954 research outputs found

    Sampling variance and distribution of the D' measure of overall gametic disequilibrium between multiallelic loci

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    The development of the theory of estimation of gametic disequilibrium for multiallelic systems is particularly necessary, since a large number of the genetic markers available at present are highly polymorphic multiallelic systems. The D' coefficient is one of the most commonly used measures of the extent of overall disequilibrium between all possible pairs of alleles at two multiallelic loci. Nevertheless, the sampling properties of this measure of overall disequilibrium, are to date, unknown. In this work, we have derived explicit expressions by large-sample theory to compute the approximate sampling variance of D^' between pairs of multiallelic loci, when samples of haplotypes are taken from populations. Formulae for calculating the asymptotic sampling variance were checked by Monte Carlo simulation. In addition, the magnitude of the sampling variance of D^' was investigated under different scenarios of disequilibrium between multiallelic loci. Extensive simulations were also carried out for describing the sampling distribution of D^', conditioned on the sample size, number of alleles and their frequencies, and disequilibrium components. It was found that the sampling distribution of D^' generally approaches well the theoretical normal distribution for experimental sample sizes, particularly when loci have many alleles. Disequilibrium data between microsatellite loci of human chromosome 11p are used for illustration. These investigations increase substantially our knowledge about this widely used measure of overall disequilibrium, which is relevant to evaluate disequilibrium between multiallelic loci in populations

    Holonomic quantum computation

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    In this brief review we describe the idea of holonomic quantum computation. The idea of geometric phase and holonomy is introduced in a general way and we provide few examples that should help the reader understand the issues involve

    LCA approach for the C&D waste management system in different countries of the world

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    The main problem with the recovery of construction and demolition (C&D) waste is the huge amount of recycled aggregates that remain unsold, due, maybe, to the lack of trust by sector operators. Carry on an environmental assessment would be a useful method to reveal the advantages in the use of the secondary resources. Through a literature review, this paper will analyze the application of Life Cycle tools for evaluating circular strategies in C&D waste management to compare different scenarios, hypotheses, and approaches adopted in life cycle assessment (LCA). The comparison will be done between four scientific articles from different countries (Italy, Spain, Denmark, and Brazil), in which an LCA analysis regarding C&D waste management has been carried out

    Life cycle costing della catena di gestione dei rifiuti da costruzione e demolizione

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    Il seguente lavoro si pone l’obiettivo di valutare i costi della demolizione selettiva e dell’uso degli aggregati riciclati attraverso l'applicazione della metodologia dell’Environmental Life Cycle Costing (eLCC). L'analisi eLCC ha incluso i costi preliminari, di acquisizione macchinari, operativi e di conferimento relativi all'intera catena di gestione dei rifiuti da costruzione e demolizione (C&D). Sulla base dei risultati ottenuti è stato possibile delineare alcuni scenari prevedendo meccanismi di incentivazione a beneficio della demolizione selettiva e dell’uso degli aggregati riciclati per favorire il raggiungimento di un’economia circolare nel settore delle costruzioni

    Studio LCA della catena di gestione dei rifiuti da Costruzione e Demolizione (C&D)

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    L’obiettivo dello studio LCA qui presentato è duplice. Da un lato lo studio si propone di valutare gli impatti ambientali dell'intera catena di gestione dei rifiuti C&D, dall’altro, di realizzare 24 dataset relativi ai processi di gestione, recupero e smaltimento dei rifiuti da costruzione e demolizione, con particolare riferimento alla regione Lombardia, per l’inserimento nella BDI-LCA di Arcadia

    Effects of Lévy noise on the dynamics of sine-Gordon solitons in long Josephson junctions

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    We numerically investigate the generation of solitons in currentbiased long Josephson junctions in relation to the superconducting lifetime and the voltage drop across the device. The dynamics of the junction is modelled with a sine-Gordon equation driven by an oscillating field and subject to an external non-Gaussian noise. A wide range of α-stable Levy distributions is considered as a noise source, with varying stability index α and asymmetry parameter β. In junctions longer than a critical length, the mean switching time (MST) from the superconductive to the resistive state assumes a value independent of the device length. Here, we demonstrate that this value is directly related to the mean density of solitons which move into or from the washboard potential minimum corresponding to the initial superconductive state. Moreover, we observe: (i) a connection between the total mean soliton density and the mean potential difference across the junction; (ii) an inverse behaviour of the mean voltage in comparison with the MST, with varying the junction length; (iii) evidence of non-monotonic behaviours, such as stochastic resonant activation and noise-enhanced stability, of the MST versus the driving frequency and noise intensity for different values of α and β; (iv) finally, these non-monotonic behaviours are found to be related to the mean density of the solitons formed along the junction

    Multiparameter quantum critical metrology

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    Single parameter estimation is known to benefit from extreme sensitivity to parameter changes in quantum critical systems. However, the simultaneous estimation of multiple parameters is generally limited due to the incompatibility arising from the quantum nature of the underlying system. A key question is whether quantum criticality may also play a positive role in reducing the incompatibility in the simultaneous estimation of multiple parameters. We argue that this is generally the case and verify this prediction in paradigmatic quantum many-body systems close to first and second order phase transitions. The antiferromagnetic and ferromagnetic 1-D Ising chain with both transverse and longitudinal fields are analysed across different regimes and close to criticality

    Self-consistent triaxial de Zeeuw-Carollo models

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    We use the standard method of Schwarzschild to construct self-consistent solutions for the triaxial de Zeeuw & Carollo (1996) models with central density cusps. ZC96 models are triaxial generalizations of spherical γ-models of Dehnen whose densities vary as rγr^{-\gamma} near the center and r-4 at large radii and hence, possess a central density core for γ=0\gamma=0 and cusps for γ>0\gamma > 0. We consider four triaxial models from ZC96, two prolate triaxials: (p,q)=(0.65,0.60)(p, q) = (0.65, 0.60) with γ=1.0\gamma = 1.0 and 1.5, and two oblate triaxials: (p,q)=(0.95,0.60)(p, q) = (0.95, 0.60) with γ=1.0\gamma = 1.0 and 1.5. We compute 4500 orbits in each model for time periods of 105TD10^{5} T_{\rm D}. We find that a large fraction of the orbits in each model are stochastic by means of their nonzero Liapunov exponents. The stochastic orbits in each model can sustain regular shapes for ~103TD10^{3} T_{\rm D} or longer, which suggests that they diffuse slowly through their allowed phase-space. With the exception of the oblate triaxial models with γ=1.0\gamma =1.0, our attempts to construct self-consistent solutions employing only the regular orbits fail for the remaining three models. However, the self-consistent solutions are found to exist for all models when the stochastic and regular orbits are treated in the same way because the mixing-time, ~104TD10^{4} T_{\rm D}, is shorter than the integration time, 105TD10^{5} T_{\rm D}. Moreover, the “fully-mixed” solutions can also be constructed for all models when the stochastic orbits are fully mixed at 15 lowest energy shells. Thus, we conclude that the self-consistent solutions exist for our selected prolate and oblate triaxial models with γ=1.0\gamma = 1.0 and 1.5

    Self-consistent triaxial de Zeeuw-Carollo models

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    [[abstract]]We use the standard method of Schwarzschild to construct self-consistent solutions for the triaxial de Zeeuw & Carollo ( 1996) models with central density cusps. ZC96 models are triaxial generalizations of spherical gamma-models of Dehnen whose densities vary as r(-gamma) near the center and r(-4) at large radii and hence, possess a central density core for gamma = 0 and cusps for gamma > 0. We consider four triaxial models from ZC96, two prolate triaxials: ( p, q) = ( 0.65, 0.60) with. = 1.0 and 1.5, and two oblate triaxials: ( p, q) = ( 0.95, 0.60) with. = 1.0 and 1.5. We compute 4500 orbits in each model for time periods of 10(5)T(D). We find that a large fraction of the orbits in each model are stochastic by means of their nonzero Liapunov exponents. The stochastic orbits in each model can sustain regular shapes for similar to 10(3)T(D) or longer, which suggests that they diffuse slowly through their allowed phase-space. With the exception of the oblate triaxial models with. = 1.0, our attempts to construct self-consistent solutions employing only the regular orbits fail for the remaining three models. However, the self-consistent solutions are found to exist for all models when the stochastic and regular orbits are treated in the same way because the mixing-time, similar to 10(4)T(D), is shorter than the integration time, 105TD. Moreover, the "fully-mixed" solutions can also be constructed for all models when the stochastic orbits are fully mixed at 15 lowest energy shells. Thus, we conclude that the self-consistent solutions exist for our selected prolate and oblate triaxial models with. = 1.0 and 1.5.[[fileno]]2010503010003[[department]]天文

    Stabilization by dissipation and stochastic resonant activation in quantum metastable systems: Noise induced phenomena in quantum metastable systems

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    In this tutorial paper we present a comprehensive review of the escape dynamics from quantum metastable states in dissipative systems and related noise-induced effects. We analyze the role of dissipation and driving in the escape process from quantum metastable states with and without an external driving force, starting from a nonequilibrium initial condition. We use the Caldeira–Leggett model and a non-perturbative theoretical technique within the Feynman–Vernon influence functional approach in strong dissipation regime. In the absence of driving, we find that the escape time from the metastable region has a nonmonotonic behavior versus the system-bath coupling and the temperature, producing a stabilizing effect in the quantum metastable system. In the presence of an external driving, the escape time from the metastable region has a nonmonotonic behavior as a function of the frequency of the driving, the thermal-bath coupling and the temperature. The quantum noise enhanced stability phenomenon is observed in both systems investigated. Finally, we analyze the resonantly activated escape from a quantum metastable state in the spin-boson model. We find quantum stochastic resonant activation, that is the presence of a minimum in the escape time as a function of the driving frequency. Background and introductory material has been added in the first three sections of the paper to make this tutorial review reasonably self-contained and readable for graduate students and non-specialists from related areas
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