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Un “ecdysone response element” in grado di legare diversi membri della famiglia di recettori nucleari di Drosophila melanogaster.
No full textCombined anticancer therapies: An overview of the latest applications
No full textTumor resistance and low drug efficacy prompt to investigate new therapeutic strategies that have high efficacy and low toxicity, especially for cancers with poor prognosis. This goal has been recently achieved using particular pharmaceutical combination or nanotechnologies to specifically deliver drugs at the tumor site. Novel combined treatments employ either naturally active ingredients or drugs already intended for other uses, with the aim to increase cell sensitivity to therapy and reduce drug toxicity. Combined treatments usually improve the overall therapeutic efficacy of the single drug. Drug–drug interactions allow synergistic effects. Several evidences indicate that synergy can be affected by drug–drug ratio and drug administration order. Therapeutic efficacy can be enhanced through drug entrapment in nanocarriers that allow a site-specific targeting, resulting in a build-up of the drug in the tumor with a significant toxicity reduction. Several studies investigated combined entrapment of two or more drugs each one characterized by different mechanisms of action. These nanosystems improve synergistic efficacy and could be a device to resolve toxicity and multi-drug resistance. Nano-encapsulation of anticancer agents by targeting specific tumor tissues significantly optimizes drug bioavailability, biocompatibility and therapeutic efficacy. The efficacy of these formulations results from receptor-mediated endocytosis and prolonged circulation time. Drug encapsulation also allows using limited final concentration while avoiding its activity within the blood circulation. In this review we report recent findings about novel combined treatment focusing on synergistic effects and mechanisms of action. We will also overview the latest drug delivery system and their therapeutic benefits in cancer treatment
Advances in cancer therapy: Novel approaches in combined drug treatments
No full textDrug resistance and poor efficacy of anticancer therapies prompt to investigate innovative therapeutic strategies aimed to improving efficacy and lowering toxicity. Recent advances in chemotherapeutics have been achieved using specific pharmaceutical combinations or ameliorating drug delivery by drug encapsulation. Novel combined treatments are based on the use of drugs, typically natural active or intended for other uses combined with the classical anti-cancer drug. These compounds promote synergistic effects even more enhanced when drug delivery is achieved by nanocarriers. Nanotechnologies provide a site-specific delivery at the tumor site, resulting from receptor-mediated endocytosis and prolonged circulation time. Nanocarriers also increase drug bioavailability and biocompatibility contributing to a drug increase inside the tumor and determining a minor toxicity and a better efficacy. This chapter reports recent findings about novel anticancer combined treatments and about the latest drug delivery systems based on the use of nanocarriers
Un “ecdysone response element” in grado di legare diversi membri della famiglia di recettori nucleari di Drosophila melanogaster.
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The role of the BR-C locus on the expression of genes at the ecdysone-regulated 3C11 puff of Drosophila melanogaster
No full textThe role of the Broad-Complex locus in the expression of genes located at the ecdysone-regulated 3C puff of D. melanogaster.
No full textThe moulting hormone ecdysone is able to recognize target elements composed of direct repeats.
No full textThe role of the Broad-Complex locus in the expression of genes located at the ecdysone-regulated 3C puff of D. melanogaster.
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