1,721,025 research outputs found

    Improving risk assessment of vineyard mancozeb applicators by integrating environmental and biological monitoring results

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    Background: Ethylene-bis-dithiocarbamate (EDBC) fungicides have been used for decades, and although they have a low acute toxicity, there have been reports of possible negative health effects. Due to the specificities of agriculture, it is necessary to perform real-life risk assessment to validate the pre-marketing results. Additionally, many authors have raised concerns about using fixed absorption coefficients, together with other generic estimates, in absorption assessment. Implications are especially severe in modeling efforts, as the estimated absorbed dose is the key variable. Aim of the study: The aim of this study was to estimate the absorbed dose and risk using a fixed absorption coefficient and a first-order kinetics model and evaluate environmental and biological monitoring endpoints’ potential for modeling purposes. Methods: This study was carried out in 2011 in the Region of Lombardy (Italy). Environmental monitoring was done using the “patch” method and by collecting hand wash liquid, and biological monitoring was done by collecting 24-hour pre- and post-exposure urine samples. The determination of mancozeb and ETU in different samples (pads, hand wash, and urine) was done by liquid chromatography-mass spectrometry. Risk assessment was done by comparing the estimated absorbed dose to the Acceptable Operator Exposure Level (AOEL) and repeated after accounting for the duration of exposure. Suitability of different exposure variables for modeling purposes was assessed using Spearman correlation coefficients. Results: 29 healthy male farmers applied mancozeb on 38 work-days. Median total absorbed dose was 3 ng/kg body weight. Expressed as risk, the median absorbed dose was more than 10,000 times lower than the AOEL. After accounting for the duration of exposure, hand dose was reduced by more than 80% and body dose by around 50%. In general, best correlations were seen between the total dose and body dose, and the 24-hour post-exposure ETU urine levels (with and without correction for creatinine). The total absorbed dose and body dose had correlation coefficients with 24-hour post exposure ETU levels of 0.67 and 0.66, respectively (p<0.05). Short discussion/conclusions: Workers’ exposure to mancozeb is significantly below the AOEL. Using a first-order kinetics model for dermal absorption led to a major decrease in the estimated absorbed dose. This reduction could play a crucial role when environmental and biological monitoring results are used for modeling purposes

    'Coastal lagoons, shifting environments, and control of natural resources’

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    Lagoons and wetlands are environments that offer very valuable natural resources and as such have been exploited by humans since early times. This paper touches on the important role lagoons had in the Roman era not only in the production of salt but also for large-scale fishing and fish salting. It then focuses on cases of territorial disputes concerning lagoonal areas that involved local authorities against Roman tax farmers. It is argued that the reasons for these disputes were on the one hand the economically important resources offered by wetlands and on the other the morphological changes to which lagoons are prone, which could modify the interface between lagoon and sea. This mattered because in Roman law the sea and costal lagoons had different status regarding ownership

    Going Beyond Counting First Authors in Author Co-citation Analysis

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    The present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed

    Variations on the Author

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    “Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
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