174 research outputs found
Indigenous Reusable Chest Electrode A Cost Effective Alternative To Commercial Disposable Electrode For ECG Monitoring.
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The Synaptonuclear Messenger RNF10 Acts as an Architect of Neuronal Morphology
No full textThe Ring Finger Protein 10 [RNF10] is a novel synapse-to-nucleus signaling protein that specifically links activation of synaptic NMDA receptors to modulation of gene expression. RNF10 dissociation from the GluN2A subunit of the NMDA receptor represents the first step of its synaptonuclear transport and it is followed by an importin-dependent translocation into the nucleus. Here, we have identified protein kinase C [PKC]-dependent phosphorylation of RNF10 Ser31 as a key step for RNF10 detachment from NMDA receptor and its subsequent trafficking to the nucleus. We show that pSer31-RNF10 plays a role both in synaptonuclear signaling and in neuronal morphology. In particular, the prevention of Ser31 RNF10 phosphorylation induces a decrease in spine density, neuronal branching, and CREB signaling, while opposite effects are obtained by mimicking a stable RNF10 phosphorylation at Ser31. Overall, these results add novel information about the functional and structural role of synaptonuclear protein messengers in shaping dendritic architecture in hippocampal neurons
Resilience: an all-encompassing solution to global problems? A biopolitical analysis of resilience in the policies of EC, FEMA, UNDP, USAID, WB, and WEF
No full textThis thesis examines the use of resilience in international policy-making. A concept that originally meant an ability of ecosystems to absorb disturbance has not only been welcomed in many disciplines outside ecology, but lately become popular in the policies of international organisations that claim resilience as a solution to various ‘global problems’ such as climate change, underdevelopment, or economic crises. The study contributes to the ongoing critical discussion on the governance effects of resilience. Here, the Foucauldian theory of biopolitics and the concept of governmentality are useful. Resilience now addresses human systems and communities with concepts from natural sciences, thus making it a biopolitical phenomenon.
Specifically, the thesis asks how mainstreaming resilience affects the pursuit of agendas in six organisations: European Commission, Federal Emergency Management Agency, United Nations Development Programme, United States Agency for International Development, World Bank, and World Economic Forum. Using Foucauldian discourse analysis, the study is thematically divided into adaptive, entrepreneurial and governing aspects of resilience. Each part explicates how truth, power and subjectivity are constructed in the discourse. The analysis shows that contrary to the policy claims, resilience does not function as a solution but is constitutive of the problems it attempts to solve. The current policy discourse confirms pre-existing practices and power relations, and further problematizes issues on the agendas.
The thesis confirms that the policies are trapped in a neoliberal biopolitics that has problematic implications for human subjectivity and political agency. It further concludes that if resilience is to have any practical relevance and positive effects, the policy discourse has to be changed, for which current critical accounts do not offer a plausible direction. Therefore, a distinction between resilience as a policy tool and social resilience is needed, whereby the use of resilience as a policy solution is reduced to disaster risk reduction and similar technical functions, and social resilience is recognised as a communal capacity that cannot be subject to policy regulation
Evidence of 9Be + p nuclear reactions during 2ω CH and hydrogen minority ICRH in JET-ILW hydrogen and deuterium plasmas
No full textThe intensity of 9Be + p nuclear fusion reactions was experimentally studied during second harmonic (2ω CH) ion-cyclotron resonance heating (ICRH) and further analyzed during fundamental hydrogen minority ICRH of JET-ILW hydrogen and deuterium plasmas. In relatively low-density plasmas with a high ICRH power, a population of fast H+ ions was created and measured by neutral particle analyzers. Primary and secondary nuclear reaction products, due to 9Be + p interaction, were observed with fast ion loss detectors, γ-ray spectrometers and neutron flux monitors and spectrometers. The possibility of using 9Be(p, d)2α and 9Be(p, α)6Li nuclear reactions to create a population of fast alpha particles and study their behaviour in non-active stage of ITER operation is discussed in the paper
Determination of isotope ratio in the divertor of JET-ILW by high-resolution H alpha spectroscopy: H-D experiment and implications for D-T experiment
No full textThe data of the H alpha high-resolution spectroscopy, collected on the multiple lines of sight, which cover the entire divertor space in poloidal cross-section, during the recent hydrogen-deuterium experiments in JET-ILW (ITER-like wall), are processed. A strong spatial inhomogeneity of the hydrogen concentration, H/(H + D), in divertor is found in many pulses. Namely, the H/(H + D) ratio may be lower in the inner divertor than that in the outer divertor by the values of 0.15-0.35, depending on the conditions of gas puffing and plasma heating. This effect suggests the necessity of spatially-resolved measurements of isotope ratio in the divertor in the upcoming deuterium-tritium experiments. Also, separation of the overlapped T alpha and D alpha spectral lines is shown to be a challenging task especially when the local Doppler-broadened (Gaussian) line shapes are noticeably distorted by the net inward flux of fast non-Maxwellian neutral atoms. We use the respective, formerly developed model of an asymmetric spectral line shape, while analysing the data of the first deuterium-tritium experiment in JET-C (carbon wall), and test the model via comparing the isotope ratio results with another diagnostic's measurements. This model is shown to increase the accuracy of tritium concentration measurements in the divertor
Scenario development for D-T operation at JET
No full textThe JET exploitation plan foresees D-T operations in 2020 (DTE2). With respect to the first D-T campaign in 1997 (DTE1), when JET was equipped with a carbon wall, the experiments will be conducted in presence of a beryllium-tungsten ITER-like wall and will benefit from an extended and improved set of diagnostics and higher additional heating power (32 MW neutral beam injection + 8 MW ion cyclotron resonance heating). There are several challenges presented by operations with the new wall: a general deterioration of the pedestal confinement; the risk of heavy impurity accumulation in the core, which, if not controlled, can cause the radiative collapse of the discharge; the requirement to protect the divertor from excessive heat loads, which may damage it permanently. Therefore, an intense activity of scenario development has been undertaken at JET during the last three years to overcome these difficulties and prepare the plasmas needed to demonstrate stationary high fusion performance and clear alpha particle effects. The paper describes the status and main achievements of this scenario development activity, both from an operational and plasma physics point of view
<i>mbl-1</i> mutants display a defect in D-type GABAergic motor neurons, related to Fig 2.
No full text(A-C). Confocal images of wild type (A) and mbl-1(0) (B) worms expressing a presynaptic reporter Pmec-7-ELKS-1::TagRFP (jsIs1075), shown in magenta color. The neuron is also labeled with diffusible reporter Pmec-7-GFP (muIs32), shown in green. The ectopic synapse in the PLM anterior process in the mbl-1(0) background is marked by a red arrowhead, whereas the original synapse is marked by a white arrowhead. (C) The histogram shows the percentage of PLM neurons with ectopic synapses in the mbl-1(0) background. N = 3 independent replicates, n (number of worms) = 25–30. (D-F) Representative images (D) and schematic (E) of D-type motor neurons labeled with Punc-25::GFP (juIs76) in the wild-type and mbl-1(0) at the L4 stage. Red arrow showing a defect in neurite growth in mbl-1(0) background. (F) The histogram shows the percentage of worms showing neurite defects in the mbl-1(0). N = 3–4 independent replicates, n (number of worms) = 30–50. (G) Representative confocal images of touch neurons in the mutants of different RNA binding proteins. The names of the mutants are mentioned next to the respective image panels. (H) Quantification of any defects in PLM morphology seen in the mutants mentioned in (G) N = 3 independent replicates, n (number of worms) = 80–130. For C, F, and H ***P (TIF)</p
Observation of enhanced ion particle transport in mixed H/D isotope plasmas on JET
No full textParticle transport in tokamak plasmas has been intensively studied in the past, particularly in relation to density peaking and the presence of anomalous inward particle convection in L- and H-modes. While in the L-mode case the presence of the anomalous inward pinch has previously been unambiguously demonstrated, particle transport in the H-mode was unclear. The main difficulty of such studies is that particle diffusion and convection could not be measured independently in steady-state conditions in the presence of a core particle flux. Therefore, it is usually not possible to separate the transport effect(inward convection), from the source effect (slow diffusion of particles introduced to the plasma core by neutral beam injection heating). In this work we describe experiments done on JET with mixtures of two hydrogenic isotopes: H and D. It is demonstrated that in the case of several ion species, convection and diffusion can be separated in a steady plasma without implementation of perturbative techniques such as gas puff modulation. Previous H-mode density peaking studies suggested that for this relatively high electron collisionality plasma scenario, the observed density gradient is mostly driven by particle source and low particle diffusivity D < 0.5 ∗ χ eff. Transport coefficients derived from observation of the isotope profiles in the new experiments far exceed that value - ion particle diffusion is found to be as high as D 2 ∗ χ eff, combined with a strong inward convection. Apparent disagreement with previous findings was explained by significantly faster transport of ion components with respect to the electrons, which could not be observed in a single main ion species plasma. This conclusion is confirmed by quasilinear gyrokinetic simulations
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