169,894 research outputs found
Legea chiriilor, 16 aprilie 1927
No full textBucureşti : Editura Tip. "Curierul Judiciar", 1927. - 93 p. ; 16 cm. - (Biblioteca legilor uzuale adnotate ; No. 5 ). - Mai cuprinde: Expunerea de motive a minstrului justiţiei [T. Cudalbu] ; Avizul Consiliului legislativ ; Raportulu deputatului raportor Braiesku ; Raportul senatorului raportor Darvari ; Legea Micului Parche
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Mitomycin C in highly myopic eyes - Author reply
No full textOphthalmology. 2005 Feb;112(2):208-18; discussion 219.
Mitomycin C modulation of corneal wound healing after photorefractive keratectomy in highly myopic eyes.
Gambato C, Ghirlando A, Moretto E, Busato F, Midena E.
SourceRefractive Surgery Service and Antimetabolite Therapy Research Unit, Department of Ophthalmology, University of Padova, Padova, Italy.
Abstract
PURPOSE: To evaluate the role of topical mitomycin C in corneal wound healing (CWH) after photorefractive keratectomy (PRK) in highly myopic eyes.
DESIGN: Prospective, double-masked, randomized clinical trial.
PARTICIPANTS: Seventy-two eyes of 36 patients affected by high (>7 diopters) myopia.
METHODS: In each patient, one eye was randomly assigned to PRK with intraoperative topical 0.02% mitomycin C application, and the fellow eye was treated with a placebo. Postoperatively, mitomycin C-treated eyes received artificial tears (3 times daily, tapered in 3 months), whereas the fellow eye was treated with fluorometholone sodium 2% and artificial tears (3 times daily, tapered in 3 months).
MAIN OUTCOME MEASURES: Uncorrected visual acuity (UCVA) and best-corrected visual acuity (BCVA), contrast sensitivity, manifest refraction, and biomicroscopy. Contrast sensitivity was determined using the Pelli-Robson chart. Corneal confocal microscopy documented CWH.
RESULTS: Mean follow-up was 18 months (range, 12-36). No side effects or toxic effects were documented. At 12-month follow-up examination, UCVAs (logarithm of the minimum angle of resolution) were 0.4+/-0.48 and 0.5+/-0.53 (P = .03) in mitomycin C-treated eyes and corticosteroid-treated eyes, respectively. At 1 year, corneal haze developed in 20% of corticosteroid-treated eyes, versus 0% of mitomycin C-treated eyes. At 12, 24, and 36 months, corneal confocal microscopy showed activated keratocytes and extracellular matrix significantly more evident in untreated eyes (Ps = 0.004, 0.024, and 0.046, respectively).
CONCLUSION: Topical intraoperative application of 0.02% mitomycin C can reduce haze formation in highly myopic eyes undergoing PRK.
Comment in
Ophthalmology. 2006 Feb;113(2):357; author reply 357-8
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
A Multi-Language Comparison of Influences on Author Verification using Character N-Grams
No full textWe create a new multi-language corpus for author verification based on Wikipedia talkpages, and evaluate the influence that differences in topic and time have on character n-gram author profiles. Topic alignment between two texts is found to increase author verification precision, and an authors writing style is found to change over time, but not more significantly after 3 years than after 1 year.Information ArchitectureWISElectrical Engineering, Mathematics and Computer Scienc
A 0.12mm<sup>2</sup> Wien-Bridge Temperature Sensor with 0.1°C (3σ) Inaccuracy from -40°C to 180°C
No full text Resistor-based temperature sensors can achieve much higher resolution and energy efficiency than conventional BJT-based sensors [1], but they typically occupy more area (> 0.25 mm 2 ) and have lower operating temperatures (le 125 {circ} {C}) [2]-[4]. This work describes a 0.12mm 2 resistor-based sensor that uses a Wien-bridge (WB) filter to achieve 0.1 {circ} {C} (3 sigma) inaccuracy from - 40 {circ} {C} to 180 {circ} {C}. Compared to a state-of-the-art WB sensor [4], it occupies 6 × less area and achieves comparable relative accuracy over a 76% wider operating range. Session 10.3 Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
A ±25A Versatile Shunt-Based Current Sensor with 10kHz Bandwidth and ±0.25% Gain Error from -40°C to 85°C Using 2-Current Calibration
No full textAccurate current sensing is critical in many industrial applications, such as battery management and motor control. Precise shunt-based current sensors have been reported with gain errors of less than 1% over the industrial temperature range (-40°C to 85°C) [1]–[4]. However, since they are intended for coulomb counting, their bandwidth is limited to a few tens of Hz, making them unsuitable for battery impedance or motor-current sensing. This paper presents a current sensor with a wide (10kHz) bandwidth and a tunable temperature compensation scheme (TCS), which allows it to be flexibly used with different types of shunts while maintaining high accuracy. A low-cost room-temperature calibration scheme is proposed to optimize gain flatness over temperature by exploiting the shunt's self-heating at large currents. Over the industrial temperature range and a ±25A current range, it achieves state-of-the-art gain error (±0.25%) with both low-cost PCB and stable metal-alloy shunts.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Electronic InstrumentationMicroelectronic
An Article About Albertus C. Van Raalte, Author Unknown, Except for Parts Taken from an Article by Anna C. Post
No full textAn article about Albertus C. Van Raalte, author unknown, except for parts taken from an article by Anna C. Post. The author knew first generation persons in the Holland settlement and therefore, the article has some value.https://digitalcommons.hope.edu/vrp_1890s/1012/thumbnail.jp
Processing of MM signals acquired in vivo at 9.4T using 1H SVS
No full text<p>Processing of MM signals acquired in vivo at 9.4T using 1H SVS @ <a href="https://www.epfl.ch/labs/mrs4brain/">MRS4Brain research group</a>. </p>
<p>The video was recording during a presentation done by Dunja Simicic for the Virtual jMRUI Training Course @ <a href="https://inspire-med.eu/events">INSPiRE-MED EU project </a>H2020-MSCA-ITN-2018, no 813120. </p>
<p>Please use the VLC media player to view this video.</p>
<p>Please cite the following article if you are using the protocol described herein: <a href="https://pubmed.ncbi.nlm.nih.gov/34268821/">In vivo macromolecule signals in rat brain 1 H-MR spectra at 9.4T: Parametrization, spline baseline estimation, and T2 relaxation times - PubMed (nih.gov)</a></p>
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<div>Magn Reson Med</div>
. 2021 Nov;86(5):2384-2401.</div>
doi: 10.1002/mrm.28910. Epub 2021 Jul 15.</div>
<h1>In vivo macromolecule signals in rat brain <sup>1</sup> H-MR spectra at 9.4T: Parametrization, spline baseline estimation, and T<sub>2</sub> relaxation times</h1>
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<div><a href="https://pubmed.ncbi.nlm.nih.gov/?sort=pubdate&term=Simicic+D&cauthor_id=34268821">Dunja Simicic</a><sup> <a title="CIBM Center for Biomedical Imaging, Switzerland." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-1">1</a> <a title="Animal Imaging and Technology, EPFL, Lausanne, Switzerland." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-2">2</a> <a title="Laboratory for functional and metabolic imaging (LIFMET), EPFL, Lausanne, Switzerland." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-3">3</a></sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?sort=pubdate&term=Rackayova+V&cauthor_id=34268821">Veronika Rackayova</a><sup> <a title="CIBM Center for Biomedical Imaging, Switzerland." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-1">1</a> <a title="Animal Imaging and Technology, EPFL, Lausanne, Switzerland." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-2">2</a></sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?sort=pubdate&term=Xin+L&cauthor_id=34268821">Lijing Xin</a><sup> <a title="CIBM Center for Biomedical Imaging, Switzerland." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-1">1</a> <a title="Animal Imaging and Technology, EPFL, Lausanne, Switzerland." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-2">2</a></sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?sort=pubdate&term=Tk%C3%A1%C4%8D+I&cauthor_id=34268821">Ivan Tkáč</a><sup> <a title="Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-4">4</a></sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?sort=pubdate&term=Borbath+T&cauthor_id=34268821">Tamas Borbath</a><sup> <a title="High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-5">5</a> <a title="Faculty of Science, University of Tübingen, Tübingen, Germany." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-6">6</a></sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?sort=pubdate&term=Starcuk+Z+Jr&cauthor_id=34268821">Zenon Starcuk Jr</a><sup> <a title="Institute of Scientific Instruments, Czech Academy of Sciences, Brno, Czech Republic." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-7">7</a></sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?sort=pubdate&term=Starcukova+J&cauthor_id=34268821">Jana Starcukova</a><sup> <a title="Institute of Scientific Instruments, Czech Academy of Sciences, Brno, Czech Republic." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-7">7</a></sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?sort=pubdate&term=Lanz+B&cauthor_id=34268821">Bernard Lanz</a><sup> <a title="Laboratory for functional and metabolic imaging (LIFMET), EPFL, Lausanne, Switzerland." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-3">3</a></sup>, <a href="https://pubmed.ncbi.nlm.nih.gov/?sort=pubdate&term=Cudalbu+C&cauthor_id=34268821">Cristina Cudalbu</a><sup> <a title="CIBM Center for Biomedical Imaging, Switzerland." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-1">1</a> <a title="Animal Imaging and Technology, EPFL, Lausanne, Switzerland." href="https://pubmed.ncbi.nlm.nih.gov/34268821/#full-view-affiliation-2">2</a></sup></div>
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Advanced metabolite mapping at ultra-high field using 1H-MRS, 1H-MRSI and macromolecules: applications in a rat model of type C hepatic encephalopathy
No full textMagnetic Resonance Spectroscopy (MRS) is the only technique capable of measuring a large number of metabolites simultaneously in vivo. Ultra-high magnetic fields (UHF) combined with ultra-short echo time (TE) sequences allow the detection of high-quality 1H MR spectra and the quantification of 20 different metabolites in the brain (markers of energy metabolism, osmoregulation etc.).
In vivo brain localized 1H MR spectra at short TEs contain the contribution of mobile macromolecules (MM). Reliable detection and fitting of MM are crucial for accurate quantification. Higher spectral resolution at UHF led to increased interest in using a parametrized MM spectrum and flexible spline baselines to address unpredicted spectroscopic components.
In this thesis the MM spectra (from the rat brain at 9.4T) were characterized using an improved methodological approach for their post-processing, fitting and quantification. This method provided an efficient tool for parametrization of the MM spectrum into individual components and estimation of their T2app relaxation times. An extensive assessment on how the MM spectrum and spline baseline stiffness affect the metabolite and MM quantification is also reported
Type C hepatic encephalopathy (HE) is a complication of chronic liver disease (CLD). Children and adults respond differently to CLD and its related toxic accumulation of molecules (i.e. ammonium (NH4+), glutamine (Gln)). Children with CLD may grow up with significant neurocognitive deficits even after liver transplantation. Despite considerable advances in understanding the pathogenesis of type C HE, the exact metabolic mechanisms and their regional variations are not fully understood.
The advantages of UHF short TE 1H MRS were used herein to describe the regional distribution of metabolites in the developing and adult brain using the bile duct ligated model (BDL) of type C HE (adult and postnatal day 21 rats). Three brain regions were assessed (hippocampus, cerebellum and striatum) pointing towards cerebellum as a region with the heaviest burden of Gln and unique metabolic response. Changes in cell morphology were followed longitudinally and related to the metabolic alterations. Elevated oxidative stress is reported using electron paramagnetic resonance, together with the decreased antioxidants (1H MRS) emphasizing its important role in HE. The brain regional measurements confirmed the higher susceptibility of developing brain to the disease and the increased vulnerability of cerebellum. Finally, the beneficial effect of Cr supplementation on the neurometabolic profile is described using 1H MRS and 31P MRS in CLD pups (BDL at postnatal day 15) suggesting that an appropriate treatment may have significant public health impact.
MRSI is a powerful tool to non-invasively and spatially map the brain regional distribution of metabolites in vivo. While MRSI in human brain is increasingly used, preclinical MRSI is not widely applied mainly due to the small rodent brain, long acquisition times and low signal to noise ratio.
The implementation of a novel approach: free induction decay (FID) MRSI on the 14.1T preclinical scanner is described herein. This method offers a fast and robust data acquisition with high spatial resolution resulting in high quality spectroscopic maps. Finally, preliminary assessment of the effect of two noise reduction techniques (MP-PCA and TGV reconstruction) on the spectra from preclinical MRSI datasets is briefly presented.LIFME
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