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Histological and immunohistochemical features of a recurrent epithelial-myoepithelial lacrimal gland tumor in a dog
No full textPurpose: To describe histological and immunohistochemical features of a rare lacrimal
gland tumor. Methods: A conjunctival mass in the upper eyelid, lateral cantus, was surgically
excised from an 11 year-old female mongrel dog. Eight months later the dog presented
with recurrence of a larger orbital mass, and complete orbital exenteration was performed.
Samples from both surgeries were formalin fixed and submitted for histology. Microtomic
sections were stained with hematoxylin and eosin and serial sections immunostained with the
standard ABC method in order to characterize neoplastic cells. Monoclonal antibodies antivimentin,
cytokeratin 14 (CK14), CK19, CK8/18 and alpha smooth-muscle-actin (aSMA)
were applied. AEC served as the chromogen. Results: Histologically, the first mass excised
was a large, capsulated, neoplastic nodule with expansive growth. The second mass was a
large multilobulated un-encaspulated nodule with multifocal signs of infiltrative growth. In
both tumors two distinct cell populations were present: cuboidal cell lining small ductular
structure and elongated cells with scant, clear cytoplasm disposed in short bundles or in
whorls around ductal structures. Cuboidal cells were positive for CK19 and CK8/18, spindle
cells were CK14 and aSMA positive. Both cell types were vimentin negative. Based on histological
and immunohistochemical feature a diagnosis of epithelial-myoepithelial carcinoma
(ECM) was posed. Conclusions: ECM is a rare tumor of lacrimal gland, whose histological
features parallel those of salivary tumors, in which both component of secretory parenchyma,
i.e. epithelial and myoepithelial cells, undergo neoplastic transformation. Further
investigations are necessary to understand the specific prognostication criteria for this type
of neoplasm
Il carcinoma squamocellulare oculare nel cavallo: attualita' in terapia e casistica clinica.OCULAR SQUAMOUS CELL CARCINOMA IN HORSES: TREATMENTS AND CLINICAL CASES
No full textSCC is the most common neoplasm that affecting the eye and the periocular tissues in horses. During the last years several options have been described in order to increase the efficacy of the therapy. Most of these studies have been made in United States and Australia, in areas where the SCC is more common. No data can be found in our country. We report 16 cases of SCC collected in Italian field providing informations about breed, hair colour, gender, age and localizations. The aim of this study is to compare our results with the current therapies described in literature
A case of third eyelid hibernoma in a dog
No full textPurpose: To describe an unusual tumor of the third eyelid. Methods: A 10‐year‐old, female, beagle was presented for
an ophthalmological consult with a slowly progressive pro- trusion of the third eyelid OS. The dog received a complete
ophthalmic examination. The only abnormal ocular finding was a very subtle lateral strabismus and slight third eyelid displacement. For diagnostic investigation, an MRI was performed, demonstrating an oval, well‐defined mass, 18 × 19 mm, at the base of the third eyelid. Treatment included surgical excision with orbital exenteration. All orbital tissues were submitted for histopathology.
Results: Histologically, the nictitans gland was completely replaced by a large, multilobulated, partially encapsulated neoplasia composed of small dense lobules of polygonal or elongated cells, separated by subtle fibrovascular septa. Foci of mineralization were multifocally detectable. Neo- plastic cells were characterized by well‐defined cell bor- ders, abundant, finely vacuolized cytoplasm, and small round paracentral nuclei. Anisokaryosis and anisocytosis were mild, and mitotic index was 0.1. Immunohistochemi- cally, neoplastic cells stained negative for pancytokeratin and cytokeratin 14 (epithelium), PNL2 (melanocytes), Iba1 (histiocytes), chromogranin A, and NSE (neuroendocrine/ neuronal cells), occasionally positive for vimentin (mes- enchyme) and positive for UCP‐1 and alpha‐smooth muscle actin (smooth muscle). Based on histological and immuno- histochemical results, a hibernoma was diagnosed. The dog was recurrence‐free one year after surgery without adjunc- tive therapy.
Conclusions: Hibernomas have been demonstrated to express both muscle antigens and UCP1. To the best of author's knowledge, hibernomas have been previously described in the canine orbit but not within the third eyelid
Lacrimal Gland Tumours in Dogs: A Histological and Immunohistochemical Study
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Introduction: Lacrimal gland tumours (LGTs) are well-known neoplasms affecting both the nictitating membrane and the main lacrimal glands in dogs; however, extensive histological and immunohistochemical studies are currently lacking. In recent years an increasing number of LGTs with a complex (i.e. epithelial and myoepithelial) phenotype have been recorded in our routine histopathology service. The aim of the present study was to review histological and immunohistochemical features of LGTs in dogs.
Material and Methods: Nictitating membrane (NM) and main lacrimal gland (LG) biopsy samples from the departmental archive (2010–2016) were reviewed. HE sections were re-evaluated by light microscopy. Since a specific classification for LGTs is currently lacking, the classification proposed by Goldschmidt (2011) for mammary gland tumours was applied. Immunohistochemistry for pancytokeratin (CK AE1/AE3), CK14, α-smooth muscle actin, calponin and p63 was performed.
Results: One-hundred and sixty-one NM and LG specimens were reviewed: 106 neoplastic lesions were diagnosed, 28 were epithelial gland tumours (25 NM; three LG). Twenty-four of 28 were carcinomas: seven complex, five solid, two simple tubular, two tubulopapillary, two comedocarcinoma, one ductal, four carcinoma and malignant myoepithelioma, one malignant myoepithelioma. Four were benign tumours: two complex adenomas, two multilobular adenomas. CKAE1/AE3 labelled tubular cells, while CK14, α-SMA, calponin and p63 labelled myoepithelial cells, when present.
Conclusions: In the present cohort of cases, NM and LG complex carcinomas and adenomas were highly represented among LGTs. NM and LG carcinomas outnumbered adenomas and were characterized by marked intratumoural variability. A specific classification for lacrimal tumours is needed
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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