1,721,049 research outputs found
Analysis of virulence factors in cases of enterococcal endocarditis.
No full textClin Microbiol Infect. 2004 Nov;10(11):1006-8.
Analysis of virulence factors in cases of enterococcal endocarditis.
Baldassarri L, Creti R, Arciola CR, Montanaro L, Venditti M, Di Rosa R.
Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate, Istituto Superiore di Sanita, Rome, Italy. [email protected]
Eleven isolates of Enterococcus faecalis causing endocarditis were screened for possible virulence factors with PCR and phenotypic assays. The gene coding for the enterococcal surface protein (esp) was detected in one isolate only, and haemolysin was produced by two isolates. Aggregation substance, biofilm formation and gelatinase were present in seven, nine and eight isolates,
respectively. Predisposing factors, particularly hospitalisation and multiple antibiotic therapy, appeared to be more relevant to the development of enterococcal endocarditis following bloodstream infections than the pattern of virulence factors
The Alpha-like surface proteins: An example of an expanding family of adhesins
No full textThe Alpha-like protein (Alp) family, repeat-containing surface proteins once thought to be important adhesion factors confined to pathogenic streptococci and enterococci, is broader than previously known. Analysis of the annotated microbial genomes has identified new potential members of the Alp family not only in other Gram- positive opportunistic pathogens but also in commensal microflora of the human gut and the skin. This finding has highlighted the importance of genome sequencing projects for unraveling in greater detail lateral gene transfer events involving virulence factors between pathogens and commensals. These should receive constant attention not only as part of infectious disease prevention programs, but also in the food and biotechnology industrie
Underestimated collateral effects of antibiotic therapy in prosthesis-associated bacterial infections
No full textAntibiotic treatment of infections associated with the use of indwelling medical devices in ageing and/or severely ill patients represents a significant healthcare problem due to the difficulty of treating such infections and to the various collateral effects that may be observed following the often aggressive therapy. We summarize some effects of antibiotics on the expression of virulence factors of the microorganisms which cause such infections. These effects, particularly those resulting in a stimulation of bacterial virulence, might be usefully included among the other well-known collateral effects of antibiotic therapy
Group B Streptococcus Late-onset Neonatal Disease: An Update in Management and Prevention
Full text linkLaboratory breakpoints for assessing high level gentamicin resistance in Streptococcus agalactiae: it is the time for a consensus
No full textThe archaea monophyly issue: A phylogeny of translational elongation factor G(2) sequences inferred from an optimized selection of alignment positions
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