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Fenwick on civil liberties and human rights /
No full text"More than merely describing the evolution of human rights and civil liberties law, this...textbook provides students with...coverage of the most crucial developments in the field, clearly explaining the law in context and practice. Updated throughout for this new edition, [the author] considers a number of recent major changes in the law, in particular proposals to replace the Human Rights Act with a British Bill of Rights, and the Counter-Terrorism and Security Act 2015, whilst also contextualising the impact of reforms on hate speech and contempt due to advances in new media."-
Falcated Teal:
No full text1994Purchased for the Camosun College Art Collection by the Camosun College Cultural Enhancement Committee from the Art Gallery of Greater Victoria (Art Rental and Sales Gallery).James Fenwick Lansdowne (Order of Canada, Order of BC, Royal Canadian Academy of the Arts), was an internationally renowned wildlife artist and author. Born to British parent in Hong Kong in 1937, Lansdowne grew up in Victoria, BC and was taught to paint by his mother, an accomplished artist trained in Chinese watercolour painting. He began his artistic career at a young age presenting his first exhibition at the Royal Ontario Museum at the age of nineteen. His work has been closely compared to the paintings of John James Audubon, as it often portrayed a specific bird species over a neutral coloured background. Lansdowne’s work however has been lauded for its life-like realism and ability to present birds in naturalistic poses. He studies his subjects in their natural habitat and paints them in gouache. In 1977, Lansdowne was made an Officer of the Order of Canada, and in 1979, received an honourary Doctor of Laws from the University of Victoria. Lansdowne’s works have exhibited internationally at museums and galleries including Audubon House in New York, London’s Truon Galleries, and the Smithsonian Institute in Washington DC.
ARTIST INFO: Times Colonist Obituary: http://www.legacy.com/obituaries/timescolonist/obituary.aspx?n=james-fenwick-lansdowne&pid=114495190 (Accessed January 9, 2017); CBC Obituary: http://www.cbc.ca/news/entertainment/renowned-b-c-bird-artist-and-author-james-fenwick-lansdowne-dies-at-71-1.694563 (Accessed January 9, 2017); University of Victoria Collection Search Results: http://collection.legacy.uvic.ca/index.php?artist_id=2123&artist_action=get_art_w_bio (Accessed February 26, 2017)Robbyn LanningGouache is an watermedia which possesses qualities of both watercolour and acrylic/oil paints. Similar to watercolour paint, gouache has a matte finish, can be rewet, and can permeate its paper support. Like acrylic or oil paints, gouache is opaque and can also be used to form a superficial layer on top of its support.
NUMBER & COUNT: Print 20 of 30
Internet daemons: digital communications possessed
No full textWe’re used to talking about how tech giants like Google, Facebook, and Amazon rule the internet, but what about daemons? Ubiquitous programs that have colonized the Net’s infrastructure—as well as the devices we use to access it—daemons are little known. Fenwick McKelvey weaves together history, theory, and policy to give a full account of where daemons come from and how they influence our lives—including their role in hot-button issues like network neutrality.
Going back to Victorian times and the popular thought experiment Maxwell’s Demon, McKelvey charts how daemons evolved from concept to reality, eventually blossoming into the pandaemonium of code-based creatures that today orchestrates our internet. Digging into real-life examples like sluggish connection speeds, Comcast’s efforts to control peer-to-peer networking, and Pirate Bay’s attempts to elude daemonic control (and skirt copyright), McKelvey shows how daemons have been central to the internet, greatly influencing everyday users.
Internet Daemons asks important questions about how much control is being handed over to these automated, autonomous programs, and the consequences for transparency and oversight.
Table of Contents
Abbreviations and Technical Terms
Introduction
1. The Devil We Know: Maxwell’s Demon, Cyborg Sciences, and Flow Control
2. Possessing Infrastructure: Nonsynchronous Communication, IMPs, and Optimization
3. IMPs, OLIVERs, and Gateways: Internetworking before the Internet
4. Pandaemonium: The Internet as Daemons
5. Suffering from Buffering? Affects of Flow Control
6. The Disoptimized: The Ambiguous Tactics of the Pirate Bay
7. A Crescendo of Online Interactive Debugging? Gamers, Publics and Daemons
Conclusion
Acknowledgments
Appendix: Internet Measurement and Mediators
Notes
Bibliography
Index
Reviews
Beneath social media, beneath search, Internet Daemons reveals another layer of algorithms: deeper, burrowed into information networks. Fenwick McKelvey is the best kind of intellectual spelunker, taking us deep into the infrastructure and shining his light on these obscure but vital mechanisms. What he has delivered is a precise and provocative rethinking of how to conceive of power in and among networks.
—Tarleton Gillespie, author of Custodians of the Internet
Internet Daemons is an original and important contribution to the field of digital media studies. Fenwick McKelvey extensively maps and analyzes how daemons influence data exchanges across Internet infrastructures. This study insightfully demonstrates how daemons are transformative entities that enable particular ways of transferring information and connecting up communication, with significant social and political consequences.
—Jennifer Gabrys, author of Program Eart
Sub-National Governance in England
No full textThis discussion is concerned with sub-national governance in England. It will suggest that the most striking characteristic of English sub-national governance is its fragmentary and incoherent nature, embracing regions (if they can still be said to exist), city-regions (which are subject to a number of different definitions) and local government (which itself is sub-divided from place to place into metropolitan, non-metropolitan, unitary and two-tier systems, with a range of differing political management arrangements). This pattern of sub-national provision has grown ever-more varied, subject to ad hoc initiatives, and with no overall rationale. It will be argued that - in contrast to other parts of the United Kingdom - there is currently no political incentive to address the nature of
English sub-national governance. Hence there is little likelihood that the pattern of governance depicted here will change, unless new factors are brought into play. Some of these are suggested at the end of this paper
Social media and medical professionalism: rethinking the debate and the way forward
No full textThis Perspective addresses the growing literature about online medical professionalism. Whereas some studies point to the positive potential of social media to enhance and extend medical practice, the dominant emphasis is on the risks and abuses of social media. Overall evidence regarding online medical professionalism is (as with any new area of practice) limited; however, simply accumulating more evidence, without critically checking the assumptions that frame the debate, risks reinforcing negativity toward social media. In this Perspective, the author argues that the medical community should step back and reconsider its assumptions regarding both professionalism and the digital world of social media. Toward this aim, she outlines three areas for critical rethinking by educators and students, administrators, professional associations, and researchers. First she raises some cautions regarding the current literature on using social media in medical practice, which sometimes leaps too quickly from description to prescription. Second, she discusses professionalism. Current debates about the changing nature and contexts of professionalism generally might be helpful in reconsidering notions of online medical professionalism specifically. Third, the author argues that the virtual world itself and its built-in codes deserve more critical scrutiny. She briefly summarizes new research from digital studies both to situate the wider trends more critically and to appreciate the evolving implications for medical practice. Next, the author revisits the potential benefits of social media, including their possibilities to signal new forms of professionalism. Finally, the Perspective ends with specific suggestions for further research that may help move the debate forward
Identifying Content for the Glaucoma-specific Item Bank to Measure Quality-of-life Parameters
No full text"This is a non-final version of an article published in final form in Khadka J, McAlinden C, Craig JE, Fenwick EK, Lamoureux EL, Pesudovs K. Identifying content for the glaucoma-specific item bank to measure quality-of-life parameters. Journal of Glaucoma . 2015 Jan;24(1):12-9. doi: 10.1097/IJG.0b013e318287ac11.". Author manuscript version made available in accordance with publisher copyright policy.PURPOSE:
Patient-reported outcomes (PROs) have become essential clinical trial end points. However, a comprehensive, multidimensional, patient-relevant, and precise glaucoma-specific PRO instrument is not available. Therefore, the purpose of this study was to identify content for a new, glaucoma-specific, quality-of-life (QOL) item bank.
METHODS:
Content identification was undertaken in 5 phases: (1) identification of extant items in glaucoma-specific instruments and the qualitative literature; (2) focus groups and interviews with glaucoma patients; (3) item classification and selection; (4) expert review and revision of items; and (5) cognitive interviews with patients.
RESULTS:
A total of 737 unique items (extant items from PRO instruments, 247; qualitative articles, 14 items; focus groups and semistructured interviews, 476 items) were identified. These items were classified into 10 QOL domains. Four criteria (item redundancy, item inconsistent with domain definition, item content too narrow to have wider applicability, and item clarity) were used to remove and refine the items. After the cognitive interviews, the final minimally representative item set had a total of 342 unique items belonging to 10 domains: activity limitation (88), mobility (20), visual symptoms (19), ocular surface symptoms (22), general symptoms (15), convenience (39), health concerns (45), emotional well-being (49), social issues (23), and economic issues (22).
CONCLUSIONS:
The systematic content identification process identified 10 QOL domains, which were important to patients with glaucoma. The majority of the items were identified from the patient-specific focus groups and semistructured interviews suggesting that the existing PRO instruments do not adequately address QOL issues relevant to individuals with glaucoma
Erratum to: Is Sensory Loss an Understudied Risk Factor for Frailty? A Systematic Review and Meta-analysis
No full textIn the article “Is Sensory Loss an Understudied Risk Factor for Frailty? A Systematic Review and Meta-analysis,” an author was missing. Ana Maseda should be listed as the 11th author. The correct author list is: Benjamin Kye Jyn Tan, Ryan Eyn Kidd Man, Alfred Tau Liang Gan, Eva K Fenwick, Varshini Varadaraj, Bonnielin K Swenor, Preeti Gupta, Tien Yin Wong, Caterina Trevisan, Laura Lorenzo-López, Ana Maseda, José Carlos Millán-Calenti, Carla Helena Augustin Schwanke, Ann Liljas, Soham Al Snih, Yasuharu Tokuda, Ecosse Luc Lamoureux. This error has been corrected
Anti-PD-1 mediated depletion of cellular reservoir from HIV infected donor blood mononuclear cells: A proof of concept study
No full textBackground: The advances of HIV research and especially the advent of antiretroviral therapy (ART)
led to strong and long-lasting viral suppression in peripheral blood of most treated individuals. Despite
the efficacy of ART, treatment interruption results in vial rebound and disease progression due to the
persistence of HIV in reservoirs that cannot be reached by ART. Recent studies have shown that
PD-1+CD4 T cells serve as a major cellular reservoir for HIV-1 replication and production, thus providing
a strong rationale for developing therapeutic strategies targeting the elimination of PD-1+CD4 T cells.
Aim: The current project aims at killing HIV infected cells based on PD-1 as a marker for HIV cellular
reservoir using the antibody-dependent cellular cytotoxic activity (ADCC) of humanized IgG1 antibodies
or antibody-drug conjugates (ADC).
Methods: Humanized anti-human PD-1 antibodies (hPD-1 IgG1/IgG4) were developed to evaluate
ADCC activity. In parallel, mouse or humanized anti-PD-1 antibodies (mPD-1 or hPD-1 Ab) were
conjugated with an anthracycline toxin to produce an antibody-drug conjugate (ADC). ADCC and ADCs
were evaluated on blood mononuclear cells and isolated CD4+ T cells, respectively, isolated from viremic
untreated or ART suppressed HIV infected donors in 5-day assays. Cells undergoing apoptosis and cell
death were assessed by flow cytometry and culture supernatants were analyzed for viral p24 (ECL
COBAS HIV Ag) or HIV RNA (COBAS AmpliPrep/TaqMan HIV-1) production. Cells from ART treated
donors were tested in a quantitative viral outgrowth assay (QVOA) to evaluate the frequency of cells
harboring replication competent and infectious viruses following Ab or ADC treatment.
Results: In HIV viremic donors, hPD-1 IgG1 lead to the targeted depletion of PD-1+CD4 T cells, which
was associated with 59% and 43% reduction of HIV RNA and p24 production from infected cells,
respectively (n=4). Similarly, m/hPD-1 ADCs efficiently depleted PD-1+CD4 T cells as indicated by the
increased frequencies of apoptotic and dead cells compared to unconjugated m/hPD-1 Ab (n=7 and
n=5, respectively). Targeted cytotoxicity was associated with 80% and 83% reduced viral p24 production
in the culture supernatants compared to unconjugated m/hPD-1 Ab, respectively. In ART suppressed
individuals, increased frequencies of apoptotic cells and cell death after incubation with hPD-1 IgG1
treatment reduced the frequency of infected cells harboring replication competent viruses by 66% (n=4).
Similarly, mPD-1 ADC was associated with 88% reduction of infected cells harboring replication
competent viruses and cells harboring infectious viruses were undetectable (n=5; n=4).
Discussion: These results indicate that the depletion of PD-1+CD4 T cells by hPD-1 IgG1 or m/hPD-1
ADC strongly reduces HIV-1 infected cells capable to produce infectious viruses. In these proof of
concept studies, hPD-1 IgG1 or anti-PD-1 ADC represent novel interventions that could contribute to a
functional cure for HIV-1 infected individuals
Leading Beautifully : Educational Leadership as Connoisseurship
No full textLeading Beautifully provides a new dimension to understanding effective leadership. Drawing from lessons in the arts and the humanities, English and Ehrich explore how educational decision-making in schools can be informed by identity, personal competence, and an understanding of the field's intellectual foundations. Based on in-depth interviews of artists and educational leaders, this book provides insight into the inner world of successful leaders who have developed competencies and understandings that extend beyond the standard leadership tool box. This exciting new book explores the theory and practice of leadership connoisseurship as a human-centered endeavor and as an antidote to mechanistic, business-oriented practices. The authors' well-grounded reconsideration of educational leadership will enliven and enhance any educational leader's practice
IPEM topical report: current molecular radiotherapy service provision and guidance on the implications of setting up a dosimetry service.
No full textDespite a growth in molecular radiotherapy treatment (MRT) and an increase in interest, centres still rarely perform MRT dosimetry. The aims of this report were to assess the main reasons why centres are not performing MRT dosimetry and provide advice on the resources required to set-up such a service. A survey based in the United Kingdom was developed to establish how many centres provide an MRT dosimetry service and the main reasons why it is not commonly performed. Twenty-eight per cent of the centres who responded to the survey performed some form of dosimetry, with 88% of those centres performing internal dosimetry. The survey showed that a 'lack of clinical evidence', a 'lack of guidelines' and 'not current UK practice' were the largest obstacles to setting up an MRT dosimetry service. More practical considerations, such as 'lack of software' and 'lack of staff training/expertise', were considered to be of lower significance by the respondents. Following on from the survey, this report gives an overview of the current guidelines, and the evidence available demonstrating the benefits of performing MRT dosimetry. The resources required to perform such techniques are detailed with reference to guidelines, training resources and currently available software. It is hoped that the information presented in this report will allow MRT dosimetry to be performed more frequently and in more centres, both in routine clinical practice and in multicentre trials. Such trials are required to harmonise dosimetry techniques between centres, build on the current evidence base, and provide the data necessary to establish the dose-response relationship for MRT
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