265 research outputs found
Strategies for the valorisation of monastic architectures. The Case of the Badia of Pattano in Cilento
No full textThe regeneration of rural areas is a current issue that needs valorization strategies, on a small and
large scale, of the cultural heritage hosted in it and often forgotten or abandoned. Cultural heritage
represents a precious resource, the result of interaction and connections over the centuries between
populations and places. The main route consists in the innovation of the forms of management and
dissemination through the current ITC, placing as a basis the synergy interaction of different fields of
research. This paper is part of a wider research on Cilento’s monastic architectures, on their interrelationships
and ramifications in a fabric generally not prone to contamination. The attention is focused
on the Badia of Santa Maria of Pattano in Vallo della Lucania (SA), testimony of eastern monasticism
in southern Italy, an almost forgotten Byzantine architecture that needs enhancement by means of
strategies and processes based on multiscalar approaches and open minded.
Through the contextual critical reading of the archive documents and the infographic models produced
by systematic surveys, the initial objective is to identify and date the most significant transformations
of the monastery, to understand its relationship with the territory
Evaluation of DOWNSTAGING as leading concept in sphincter-saving surgery for rectal cancer after preoperative radio-chemotherapy (Preop RCT).
No full textAbstract
AIM:
To evaluate the downstaging of rectal cancer after preop R +/- CT.
METHODS:
392 patients (pts) with rectal cancer were observed. Only 172 pts (58%) with II and III stage cancer of middle and lower third were examined. Enrol-led pts were 168: 52 of them received preop R +/- CT (32 RT, 20 R + CT). Preop R +/- CT group included 14 middle third cancers (73%), 38 lower third (17%). In this group, tumor stage was as follows: 44 T3 stage tumors (86.4%), 8 (15.4%) T4. Mean age of this group was 57 years (range 42-67). Patients received 45 Gy for 5 weeks in 25 fractions and continuous administration of 5-FU (300-500 mg/m2/die). Surgery was performed 6 weeks +/- 7 days after the therapy.
RESULTS:
Downstaging, at least of 1 T-stage level, was detected in 45 patients (86%) (8 middle third; 32 lower third), in 5 (9.6%) (4 middle third, 1 lower third), tumor decreased to pT0N0, while in 7 (13.5%) (2 middle third, 5 lower third), there was no response. An Anterior Resection (AR) was performed in 40 patients (77%) [4 Downstaged to pT0N0 middle third cancers; 36 downstaged but with residual disease (8 middle third, 28 lower third)]; APR was performed in 12 (23%) (7 No responders patients, 1 Downstaged to pT0N0 lower third cancer, 4 downstaged but with residual disease of lower third).
CONCLUSIONS:
Preop R +/- CT is effective in obtaining a significative downstaging to allow sphincter saving surgery, without compromising oncological results
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