1,720,994 research outputs found
SALUTE RIPRODUTTIVA NELLE PAZIENTI CON MALATTIE REUMATOLOGICHE SEGUITE PROSPETTICAMENTE DA TEAM MULTIDISCIPLINARI: ANALISI DELL’OUTCOME MATERNO-FETALE, VALUTAZIONE DELLA TERAPIA IN GRAVIDANZA E IDENTIFICAZIONE DI FATTORI DI RISCHIO PER EVENTI AVVERSI
Full text linkLe malattie reumatologiche spesso vengono diagnosticate in donne in età fertile, le quali possono desiderare una gravidanza. Negli ultimi anni, grazie alla diagnosi precoce, alla disponibilità di terapie efficaci a alla pianificazione e gestione multidisciplinare della gravidanza, è stato possibile ottenere un miglior controllo dell’attività di malattia ed un miglioramento degli outcome materno-fetali in queste pazienti. Tuttavia, le complicanze rimangono più frequenti rispetto alla popolazione ostetrica generale.
L’influenza dell’attività di malattia sull’outcome della gravidanza e, viceversa, l’influenza della gravidanza sull’attività di malattia, così come le modifiche terapeutiche da apportare prima della gravidanza, sono solo alcuni degli aspetti che devono essere considerati in questo ambito.
Ad oggi sono ancora numerosi gli unmet needs, soprattutto per le pazienti con malattie rare. Inoltre, i dati disponibili in letteratura circa l’attività di malattia e la frequenza delle riacutizzazioni durante la gravidanza, la sicurezza e l’efficacia dei trattamenti anti-reumatici e l’identificazione di marker predittivi di eventi avversi, sono parziali e riguardano soprattutto alcune malattie reumatiche.
Lo scopo della presente tesi e del progetto di ricerca da cui deriva, è stato quello di esaminare il tema della salute riproduttiva su scala nazionale ed internazionale, in diverse coorti di pazienti con diagnosi di malattia reumatologica seguite durante la gravidanza da team multidisciplinari. In questo contesto, sono stati valutati gli outcome materno-fetali, l’attività di malattia e le terapie assunte durante la gravidanza in pazienti con diverse malattie reumatologiche, con l’obiettivo di identificare eventuali marker predittivi di outcome avversi. Inoltre, è stata approfondita la tematica del benessere psicologico delle pazienti con malattia reumatologica durante la gravidanza e nel post-partum.
I risultati di questa tesi hanno contribuito a una maggiore comprensione di numerosi aspetti riguardanti la salute riproduttiva nelle donne con malattie reumatologiche e hanno evidenziato l’importanza della gestione multidisciplinare e dello stretto monitoraggio della gravidanza e del post-partum in queste pazienti.Rheumatic diseases are often diagnosed in women of childbearing age, who may desire pregnancy. In recent years, thanks to early diagnosis, the availability of effective therapies, and pregnancy planning together with multidisciplinary management, it has been possible to achieve better control of disease activity and to improve maternal-fetal outcomes in these patients. However, complications are still more frequent compared to the general obstetric population.
The influence of disease activity on pregnancy outcomes and, conversely, the impact of pregnancy on disease activity, as well as therapeutic modifications required before pregnancy, are just some of the aspects that need to be considered in this context. To date, there are still numerous unmet needs in this field, especially for patients with rare diseases. Indeed, available data regarding disease activity, frequency of flares during pregnancy, safety and efficacy of anti-rheumatic treatments, and predictive markers of adverse events are partial and limited to some rheumatic diseases. The aim of this thesis and the research project from which it originates has been to investigate the topic of reproductive health on a national and international scale, evaluating different cohorts of patients diagnosed with rheumatic diseases, who were monitored during pregnancy by multidisciplinary teams. In this context, maternal-fetal outcomes, disease activity, and therapies used during pregnancy were assessed in patients with different rheumatologic diseases, with the aim also of identifying potential predictive markers of adverse outcomes. Furthermore, the issue of the psychological well-being of patients with rheumatologic diseases during pregnancy and in the postpartum period has been explored. Overall, the results of this thesis have contributed to a better understanding of different aspects concerning reproductive health in women with rheumatic diseases and have highlighted the importance of multidisciplinary management and close monitoring during pregnancy and post-partum in these patients
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
- …
