268 research outputs found
Craig, John Charles
No full textBiographical information for architect John Charles Craig; includes photos of his work, the New Grand Hotel, the Herald Building, the Salt Lake Stock Exchange, and the Shubrick Apartment Hotel, all in Salt Lake City, Utah
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ENVIRONMENTAL STEWARDSHIP AND SUSTAINABILITY GOAL SETTING IN THE COMMUNITY
No full textLoss of biodiversity is a complex global scale problem that manifests in all ecological systems. That said many solutions are found at the individual and local scale and reside in the value that people place on nature. This research targets the local scale by improving coordination and collaboration between those involved in solutions. It also targets the individual scale by seeking to improve people’s relationships with the natural world. This dissertation research has been organized into three chapters.The first chapter is a case study that the first author will describe through the lens of a neutral facilitator and participant observer, will working towards a collaborative effort between local environmental entities to build environmental goals for the Pullman, Washington community. The co-author Dr. Allyson Beall King provided valuable insight for the theoretical and organizational framework of the paper.The second chapter is focused on understanding an individual’s interaction, relationship and perception to nature through survey implementation after a two-week restoration. The population sampled in this chapter were students from an introductory environmental science course, primarily from the Pacific Northwest. The co-authors, Dr. Allyson Beall King and Dr. Alexander Fremier provided valuable insight on organizational structure and revisions to the conceptual framework of the paper. Dr. Kira Carbonneau provided insight and mentorship on the statistical analysis and results of the chapter. The co-authors Dr. Alex Fremier and Dr. Allyson Beall King provided valuable revisions and feedback, as well as organizational restructuring of the chapter. Dr. Kira Carbonneau provided guidance on statistical analysis for the chapter.Chapter three will further investigate the similarities and differences between participants by grouping them based on the impact of the restoration activities. It will explore the practical application of using known preferences as a way for environmental practitioners to tailor their volunteering events. The co-author Dr. Craig Woodruff provided insight, mentorship, and revised the R-code package to complete the text-mining analysis for chapter 3. Dr. Allyson Beall King provided constructive revisions to the conceptual theory of the chapter
Ernest Hemingway’s Reading of James Joyce’s \u3cem\u3eUlysses\u3c/em\u3e
No full textDrawing on biographies, correspondence, and other archives, Beall investigates Hemingway’s reading of an unbound press copy of Ulysses sent to him by Beach at Joyce’s request. Beall refutes the widely held opinion that Hemingway was uninterested in Ulysses (1922), providing evidence that he read over two-thirds of the novel. Points to a passage in “Cat in the Rain” and Hemingway’s inscription of A Farewell to Arms to the author as evidence of Joyce’s influence on the young writer and calls for a fuller examination of the subject
Five Scholarly Open Access Publishers
No full textThis review critically examines five international scholarly publishers that publish academic journals using the gold (author pays) Open Access model. The author-pays model is changing scholarly publishing because authors, rather than libraries or other subscribers, become the publishers' customers, an arrangement that creates a built in conflict of interest. The more articles a publisher accepts, the more revenue it earns. New gold Open Access publishers are appearing almost weekly, and many are engaged in unethical practices. The review covers four predatory publishers, Academy Publish, BioInfo, ScienceDomain International, and Scientific Research Publishing, and one legitimate publisher, AOSIS Open Journals
The Dark Humor of Hemingway’s A Way You’ll Never Be
No full textManuscript study. Beall chronicles Hemingway’s extensive drafting and revision process, contending that the author carefully constructs the opening battle scene with Nick as a rational and detached military analyst to underscore his later manic loss of control, as evidenced in his rambling interior monologues and comedic lecture to the adjutant connecting American troops with plagues of locusts. Contrasts Nick’s comical monologues on locusts in “Big Two-Hearted River” with the sharper and edgier humor of his exchange with the adjutant. Reads the latter story’s conclusion as evidence of Nick’s resilience and ability to move forward despite his wounding
Factors influencing Beall degermination of corn for dry milling
No full textPilot scale corn dry milling experiments were conducted to compare the throughput and the product yields obtained from the most widely reported procedure in scientific literature, 3-stage tempering, with those obtained from the most commonly commercially practiced procedure, 1-stage tempering. For certain conditions of temper duration and tail gate weight distance (tail gate loading), both procedures produced statistically similar results.Based upon these results, further experiments were conducted to examine the factors influencing the optimum tempering for dry milling. Central composite design was used to study the effects of temper duration and the operating parameters of temperature (corn and water), moisture (initial corn and temper), and the Beall degerminator controls (rotor position and weight distance) on the throughput and product yields. A single set of conditions that would maximize the throughput and the yields of the prime products was not found. The water temperature had a stronger effect than the corn temperature on most of the product yields for shorter temper durations, while the inverse was true for longer temper durations. The yield of flaking grits increased with an increase in the initial corn moisture, though the storage of corn at high initial moisture may result in corn spoilage. The throughput was more dependent upon the rotor position than the tail gate weight distance at higher rotor positions (closed position), while the opposite was true at lower rotor positions (open position).The effects of blocking certain sections of the degerminator casing and placing three different sized screens on the conical cage were also studied. Blocking section #3 alone (control condition) or together with any of the other sections, decreased the throughput and increased the flaking grits yield. Significantly higher flaking grit yield was also observed when the screen size was increased from 0.0056 (14/64 in) to 0.006 m (16/64 in) although the tail stock percentage was significantly reduced by 7% points when the screen size was increased.Experiments were also conducted to study the effect of using steam for tempering corn at two different initial corn temperatures (5 and 30\sp\circC). When steam and water were used together, the flaking grits yield from the corn at lower temperature (5\sp\circC) showed a significant improvement, though at the expense of throughput. The milling action of the Beall degerminator and the horizontal drum degerminator were also compared. Poor correlations were observed for the yields of similar sized products from the two degerminators, however, the Beall degenninator produced higher yields of prime products.All the experiments conducted in this study revealed inherent trade-offs in the recovery of the throughput and yields of prime products. The results clearly indicate that the selection of the levels and combinations of various operating variables depends on the overall milling objectives, since an increase in the yield of a prime product is often achieved at the expense of another.Made available in DSpace on 2011-05-07T13:14:04Z (GMT). No. of bitstreams: 2
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The role of AMPK and purinergic signaling in astrocytic hypoglycaemia detection
No full textFollowing recurrent hypoglycaemia (RH) patients with type 1 diabetes (T1D) may develop an impaired counter-regulatory response (CRR) to future hypoglycaemic episodes. This is a result of maladaptive responses to hypoglycaemia, involving AMP-activated protein kinase (AMPK) activity in the ventromedial hypothalamus (VMH). Research has focused mainly on glucosensing neurones, with little emphasis on the potential role of astrocytes. This study aims to examine the response of astrocytes to a hypoglycaemic stimulus and changes to this following RH.
The U373 human astrocytoma cell line and mouse primary cortical astrocytes (CRTAS), as well as wild type (WT) and α1/α2 AMPK knockout (KO) mouse embryonic fibroblasts (MEF), were used. Astrocytes were maintained at 25mM glucose, and stepped down to physiological (2.5mM) glucose for the experiments. Western blotting was used to measure total and phosphorylated protein expression. Luminescence and absorbance plate-based assays were used to measure ATP and lactate levels, respectively. A plate-based assay was used to measure intracellular calcium ([Ca2+]i) using Fluo4.
Our study demonstrates that astrocytes intrinsically respond to a hypoglycaemic stimulus by increasing AMPK activation. Following RH there was a blunted AMPK activation, accompanied by a reduction in extracellular ATP (eATP). Using the AMPK activator, A-769662, we saw a concentration-dependent increase in AMPK activation and eATP. However, enhancing AMPK activation by co-application of A-769662 and 5-aminoimidazole-4-carboxamide riboside (AICAR), or by exposing astrocytes to a hypoglycaemic stimulus in the presence of A-769662, did not enhance ATP release. A-769662 also caused an increase in [Ca2+]i. Both the A-769662-mediated increase in eATP and [Ca2+]i persisted in MEF α1/α2 AMPK KO cells. The effect of A-769662 on eATP was not attenuated by pre-treating cells with the gap junction blocker carbenoxolone, or by removing extracellular Ca2+, however there was a small attenuation following pre-treatment with the [Ca2+]i chelator, BAPTA-AM.
In our study we show that astrocytes intrinsically respond to a hypoglycaemic stimulus by increasing phospho AMPK (pAMPK). Following RH, the AMPK response to hypoglycaemia is blunted, alongside a significant reduction to eATP. We also demonstrate that the changes in eATP observed are likely independent of changes in AMPK activity. Importantly, the AMPK activator, A-769662, has AMPK-independent effects on eATP and [Ca2+]i, and these changes in eATP are mediated by changes in [Ca2+]i.Diabetes UKUniversity of Exeter Medical Schoo
The poetics of subversion: irony and the central European novel
No full textThe literatures of Central Europe's small countries were seriously engaged in the national project during the nineteenth century, standardizing and exemplifying both the national language and national heroes. However, the breakup of the Austro-Hungarian Empire in 1918 produced a new ironic consciousness in the literatures of the newly-independent Central European nations. Surprisingly, at a time when the peoples of Central Europe achieved national self-determination, their literatures began using irony to call nation and nationalism into question. Novels such as Jaroslav Hašek's The Good Soldier Švejk, Robert Musil's The Man without Qualities, Witold Gombrowicz's Trans-Atlantyk, and Milan Kundera's The Book of Laughter and Forgetting criticize the national project, its cultural manifestations, and its effect on modern subjectivity. The similarities between these novels are obscured by the multiple historical changes that swept through Central Europe throughout the twentieth century. The breakup of the Austro-Hungarian Empire and the independence of Czechoslovakia and Poland in 1918 was followed a generation later first by the Nazi invasion of these countries, and then the rise of Communism less than a decade later. Cold War geopolitics redrew the map of Europe, grouping Communist countries in "Eastern" Europe while Austria, now a small nation itself, remained in the West. The critical result of this temporally limited topography is a conspicuous absence of comparative scholarship engaging these authors. Despite this critical lacuna, the influence of the cultural development shared by German-speaking Austria and its Slavic neighbors on Central European poetics is undeniable. These novels are products not only of the modernist impulse as a whole but also of the twentieth-century Central European Zeitgeist. This dissertation develops a theory of irony in order to examine the structure of subversion common to all four of the novels in this study and then shows how irony structures the text's interaction with the reader as a political subject and implicates the reader in a network of multivalent textual desire that subverts political hegemony, nationalism, and literary genre convention.Ph.D.Includes abstractVitaIncludes bibliographical referencesby Joshua Patrick Beal
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