191 research outputs found
Etude de la réception d'une oeuvre littéraire (Jean Forton, écrivain oublié ?)
No full textPourquoi Jean Forton (1930-1982), romancier français publié par Gallimard de 1954 à 1966, salué par la critique de l époque et candidat au Goncourt à plusieurs reprises, est-il tombé dans un oubli quasi-complet ? Pour répondre à cette question, nous avons étudié l évolution de la réception de son œuvre de 1951 à nos jours, à travers la presse régionale et nationale, afin de clarifier le rôle des événements, des critiques et du contexte littéraire. Au travers de la destinée éditoriale de Forton, nous avons cherché à savoir si le fait de vivre en province pouvait avoir des incidences sur la notoriété d un auteur. Enfin, nous avons formulé des hypothèses sur la réception future de l'œuvre de Jean Forton, en prenant en compte les bouleversements récents et actuels du monde de l édition, la place de plus en plus restreinte de la littérature française dans le monde, ainsi que les changements d attitude dans la lecture.Why has Jean Forton a French novelist published by Gallimard from 1954 to 1966, hailed by the critics of the time and a one-time Goncourt Prize runner fallen into near-oblivion ? To answer this question, we have examined the evolution of the way his works have been received from 1951 to this day, through both the national and regional press, with a view to clarifying the influence of events, critiques and literary context. By examining Forton s varied editorial fortunes, we try to determine whether the fact of living in the provinces has an effect on the fame of an author. The last part of our dissertation deals with a number of hypotheses concerning the future reception of Jean Forton s works. We take into account the recent and current upheavals within the world of publishing, the increasingly confined status accorded to French literature worldwide, as well as the changes in readers attitudes to literature.LE MANS-BU Lettres (721812108) / SudocSudocFranceF
Effect of alpha-interferon on the evolution of hepatitis C virus hyper-variable region 1
No full textHCV sensitivity to IFN correlates with a higher degree of variability in the NS5a protein
No full textExtra-hepatic Morbidity and Mortality of Chronic Hepatitis C
No full textChronic hepatitis C virus (HCV) infection is associated with several extra-hepatic
manifestations. Patients with HCV may develop mixed cryoglobulinemia and its sequelae,
ranging from cutaneous and visceral vasculitis to glomerulonephritis and B cell non-Hodgkin’s
lymphoma. HCV-infected patients have increased rates of insulin resistance, diabetes and
atherosclerosis, which may lead to increased cardiovascular morbidity and mortality. Neurologic
manifestations of HCV infection include fatigue and cognitive impairment. The mechanisms
causing the extra-hepatic effects of HCV infection are likely multifactorial and may include
endocrine effects, HCV replication in extra-hepatic cells, or a heightened immune reaction with
systemic effects. Successful eradication of HCV with interferon alpha and ribavirin was shown to
improve some of these extra-hepatic effects: sustained virologic response is associated with
resolution of complications of cryoglobulinemia, reduced levels of insulin resistance, reduced
incidence of diabetes and stroke, and improved fatigue and cognitive functioning. The
availability of new interferon-free, well-tolerated anti-HCV treatment regimens is broadening the
spectrum of patients available for therapy, including those in whom interferon was
contraindicated, and will likely result in greater improvements in the extra-hepatic manifestations
of HCV. If these regimens are shown to confer significant benefit in the metabolic,
cardiovascular, or neuropsychiatric conditions associated with HCV infection, extra-hepatic
manifestations of HCV may become a major indication for treatment even in the absence of liver
disease
New insights into hepatitis C
No full textHepatitis C infection is characterised by three key features, which are the consequence of a complex interaction between genetic determinants of immune and other host factors and viral characteristics: 1. A high rate of viral persistence after acute infection resulting from a combination of weak T cell responsiveness and specific viral mechanisms of immune escape. 2. Marked interindividual variability in end-organ damage (fibrosis and cirrhosis), probably due to host genetic polymorphisms in genes governing the immune response and fibrosis pathways in addition to viral pathogenicity factors. 3. Significant resistance to antiviral therapies. Viral mechanisms of antiviral resistance parallel those of viral persistence, and include the intriguing possibility that hepatitis C may infect immunologically privileged sites such as the central nervous system.</p
Genetic association of IFN-gamma loci with immuno-parasitological phenotypes in Mossi and Fulani of Burkina Faso
No full text
Interferon Regulatory Factor 1 polymorphisms and susceptibility to Plasmodium falciparum malaria.
No full textAnalysis of glass fiber reinforced cement (GRC) fracture surfaces
No full textGlass fiber reinforced cement (GRC) is a composite material produced by the union of a cement mortar matrix and chopped glass fibers. Its good mechanical properties deteriorate with time. This phenomenon has been studied performing a tensile test program on both young and aged samples of GRC produced by using different chemical additives. Once the tests were carried out, a microstructural analysis of fracture surfaces was performed using a scanning electronic microscope (SEM). Pictures taken showed that the addition of metakaolin enables more fibers to be pulled out from the matrix instead of being broken in aged GRC samples. However, the increase in the number of such fibers pulled out did not prevent the embrittlement of GRC. Also, all the other chemical additions used did not show any improvement in the mechanical properties of GRC
Failure and impact behavior of facade panels made of glass fiber reinforced cement(GRC)
No full textGRC is a cementitious composite material made up of a cement mortar matrix and chopped glass fibers. Due to its outstanding mechanical properties, GRC has been widely used to produce cladding panels and some civil engineering elements. Impact failure of cladding panels made of GRC may occur during production if some tool falls onto the panel, due to stone or other objects impacting at low velocities or caused by debris projected after a blast. Impact failure of a front panel of a building may have not only an important economic value but also human lives may be at risk if broken pieces of the panel fall from the building to the pavement. Therefore, knowing GRC impact strength is necessary to prevent economic costs and putting human lives at risk.
One-stage light gas gun is an impact test machine capable of testing different materials subjected to impact loads. An experimental program was carried out, testing GRC samples of five different formulations, commonly used in building industry. Steel spheres were shot at different velocities on square GRC samples. The residual velocity of the projectiles was obtained both using a high speed camera with multiframe exposure and measuring the projectile’s penetration depth in molding clay blocks. Tests were performed on young and artificially aged GRC samples to compare GRC’s behavior when subjected to high strain rates. Numerical simulations using a hydrocode were made to analyze which parameters are most important during an impact event.
GRC impact strength was obtained from test results. Also, GRC’s embrittlement, caused by GRC aging, has no influence on GRC impact behavior due to the small size of the projectile. Also, glass fibers used in GRC production only maintain GRC panels’ integrity but have no influence on GRC’s impact strength. Numerical models have reproduced accurately impact tests
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