1,720,981 research outputs found
Treatment of hypothalamic infertility with pulsatile GN-RH administration.
No full textIn this study the Authors have obtained an ovulatory response using intravenous Gn-RH treatment in four patients with hypothalamic hypogonadotropic amenorrhea. The Gn-RH was administered in a pulsatile manner with a small portable autoinfusion pump (Autosyringe, Inc., Hooksett). The ovarian follicular maturation, as it appears from the pelvic echography, was perfectly similar to that observed in a spontaneous ovulatory cycle. Endocrine picture by serial determination of gonadotropin; prolactin, estradiol and progesterone concentrations showed hormone values to be in the normal range. During the therapy no complications were observed; at the present time no pregnancy has occurred
FSH receptor polymorphisms in a population of infertile women and controls
No full textOBJECTIVE: Two single nucleotide polymorphisms at position 680 and 307 of the FSH receptor gene have been associated with infertility and ovar- ian response in IVF. The aim of this study was to examine the frequency dis- tribution of FSH receptor polymorphisms in infertile patients and controls and to correlate these polymorphisms with the outcome of IVF cycle.
DESIGN: Case-control study.
MATERIALS AND METHODS: 86 IVF infertile patients undergoing ovarian stimulation in a long suppression protocol and 60 fertile controls were included in the study. Fertile patients included were enrolled among women who delivered and had no history of infertility. Blood samples were obtained and DNA was analyzed to determine the FSH receptor geno- type. Among IVF cycle: basal FSH levels, number of antral follicles, number of preovulatory follicles (>15mm), number of retrieved oocytes, duration of stimulation (days), number of transfer embryo, pregnancy rate and amount of FSH were assessed and correlated with genotypes.
RESULTS: No statistically significant differences in the distribution of polymorphisms were found among the group of infertile women and controls. Basal FSH levels, number of antral follicles, number of preovulatory follicles (>15mm), number of retrieved oocytes and number of transfered embryos was comparable between infertile patients with different FSH receptor geno- type. However, patients who carry TT (thr-thr) and NN (asn-asn) genotype need fewer days of ovarian stimulation to oocyte retrieval. (TT: 9,07 days, p1⁄40,028; NN: 9,08 days, p1⁄40,037). A trend of better pregnancy rate in the AA genotype carrying patients was found, although not statistically signifi- cant. The dose of FSH required for a successful stimulation was similar in the two polymorphisms.
CONCLUSIONS: FSH receptor genotype is not different between infertile and fertile patients. TT and NN genotype acchieve a significantly higher ovarian response. There is a not significant trend for better pregnancy rate in AA subgroup patients. Our results seem to support some role of FSH re- ceptor polymorphism in infertile patients: the clinical relevance of this factor is however probably low
A new method for free testosterone assay: clinical evaluation.
No full textThe Authors propose a new direct method for the determination of free Testosterone (F. Te).
Our study was made following this method: 1) on a control group composed of 12 healthy
men and 21 healthy women, and 2) on a group of 29 patients suffering from Polycystic Ovary
Syndrome (PCOS) with clinical signs of hyperandrogenism. This pathological group
presented acne and hirsutism in 95% of the cases. The Authors demonstrate how the
determination of F
Fibrocystic Disease of the Breast Associated with Pituitary‐Ovarian Dysfunction: Results of Treatment with Bromocriptine
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
The Effect of HRT on Endometrial Thickness (ET) and Uterine Arterial Blood Flow Assessed by Transvaginal Ultrasound (TVU).
No full textThe aim of our study was to evaluate the TVU effectiveness compared to hysteroscopy plus
endometrial biopsy (HS/B) to identity endometrial alterations and to find a cut‐off value
under which invasive techniques are useless; furthermore, we aimed to determine whether
HRT had any positive effect on uterine arterial blood flow, 96 postmenopausal women
(pmw) consented to enter the study. Patients*(pts) mean age was 56.1 years. with
menopausal amenorrhoea for at least 9 months and on HRT for at least 6 month
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Endometrial changes in postmenopausal breast cancer patients receiving tamoxifen: a transvaginal ultrasound study
No full textAbstract: The purpose of the study was to evaluate the effects of tamoxifen therapy on the
endometrium by transvaginal sonography. Seventy-nine asymptomatic postmenopausal
women treated with tamoxifen (20 mg/day) for at least one year were recruited. Twenty
healthy postmenopausal women served as controls. All patients underwent transvaginal
ultrasound to evaluate endometrial thickness and echotexture
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