9 research outputs found

    Adipokines, hormonal parameters, and cardiovascular risk factors : similarities and differences between patients with erectile dysfunction of arteriogenic and nonarteriogenic origin

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    Introduction. Erectile dysfunction (ED) is often associated with metabolic disorders. Leptin and adiponectin are adipose tissue-derived hormones involved in the regulation of metabolic homeostasis and considered important players in the relationship among obesity and cardiovascular diseases. Aim. Leptin, adiponectin, leptin to adiponectin ratio (L/A), and their correlation with hormonal and metabolic parameters were examined in male with arteriogenic- (A-ED) and nonarteriogenic-ED (NA-ED). Main Outcome Measures. Biochemical, metabolic, and hormonal parameters of men with A-ED were compared with those of male with NA-ED. Methods. Diagnosis of ED was based on the International Index of Erectile Function Score. Its etiology was classified with penile echo-color Doppler at baseline and after intracavernous injection of prostaglandin E1. Leptin and adiponectin were measured by enzyme-linked immunosorbent assay. Results. In A-ED subjects, increased levels of insulin, glycated hemoglobin, homeostasis model assessment of insulin resistance (HOMA-IR) index, body mass index (BMI), leptin, and L/A and decreased levels of total, free, and bioavailable testosterone were observed compared with NA-ED subjects. A trend toward lower estradiol level was also present in A-ED patients, even if not statistically significant. Reduced levels of adiponectin have been observed in both groups compared with patients without ED. Leptin and L/A correlated similarly with several parameters (negatively with testosterone/estradiol ratio and positively with BMI, insulin, HOMA-IR, and 17-beta estradiol). L/A resulted further correlated negatively with high-density lipoprotein and positively with triglycerides. Conclusions. Not all ED cases are similar. In fact, A-ED patients display a more complicated metabolic status characterized by overweight and obesity and associated to sexual hormone alteration. Whether changes in body composition and modulation of adipokine levels can improve local endothelial function need further investigation. Dozio E, Barassi A, Dogliotti G, Malavazos AE, Colpi GM, D'Eril GVM, and Corsi MM. Adipokines, hormonal parameters, and cardiovascular risk factors: Similarities and differences between patients with erectile dysfunction of arteriogenic and nonarteriogenic origi

    Nonlinear Measurement Update for Recursive Filtering Based on the Gauss von Mises Distribution

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    AbstractIn conventional Kalman-based state estimation algorithms, there is an assumption that the uncertainties in the system state and measurements are Gaussian distributed. However, this Gaussian assumption ignores the periodic nature of angular or orientation quantities. In this paper, the Gauss von Mises (GVM) distribution model defined on a cylindrical manifold is employed, the Dirac mixture approximation method is extended to deal with sampling with GVM, in order to perform recursive filtering, the GVM approximation to joint distribution is proposed, the formula to compute posterior distribution is derived. Finally, the measurement update algorithm is developed. Simulation results show that when the system state contains a circular variable, the proposed GVM filter can achieve more accurate estimates than the traditional extended Kalmanfilter(EKF), thereby providing a novel method to estimate system state specialized to GVM distribution

    Mental health conditions and use of rhythm control therapies in patients with atrial fibrillation: a nationwide cohort study

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    Publisher Copyright: © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.OBJECTIVES: Mental health conditions (MHCs) have been associated with undertreatment of unrelated medical conditions, but whether patients with MHCs face disparities in receiving rhythm control therapies for atrial fibrillation (AF) is currently unknown. We assessed the hypothesis that MHCs are associated with a lower use of antiarrhythmic therapies (AATs). DESIGN: A nationwide retrospective registry-based cohort study. SETTING: The Finnish AntiCoagulation in Atrial Fibrillation cohort included records on all patients with AF in Finland during 2007-2018 identified from nationwide registries covering all levels of care as well as drug purchases. MHCs of interest were diagnosed depression, bipolar disorder, anxiety disorder, schizophrenia and any MHC. PARTICIPANTS: We identified 239 222 patients (mean age 72.6±13.2 years; 49.8% women) with incident AF, in whom the prevalence of any MHC was 19.9%. OUTCOMES: Primary outcome was use of any AAT, including cardioversion, catheter ablation, and fulfilled antiarrhythmic drug (AAD) prescription. RESULTS: Lower overall use of any AAT emerged in patients with any MHC than in those without MHC (16.9% vs 22.9%, p<0.001). Any MHC, depression, bipolar disorder, anxiety disorder and schizophrenia were all associated with lower incidence of any AAT with adjusted subdistribution HRs of 0.790 (95% CI 0.771 to 0.809), 0.817 (0.796 to 0.838), 0.811 (0.789 to 0.835), 0.807 (0.785 to 0.830) and 0.795 (0.773 to 0.818), respectively. Adjusted rates of AAD, cardioversion and catheter ablation use were lower in all MHC groups compared with patients without MHC. The findings in patients with any MHC were confirmed in propensity score matching analysis. CONCLUSIONS: Among patients with AF, a clear disparity exists in AAT use between those with and without MHCs. TRIAL REGISTRATION NUMBER: ClinicalTrials Identifier: NCT04645537; ENCePP Identifier: EUPAS29845.Peer reviewe

    Perioperative Bleeding Requiring Blood Transfusions is Associated With Increased Risk of Stroke After Transcatheter and Surgical Aortic Valve Replacement

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    Objectives: The authors aimed to investigate the impact of severe bleeding and use of red blood cell (RBC) transfusion on the development of postoperative stroke after surgical (SAVR) and transcatheter aortic valve replacement (TAVR), taken from the FinnValve registry. Design: Nationwide, retrospective observational study. Setting: Five Finnish university hospitals participated in the registry. Participants: A total of 6,463 patients who underwent SAVR (n = 4,333) or TAVR (n = 2,130). Interventions: Patients who underwent TAVR or SAVR with a bioprosthesis with or without coronary revascularization. Measurements and Main Results: The incidence of postoperative stroke after SAVR was 3.8%. In multivariate analysis, the number of trans-fused RBC units (odds ratio [OR], 1.098; 95% confidence interval [CI], 1.064-1.133) was one of the independent predictors of postoperative stroke. The incidence of stroke increased, along with the severity of perioperative bleeding, according to the European Coronary Artery Bypass Grafting (E-CABG) bleeding grades were as follows: grade 0, 2.2% (reference group); grade 1, 3.4% (adjusted OR, 1.841; 95% CI, 1.105-3.066); grade 2, 5.5% (adjusted OR, 3.282; 95% CI, 1.948-5.529); and grade 3, 14.8% (adjusted OR, 7.103; 95% CI, 3.612-13.966). The inci-dence of postoperative stroke after TAVR was 2.5%. The number of transfused RBC units was an independent predictor of stroke after TAVR (adjusted OR, 1.155; 95% CI, 1.058-1.261). The incidence of postoperative stroke increased, along with the severity of perioperative bleeding, as stratified by the E-CABG bleeding grades: E-CABG grade 0, 1.7%; grade 1, 5.3% (adjusted OR, 1.270; 95% CI, 0.532-3.035); grade 2, 10.0% (adjusted OR, 2.898; 95% CI, 1.101-7.627); and grade 3, 30.0% (adjusted OR, 10.706; 95% CI, 2.389-47.987). Conclusions: Perioperative bleeding requiring RBC transfusion and/or reoperation for intrathoracic bleeding is associated with an increased risk of postoperative stroke after SAVR and TAVR. Patient blood management and meticulous preprocedural planning and operative technique aiming to avoid significant perioperative bleeding may reduce the risk of cerebrovascular complications. (C) 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)Peer reviewe

    0007

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    Young man I Buy your will be when you get a home* and if you will take the time to call at my office, or write me I will be glad to explain a plan whereby you can get a home |ust like paying rent. Cast your eye on the following homes offered for sale: COTTAGE of 4 rooms and bath, modern, sunny side of street, size of lot 50x112; location four blocks from Palo Alto Hotel COTTAGE of 5 rooms and bath, size of lot 40x115 with a barn; location one block from schoolhouse This property can be purchased at 1,600NEWBUILDINGATBERKELEY.TberegentsoftbeStateUniversityatameetingbeldthisweekdecidedtoliigiiiatoncetheerectionofCaliforniaHull,moneyforwhichwaaappropriatedbythelaatlegislature.ThihallIstobe200feetloDgandT5feetwide,andwillbetwostoriesinheight.ItIstobebuiltwestoftbepieseotsiteofNorthHallandwillbeofthecentralorlibrarygroupofbuildings.TbeentireareaoftheoniveraityIsdividedintosixgroups,andCaliforniaHallwillbeoftbegroupdesignatedasthelibrarygroup.Theotherfivestructureswillbetbelibrary,oneforhistory,politicalsciencesandeconomics,oneforancient,modernandOrientallanguages,oneforpbUosopby,JurisprudenceandredagogyaudCallfonilaHall,wblcbwillbeuaodbytboEnglii.iidepartmentundbytboadminlsLaLlou.Abuldlogfortbeadministrationliiii.tiuictiwillnotbeerectedfortenyears,andItwasossontlultbatprovisionbomadonowforthaoUlcesoftherecorderandpresident.ThevaluablepaperoftheunlvoraltyarenowkeptinSouthHall,andthoincroasi.itnumberofstudoutstaxestbocapacityoftherecoideraoffice.ItwasalsodecidedtospendISO,000Intbeerectionofacentralpermanentbeatandpowerplantfortbeuniversity.PlantHENUNUNIMPROVEDThisisthebestplacetoputyourmoney,Realestate,wheneverythingelsegoesbackonyou,stayswithyou.Castyour/eyeoverthefollowinglistoflots:1,600 NEW BUILDING AT BERKELEY. Tbe regents of tbe State University at a meeting beld this week decided to lii-giii at once the erection of California Hull, money for which waa appropriated by the laat legislature. Thi* hall Is to be 200 feet loDg and T5 feet wide, and will be two stories in height. It Is to be built west of tbe pieseot site of North Hall and will be of the central or library group of buildings. Tbe entire area of the oniveraity Is divided into six groups, and California Hall will be of tbe group designated as the library group. The other five structures will be tbe library, one for history, political sciences and economics, one for ancient, modern and Oriental languages, one for pbUosopby, Jurisprudence and -r-edagogy aud Callfonila Hall, wblcb will be uaod by tbo Eng- lii.ii department und by tbo adminls* LaLlou. A buldlog for tbe administration lii-i'i.ti uicti' will not be erected for ten years, and It was ossontlul tbat provision bo mado now for tha oUlces of the recorder and president. The valuable paper* of the unlvoralty are now kept in South Hall, and tho incroasi.it*n umber of stud outs taxes tbo capacity of the recoider'a office. It was also decided to spend ISO,000 In tbe erection of a central permanent beat and power plant for tbe university. Plant 'HEN UN UNIMPROVED This is the best place to put your money, Real estate, when every thing else goes back on you, stays with you. Cast your / eye over the following list of lots: 500—Location Horner Avenue 50x200. This is a splendid lot for the monoy. $-00—Location Hawthorne Ave. 50,200. Tins is also a splendid bargain. * A word to any um- desiring tu purchase Pain Altu property. I believe thai all unimpruved property ana' utTercd fur sale in Pain Aim sbnuld be suld at least one-tbird hiiihti. In nu place in California can tbe same amount nf mnney lie invested and equally, as good re- - turns be obtained as in Palo Alto real estate. Call ur vita, tur raj .1.1 af bar.alas la l,„|,,,,rr,l as w«ll as anirapritvril jirnpertjr. J. J. Morris Palo Alto. Cal. AN OLD BOOK. B. P. Hall bas Ln his possession a volume that waa a popular addition to the Sunday scbool libraries a half century ago. It was written by Amelia Ople and is eoUUed "Lying In All IU Branches." The author must have been another, judging by tbe startling occurrences related iu tbi* volume, mauy of wbicb could not possibly bavo happened except by special dispell Mil imi uf providence. Tbe book must bave afforded the children wbo read it mauy new ideas iu tbe art of lylug plausibly to tbeir puritanic jiareut*. Yot sucb a book was suppoaeed to be proper reading for young people. It would not be allowed in a Sunday scbool library at tbe present day aud aurely no obild aould bo loducod to read It now. Tho child of tbo proe- ent day baa a better mental training for hfc than did the children of earlier generations, but perhaps thl* advantage ia offset by tbo lack or oourteey and good breediug that pro* vails among twentieth century children. Church News Congregational Cburob—Tbe First Congregational cburcb will bold Ita Sunday school a; Fraternity Hall at G: t... will null" with the Presbyterian church at 11 a. m. and 6:45, and with all the churches of the city at 8 p. m. In Mullen's Hall. At tbe union service* of all tbe churches to be held fSuuday evening at 8 o'olook at Mullen'* Hall, Miss Emily Blssell uf India will luij-eraon- ate a blgb caste Indian woman and will tell ber story iu costume". Miss Hi- ''ll bos herself been a missionary lu ludia : n.i'i- 1885 aud ber mother haa boot, a missionary thereover flfty- two years. The aervlce will be instructive uud lntereatlug to all. Methodist Church— Hamilton are* hue. aud Webster atreet. AIG:45 the KpworLb League will have u -special ttoug uud ri ni'-c service. Tbe music will bo both lustrumental and vocal. All are Invited to this service. Tbo subject or tbe evening service is "Wakllng witb Uod." Tbo Gloe Club will slug at both or those services, aud there will bo otber mualo. Mornlug worship at 11 a. m. Sunday school at 0:46 Baptist Cburcb—Tbe pastor has returned from the coast and will be preseut at tbe aervlce* Sunday. In tbe morning he will preach from tbe same text u*ed by Mr. Wnitsker lost Sunday evenlog, 2 Cor. 3:18. Tbe church U to be congratulated on ae* curing thoaerrlces ol Mr*. Dots Gibson, pupil or Llebliog or Chicago, for tbe morning snd Professor Scott Brook, the eminent organist of tbe Memorial cburcb, 1* to play In tbe evening. The morning numbers are: Voluntary, AdagioSoatenuto, "Moonlight;" Sonata, Beethoven; offertory, "To Spring," Orieg; Recessional, Ve'raot, Lefebiiro-Wely. Tbe Sunday achool meet* at 9:.5 a. m. and this Suuday Bov. It. S. Tbompaou ol Clovla, wIioho oomiug hH* oortainly added much to tho working force of j tho church, ha* kludly consented to begin teaching tho adult Biblo class. Tbe Voting Pooplo'a aoolety ia grow- iug lu interest and attendance and meeta at 7 :00 o'clock Suuday evening. Uulon service In Mullon'a Hall lo tbe evening. TITLE QUIETED. The trustees of tbe Congregational cburcb purchased a lot near tbe corner of Hamilton avenue and Cowper street a year or so ago and thia lot was deeded to tbe late H. L. Brown as trustee. Tbe lot was exchanged for one opposite tbe Episcopal church, but Mr. Brown'* death left no one authorised to deed tbe lot to tbo new owner. A friendly suit wus brought by the trustees of tbo cburcb against the heirs of Mr. Brown tu adjust tho matter. On Weducsdity Judge BhodeH ordered tho heirs to execute it deed to tho fTuHit'i-.-. uud iu event of tholr failure ao to do then the oounty clerk In appointed commissioner to execute auch deed. Norman E. Malcolm was attorney for lbe plaintiffs and S. VV. Cbarlea for tho defendants. A POOR DIET. Senator "Joe" Hitwley has a collection of dog stories, any ono of which wins friends and votes. He was taking a constitutional lu a weateru New Vork village on a plena* ant Hummer's day. While pas*ing a cottage he wa* approached by Its tenant, who looked like a panhaudlcr. "Cau't you help me, sir?'* said tbe man. "Why, you cau't m---l anything," returned tbe Senator. "Vou have four or five dog-i aiouud the place, my man." "That** true, sir," won the reply, "but I can't compel my family lo eat dog*."—Now Vork Time*. BIDS ASKED. Tbo regular date for the next meeting of the towo trustee* falls on July 4tb, a legal holiday, therefore tbe meeting ba* been postponed to Thursday erenlng, July 0th. Bids will bo received up to that time for tbe extension of tbe water system and for 500 feet uf Are hose. All wbo wish to bid will Dud notice* in this issue, or can gel any desired Information from tbo towu clerk. I). II. Wood met witb an accident Wcdiicitduy night that laid him up with a sprained ankle. He was riding Im!i.fi.ui'l-. uud in turning the corner at High uud University tbe horse fell with .Mr. Wood underneath. ProfoHnor Doiiglus Houghton Campbell of tho liotuuy department ut Stanfonl In olf on u trip to A nut ml in and New Zealand. Flo will apoud the Hummer vacation investigating plant life in those countries. E. K. I .--*- t-ll. wife and daughter will go Into the l.i Honda couutry next week, where they will enjoy camji life foi a mouth or ao. Mr*. Alfred Oriawold of Sau Francisco la vlaltlng her son, W. 11. Oris* wold. IN THE ARK. It hub during tho llrnt bi-weekly oakewalk In tbe iirk. The other uuimtiltt hud done Iheir best. Then the Porcupine mid his wife were teen coming down tho line doing uu cMTuuiutliigly. funny atop. "Isn't thut u pouch?" exclaimed Father Ape, who was one of tho Judges. "1 thought it wurt a prickly pair?" responded the Monkey, who limned!* uli'ly round it advisable to seek the j highest perch iu tbo vessel B«ltl* I more American. SUNDAY AT SEASHORE. Low excursion rates to Sauta Cruz, Monterey. Del Monte, Pacific Orovc, C*plana. Try one day boating, bathing. Hulling, swimming, yachting. Sec agent of Southern Pucillc. RATES FOR THE FOURTH. I The Southern Pacific Company announce* the usual low rates for Fourth {of July travel. Tbo price* for round- ! trip tickets will be as follows: Ooe j and ODe-thlrd fsre to points where tbe rate I* 4,3.75 or less; 15 wben tbe one way (arc hi 13.75 to 14.15; oue and one-flfth fare wben tbe one-way rate i* M. 15 to 90; 97.20 wben tbe one-way fare is Id to 97.20; ono fore wben tbe one-way rate Is 97.20 to 910. Tick.-i . will be sold on July 3d and 4th, and will be good returning until July 7th. Profoesor .and* Mra. Eugene Smile left tbla morning for (.leuwood, Santa Cms oounty, for a month's vacation. SPECIAL NOTICES. LOST—A rnttorfiity pin. Finder ploi.no return to postuiuuter and io- celvo reward. 2f.lt* 0- II. ALLEN OIL CO. wish to nu- iioiiuiio thut notwlthtiluiidlng the existing shortage In gum-Hue thoy are prepared to III! or.lent tor gitso- llno Ht tho old price, 91.15 per 5 galloiis. 2U-tr WANTED-Posltlou by u retlt.ed lady to do light bouso work, plain cook, take care of child, oi would take charge of houne duriug owner's sb- ■euce. Befereuet**. Address Time* office. 26tf WANTED- Olri for general housework, uo cooking, wage* 915. Addreaa P. O. Box 7C, Menlo Park. 2G-lt Miss Van Syckel has sold her. Interest In the novelty stoie to C. H. William* roMutly of Fresno. Meura.Whltmer k William* expect toonlarge their present stock and extend the business. Chas, Whoatley representing tbe F. Thomoo Dyeing and Cleaning Work* ' will make regular tripe to Palo Alto commanding next Monday. Look for announcement next week. fill RENT— 358 Homer avenue, 5 roomed cottage.two roar rooma woll rurnlabed. Three front rooma now ien!.'.I for 910; wbolo cottago 925, or 2 rear room. 912. Also 3 room cottage In rear lot, partly furnished. Rent 910-60. Uood plumbing. Free water. Apply to S. E. von derMeb den, 26 O'Parrel I. St., San Francisco. 3t* WANTED—Household work by the day by competent woman. Apply st Mr. Barker's on Waverfy near tbe creek. Mrs. Ueo. Hall. 4t* FOft SALE— Seven room bouse at a bargain, 418 Ramona street. tf 945—To Jet for tbe summer; completely furnished upper flat.of movou rooms and bath. All modern convenience*, gas range lu kitchen, telephone, piano, etc. Family going to tho couutry ror thu summer. Addross J. Q. II., 1003 McAllister street, Ssu Frauotsoo. FOR LOTS In tho Coleman Truck, Menlo Park, seo J. T. Dunn, local agent, 521 Emerson atroot. THE EAGLE DRUG CO. ta head* quarters [or Wakalou'a wull known specialties—Camolllne, for the com- nlt-xlon: Llkola, tbo tonic; Rosea and Itosomar-/, for thc hair; Ma-suango Hoadscbe Powders; Wak aloe's Foot Powder; Cold Cream, Cucumber Cream, Squirrel poison and many other**. FOR LOTS in tho Coleman Track at Menlo Park, see J. T. Dunn, local agent, 521 Emerson sir-.—t. TO LET— During vacations very nloo 4-room cottage, fioely furnished, low rent. J. T. DUNN, 521 Emerson Si. TO RENT—From June let. A nine- room furnished bouse ln Palo Alto. All modern improvements and ample grounds. Address, P. O. Box 42, Stanford University. tt. DRESSMAKING— .Miss liatcheller. Room 16, Stauford Building. TO RENT—House of flvo rooma, fur- nlubod. Corner or Huwthoruu and Kamona streets. Address < Im. Nunu, Moulu Park, LOST- -Gold rlna. In tho vicinity ot Pulo Alto. FiiidurpleaBerett.ru to Times ollico aud rucelvo reward. .IL FOR SALE—A good second-hand surrey cheap, lor cash or ln ox- change ror a good family horse. A. B. Show. tf-25 353 Melville Avenue. WANTED—To buy a fn**h milch cow, Jersey breed only. Inquire of N. S. Gulbersoo, last bouse on Emerson street, near creek. 25-2t SALE—Of household furniture on account of removal. Call at residence, 455 University Ave. 25-3t PROFITALBE to BUVER and SELLER—Steady employment for an Bgent, lady or gentleman, to supply the de.uaud lor au up-tu date medical book, OH|KH-iully for womeu uud children. How to keep well, diet iu health aud i--'.- in very helpful hi the cure of the sick. Is explicit lu the truutmeuL of fevers. Cost about tho sumo u* one or two visits of a physician or a duy'u aorvico of u nurse. No married couple ahoold be without It, with childreu it Is n crlmo to bo without sucb a book. Circular tmiiled free, address, "Publishers' Ageut," 417 Purrott Bldg., San Francisco, or care ol the Times oflice, Palo Alto. PROFESSIONAL NURSE—Will go out by tbe day. Doctor's lefcrerices. Address .Mrs. K. Inez Faby- at Menlo Park, or Tel. "Red 26. kwfwood Citv. tf. IP VOU ARE INTERESTED in spring Harness and Saddlery goode, or Carriages see I. Stewart. Sewing machine- lor sale on easy terms, or to rent. tf. WANTED—A reliable, Intelligent local man an agent fur Metropolitan Life Ins. Co. Good op*>nrtiiDlty to engage iu a permanent anti profitable iii-iii.-;. olferlug eteiuly it')- viiucement. Call or i-ddrc-**, A. M. Castle. Ass't Sup't. Rooms 4 k 5 Patrick Block, Pulo Alto. tf. FOR SALE— 358 Homer avenuo. Cottago of llvu large ninnm uud iiutii,'i>i-iii imall cottage r :i roomi with good ;.|i; in l.i in.- in rear lot. Apply to S. E, Vou dor Mohtlou 26 0'FurrolISt.,Sau Frauclsco. 3t* s--SV-"sV-sO.-*«y-*a--^^^. *S>-s»*r-sV-*^ j White Mountain Freezers ' At I.liSS Than City Prices 1 QUART tl.25 2 " 1.75 3 '• 210 4 " 2.60 0' " 3.15 8 QUART U.C0 10 " 6.25 12 " 7.00 15 " 10.00 We need not explain the merits of this Freezer, It is too widely known for that, the freezer is all right and so is the price. THE REASON we are selling them so cheap is because we have lots of them and want to sell them. J. F. Partinson Six O'CarxL Store The Haberdasher Millinery R.&G. 10RSII 2 TWO STORES 2 A COW SI.ml III Oil LAWNS! LAWNS! IOOO yards of choice patterns in Lawns. Regular 8lc, 10c, i.jajc, and ice per yard Sale Price 5c yard THE BEST, THE VERY BEST—THAT'S OUR MOTTQ EARLE & CO. GROCERS All High Grade Groceries—They Speak for Themtelve, COLUMBIA tiocktmltbiog Repairing Renting Sundries TRIBUNE Smith's i Columbia! \ Cyelery / FRED M. SMITH.: .MO.. CLEVELAND On the Circle Palo Alto F.ncin.-i Gvm WOLF-AMERiriN Just armed ! Fresh stock ol lowncy'a IMiii.iM- Cbocolates-PAUCl PMAKU'CY. Notice to Creditors. Estate of lliaui* Tarbell. Deceased. Notice la hereby given by tbe undersigned administratrix of tbe Estate of Blanca Tarbell. deceased, to tbe creditors or and all pereona having claims against tbe aald deceased, to exhibit tbe aame. with the uocea- sary vouchors, within 4 months after tbe Hi.-' publicatiou or tbis Notice, to tbe said Administratrix at tbe oBlce or Corbet k Ooodwln, No. 331 Pine Street, City and County or San Francisco, sti.t... ot California. Sao Jose, this 29 day of May, A. D. 1903. OLUA 8. TARBELL, As administratrix of tbe estate of Blanca Tarbell. 'Jl.lt siiffi 10 GRAND. Tho Popular Soonlc Line to Salt Lake City, Lcadville, Pueblo,Colorado Springs, Denver Omaha, .Kansas Gty, St. Louis, Chicago and all Points East Connecting ut Ogdon Union Dopol with all Southern Paclllc Trains Only Truiui-e-mtiiH-ntal line passing directly tliroagll Suit Luke City Personally conducted Tourist Excursions daily from California to St. Louis, Chicago ami Botjlon Choir.! of three separate routes through the Rocky Mountains Through Pullman and Ordinary Sleeping Cars To Denver, Omaha, Kansas City, Chicago and St. Louis Without cbangu Fkke Reclisiso Ciiaik Cars DIN1NG CARS—Sqrrlco a la Carto ON ALL tbrough trains Por Rite*. Free II lu. listed Hook* of Trs.rl. etc , i = ', ulre of o. a nit lo L. a. JOHNSON, Prt. ft Pa-*. Aft. J. D. M.inm'|i;i.'.i C«b. Agt. ps-i. D-pL "■ Jo-*. Cal. S15 Ms.Itet St.. etso ft. di-Imx). c*l . 1 »>! -..-.t* i.:.i. ■i+l .*«>!-■--*>--.*>a-a>--jr^ !■} ^-a^H^^, ■) - y V |r ,,, ,, [■■SS-.K-H Coal Wood F.L. WORRELL ? PHONE RED 205 Hay Grain *'.a.otr.j|i:si*ii;>i.:i.i;>.o>;>i.>>:,..sr;^avi:iaai

    A multi-element psychosocial intervention for early psychosis (GET UP PIANO TRIAL) conducted in a catchment area of 10 million inhabitants: study protocol for a pragmatic cluster randomized controlled trial

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    Multi-element interventions for first-episode psychosis (FEP) are promising, but have mostly been conducted in non-epidemiologically representative samples, thereby raising the risk of underestimating the complexities involved in treating FEP in 'real-world' services
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