1,720,956 research outputs found
Design of a multi-functional, nanoparticles-loaded supramolecular hydrogel to treat chronic wounds
No full textL'abstract è presente nell'allegato / the abstract is in the attachmen
Dual-function nanoparticles enzymatically conjugated with a custom-made polyurethane hydrogel for chronic wound treatment
Get PDFHydrogels are attractive drug delivery systems with the potential to protect their
cargo and control its release. In particular, hydrogels based on synthetic polymers
are gaining increasing interest by virtue of their controllable chemistry, ease of
modification, and reproducibility. Moreover, the presence of specific side chains
and pending functional groups in the polymer structure allows for the conjugation
of drugs and other compounds resulting in improved control over drug release.
Enzymes that catalyse reactions in a very specific way could also be used to control
the conjugation of compounds to the polymeric chains to improve reproducibility
and biocompatibility of the conjugation process.
This contribution describes an innovative system for drug delivery comprising a
bioartificial supramolecular hydrogel based on a customised polyurethane and α-
cyclodextrins, and nanoparticles, for application in the treatment of chronic
wounds. The system has the potential to reduce inflammation and eradicate
infection by virtue of dual-function nanoparticles which incorporate cobalt as
antimicrobial agent, and phenolated lignin as antioxidant. The nanoparticles are
enzymatically conjugated to the hydrogel by means of the amine side groups
exposed along the backbone of the ad-hoc synthesised polyurethane. The oxidase
enzyme laccase is exploited to oxidize the phenol groups of lignin, to allow their
interaction with the amines on the hydrogel. The effects of nanoparticles
conjugation to the hydrogel are studied through gelification tests, stability tests,
and rheology. Moreover, the release of nanoparticles from the hydrogel and their
effects on patients’ wound fluids and against relevant bacterial strains are analysed
in vitro
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
- …
