4,461 research outputs found
Lomas de Meléndez – Cali
No full textPlano, Dimensión : 60 x 40 cm. ; Escala : 1:5000Plano topográfico. Contiene ilustraciones sobre las lomas de Meléndez. Se ofrecen detalles técnicos adicionales acerca de la distribución espacial del proyecto
Neuroserpin: a serpin to think about
No full textProteinases and their inhibitors play important roles in neural development, homeostasis and disease. Neuroserpin is a member of the serine proteinase inhibitor (serpin) superfamily that is secreted from the growth cones of neurons and inhibits the enzyme tissue-type plasminogen activator (tPA). The temporal and spatial pattern of neuroserpin expression suggests a role in synaptogenesis and is most prominent in areas of the brain that participate in learning, memory and behaviour. Neuroserpin also provides neuronal protection in pathologies such as cerebral ischaemia and epilepsy by preventing excessive activity of tPA. Point mutations in neuroserpin cause aberrant conformational transitions and the formation of loop-sheet polymers that are retained within the endoplasmic reticulum of neurons, forming inclusion bodies that underlie an autosomal dominant dementia that we have called familial encephalopathy with neuroserpin inclusion bodies or FENIB. We review here the role of neuroserpin and other proteinase inhibitors in brain development, function and disease
DS1_JVDI_10.1177_1040638719867124 – Supplemental material for Equine urinary N-acetyl-β-D-glucosaminidase assay validation and correlation with other markers of kidney injury
No full textSupplemental material, DS1_JVDI_10.1177_1040638719867124 for Equine urinary N-acetyl-β-D-glucosaminidase assay validation and correlation with other markers of kidney injury by Rosemary L. Bayless, A Russell Moore, Diana M. Hassel, Brittney J. Byer, Gabriele A. Landolt and Yvette S. Nout-Lomas in Journal of Veterinary Diagnostic Investigation</p
Design strategy for low-energy ventilation and cooling within an urban heat island
No full textThe implementation of passive down-draught cooling (PDC) in a substantial building is a world first. The PDC technique won the CIBSE Environmental Initiative of the Year Award in 2006; the work was submitted by the IESD. The School of Slavonic and East European Studies (SSEES) building has won other awards for both its engineering and its architecture (see RA5 Esteem).
The PDC strategy is the practical culmination of IESD research work begun in 1997 in an EU FP5 project (Scientific Co-ordinator, Lomas). The technical content of this paper builds on four earlier papers, all published since January 2001, which flowed from that EU project: “Bowman NT, Eppel H, Lomas KJ, Robinson D and Cook MJ, Passive downdraught evaporative cooling - I: Concept and precedents, Indoor and Built Environment, Vol 9, No 5, pp 284-290, (2001), ISSN 1420-326X”; “Cook MJ, Robinson D, Lomas KJ, Bowman NT and Eppel H, Passive downdraught evaporative cooling - II: airflow modelling, Indoor and Built Environment, Vol 9, No 6, pp 325-334, (2001), ISSN 1420-326X”; “Robinson D, Lomas KJ, Cook MJ and Eppel H, Passive down-draught evaporative cooling: thermal modelling of an office building, Indoor and Built Environment, No 13, pp 205-221, (2004), ISSN 1420-326X”; and insights gained from writing “Lomas KJ, Fiala D, Cook MJ and Cropper PC, Building bioclimatic charts for non-domestic buildings and passive downdraught evaporative cooling, Building and Environment, Vol 39, pp 661-676, (2004), ISSN 0360-1323”.
Lomas wrote the paper, Woods (Cambridge) provided some experimental results
Low energy architecture for a severe US climate: design and evaluation of a hybrid ventilation strategy
No full textThis paper presents the novel hybrid ventilation strategy developed by Lomas for the Judson College Library and Faculty building, located near Chicago, USA. The project was won against a short list of 12 competition entrants drawn from a total of 85 submissions; Lomas was a member of the competition team. He was the lead author of this paper and headed the environmental design and evaluation work, co-authors Cook and Fiala conducted simulation analyses.
A companion paper, for which Lomas was the lead writer and corresponding author, ‘Short CA and Lomas KJ, Exploiting a
hybrid environmental design strategy in a US continental climate, Building Research and Information, Vol 35, No 2, pp 119-143,
(2007)’: describes the ventilation strategy in the context of the architecture; elucidates the ventilation control strategy devised by
Lomas; and presents the projected energy savings.
The building’s design resulted in the awarding of a number of prestigious grants (see RA5 Esteem). The research reported in this paper, and the research for the SSEES building (Lomas Output 1), won the RIBA President’s Awards for Research, gold medal, in 2007; the work was submitted by Short and Associates (the IESD is ineligible for this competition)
D. Pedro de Mora y Lomas, del Consejo de S.M. ... Intendente de la Provincia de Madrid, y Corregidor de esta Villa y su partido ... con motivo de haberse de verificar mañana á las cinco de la tarde la Proclamación del Rey nuestro Señor ... habrá salvas de artillería ..
No full textTít. tomado de cabecera de textoA fin de texto consta: "Madrid 24 de Julio de 1808. Pedro de Mora y Lomas. Por mandato de S.S. Francisco Rodriguez Gallego
An autoethnography exploring the engagement of records management through a computer mediated communication focused co-operative inquiry
No full textThis thesis is an autoethnography exploring the engagement of records management (RM) through the vehicle of a computer mediated communication (CMC) focused co-operative inquiry. CMC is defined as, “communication that takes place between human beings via the instrumentality of computers” (Herring, 1996, p.81). The PhD stance was that with the advent of new technologies, such as CMC, the role and place of RM has been challenged. RM practitioners needed to evaluate their principles and practice in order to discover why RM is not uniformly understood and also why it fails to engage many CMC users and information professionals. The majority of today’s information is generated as the result of unstructured communications (AIIM, 2005 and 2006) that no longer have a fixed reality but exist across fragmented globalised spaces through the Cloud, Web 2.0 and software virtualisation. Organisational boundaries are permanently perforated and the division between public and private spaces are blurred. Traditional RM has evolved in highly structured organisational information environments. Nevertheless, RM could lie at the heart of the processes required for dealing with this splintered data. RM takes a holistic approach to information management, establishing the legislative requirements, technical requirements and the training and support for individuals to communicate effectively, simultaneously transmitting and processing the communications for maximum current and ongoing organisational benefits. However RM is not uniformly understood or practiced. The focus of the thesis was to understand how RM engagement can and should be achieved.
The research was conducted by establishing a co-operative inquiry consisting of 82 international co-researchers, from a range of disciplines, investigating the question, ‘How do organisations maximise the information potential of CMC for organisational benefit, taking into account the impact of the individual?” The PhD established a novel approach to co-operative inquiry by separating, managing and merging three groups of co-researchers (UK Records Managers, UK CMC users, international Records Managers and CMC users). I was embedded as a co-researcher within this wider inquiry personally exploring as an autoethnography the relevance of RM to the wider research question, the ability of RM practitioners to advocate for RM and the co-researchers’ responses to the place of RM within this context.
The thesis makes several contributions to the research field. It examines how records managers and RM principles and practice engaged through the inquiry, articulating the reasons why users sometimes failed to engage with RM principles and practice, and what assists users to successfully engage with RM. It was found that national perspectives and drivers were more significant as to whether or not individuals engaged with RM concepts than age, gender or professional experience. In addition, users engaged with RM when it was naturally embedded within processes. In addition, as a result of the inquiry’s discussions and actions, the thesis suggests that RM principles and practice need to be refined, for example in regards to the characteristics that define a record. In this respect it concludes that there is rarely likely to be an original archival record surviving through time given the need for migration. The research delivered a novel approach to co-operative inquiry whereby merging groups through time produced new learning at each merger point. The thesis recommends further research to build upon its findings
Moderate beta baseline scenario in preparation to D-T operations at JET
No full textIn 2021, JET will operate with a D-T plasma mixture. To achieve high fusion power with a steady performance, two ELMy H-mode scenarios are under development: the baseline scenario, with low βN where good confinement is achieved at high current and the hybrid scenario, at lower current and higher βN, with a shaped current profile. Most of the extrapolations done for baseline plasmas used as reference one of the baseline most performing pulses with a βN ≈ 2.2 which is higher
than usual in typical baseline pulses. In this work we present the results of the predictive simulations done with the JINTRAC suite of codes and the QuaLiKiZ transport model, using as reference a more conventional baseline with q95 ≈ 3 and βN ≈ 1.8. The simulation settings and the transport model have been validated against the experimental results obtained in D-T plasma mixture during DTE1, when JET was equipped with a carbon wall, and against the experimental results obtained in D plasmas both with the C wall and the ITER-like wall (Be/W) installed in 2011. The extrapolations to D-T plasma mixture at high current show that 10 MW of fusion power are achievable in a wide range of experimental conditions, while 15 MW of fusion power could be approached only with full auxiliary
power (40 MW)in particularly pure plasmas
Linderiella baetica Alonso & Garcia-de-Lomas 2009 (Crustacea, Branchiopoda, Anostraca): On the verge of extinction?
No full textThe province of Cadiz (South of Spain) hosts the only known locality in the world of Linderiella baetica Alonso & Garcia-de-Lomas 2009 (Anostraca). In this paper, the geographical distribution of the species based on published sampling data focused on large branchiopods and temporary pools in Andalusia and the entire Iberian Peninsula is assessed. The current situation is summarized based on the threats to their survival, which are mainly related to habitat alteration. In the Iberian Peninsula, at least 1,648 bodies of water (about 720 in Andalusia) have been explored. Prevalence data suggest that L. baetica is a rare species (localities with presence / sample locations = 6.07 . 10-4). The application of the IUCN (2012) criteria suggests that L. baetica is a threatened species, catalogued as "critically endangered". Several emergency solutions such as translocation of individuals or their propagules to newly created ponds and to sustain the efforts of exploration have been proposed. However, conservation of the species in the current circumstances it is not considered viable if the natural habitat remains unprotected. The legal protection of L. baetica is proposed
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