1,721,014 research outputs found
Farmacoutilizzazione e farmacovigilanza nell'anziano : analisi delle segnalazioni spontanee di sospette reazioni avverse in italia nel 2007
No full textL'influenza e l'incertezza: Un binomio inscindibile nella storia e nella letteratura del "nemico invisibile" : riflessioni clinico-storiche per il prossimo autunno
No full textInvecchiamento e consumo di farmaci : uno studio campionario
No full textOfficial statistics of the SSN (Italian National health service) do not provide information about how many drugs are used by whom and for what diseases. The study carried out by Saniteia on a large Health District (ASL) in Lombardy can supply exhaustive responses to these questions and allow to build-up scenarios for the next future. In this ASL elderly patients, representing 16% of the population, attract 47% of pharmaceutical expenditure. An elderly person costs, for drugs, four times more than an adult. In general, those buying drugs are chronic ill patients (16% of population and 64% of expenditure), whose demand is inelastic to co-payments, while most of the population uses drugs occasionally (less than 100 euros per year) and has a demand elastic to charges. The ageing of the population, associated with many other factors affecting drug spending, could increase the SSN pharmaceutical expenditure - by 2010 - from a minimum of 9%, due to demographic changes only, to a maximum of 124%, including rises in consumption and average prices, similar to those occurred in the last five years
Effect of diastereoisomeric epoxyrotenones on hepatic epoxide hydrase activity
No full textThe effect on epoxide hydrase activity of the two diastereomeric (6′R) and (6′S)-6′,7′-epoxyrotenones formed during the oxidative metabolism of rotenone on the isopropenyl side chain is reported. The activity of microsomal epoxide hydrase was determined using styrene oxide as substrate. The results indicate that the two diastereomeric 6′,7′-epoxyrotenones are good substrates for epoxide hydrase and are noncompetitive inhibitors for the hydration of styrene oxide. The more polar of the two isomers is more active as inhibitor of this enzyme
Epoxide metabolites of opiates and their interaction with the hepatic microsomal epoxide hydrolase
No full text
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Stress ossidativo e invecchiamento : l'inattivazione dell'istone-deacetilasi, chiave di volta nella resistenza agli steroidi in pazienti con broncopneumopatia cronica ostruttiva (BPCO)
No full textInflammatory lung diseases are characterized by increased expression of multiple inflammatory genes that are regulated by pro-inflammatory transcription factors such as nuclear factor-κB and AP-1. Gene expression is regulated by acetylation of core histones through the action of activators with intrinsic histone acetyltransferase activity. Conversely gene repression is mediated via histone deacetylases and other corepressors. By contrast with patients with asthma, those with chronic obstructive pulmonary disease (COPD) are poorly responsive to the anti-inflammatory action of steroids and these drugs provide little clinical benefit. Steroids recruit histone deacetylase-2 (HDAC2) to the actively transcribing gene, which switches of inflammatory gene transcription. It is proposed that in patients with COPD, HDAC2 function is impaired by cigarette smoking and oxidative stress, leading to a pronounced reduction in responsiveness to corticosteroids. This proposal rises the possibility that novel therapeutic approaches might unlock this corticosteroids resistance, leading to more effective anti-inflammatory treatments for COPD and other severe inflammatory diseases
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