 1991, PHYS REV B, V44, P12180 SMITH DL, 1990, J ELECTROCHEM SOC, V137, P614 SMITH DL, 1990, MATER RES SOC S P, V165, P69; NR: 21; TC: 1; J9: J APPL PHYS; PG: 5; GA: TY119Source type: Electronic(1
Kanter Revisited: Gender, Power and (In)visibility
No full textThis paper revisits Kanter's (1977) seminal work Men and Women of the Corporation, rereading her account of numerical advantage and disadvantage through a poststructuralist lens which exposes hidden dimensions of gendered power. This lens is captured in the ‘(In)visibility Vortex’ (Lewis and Simpson, 2010) which highlights struggles and tensions around the norm through processes of preservation and concealment within the norm as well as dynamics of revealing, exposure and disappearance as features of the margins. The study draws on developments in feminist theorizing, specially around visibility, invisibility and power, to facilitate this rereading. In so doing, the author demonstrate that while Kanter retreated from explanations based on the gendering of organizations or from recognition of gendered power, these dynamics can be identified in her text. The authors suggest that rereading classic texts can surface dimensions of organizations that have contemporary significance and can inform future research
Bivalirudin for the treatment of ST-segment elevation myocardial infarction: a NICE Single Technology Appraisal
No full textThe National Institute for Health and Clinical Excellence (NICE) invited the manufacturer (The Medicines Company) of bivalirudin to submit evidence for its clinical and cost effectiveness within its licensed indication for the treatment of adults with ST-segment elevation myocardial infarction (STEMI) intended for primary percutaneous coronary intervention (PPCI), as part of NICE's single technology appraisal (STA) process. The School of Health and Related Research (ScHARR) at the University of Sheffield was commissioned to act as the Evidence Review Group (ERG), which produced a review of the evidence within the manufacturer's submission to NICE. This article describes the manufacturer's submission, the ERG review and NICE's subsequent decisions. The main evidence was derived from one randomized controlled trial (RCT) of STEMI patients intended for PPCI, comparing bivalirudin with unfractionated heparin plus glycoprotein IIb/IIIa inhibitors (GPIs). Bivalirudin was associated with a significant reduction in cardiac mortality at 30 days (p = 0.03) and at 1-year follow-up (p = 0.005), and a significant reduction in major bleeding at 30 days (p < 0.001) and 1 year (p < 0.0001), compared with heparin plus GPI. Stent thrombosis up to 24 hours following PPCI was significantly (p < 0.001) more common with bivalirudin. However, there was no significant treatment effect for stent thrombosis from 1 to 30 days (p = 0.28), or at 1-year follow-up (p = 0.53). There were no significant treatment group differences at 30 days and at 1 year in stroke (p = 0.68 and p = 0.99, respectively), in myocardial infarction [MI] (p = 0.90 and p = 0.22, respectively), or in the need for the revascularization of the target vessel for ischaemia (p = 0.18 and p = 0.12, respectively). There were two decision-analytic models: the base-case scenario used 1-year follow-up data from the RCT; and a sensitivity analysis used 3-year follow-up data. Resource use was primarily drawn from this RCT. Health-related quality-of-life (HR-QOL) estimates were drawn from a UK cohort study. Both models evaluated the incremental costs and outcomes of bivalirudin compared with heparin plus GPI for patients with STEMI intended for PPCI. The analysis adopted a UK NHS perspective over a lifetime horizon. Unit costs were based on year 2009-2010 prices. The model adopted a decision-tree structure to reflect initial events for the initial period (stroke, repeat MI, minor/major bleeding events, repeat revascularization and death) and a two-state Markov component to simulate longer-term survival. The economic analysis suggested that bivalirudin is expected to dominate the heparin plus GPI strategy. This finding was consistent across the probabilistic sensitivity analysis and the vast majority of deterministic sensitivity analyses undertaken. Three exceptions to this finding were observed for the following sensitivity analyses: (1) the exclusive use of eptifibatide as the GPI (incremental cost-effectiveness ratio [ICER] = £1,764); (2) the combination of 100 % eptifibatide use, 100 % radial arterial access and no differential length between strategies for initial hospital stay (ICER = £4,106); and (3) a longer length of ward stay (increase of 0.33 days) for the initial hospitalization (ICER = £415). The Appraisal Committee (AC) gave a positive recommendation for bivalirudin for the treatment of adults with STEMI undergoing PPCI.</p
Correspondance de Simpson p-adique II : fonctorialité par image directe propre et systèmes locaux de Hodge-Tate
No full textFrench, 372 pages. arXiv admin note: text overlap with arXiv:2003.04714, arXiv:1301.0904Faltings initiated in 2005 a p-adic analogue of the (complex) Simpson correspondence whose construction has been taken up by various authors, according to several approaches. Following the one we initiated previously, we develop in this new monograph new features of the p-adic Simpson correspondence, inspired by our construction of the relative Hodge-Tate spectral sequence. First, we address the connection to Hodge-Tate local systems. Second, we establish the functoriality of the p-adic Simpson correspondence by proper direct image. Along the way, we expand the scope of our original construction. Faltings a d\'egag\'e en 2005 un analogue p-adique de la correspondance de Simpson (complexe) dont la construction a \'et\'e reprise par diff\'erents auteurs, selon plusieurs approches. Poursuivant celle que nous avons initi\'ee pr\'ec\'edemment, nous d\'eveloppons dans la pr\'esente monographie de nouveaux aspects de la correspondance de Simpson p-adique, inspir\'es par notre construction de la suite spectrale de Hodge-Tate relative. Nous traitons tout d'abord du lien avec les syst\`emes locaux de Hodge-Tate. Nous \'etablissons ensuite la fonctorialit\'e de la correspondance de Simpson p-adique par image directe propre. Chemin faisant, nous \'elargissons la port\'ee de notre construction initiale
Deltatheroides cretacicus Gregory & Simpson 1926
No full text<p> <i>Deltatheroides cretacicus</i> Gregory & Simpson, 1926</p> <p> Gregory & Simpson (1926); Rougier <i>et al.</i> (2004).</p>Published as part of <i>Suarez, Catalina, Forasiepi, Analia M., Babot, María Judith, Shinmura, Tatsuya, Luque, Javier, Vanegas, Rubén D., Cadena, Edwin A. & Goin, Francisco J., 2023, A sabre-tooth predator from the Neotropics: Cranial morphology of Anachlysictis gracilis Goin, 1997 (Metatheria, Thylacosmilidae), based on new specimens from La Venta (Middle Miocene, Colombia), pp. 497-572 in Geodiversitas 45 (18)</i> on page 541, DOI: 10.5252/geodiversitas2023v45a18, <a href="http://zenodo.org/record/8434228">http://zenodo.org/record/8434228</a>
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