1,721,375 research outputs found
Understanding surrogate measures of overall survival after trans-arterial chemoembolization of hepatocellular carcinoma
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Assessing Competing Risks for Death Following Liver Transplantation for Hepatocellular Carcinoma
No full textHepatocellular carcinoma (HCC) as an indication to liver transplant (LT) started as palliative treatment, then moved to potentially curative anti-cancer therapy and more recently entered the era of competition with non-cancer indications, consequent to the need of the society to target equal distribution of the limited resource of donated organs among different indications. Nowadays HCC is a leading indication to LT, currently representing up to 50% of the indications in most transplant Centers. The risk of post-transplant death and the causes of mortality significantly vary along the post-transplant follow-up. Overall, the main causes of death after LT are multiple organ failure and cerebrovascular, cardiovascular, pulmonary, and renal complications. However, after the first post-LT year, mortality for technical complications, infections and general complications significantly decrease, while recurrence of primary liver diseases (particularly malignancies) increase, turning to be the main causes of death. In studies with time-to-event or survival outcomes, a competing risk is an event whose occurrence precludes the occurrence of the primary event of interest. In the setting of LT for HCC, when the primary outcome of interest is death due to HCC recurrence, death due to causes different from this serves as a competing event because subjects who die from such different causes are no longer at risk of death due to HCC recurrence. The introduction of HCC-specific survival as a primary endpoint in studies assessing the outcomes of LT for HCC allows the identification of independent oncologic determinants of post-LT survival and their relative weight on patients’ prognosis. In this view, a continuous model based on level of AFP, tumor size and tumor number that allows to determine the risk of death from HCC-related factors after liver transplantation (www.hcc-olt-metroticket.org/) has been recently developed. Since the endpoint of HCC-specific survival is not influenced by the changes observed in short-term post-LT survival (thanks to advances in the clinical management) nor in long-term post-LT survival (thanks to the introduction of effective treatments achieving control of hepatitis B and C viruses), a model predicting HCC-specific survival will be an helpful prognostic tool in the context of the changing scenarios of LT for HCC
Adding credibility to meta-analytic results of metal versus plastic stents for preoperative biliary drainage in patients with periampullary cancer
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Prognostic prediction and identification of candidates for salvage liver transplantation among patients with early hepatocellular carcinoma.
No full textMeta-analysis of anatomic resection versus non-anatomic resection for hepatocellular carcinoma: Are they comparing apples with oranges?
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Simultaneous presence of focal nodular hyperplasia and hepatocellular carcinoma: case report and review of the literature
No full textFocal nodular hyperplasia (FNH) is an infrequent benign tumor of the liver that is generally believed to have no potential for malignant transformation; the coexistence of FNH and hepatocellular carcinoma (HCC) has seldom been reported. Here we describe an exceptional case of simultaneous FNH and HCC in the same patient and discuss the clinical and therapeutic management of FNH on the basis of a review of the literatur
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
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