3,347 research outputs found
Host-bacterial interaction in peri-implantitis
No full textCrielaard, W. [Promotor]Loos, B.G. [Promotor]Wismeyer, D. [Promotor]Laine, M.L. [Copromotor
LooS: co-producing youth mental healthcare
No full textThe increasing waiting times in youth mental health care pose a significant challenge, driven by a shortage of specialists and external factors that complicate diagnosis and prolong treatment. Shoshin, a multidisciplinary strategic design and innovation agency, has developed a solution known as the Fit Op Weg Poli (FOWP) to address this issue for adult care at GGZ Delfland. This thesis aims to engage youth healthcare providers in the development of a youth FOWP.To tackle the design challenge, the double diamond method is applied, involving extensive research and collaborative sessions. This process led to the development of LooS, a co-production framework tailored for young individuals aged between twelve and twenty-seven years old. Co-production for LooS leads to improved service delivery and increased efficiency, aiming to transform youth mental health care.LooS incorporates several crucial elements to support youth mental health. An easily accessible well-being gym is provided, empowering young individuals to enhance their resilience and overall well-being. A walk-in centre offers a safe and non-judgmental space for peer interaction and support. The intake process involves a comprehensive assessment, and each young person is assigned a dedicated buddy who provides support throughout their recovery journey. Welcome packages are provided to manage expectations and offer essential resources, including e-health tools and information about the recovery process.Recovery is facilitated through group sessions with a recovery coach, accompanied by the use of e-health tools for progress monitoring and exercises for continued growth. LooS aims to transition 20-30% of clients to a stage where therapy is no longer required, while those who still need therapy will receive specialised group therapy, after recovery.In the case of a crisis, the program can be scaled up swiftly to provide immediate support. After a crisis, diagnosis-specific therapy will always be provided, and the recovery coach ensures continued aftercare. The aftercare is structured in layers, offering self-testing and a safety net for a smooth transition. Once individuals no longer require aftercare, they bid farewell to their buddy and continue working on their mental resilience in the well-being gym.LooS is designed to be adaptable for implementation in multiple centres/locations across The Netherlands, allowing for widespread access to youth mental health care. To support open discussions with healthcare providers, a visual aid called the “Praatplaat” and a brochure have been created. These tools highlight the impact of LooS on the care pathway and waiting times to enable engagement among healthcare providers to co-produce their own LooS centres. A comprehensive blueprint has been developed, providing a clear and structured guide for the co-development process of Shosin with healthcare providers.In conclusion, LooS is a new approach to youth mental health care, focusing on proactive work on mental resilience, accessible support services, and collaborative engagement. By implementing LooS, the aim is to transform the youth mental health care system, reduce waiting times, and provide holistic care for youth. LooS offers a path towards improved outcomes and well-being, ultimately creating a brighter future for the youth of The Netherlands.Strategic Product Desig
Correlation energy of two electrons in a ball
No full textWe study the ground-statecorrelationenergyEc of two electrons of opposite spin confined within a D-dimensional ball (D≥2) of radius R. In the high-density regime, we report accurate results for the exact and restricted Hartree–Fock energy, using a Hylleraas-type expansion for the former and a simple polynomial basis set for the latter. By investigating the exact limiting correlationenergyEc⁽⁰⁾=limR→0Ec for various values of D, we test our recent conjecture [P.-F. Loos and P. M. W. Gill, J. Chem. Phys.131, 241101 (2009)] that in the large-D limit, Ec⁽⁰⁾∼−δ2/8 for any spherically symmetric confining external potential, where δ=1/(D−1)
Activación de los sistemas arquitectónicos compactos. La construcción del mecanismo de proyección diagonal en la obra de Adolf Loos
No full text[EN] The activation of compact architectural systems, built by attached spatial units –specialized, qualified, related to each other within a defined and regular container– requires specific tools capable of supplying the lack of dynamic, interstitial and communication spaces. The construction of Loos’ Raumplan implies the development of different relational mechanisms, based on the use of some of these tools. Among them, we can highlight one of great importance for its capacity to activate the interior space. Its construction arises from the evolution of fluctuation and frontality operations inherited from the architectural tradition and it gradually incorporates focal alterations that lead to the diagonal projection. Tools for the qualification of this diagonal perceptual mechanism are studied through a graphic analysis developed by the author.[ES] La activación de los sistemas arquitectónicos compactos, formados por unidades espaciales adosadas, especializadas, cualificadas, relacionadas entre sí en un contenedor definido y regular, requiere de herramientas específicas, capaces de suplir la carencia de espacios dinámicos, intersticiales y de comunicación. En la construcción del Raumplan, Adolf Loos desarrolla diferentes mecanismos relacionales. Entre ellos, destaca uno de gran capacidad dinamizadora del espacio interior. Su construcción parte de la evolución de las operaciones de fluctuación y frontalidad heredadas de la tradición arquitectónica para incorporar gradualmente alteraciones focales que conducen a la proyección diagonal. Mediante el análisis gráfico elaborado por el/la autor/a, se estudian las herramientas empleadas para la cualificación de este mecanismo perceptivo, que potencia la disociación entre el recorrido físico y perceptivo del observador.Toral Guinea, M. (2019). Activation of compact architectural systems. The construction of the diagonal projection mechanism in Adolf Loos’ work. EGA Expresión Gráfica Arquitectónica. 24(37):74-85. https://doi.org/10.4995/ega.2019.10832OJS74852437CACCIARI, M. (1989) "Adolf Loos y su ángel". En: ANDERSON, S., et al. Adolf Loos. Barcelona: Stylos. [Original: CACCIARI, M. (1981) Adolf Loos e il suo Ángelo. Milano: Electa].COLOMINA, B. (1988) "On Adolf Loos and Josef Hoffman: Architecture in the Age of Mechanical Reproduction". En: RISSELADA, M. (ed.). Raumplan Versus Plan Libre. New York: Rizzoli.COLOMINA, B. (1992) "The Split Wall: Domestic Voyeurism". En: COLOMINA, B. (ed.). Sexuality and space. New York: Princeton Architectural Press.CRARY, J. (1990) Techniques of the Observer: On Vision and Modernity in the Nineteenth Century. Massachusetts: MIT Press.FRAMPTON, K. (1996) "Adolf Loos: El arquitecto como maestro de obras". En: Adolf Loos Arquitectura 1903-1932. SCHEZEN, R. (ed.). Barcelona: Gustavo Gili.GARCÍA, M., MARTÍ, C. (2009) La Arquitectura del cine: estudios sobre Dreyer, Hitchcock, Ford y Ozu. Barcelona: Fundación Caja de Arquitectos.GRAVAGNUOLO, B. (1982) Adolf Loos: Theory and Works. New York: Rizzoli.KULKA, H. (1979) Adolf Loos: Das werk des architekten. Wien: Löcker Verlag. [Primera edición: 1931]LOOS, A. (1980) "Arquitectura". En: Ornamento y delito y otros escritos. Barcelona: Gustavo Gili. [Original: "Architektur". Der Sturm, 1910].LOOS, A. (1993) "El principio del revestimiento". En: Escritos I: 1897/1909. Madrid: El Croquis. [Original: "Das Prinzip der Bekleidung", Neue Freie Presse, Vienna, 1898].POSENER, J. (1983) "Der Raumplan. Vorläufer und Zeitgenossen von Adolf Loos". En: WORBS, D. (ed.), Adolf Loos 1870-1933: Raumplan Wohnungsbau. Berlin: Akademie der Künste.RISSELADA, M. (1988) "Introduction". En: RISSELADA, M. (ed.). Raumplan Versus Plan Libre. New York: Rizzoli.TRÍAS, E. (2000) Los límites del mundo. Barcelona: Destino.VAN DE BEEK, J. (1988) "Adolf Loos -pattern of town houses". En: RISSELADA, M. (ed.), Raumplan Versus Plan Libre. New York: Rizzoli
QUESTDB: A database of highly accurate excitation energies for the electronic structure community
No full textWe describe our efforts of the past few years to create a large set of more than 500 highly accurate vertical excitation energies of various natures (π → π*, n → π*, double excitation, Rydberg, singlet, doublet, triplet, etc.) in small- and medium-sized molecules. These values have been obtained using an incremental strategy which consists in combining high-order coupled cluster and selected configuration interaction calculations using increasingly large diffuse basis sets in order to reach high accuracy. One of the key aspects of the so-called QUEST database of vertical excitations is that it does not rely on any experimental values, avoiding potential biases inherently linked to experiments and facilitating theoretical cross comparisons. Following this composite protocol, we have been able to produce theoretical best estimates (TBEs) with the aug-cc-pVTZ basis set for each of these transitions, as well as basis set corrected TBEs (i.e., near the complete basis set limit) for some of them. The TBEs/aug-cc-pVTZ have been employed to benchmark a large number of (lower-order) wave function methods such as CIS(D), ADC(2), CC2, STEOM-CCSD, CCSD, CCSDR(3), CCSDT-3, ADC(3), CC3, NEVPT2, and so on (including spin-scaled variants). In order to gather the huge amount of data produced during the QUEST project, we have created a website (https://lcpq.github.io/QUESTDB_website) where one can easily test and compare the accuracy of a given method with respect to various variables such as the molecule size or its family, the nature of the excited states, the type of basis set, and so on. We hope that the present review will provide a useful summary of our effort so far and foster new developments around excited-state methods. This article is categorized under: Electronic Structure Theory > Ab Initio Electronic Structure Methods
The first president's pathway into ESTSS: memories and ideas for future issue. Patients as partners
No full textThis article addresses Wolter De Loos’ pathway into ESTSS that ended on 6th January 2004. His footsteps are still printed in the field of psychotraumatology as he showed the field how a physician was trying to integrate his working field with that of psychiatry, with a great passion for his patients. Erica M. Van der Schrieck-De Loos outlines the perspectives of her father as funding president of the ESTSS by using his Opening Address of the Fourth ESTSS Conference in 1995. This address emphasized that the mixture of righteousness and offence in warfare is ubiquitious and everlasting. The perspective of the first president's pathway has been integrated with the current vision of the author to show that the patient can be a partner of the healthcare team. A suggestion for ESTSS main objective number (8), contained within the ESTSS mission statement, is to involve patients as partners of the traumatic stress care team into accelerating traumatic stress care across Europe and beyond
Architektonische studies 1
No full textHet ontwerp van woongebieden en woninggroeperingen, dr.ir. M. Polak (Dis)kontinuïteit van het moderne, ir. L. van Duin Ruimtevorm en beeld in enkele plannen van Loos, Wright en Soane, R. VisserArchitectureArchitectur
Solar-simulated ultraviolet irradiation induces selective influx of CD4+ T lymphocytes in normal human skin.
No full textThe proportion and composition of the human cutaneous CD3+ T lymphocyte population was determined in situ following a single exposure to physiological, erythema-inducing doses of simulated solar radiation, mainly consisting of UV radiation. Biopsies were taken 1, 2 and 7 days after local irradiation of normal volunteers with 1, 2, and 4 MED by a Xenon-arc lamp and immunohistochemistry was performed on cryostat sections. UV radiation caused an initial decrease of intraepidermal CD3+ T cell numbers or even could lead to T-cell depletion 24 and 48 hours post-irradiation, and this was followed by an infiltration of T cells in the epidermis as determined 1 week after UV exposure. The number of dermal CD3+ T cells was increased 24 hours after irradiation, reached a maximum at 48 hours and subsequently declined at day 7, though remained significantly higher than the unirradiated control. Double staining demonstrated that the CD3+ T cells, which immigrated the (epi)dermis upon UV exposure, co-expressed CD4 but not CD8. Therefore the CD4/CD8 ratio in skin was markedly increased during the first week upon UV exposure. Our time course study shows that UV radiation affects the T cell population within the human skin by depleting the majority of epidermal T cells and initiating a selective influx of CD4+ T cells
The first president's pathway into ESTSS: memories and ideas for future issue. Patients as partners
No full textThis article addresses Wolter De Loos’ pathway into ESTSS that ended on 6th January 2004. His footsteps are still printed in the field of psychotraumatology as he showed the field how a physician was trying to integrate his working field with that of psychiatry, with a great passion for his patients. Erica M. Van der Schrieck-De Loos outlines the perspectives of her father as funding president of the ESTSS by using his Opening Address of the Fourth ESTSS Conference in 1995. This address emphasized that the mixture of righteousness and offence in warfare is ubiquitious and everlasting. The perspective of the first president's pathway has been integrated with the current vision of the author to show that the patient can be a partner of the healthcare team. A suggestion for ESTSS main objective number (8), contained within the ESTSS mission statement, is to involve patients as partners of the traumatic stress care team into accelerating traumatic stress care across Europe and beyond.</p
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