1,720,978 research outputs found
Sport injuries of the lower extremities : graduation thesis
No full textIn summary, the management of sports injuries to the lower extremities requires a multifaceted
approach that considers the intricate interplay of anatomical structures and biomechanical forces.
Effective management includes accurate diagnosis, tailored therapeutic interventions, preventive
measures, and comprehensive rehabilitation protocols. Precise diagnosis is essential, relying on
imaging methods like MRI and ultrasound to offer detailed insights into the injury.
This precision allows for the formulation of effective, individualized treatment plans. Therapeutic
interventions range from conservative measures like rest and physical therapy to surgical options
when necessary. Personalized rehabilitation programs that incorporate strength training, flexibility
exercises, and proprioceptive training are essential for full recovery and prevention of re-injury.
Preventive strategies are equally important, focusing on regular strength and conditioning
programs, proper warm-up and cool-down routines, appropriate footwear, and education on correct
sports techniques. Biomechanical assessments help identify individual risk factors, allowing for
the development of customized prevention programs.
Ongoing research and progress in diagnostic and treatment methods will further improve our
capacity to support athletes, enabling them to achieve their highest potential while minimizing the
impact of injuries. This holistic approach is vital for the health, performance, and overall wellbeing of athletes
Sport injuries of the lower extremities : graduation thesis
No full textIn summary, the management of sports injuries to the lower extremities requires a multifaceted
approach that considers the intricate interplay of anatomical structures and biomechanical forces.
Effective management includes accurate diagnosis, tailored therapeutic interventions, preventive
measures, and comprehensive rehabilitation protocols. Precise diagnosis is essential, relying on
imaging methods like MRI and ultrasound to offer detailed insights into the injury.
This precision allows for the formulation of effective, individualized treatment plans. Therapeutic
interventions range from conservative measures like rest and physical therapy to surgical options
when necessary. Personalized rehabilitation programs that incorporate strength training, flexibility
exercises, and proprioceptive training are essential for full recovery and prevention of re-injury.
Preventive strategies are equally important, focusing on regular strength and conditioning
programs, proper warm-up and cool-down routines, appropriate footwear, and education on correct
sports techniques. Biomechanical assessments help identify individual risk factors, allowing for
the development of customized prevention programs.
Ongoing research and progress in diagnostic and treatment methods will further improve our
capacity to support athletes, enabling them to achieve their highest potential while minimizing the
impact of injuries. This holistic approach is vital for the health, performance, and overall wellbeing of athletes
Sport injuries of the lower extremities : graduation thesis
No full textIn summary, the management of sports injuries to the lower extremities requires a multifaceted
approach that considers the intricate interplay of anatomical structures and biomechanical forces.
Effective management includes accurate diagnosis, tailored therapeutic interventions, preventive
measures, and comprehensive rehabilitation protocols. Precise diagnosis is essential, relying on
imaging methods like MRI and ultrasound to offer detailed insights into the injury.
This precision allows for the formulation of effective, individualized treatment plans. Therapeutic
interventions range from conservative measures like rest and physical therapy to surgical options
when necessary. Personalized rehabilitation programs that incorporate strength training, flexibility
exercises, and proprioceptive training are essential for full recovery and prevention of re-injury.
Preventive strategies are equally important, focusing on regular strength and conditioning
programs, proper warm-up and cool-down routines, appropriate footwear, and education on correct
sports techniques. Biomechanical assessments help identify individual risk factors, allowing for
the development of customized prevention programs.
Ongoing research and progress in diagnostic and treatment methods will further improve our
capacity to support athletes, enabling them to achieve their highest potential while minimizing the
impact of injuries. This holistic approach is vital for the health, performance, and overall wellbeing of athletes
REPAIR OF RAT CALVARIAL BONE TISSUE RESPONSE AFTER ADMINISTRATION OF XENOGENIC BIOMATERIAL WITH MAGNESIUM
No full textCiljevi istraživanja: analizirati dinamiku cijeljenja kritično velikog defekta kalvarije štakora nakon primjene novog biomaterijala životinjskog podrijetla Cerabone-a s magnezijem u odnosu na komercijalni životinjski biomaterijal Cerabone, njegovu mješavinu s autolognom kosti, devitalizirani dentin i autologni štakorski dentin.
Materijali i metode: Analizirani su uzorci koštanog tkiva kalvarije štakora i serum. Izražaj upalnih, protektivnih i osteoinduktivnih čimbenika te njihovih unutarstaničnih glasničkih molekula određen je imunohistokemijski. Razina biljega koštane pregradnje, upalnih i protektivnih citokina u serumu određena je ELISA-om. Vrijednosti 2D parametara koštanog tkiva određeni su histomorfometrijski, a 3D parametri određeni su micro-CT-om. Kvantitativna analiza broja makrofaga određena je metodom dvostruke imunofluorescencije. RT-PCR analizom određen je izražaj RUNX-2, OC, SOST i RANK. Rezultati su analizirani parametrijskim ili neparametrijskim testovima za nezavisne uzorke, ovisno o raspodjeli podataka. Vrijednosti dobivene statističkom obradom podataka smatrane su statistički Rezultati: vrijednosti obujma kosti mjerene mikro-CT-om i histomorfometrijom povećavale su se s rastućim vremenskim intervalima. Skupina Dentin štakorski imala je najveće vrijednosti promatranog parametra. Najveće vrijednosti koštanog obujma su utvrđene u skupini Cerabone s magnezijem. TNF-α je pokazao najveću tkivnu ekspresiju u skupini Cerabone s magnezijem, dočim je ista ekspresija za OSX, BMP 2/-4, BMP-7, TGF-β, SMAD-1/-5/-8, SMAD-2/3, HO-1 i COX-2 bila najveća u skupini Dentin štakorski. Izražaj VEGF-a bio je najveći u skupini Dentin. Omjer M1/M1MNGC makrofaga i M2/M2MNGC makrofaga se značajno povećao u kasnim fazama cijeljenja u skupinama Dentin i Dentin štakorski, dočim je u skupinama Cerabone i Cerabome s magnezijem taj porast utvrđen 15. dan cijeljenja. Analizom genske ekspresije SOST a utvrđen je razmjeran odnos s obujmom kosti u skupinama Dentin i Dentin štakorski, dočim ta ista, ali i serumska koncentracija VEGF-a i RANK-a je bila obrnuto proporcionalna s obujmom kosti u skupini Dentin. Serumska koncentracija HO-1 bila je obrnuto proporcionalna s obujmom kosti u skupinama Cerabone +ak, Dentin i Kontrola, dočim je genska ekspresija RUNX-2 bila razmjerna s obujmom kosti u skupinama Cerabone i Dentin. značajnima ako je P<0,05.
Zaključci: Najoptimalniji biomaterijal u cijeljenju koštanog defekta kalvarije štakora je Dentin štakorski. Novi biomaterijal životinjskog podrijetla Cerabon s magnezijem pokazuje bolja osteokonduktivna svojstva u odnosu na komercijalni životinjski biomaterijal Cerabone i njegovu mješavinu s autolognom kosti.Objectives: to analyze the healing dynamics of a critically large rat calvarial defect after the application of the new biomaterial of animal origin Cerabone with magnesium, in comparison to the commercial animal biomaterial Cerabone, its mixture with autologous bone, devitalized dentin and autologous rat dentin.
Materials and methods: Rat calvarial bone tissue and serum were analysed. Expression of inflammatory, protective and osteoinductive factors and their intracellular messenger molecules was determined by immunohistochemistry. Bone remodeling markers, inflammatory and protective cytocines were determined by ELISA. 2D parameters of bone tissue was determined by histomorphometry, while #D parameters were determined by micro-CT. Quantitative analysis of macrophages was done by double immunofluorescence. Expression of RUNX-2, OC, SOST and RANK were determined by RT-PCR. Results were statisticaly analysed with parametric and non-parametric tests. Statistical significance was set at p<0,05.
Results: bone volume was measured by micro-CT and histomorphometry increase with increasing time intervals and that rat dentin had the highest values of the observed parameter. Comparing the representatives of the Cerabone group, the highest bone volume values were found in the Cerabone with magnesium group. The same trend was observed in the mentioned groups for the thickness and number of bone trabeculae. TNF-α showed the highest tissue expression in the Cerabone group with magnesium, while the expression was the same for OSX, BMP-2/-4, BMP-7, TGF-β, SMAD-1/-5/-8, SMAD-2/3, HO-1, while COX-2 was the largest in the Rat dentin group. Expression of VEGF was the highest in the group of dentin. The ratio of M1/M1MNGC to M2/M2MNGC macrophages significantly increased in the late stages of healing in the Dentin and Rat dentin groups, while in the Cerabone and Cerabome with magnesium groups this increase was determined on the 15th day of healing. Gene expression of SOST showed a proportional relationship with bone volume in the Dentin and Rat dentin groups, while the same, but also the serum concentration of VEGF and RANK was inversely proportional to bone volume in the Dentin group. The serum concentration of HO-1 was inversely proportional to the bone volume in the Cerabone with autologous bone, Dentin and Control groups, while the gene expression of RUNX-2 was directly proportional to the bone volume in the Cerabone and Dentin groups
Conclusions: The most primal biomaterial in the healing of the bone defect of the rat calvaria is Rat dentin. The new biomaterial of animal origin Cerabon with magnesium shows better osteoconductive properties compared to the commercial animal biomaterial Cerabon and its mixture with autologous bone
REPAIR OF RAT CALVARIAL BONE TISSUE RESPONSE AFTER ADMINISTRATION OF XENOGENIC BIOMATERIAL WITH MAGNESIUM
No full textCiljevi istraživanja: analizirati dinamiku cijeljenja kritično velikog defekta kalvarije štakora nakon primjene novog biomaterijala životinjskog podrijetla Cerabone-a s magnezijem u odnosu na komercijalni životinjski biomaterijal Cerabone, njegovu mješavinu s autolognom kosti, devitalizirani dentin i autologni štakorski dentin.
Materijali i metode: Analizirani su uzorci koštanog tkiva kalvarije štakora i serum. Izražaj upalnih, protektivnih i osteoinduktivnih čimbenika te njihovih unutarstaničnih glasničkih molekula određen je imunohistokemijski. Razina biljega koštane pregradnje, upalnih i protektivnih citokina u serumu određena je ELISA-om. Vrijednosti 2D parametara koštanog tkiva određeni su histomorfometrijski, a 3D parametri određeni su micro-CT-om. Kvantitativna analiza broja makrofaga određena je metodom dvostruke imunofluorescencije. RT-PCR analizom određen je izražaj RUNX-2, OC, SOST i RANK. Rezultati su analizirani parametrijskim ili neparametrijskim testovima za nezavisne uzorke, ovisno o raspodjeli podataka. Vrijednosti dobivene statističkom obradom podataka smatrane su statistički Rezultati: vrijednosti obujma kosti mjerene mikro-CT-om i histomorfometrijom povećavale su se s rastućim vremenskim intervalima. Skupina Dentin štakorski imala je najveće vrijednosti promatranog parametra. Najveće vrijednosti koštanog obujma su utvrđene u skupini Cerabone s magnezijem. TNF-α je pokazao najveću tkivnu ekspresiju u skupini Cerabone s magnezijem, dočim je ista ekspresija za OSX, BMP 2/-4, BMP-7, TGF-β, SMAD-1/-5/-8, SMAD-2/3, HO-1 i COX-2 bila najveća u skupini Dentin štakorski. Izražaj VEGF-a bio je najveći u skupini Dentin. Omjer M1/M1MNGC makrofaga i M2/M2MNGC makrofaga se značajno povećao u kasnim fazama cijeljenja u skupinama Dentin i Dentin štakorski, dočim je u skupinama Cerabone i Cerabome s magnezijem taj porast utvrđen 15. dan cijeljenja. Analizom genske ekspresije SOST a utvrđen je razmjeran odnos s obujmom kosti u skupinama Dentin i Dentin štakorski, dočim ta ista, ali i serumska koncentracija VEGF-a i RANK-a je bila obrnuto proporcionalna s obujmom kosti u skupini Dentin. Serumska koncentracija HO-1 bila je obrnuto proporcionalna s obujmom kosti u skupinama Cerabone +ak, Dentin i Kontrola, dočim je genska ekspresija RUNX-2 bila razmjerna s obujmom kosti u skupinama Cerabone i Dentin. značajnima ako je P<0,05.
Zaključci: Najoptimalniji biomaterijal u cijeljenju koštanog defekta kalvarije štakora je Dentin štakorski. Novi biomaterijal životinjskog podrijetla Cerabon s magnezijem pokazuje bolja osteokonduktivna svojstva u odnosu na komercijalni životinjski biomaterijal Cerabone i njegovu mješavinu s autolognom kosti.Objectives: to analyze the healing dynamics of a critically large rat calvarial defect after the application of the new biomaterial of animal origin Cerabone with magnesium, in comparison to the commercial animal biomaterial Cerabone, its mixture with autologous bone, devitalized dentin and autologous rat dentin.
Materials and methods: Rat calvarial bone tissue and serum were analysed. Expression of inflammatory, protective and osteoinductive factors and their intracellular messenger molecules was determined by immunohistochemistry. Bone remodeling markers, inflammatory and protective cytocines were determined by ELISA. 2D parameters of bone tissue was determined by histomorphometry, while #D parameters were determined by micro-CT. Quantitative analysis of macrophages was done by double immunofluorescence. Expression of RUNX-2, OC, SOST and RANK were determined by RT-PCR. Results were statisticaly analysed with parametric and non-parametric tests. Statistical significance was set at p<0,05.
Results: bone volume was measured by micro-CT and histomorphometry increase with increasing time intervals and that rat dentin had the highest values of the observed parameter. Comparing the representatives of the Cerabone group, the highest bone volume values were found in the Cerabone with magnesium group. The same trend was observed in the mentioned groups for the thickness and number of bone trabeculae. TNF-α showed the highest tissue expression in the Cerabone group with magnesium, while the expression was the same for OSX, BMP-2/-4, BMP-7, TGF-β, SMAD-1/-5/-8, SMAD-2/3, HO-1, while COX-2 was the largest in the Rat dentin group. Expression of VEGF was the highest in the group of dentin. The ratio of M1/M1MNGC to M2/M2MNGC macrophages significantly increased in the late stages of healing in the Dentin and Rat dentin groups, while in the Cerabone and Cerabome with magnesium groups this increase was determined on the 15th day of healing. Gene expression of SOST showed a proportional relationship with bone volume in the Dentin and Rat dentin groups, while the same, but also the serum concentration of VEGF and RANK was inversely proportional to bone volume in the Dentin group. The serum concentration of HO-1 was inversely proportional to the bone volume in the Cerabone with autologous bone, Dentin and Control groups, while the gene expression of RUNX-2 was directly proportional to the bone volume in the Cerabone and Dentin groups
Conclusions: The most primal biomaterial in the healing of the bone defect of the rat calvaria is Rat dentin. The new biomaterial of animal origin Cerabon with magnesium shows better osteoconductive properties compared to the commercial animal biomaterial Cerabon and its mixture with autologous bone
REPAIR OF RAT CALVARIAL BONE TISSUE RESPONSE AFTER ADMINISTRATION OF XENOGENIC BIOMATERIAL WITH MAGNESIUM
No full textCiljevi istraživanja: analizirati dinamiku cijeljenja kritično velikog defekta kalvarije štakora nakon primjene novog biomaterijala životinjskog podrijetla Cerabone-a s magnezijem u odnosu na komercijalni životinjski biomaterijal Cerabone, njegovu mješavinu s autolognom kosti, devitalizirani dentin i autologni štakorski dentin.
Materijali i metode: Analizirani su uzorci koštanog tkiva kalvarije štakora i serum. Izražaj upalnih, protektivnih i osteoinduktivnih čimbenika te njihovih unutarstaničnih glasničkih molekula određen je imunohistokemijski. Razina biljega koštane pregradnje, upalnih i protektivnih citokina u serumu određena je ELISA-om. Vrijednosti 2D parametara koštanog tkiva određeni su histomorfometrijski, a 3D parametri određeni su micro-CT-om. Kvantitativna analiza broja makrofaga određena je metodom dvostruke imunofluorescencije. RT-PCR analizom određen je izražaj RUNX-2, OC, SOST i RANK. Rezultati su analizirani parametrijskim ili neparametrijskim testovima za nezavisne uzorke, ovisno o raspodjeli podataka. Vrijednosti dobivene statističkom obradom podataka smatrane su statistički Rezultati: vrijednosti obujma kosti mjerene mikro-CT-om i histomorfometrijom povećavale su se s rastućim vremenskim intervalima. Skupina Dentin štakorski imala je najveće vrijednosti promatranog parametra. Najveće vrijednosti koštanog obujma su utvrđene u skupini Cerabone s magnezijem. TNF-α je pokazao najveću tkivnu ekspresiju u skupini Cerabone s magnezijem, dočim je ista ekspresija za OSX, BMP 2/-4, BMP-7, TGF-β, SMAD-1/-5/-8, SMAD-2/3, HO-1 i COX-2 bila najveća u skupini Dentin štakorski. Izražaj VEGF-a bio je najveći u skupini Dentin. Omjer M1/M1MNGC makrofaga i M2/M2MNGC makrofaga se značajno povećao u kasnim fazama cijeljenja u skupinama Dentin i Dentin štakorski, dočim je u skupinama Cerabone i Cerabome s magnezijem taj porast utvrđen 15. dan cijeljenja. Analizom genske ekspresije SOST a utvrđen je razmjeran odnos s obujmom kosti u skupinama Dentin i Dentin štakorski, dočim ta ista, ali i serumska koncentracija VEGF-a i RANK-a je bila obrnuto proporcionalna s obujmom kosti u skupini Dentin. Serumska koncentracija HO-1 bila je obrnuto proporcionalna s obujmom kosti u skupinama Cerabone +ak, Dentin i Kontrola, dočim je genska ekspresija RUNX-2 bila razmjerna s obujmom kosti u skupinama Cerabone i Dentin. značajnima ako je P<0,05.
Zaključci: Najoptimalniji biomaterijal u cijeljenju koštanog defekta kalvarije štakora je Dentin štakorski. Novi biomaterijal životinjskog podrijetla Cerabon s magnezijem pokazuje bolja osteokonduktivna svojstva u odnosu na komercijalni životinjski biomaterijal Cerabone i njegovu mješavinu s autolognom kosti.Objectives: to analyze the healing dynamics of a critically large rat calvarial defect after the application of the new biomaterial of animal origin Cerabone with magnesium, in comparison to the commercial animal biomaterial Cerabone, its mixture with autologous bone, devitalized dentin and autologous rat dentin.
Materials and methods: Rat calvarial bone tissue and serum were analysed. Expression of inflammatory, protective and osteoinductive factors and their intracellular messenger molecules was determined by immunohistochemistry. Bone remodeling markers, inflammatory and protective cytocines were determined by ELISA. 2D parameters of bone tissue was determined by histomorphometry, while #D parameters were determined by micro-CT. Quantitative analysis of macrophages was done by double immunofluorescence. Expression of RUNX-2, OC, SOST and RANK were determined by RT-PCR. Results were statisticaly analysed with parametric and non-parametric tests. Statistical significance was set at p<0,05.
Results: bone volume was measured by micro-CT and histomorphometry increase with increasing time intervals and that rat dentin had the highest values of the observed parameter. Comparing the representatives of the Cerabone group, the highest bone volume values were found in the Cerabone with magnesium group. The same trend was observed in the mentioned groups for the thickness and number of bone trabeculae. TNF-α showed the highest tissue expression in the Cerabone group with magnesium, while the expression was the same for OSX, BMP-2/-4, BMP-7, TGF-β, SMAD-1/-5/-8, SMAD-2/3, HO-1, while COX-2 was the largest in the Rat dentin group. Expression of VEGF was the highest in the group of dentin. The ratio of M1/M1MNGC to M2/M2MNGC macrophages significantly increased in the late stages of healing in the Dentin and Rat dentin groups, while in the Cerabone and Cerabome with magnesium groups this increase was determined on the 15th day of healing. Gene expression of SOST showed a proportional relationship with bone volume in the Dentin and Rat dentin groups, while the same, but also the serum concentration of VEGF and RANK was inversely proportional to bone volume in the Dentin group. The serum concentration of HO-1 was inversely proportional to the bone volume in the Cerabone with autologous bone, Dentin and Control groups, while the gene expression of RUNX-2 was directly proportional to the bone volume in the Cerabone and Dentin groups
Conclusions: The most primal biomaterial in the healing of the bone defect of the rat calvaria is Rat dentin. The new biomaterial of animal origin Cerabon with magnesium shows better osteoconductive properties compared to the commercial animal biomaterial Cerabon and its mixture with autologous bone
Usporedba reparacijskog odgovora koštanog tkiva upotrebom dentina, ksenogenog biomaterijala i autologne kosti: plan upravljanja istraživačkim podacima
No full textNutritional status in women involved in the project "Exercise and proper nutrition against osteoporosis and diabetes"
No full textPravilna prehrana, kombinirana s adekvatnom tjelesnom aktivnošću, ima važnu ulogu u prevenciji i liječenju različitih kroničnih bolesti, kao što su osteoporoza i dijabetes.
Ciljevi ovog istraživanja se odnose na žene koje su uključene u projekt „Vježbanjem i pravilnom prehranom u borbi protiv osteoporoze i dijabetesa“. Cilj je prikupiti podatke o dnevnom unosu tri osnovna nutritivna sastojka u prehrani, koja uključuju proteine, ugljikohidrate i masti. Ostali ciljevi su se odnosili na ispitivanju učestalosti loših prehrambenih navika, koje uključuju premali ili preveliki unos određenih nutritivnih sastojaka u prehrani, kod određenih skupina. Ciljevi su: ispitati učestalost loših prehrambenih navika s obzirom na bolovanje od kroničnih bolesti, obzirom na status pušenja, te s obzirom na završeni stupanj obrazovanja.
Istraživanje se provelo u obliku papir-olovka anketnog upitnika, a u uzorak ispitanika je bilo uključeno 23 žena srednje i starije životne dobi (s navršenih 50 godina i više).
Rezultati istraživanja pokazuju kako ispitanice dnevno konzumiraju veću količinu proteina i masti, te manju količinu ugljikohidrata od referentnih vrijednosti. Isto tako se pokazalo da ispitanice koje boluju od kroničnih bolesti dnevno konzumiraju više proteina, ugljikohidrata i masti od ispitanica koje ne boluju od istih stanja, no razlike se nisu pokazale statistički značajnima. Nadalje, pušačice su imale veći dnevni unos proteina i masti, a manji unos ugljikohidrata naspram ispitanica koje ne puše. Navedena razlika u prehrani također nije statistički značajna. Posljednji rezultat ukazuje na veći unos proteina i manji unos ugljikohidrata i masti u prehrani ispitanica s nižim stupnjem obrazovanja, u odnosu na ispitanice s višim stupnjem obrazovanja.Proper nutrition, combined with adequate physical activity, plays an important role in the prevention and treatment of various chronic diseases, such as osteoporosis and diabetes.
The aims of this research refer to women who are involved in the project "Exercise and proper nutrition against osteoporosis and diabetes". The aim is to collect data on the daily intake of three basic nutritional components in the diet, which include proteins, carbohydrates and fats. Other aims were related to examining the frequency of bad eating habits, which include too little or too much intake of certain nutritional ingredients in the diet, in certain groups. The aims are to examine the frequency of bad eating habits with regard to chronic diseases, with regard to smoking status, and with regard to the completed level of education.
The research was conducted in the form of a paper-and-pencil questionnaire, and the sample of respondents included 23 middle-aged and elderly women (over 50).
The results of the research show that respondents daily consume a larger amount of protein and fat, and a smaller amount of carbohydrates than the reference values. It was also shown that respondents who suffer from chronic diseases consume more protein, carbohydrates and fat per day than respondents who do not suffer from the same conditions, but the differences did not prove to be statistically significant. Furthermore, female smokers had a higher daily intake of protein and fat, and a lower intake of carbohydrates compared to female who did not smoke. The mentioned difference in diet is also not statistically significant. The last result indicates a higher intake of protein and a lower intake of carbohydrates and fats in the diet of respondents with a lower level of education, compared to respondents with a higher level of education
Usporedba reparacijskog odgovora koštanog tkiva upotrebom dentina, ksenogenog biomaterijala i autologne kosti: plan upravljanja istraživačkim podacima
No full textUsporedba reparacijskog odgovora koštanog tkiva upotrebom dentina, ksenogenog biomaterijala i autologne kosti: istraživački podaci
No full text- …
