75 research outputs found
Trame e forme percepite nel paesaggio: storie à rebours nel territorio di Pago Veiano (BN)
No full textPioderma gangrenoso paradosso da Abatacept.
No full textIl pioderma gangrenoso è una rara dermatosi neutrofilica non infettiva
che colpisce solitamente gli arti inferiori. Si presenta più comunemente
con pustole sterili che evolvono in ulcerazioni dolorose con bordi sottominati
eritemato-violacei. È spesso associato a malattie autoimmuni e
può insorgere secondariamente all’utilizzo di farmaci. Una donna di 68
anni affetta da artrite reumatoide long standing (non responsiva a molteplici
terapie convenzionali e biologiche) sviluppava, in corso di terapia
con Abatacept, elementi eritemato-nodulari a livello delle gambe che
andavano incontro a rapida ulcerazione; la diagnosi istologica deponeva
per pioderma gangrenoso. Si instaurava, pertanto, terapia steroidea sistemica
con progressivo miglioramento del quadro cutaneo e si sospendeva
Abatacept, sospettando suo eventuale ruolo eziologico. Abatacept è una
proteina di fusione costituita dalla porzione Fc modificata di IgG1 e dal
dominio extracellulare di CTLA-4; si lega a CD80/86, espresse su APC,
inattivando la via di costimolazione mediata dell’interazione tra il recettore
CD28 (espresso sui linfociti T) e le molecole CD80/86. L’insorgenza
del pioderma gangrenoso (ritenuta patologia autoinfiammatoria), durante
terapia con Abatacept, si configura come effetto paradosso in considerazione
dell’azione immunoregolatrice del farmaco. La patogenesi di tale
nesso causale resta ignota; non sono ancora noti i pathway immunologici
coinvolti
Alteração da comunidade bentônica devido a grandes mamíferos marinhos encalhe (Península Valdés, Argentina)
No full textEn Playa Flechero, Península Valdés, Argentina, excepcionalmente se vararon juntas dos ballenas adultas muertas (Eubalaena australis) las cuales sufrieron desgarros de su piel y músculos aportando gran cantidad de fluidos al intermareal. Las almejas (Darina solenoides), de hábito exclusivo filtrador, comenzaron a morir. Se realizaron estudios de la comunidad bentónica en el sitio de los varamientos y en cuatro sitios adicionales, manteniendo el nivel de marea, y se estudió el contenido de lípidos en el sedimento. Se replicó el muestreo del bentos cuatro meses después para determinar si hubo asentamiento de poslarvas de almejas. Se encontraron lípidos en el sedimento y una relación inversa entre la presencia de los mismos y la abundancia de almejas. La estructura de la comunidad de invertebrados bentónicos resultó afectada donde se producen los varamientos, en particular la población de D. solenoides. Sin embargo, se produce el pronto reclutamiento de estas almejas, permitiendo la recuperación del sitio.In Flechero Beach, Península Valdés, Argentina were stranded together, exceptionally, two dead adults’ whales (Eubalaena australis), which suffered lacerations of their skin and muscles providing large amounts of fluids to the intertidal and, the clams (Darina solenoides), with have filter habit exclusively, began to die. Studies of the benthic community were conducted at the site of the stranding and at four additional sites, maintaining the tidal level, and the lipid content was studied in the sediment. Four month later, the benthic samples were replicated to determine whether there was settlement of clams’ post-larvae. Lipids were found in the sediment, as well as an inverse relationship between their presence and the abundance of clams. The community structure of benthic invertebrates was affected where stranding occurs, particularly of the D. solenoides population. However, the recruitment of this clam occurs soon thereafter, allowing recovery of the site.Em Flechero Praia, Península Valdés, Argentina, como uma exceção estavam juntos dois adultos mortos baleias (Eubalaena australis) encalhados na intertidal, que sofreu lacerações de sua pele e os músculos proporcionando muitos fluidos para a praia e os amêijoas (Darina solenoides), do hábito de filtração, começaram a morrer. Estudos da comunidade bentônica foram realizados no local do encalhe e em quatro sítios adicionais na manutenção do nível da maré, e o conteúdo de lipídios foi estudada no sedimento. Quatro meses depois, as amostras bentônicas foram respondidas para determinar se houv e liquidação de pós-larvas de moluscos. Lipídios no sedimento e uma relação inversa entre a presença do mesmo e da abundância de moluscos foram encontrados. A estrutura da comunidade de invertebrados bentônicos foi afetada onde encalhes ocorrem, em particular população D. solenoides. No entanto, o recrutamento destes moluscos breve ocorre permitindo local de recuperaçãoFil: Musmeci, Luciana Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; Argentin
Allergic contact dermatitis caused by isobornyl acrylate in a young diabetic patient using a continous glucose monitoring system (Freestyle Libre)
No full textn/
Occupational systemic allergic dermatitis in a football player sensitized to colophonium
No full textColophonium, also known as rosin, is a solid yellowish-transparent pine tree resin. It is used in the production of adhesives, in particular glues, mastics, insulating tapes, adhesive tapes, cosmetics, and products for depilation. Contact allergy to colophonium is relatively common and apparently increasing in frequency. We report an unusual case of systemic occupational allergic dermatitis in a professional football player
Metodologie interdisciplinari di conservazione e divulgazione dell’Architettura del Novecento. Il caso studio del ponte sul Basento di Sergio Musmeci
No full textThe architectural heritage of the XXth Century is distinguished using the modern com- bination of two materials, concrete and steel. Every city has identifying architectures of modern civilisation that have been built using the multiple construction possibilities of reinforced concrete. This recent heritage reveals day after day its vulnerability due to the lack of planned maintenance, fertile ground for concomitant causes of material- structural degradation. The work illustrates the opportunities offered by innovative methods of intervention based on the critical use of both information technologies in the fundamental phases of knowledge and diagnostics and new materials for the conservation of the architectural heritage in reinforced concrete. The work takes as a case study the bridge over the Basento (Potenza) by Sergio Musmeci, one of the masterworks of organic architecture recognised as a cultural asset in 2003
Thermal injury caused by the explosion of a lithium-ion mobile phone battery
No full textMobile phones are part of everyday life. They are generally considered safe for our health, but they may sometimes elicit contact dermatitis, especially due to metals. Furthermore, they are under investigation for being involved in the development of defective testicular function and gliomas. We report a case of thermal burn caused by the explosion of a lithium-ion mobile phone battery
Dermoscopy of patch test reactions: study of applicability in differential diagnosis between allergic and irritant reactions
No full textBackground: differentiating allergic from irritant patch test reactions may be rather hard, especially when objective features are not distinctive and clinical assessment is scarcely supportive.
Objectives: to describe the main dermoscopic features of patch test reactions and to assess the suitability of dermoscopy in differentiating allergic from irritant reactions in clinical setting.
Patients/Materials/Methods: consecutive adult outpatients patch tested at our Allergy Unit during a 6-month period who developed any skin reaction were eligible. At the 72-hour reading, allergic and irritant patch test reactions were captured with both a digital camera and a digital dermoscopic system. For each reaction, clinical and dermoscopic variables were separately assessed, scored and then compared.
Results: in 94 allergic reactions dermoscopy showed i) intense erythema (100%), ii) dense polymorphic vessels (97.9%), iii) whitish vesicles varying in size, number and arrangement (95.7%), iv) orange-yellowish patchy areas and crusts (35%). Scores of erythema and vessels were significantly higher in allergic than in the 33 irritant reactions, in which vesicles and orange-yellowish patches were a sporadic finding. “Poral pattern” was observed in 85.7% of irritant reactions to cobalt.
Conclusions: the dermoscopic patterns of allergic and irritant patch test reactions significantly differ. Highly sensitive and/or specific dermoscopic features may support differential diagnosis
Reconstructing topological properties of complex networks using the fitness model
No full textA major problem in the study of complex socioeconomic systems is represented by privacy issues—that can put severe limitations on the amount of accessible information, forcing to build models on the basis of incomplete knowledge. In this paper we investigate a novel method to reconstruct global topological properties of a complex network starting from limited information. This method uses the knowledge of an intrinsic property of the nodes (indicated as fitness), and the number of connections of only a limited subset of nodes, in order to generate an ensemble of exponential random graphs that are representative of the real systems and that can be used to estimate its topological properties. Here we focus in particular on reconstructing the most basic properties that are commonly used to describe a network: density of links, assortativity, clustering. We test the method on both benchmark synthetic networks and real economic and financial systems, finding a remarkable robustness with respect to the number of nodes used for calibration. The method thus represents a valuable tool for gaining insights on privacy-protected systems
Ciclo riproduttivo di Arbacia lixula (Linneo, 1758) (Echinodermata: echinoidea) nella AMP “Isola di Ustica”
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