1,354,155 research outputs found
A. Cump, Macon, Virginia, to Thomas Ritchie
No full textExpulsion of Ritchie from the Senate; "offence against the Senate...with which Ritchie's reporter was charged"; Senate's "rejection...of the bill for the increase of the army"; implication of withholding more men from the Army while the U.S. is at war with Mexico; mention of John C. Calhoun; dissatisfaction with Virginia's Congressional delegat
CUMP victimes et société : de la représentation des victimes aux soins
No full textCUMP = Cellule d’urgence médicopsychologiqueIntroduction. The CUMP has an original functioning regularly questioned. The main objective is to analyze and compare the representation of who is victim and what care is needed, as held by caregivers belonging to a CUMP and those of “non-specialized” psychiatry. Method. After a review of the literature aiming to create an interview guide, a qualitative study was conducted. The main inclusion criteria were: to be a psychiatrist, psychologist or psychiatric nurse in Isère. The data were analyzed independently using the thematic analysis method and then triangulated and compared. Results. In a context of inflation of the notion of victim in society, many elements are in common in the two groups. Differences appeared related to specificity. For the “CUMP” group (not for the “non CUMP” group) it was a “specific” practice needing a “specialization”. In the "non CUMP" group many questions appeared about the notion of victim with a lack of knowledge about the CUMP functioning and a feeling of helplessness in emergency situations. In both groups, it was recognized that victims of acute (collective) trauma would require specific help (more “active”) that would require a particular expertise. An emergency unit allows reassuring teamwork. Conclusion. There is a divergent opinion about the "specialization". The “non CUMP” group has a lack of knowledge about the functioning of CUMP and there should be a better collaboration between the different professionals.Introduction. Les CUMP ont un fonctionnement original remis en cause. L’objectif principal est l’analyse et la comparaison de la représentation des victimes et de leur prise en charge entre des soignants d’une CUMP et de psychiatrie « non spécialisée ». Méthode. Après une revue de la littérature pour réaliser un guide d’entretien, une étude qualitative a été réalisée. Les critères d’inclusion principaux étaient : être psychiatre, psychologue ou infirmier en psychiatrie en Isère. Les données ont été analysées selon la méthode thématique de façon indépendante puis triangulées et comparées. Résultats. Dans un contexte d’inflation du terme « victime » au niveau sociétal, beaucoup d’éléments sont communs. Des différences concernaient la spécificité de la prise en charge. Pour les « CUMP » uniquement, il s’agissait d’une pratique « spécifique » nécessitant une « spécialisation ». Dans le groupe « non CUMP » beaucoup se sont questionnés à propos de la notion de victime avec un manque de connaissance du dispositif CUMP et une difficulté face à l’urgence. Dans les deux groupes, il était reconnu que les victimes d'un traumatisme aigu (collectif) nécessiteraient une aide spécifique (plus « active ») et une expertise particulière. La cellule d’intervention permettrait le travail en équipe rassurant. Conclusion. L’opinion est divergente au sujet de la « spécialisation ». Les soignants du groupe « non CUMP » ont peu connaissance du dispositif, il faudrait une meilleure collaboration entre professionnels
Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode
No full textThe non-canonical cyclic nucleotide cUMP and the phosphodiesterase PDE9A both occur in neuronal cells. Using HPLC-coupled tandem mass spectrometry, we characterized the kinetics of PDE9A-mediated cUMP hydrolysis. PDE9A is a low-affinity and high-velocity enzyme for cUMP (V-max=6mol/min/mg; K-m=401M). The PDE9 inhibitor BAY 73-6691 inhibited PDE9A-catalyzed cUMP hydrolysis (K-i=590nM). Docking studies indicate two H-bonds between the cUMP uridine moiety and Gln453/Asn405 of PDE9A. By contrast, the guanosine moiety of cGMP forms three H-bonds with Gln453. cCMP is not hydrolyzed at a concentration of 3M, but inhibits the PDE9A-catalyzed cUMP hydrolysis at concentrations of 100M or more. The probable main reason is that the cytosine moiety cannot act as H-bond acceptor for Gln453. A comparison of PDE9A with PDE7A suggests that the preference of the former for cGMP and cUMP and of the latter for cAMP and cCMP is due to stabilized alternative conformations of the side chain amide of Gln453 and Gln413, respectively. This so-called glutamine switch is known to be involved in the regulation of cAMP/cGMP selectivity of some PDEs
L’intégration du dispositif de la cellule d’urgence médico-psychologique (CUMP) dans la pratique des médecins correspondants du SAMU (MCS) en Auvergne-Rhône-Alpes (AURA)
No full textBackground: The Emergency Medical Psychological Unit (CUMP) was created to provide psychological support in the aftermath of critical incidents. The Corresponding Physicians of the Emergency Medical Service (MCS) are general practitioners who act as first line responders, intervening upstream of the Mobile Emergency and Resuscitation Service (SMUR) upon regulation by the SAMU call center (Centre 15). As documented in numerous studies, they are frequently confronted with interventions carrying a high risk of psychological repercussions. To address this need, a new support system specifically dedicated to MCS has been implemented in the Auvergne Rhône Alpes region, in partnership with the Mountain Doctors Association. Objective: The aim of this work is to explore the experiences of MCS with the CUMP system and to identify possible avenues for its improvement. Methods: This is a qualitative study conducted according to the principles of Interpretative Phenomenological Analysis (IPA). Nine semi structured interviews were carried out with MCS from the Auvergne Rhône Alpes region who had contacted the CUMP system. Results: The MCS report a heavy emotional burden associated with critical interventions, often accompanied by feelings of isolation, guilt, or impostor syndrome. Recourse to the CUMP is generally perceived as beneficial, owing to its responsiveness and the quality of listening provided. However, several limitations are highlighted: difficulties in establishing contact, lack of systematic follow up, limited awareness of the system, and a mismatch between expectations and the current offer, which remains focused primarily on psychological support. The study suggests simple yet necessary adjustments, such as clearer presentation of the system, more accessible contact modalities, stronger medico psychological coordination, and the development of peer support networks. Conclusion: The CUMP is perceived by the MCS as a valuable source of support, thanks to its responsiveness and attentive listening. However, its integration remains limited by difficulties in establishing contact, the absence of systematic follow up, and a mismatch with their expectations, particularly regarding technical feedback. Optimizing the CUMP appears essential to prevent psychotraumatic repercussions, strengthen the resilience of the MCS, and ensure the sustainability of their commitment in isolated territories.Contexte : La cellule d’urgence médico-psychologique (CUMP) a été créée afin d’apporter un soutien psychologique à la suite d’incidents critiques. Les Médecins Correspondants SAMU (MCS) sont des médecins généralistes de premier recours qui interviennent en amont du Service Mobile d’Urgence et de Réanimation (SMUR) sur régulation du centre 15. Comme documenté dans de nombreuses études, ils sont souvent confrontés à des interventions à risque de répercussions psychologiques. Pour répondre à ce besoin, un nouveau dispositif dédié au MCS a été mis en œuvre dans la région Auvergne Rhône-Alpes, en partenariat avec l’association Médecins de Montagne. Objectif : L’objectif de ce travail est d’explorer le vécu du dispositif de la CUMP par les MCS et de dégager des pistes d’amélioration de ce dernier. Méthode : Il s’agit d’une étude qualitative menée selon les principes de l’analyse phénoménologique interprétative. 9 entretiens semi-dirigés ont été réalisés auprès de MCS de la région AURA, ayant sollicité le dispositif de la CUMP. Résultats : Les MCS décrivent une forte charge émotionnelle liée aux interventions critiques, associée à un sentiment d’isolement, de culpabilité ou d’imposture. Le recours à la CUMP est globalement perçu comme bénéfique, grâce à sa réactivité et à la qualité d’écoute proposée. Toutefois, plusieurs limites sont relevées : difficultés de contact, absence de suivi systématique, méconnaissance du dispositif et décalage entre attentes et offre actuelle centrée sur le soutien psychologique. L’étude propose des ajustements simples mais nécessaires, comme une meilleure présentation du dispositif, modalités de contact adaptées, articulation médico psychologique et réseaux de pairs. Conclusion : La CUMP est perçue par les MCS comme un soutien précieux, grâce à sa réactivité et son écoute, mais son intégration reste limitée par des difficultés de contact, l’absence de suivi systématique et un décalage avec leurs attentes, notamment en matière de retour technique. L’optimisation de la CUMP apparaît essentielle pour prévenir les répercussions psychotraumatiques, renforcer la résilience des MCS et assurer la pérennité de leur engagement dans les territoires isolés
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
No full text“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
<strong>Supplemental Video S1. Transient inter-endothelial gap formation induced by 100 µM cUMP-AM.</strong>
No full text
Supplemental Video S1. Transient inter-endothelial gap formation induced by 100 µM cUMP-AM. Phase contrast time-lapse images were taken every 5 minutes for 12 hours. A 20x objective was used from a Nikon T2 Eclipse light microscope utilizing a stage top environmental chamber (Okolab, UNO Stage Top Incubator, UNO-TH-CO2 Version 02.16) maintained in tissue cell culture conditions. 37 °C, 21% O₂, 5% CO₂, and 74% N₂). Note spaces where gaps form and close. </p
Appropriate Similarity Measures for Author Cocitation Analysis
No full textWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
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