121,736 research outputs found
L'evoluzione degòli studi sull'economia dell'azienda:brevi considerazioni sull'inquadramento della disciplina
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organic phase enzyme electrodes for the determination of pesticides, phenols, aromatic hydrocarbons as environmental pollutants
No full textG. Di Natale, A. D'Amico, D. Donadio (Eds.), World Scientific (Publ.
Relation between L-arginine-nitric oxide pathway and endothelin-1 effects in periaqueductal gray area of rats.
No full textInjection of N omega-nitro-L-arginine methyl ester (L-NAME), an L-arginine analogue and a potent inhibitor of nitric oxide (NO) synthase, in dorsolateral periaqueductal gray (PAG) area of freely moving rats at doses from 0.1 to 1 mumol per rat, dose-dependently increased arterial blood pressure (BP). Endothelin-1 (ET-1) injected in the same area at doses from 0.1 to 1 pmol per rat also induced pressor effects. Administration of L-NAME (1 mumol per rat) in the PAG area 10 min before ET-1 significantly (p < 0.01) potentiated ET-1-induced hypertension. Pretreatment with L-arginine (1 mumol per rat), precursor of NO, significantly (p < 0.01) decreased L-NAME-induced potentiation of ET-1 pressor effects. L-Arginine also prevented the ET-induced increase in arterial BP and reversed L-NAME-induced hypertensive effect. Prazosin and propranolol, adrenergic blocking agents, and reserpine, a depletor of catecholamine stores, reduced either ET-1 or L-NAME pressor effects. Our data suggest the presence of NO synthase in the PAG area, considered an important cerebral area in coordinating physiologic responses such as cardiovascular and respiratory adjustment. Moreover, our results suggest that even at the PAG area level, functional antagonism exists between NO and ET-1, possibly contributing, through sympathetic outflow, to central regulation of arterial BP
Characterization of the role of CCRL2 in lung and intestine immune surveillance
No full textThe C-C chemokine receptor-like 2 (CCRL2) belongs to the class-A GPCR receptor and is related to the atypical chemokine receptors (ACKRs) family. It regulates leukocyte migration by acting as a Chemerin-presenting molecule, as well as forming heterodimers with other chemokine receptors. CCRL2 is expressed by a large variety of leukocytes and barrier cells and controls the inflammatory response in different pathological settings. For instance, in lung cancer CCRL2 is required for NK cell recruitment and immune surveillance. This thesis explored the multifaceted role of CCRL2 in the immune regulation of the lung and intestine. Firstly, we investigated the correlation between CCRL2 variants and the severity of COVID-19. Five CCRL2 missense polymorphisms common among Europeans were selected and investigated in the meta-analysis of the COVID-19 host genetics initiative (COVID19 HGI) and in the Italian cohort referring to the Humanitas Clinical and Research Center (Rozzano, Milan). We have identified an association between the p.I243V variant and severe respiratory COVID-19 in Europeans. Functional assessments revealed that these variants do not affect CCRL2 membrane expression or Chemerin binding. Additionally, we identify CCRL2 eQTLs specific to neutrophils, linked to COVID-19 associated SNPs, suggesting a targeted influence on neutrophils. The study also delved into CCRL2 involvement in the regulation of intestinal inflammation and tumorigenesis. Genetic ablation of Ccrl2 in murine models of DSS-induced colitis and AOM/DSS-induced colon cancer revealed a more severe inflammatory phenotype, a finding corroborated in VillinCreHe-CCRL2f/f mice, emphasizing CCRL2 role in regulating the intestinal epithelium. Furthermore, we have observed an increased permeability in intestinal organoids from Ccrl2 KO mice, suggesting a role for this receptor in maintaining intestinal barrier integrity. The absence of Ccrl2 also modulated the expression and release of certain pro-inflammatory cytokines and chemokines by intestinal organoids treated with TNF-α and IFN-. In conclusion, this study highlighted the impact of CCRL2 in neutrophil-mediated responses and COVID-19 severity. CCRL2 also plays a role in the regulation of intestinal epithelium functions and permeability, especially during inflammatory responses. Collectively, these results contribute to a more comprehensive understanding of CCRL2 functions and its potential implications in the immune surveillance of the lung and intestine
Quality of Life After Restorative Proctocolectomy for Ulcerative Colitis
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Quality of life after restorative proctocolectomy for ulcerative colitis - Different questionnaires lead to different interpretations
Author(s): Scarpa, M (Scarpa, Marco); Ruffolo, C (Ruffolo, Cesare); Polese, L (Polese, Lino); Martin, A (Martin, Alessandro); D'Inca, R (D'Inca, Renata); Sturniolo, GC (Sturniolo, Giacomo C.); D'Amico, DF (D'Amico, Davide F.); Angriman, I (Angriman, Imerio)
Source: ARCHIVES OF SURGERY Volume: 142 Issue: 2 Pages: 158-165 DOI: 10.1001/archsurg.142.2.158 Published: FEB 2007
Times Cited: 15 (from Web of Science)
Cited References: 34 [ view related records ] Citation Map
Abstract: Background: According to some researchers, health-related quality-of-life scores for patients who undergo restorative proctocolectomy (RPC) for ulcerative colitis (UC) are comparable to those of healthy control subjects. Other studies show evidence that patients who undergo RPC experience a health-related quality of life similar to patients with mild UC or UC in remission.
Hypothesis: The discrepancy in health-related quality of-life scores among studies may be due to different health-related quality-of-life analyses.
Design: Cross-sectional study.
Setting: Outpatient clinic of a tertiary care center.
Patients: In the first phase of the study, we consecutively enrolled 24 patients with UC, 24 patients with Crohn disease, and 24 healthy controls. In the second phase of the study, 40 patients who underwent RPC, 43 patients with UC, and 44 controls were consecutively enrolled.
Interventions: We administered an Italian version of the Cleveland Global Quality of Life (CGQL) instrument, the Padova Inflammatory Bowel Disease Quality of Life instrument, and the Italian 36-Item Short-Form Health Survey.
Main Outcome Measures: We evaluated the construct. validity, internal consistency, test-retest reliability, sensitivity to change, and discriminant ability of the Italian CGQL instrument. We compared its discriminative ability with that of the Padova Inflammatory Bowel Disease Quality of Life instrument.
Results: The Italian CGQL instrument obtained good construct validity, internal consistency, test-retest reliability, and sensitivity to change. The Italian CGQL score did not distinguish patients who underwent RPC from healthy controls and those with mild UC or UC in remission, while the Padova Inflammatory Bowel Disease Quality of Life instrument reported similar scores for patients who underwent RPC and those with mild UC or UC in remission, and showed a difference vs healthy controls.
Conclusions: We validated an Italian version of the CGQL score. The different results obtained with the CGQL and the Padova Inflammatory Bowel Disease Quality of Life instruments can be attributed to the different discriminative ability of the 2 questionnaires
La tutela della salute dopo la L. N. 3/2018
No full textGli autori, partendo da un’analisi delle novità introdotte con la l. n. 3/2018 (c.d. “legge Lorenzin”), analizzano l’impatto che l’emergenza sanitaria ha avuto sul nostro sistema sanitario e sulle categorie più vulnerabili.Starting from an analysis of the new elements introduced with Law no. 3/2018 (the “Lorenzin Law”), the authors analyze the impact that the health emergency has had on our healthcare system and on the most vulnerable categories
Psicologia per insegnare. Un percorso di formazione
No full textScritto in sinergia da autrici e autori specializzati nei processi dell’apprendimento e nella psicologia dello sviluppo e dell’educazione, Psicologia per insegnare si rivolge a chi aspira a diventare insegnante nella Scuola secondaria di primo o secondo grado. Espone le conoscenze di base sui processi cognitivi, emotivi e sociali di ragazze e ragazzi nella fase adolescenziale per poi passare alle tematiche psicosociali ricorrenti in questa fase di vita, alla psicologia dell’adolescente in relazione al contesto classe, al gruppo dei pari e agli adulti di riferimento. Al futuro insegnante vengono forniti strumenti teorici utili per una lettura del comportamento delle sue studentesse e dei suoi studenti, e per cogliere la richiesta sottostante di ascolto, aiuto, cambiamento, intervento, ma anche per intercettare i comportamenti a rischio e le situazioni di sopraffazione e disagio.
La prima parte del volume presenta le diverse concezioni dell’intelligenza (cap. 1), descrive la relazione tra emozioni e processi cognitivi (cap. 2), spiega il concetto di metacognizione (cap. 3), delinea la formazione dell’identità (cap. 4) e traccia gli aspetti caratteristici dello sviluppo delle competenze sociali (cap. 5). La seconda parte, centrata invece sul contesto scolastico, ne prende in esame i temi più classici: il successo scolastico (cap. 6), il fenomeno del bullismo e le dinamiche antisociali (cap. 7), le dinamiche dei gruppi (cap. 8), le modalità di comunicazione e di relazione (cap. 9), la sfida della scuola interculturale (cap. 10), le questioni relative alla didattica innovativa (cap. 11), e si conclude con una riflessione sulla professione del docente (cap. 12) e sulle trasformazioni che sta attraversando questo ruolo
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