16,798 research outputs found
[Fragmentos de 362 cartas sobre asuntos del Gobierno de Valencia, desde 6 de enero de 1655 a 10 de diciembre de 1653] [Manuscrito]
No full textLos fols. 1 y 2 están impresos con una carta del autor a su hermano: 'Carta qve el Excelentissimo Señor D. Christoval Crespi de Valdaura, Clavero, y Assessor General de la Orden de Montesa, Vicecanceller de los Reynos de la Corona de Aragon, y de la Iunta del Govierno Vniversal de la Monarquia, siendo de 27 años escriviò à su Hermano el Señor Don Iuan Crespi y Brizuela, que despues fue Maesse de Campo, y Teniente Real en Flandes, Milan, y Cataluña, Comendador de Adamuz, y Castelfabi, y Lugarteniente General por su Magestad de la Orden de Montesa ... [dándole consejo para que sea] acertado Cavallero y gran soldado ... Valencia, y Mayo à 12 de 1627.' ... sin imp., recl., sin pag. imp.Tít. tomado de Alonso-CortésAl comienzo hay dos fol. impresos con una carta del aut. a su hermano; foliación moderna a lápiz; apost.; caja de escritura 26 x 13,5 cm; 28-32 lín. por p.1. Capitulos de differentes cartas del s[eño]r Vicecanc[ille]r D[o]n Christoval Crespi, a su Herm[an]o el s[eño]r D[o]n Juan Crespi Lugarteniente G[e]n[era]l de la orden de Montesa. ... (fol. 3) ... para que comunicarle. (fol. 165 v.
Exploring inconsistencies between observational and experimental studies of selenium and diabetes risk.
No full textBackground: Observational and experimental epidemiologic studies that have addressed the relation between intake of the trace element selenium and cancer risk have yielded strongly conflicting results, as recently reported by a Cochrane review. Most observational studies suggest an inverse association, while randomized controlled trials (RCTs) have indicated a null or direct relation. Little is known about the replication of such inconsistencies when dealing with the risk of other chronic disease.
Objectives: We investigated the results of observational and experimental studies linking selenium exposure to the occurrence of type 2 diabetes.
Methods: After a literature search we identified 12 observational studies (8 cross-sectional and 4 cohort) and 5 RCTs. Using a random-effects model, we computed the summary relative risk (RR) of type-2 diabetes along with its 95% confidence interval (CI) in subjects with the highest versus the lowest selenium exposure category in observational studies, and in subjects allocated to selenium compared to placebo in the RCTs.
Results: Summary RRs were 1.98 (95% CI 1.22-3.23) and 1.13 (0.15-8.45) for cross-sectional studies using serum and toenail selenium for exposure assessment, respectively. Cohort studies based on toenail selenium yielded a summary RR of 0.78 (0.62-0.98), while the only study assessing dietary selenium intake gave a RR of 2.39, (1.32-4.32). For RCTs, summary RR was 1.10 (1.00-1.21) among selenium-supplemented versus placebo. The distinctive feature of the two observational studies (one cross-sectional and one prospective) that failed to find an excess diabetes risk associated with higher selenium exposure was that the subjects were health professionals. Age, gender, study area and other demographic characteristics did not appear to have influenced the results.
Conclusions: These results suggest that the ability of observational studies to predict results of RCTs when addressing the health effects of selenium may differ on the basis of the outcome studied (diabetes versus cancer) as well as the indicator used for exposure assessment and the type of population under study
Friend or foe? The current epidemiologic evidence on selenium and human cancer risk
No full textScientific opinion on the relationship between selenium and the risk of cancer has undergone radical change over the years, with selenium first viewed as a possible carcinogen in the 1940s then as a possible cancer preventive agent in the 1960s-2000s. More recently, randomized controlled trials have found no effect on cancer risk but suggest possible low-dose dermatologic and endocrine toxicity, and animal studies indicate both carcinogenic and cancer-preventive effects. A growing body of evidence from human and laboratory studies indicates dramatically different biological effects of the various inorganic and organic chemical forms of selenium, which may explain apparent inconsistencies across studies. These chemical form-specific effects also have important implications for exposure and health risk assessment. Overall, available epidemiologic evidence suggests no cancer preventive effect of increased selenium intake in healthy individuals and possible increased risk of other diseases and disorders
The politics and economics of regulatory impact assessment
No full textThis is the author accepted manuscript. The final version is available from the publisher via the link in this record
Giacomo del Leonardis (graveur) d’après une peinture de Giuseppe Crespi : Scène de rue à Venise
No full textEau-forte et burin, 1762 (35 x 48,5 cm)Giuseppe Crespi (1665-1747) a eu de nombreux maîtres et a été marqué par de multiples influences avant de se créer une manière très personnelle. Amateur de clair-obscur, bien que n’ayant pas dédaigné les compositions religieuses ou les décorations mythologiques, il est surtout un peintre de genre. Il représente le monde de tous les jours et annonce l’école vénitienne du XVIII e siècle, qui voit le grand essor des vedutistes. Élève de Tiepolo, Giacomo del Leonardis a obtenu un premier prix à l’Académie de Venise.téléchargeabl
Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite.
No full textExposure to selenium, and particularly to its inorganic forms, has been hypothesized as a risk factor for amyotrophic lateral sclerosis (ALS), a fast progressing motor neuron disease with poorly understood etiology. However, no information is known about levels of inorganic and some organic selenium species in the central nervous system of ALS patients, and recent observations suggest that peripheral biomarkers of exposure are unable to predict these levels for several Se species including the inorganic forms. Using a hospital-referred case-control series and advanced selenium speciation methods, we compared the chemical species of selenium in cerebrospinal fluid from 38 ALS patients to those of 38 reference neurological patients matched on age and gender. We found that higher concentrations of inorganic selenium in the form of selenite and of human serum albumin-bound selenium were associated with increased ALS risk (relative risks 3.9 (95% confidence interval 1.2-11.0) and 1.7 (1.0-2.9) for 0.1μg/L increase). Conversely, lower concentrations of selenoprotein P-bound selenium were associated with increased risk (relative risk 0.2 for 1μg/L increase, 95% confidence interval 0.04-0.8). The associations were stronger among cases age 50 years or older, who are postulated to have lower rates of genetic disease origin. These results suggest that excess selenite and human serum albumin bound-selenium and low levels of selenoprotein P-bound selenium in the central nervous system, which may be related, may play a role in ALS etiology
[Utriusque Juris Adversaria] [Manuscrito]
No full textEn la primera h. de guarda hay una nota reciente que dice: 'El autor de esta obra es el Vicecanciller de Aragon D[o]n Cristobal Crespi de Valdaura. Saturnino Rivera Manescau' [rubricado]Texto en latín; Letra del S. XVIITít. tomado del lomoTexto con apost. y amplios márgenes a la izquierda; foliación moderna a lápiz; en blanco los fols. 6, 7, 189-199 y 242-277; caja de escritura 27 x 12 cm; 25-33 lín. por p.1. [Tabla] -- 2. Tomus prim[us]. Adversario[rum]. De fide commisso graduali et prohibitione alienandi extra familiam. <Ex facto queritur ... (fol. 8- ) Rodriguez d[e] quest[ione] 19 n[umer]o 5 et 42. (fol. 298 v.)
Simvastatin treatmnt reduces angiotensin II type 1 rceptor mRNA expression in human leukocytes of high-risk subjects
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