748 research outputs found

    Un libro de horas iluminado para Alfonso de Borja : influencia de los grabados alemanes en la miniaturade la Corona de Aragon a mediados del siglo 14. / Francesca Manzari.

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    Il saggio ricostruisce il contesto di produzione di un raro esempio di libro d’ore valenziano della metà del Quattrocento, indagando a fondo i diversi aspetti del raffinato manufatto. Il repertorio decorativo secondario viene ricondotto alla produzione valenziana, mentre le carte incipitarie maggiori, dotate di straordinarie ma inusuali bordure miniate, vengono spiegate identificandone i modelli nella carte da gioco prodotte da un proto-incisore tedesco, spesso utilizzato come repertorio di modelli anche in ambito fiammingo. L’identificazione di un ritratto del destinatario e del suo nome, Alfonso, insieme all’indagine “archeologica” sulle tracce di fogli perduti hanno permesso di proporre Alfonso Borgia, quale committente, alla metà del secolo, prima della sua elezione come papa Callisto IIIThe essay reconstructs the context of production of a rare example of Valencian Book of Hours from the mid-15th century, investigating in-depth the different features of the elegant artefact. The secondary decorative repertory is linked with the illuminated production at Valencia, while the major incipit pages, with extraordinary but unusual illuminated borders, are explained identifying their models in the printed playing cards produced by a German engraver; these were used as model books especially in Flanders. The identification of the owner’s portrait and name, Alfonso, together with the “archeological” analysis of the traces of lost leaves, have enabled the author to propose Alfonso Borgia as the patron, dating the book to the middle of the century, before his election as pope Callixtus II

    Le funzioni delle citazioni bibliche nella letteratura della Slavia ortodossa

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    Biblical quotations play a central role in the literature of Slavia orthodoxa. Their importance, together with the necessity of their systematic study, has been underlined several times. The biblical element should be analysed at several levels, within differ - ent literary forms. First it should be identified and classified, then understood in the context of liturgy and liturgical books. Through biblical quotations, the author gave an interpretation of history and present situation according to the Holy Scripture and, by means of rhetoric, he tried to make the biblical message actual and to renew its meta - morphic power. The present study focuses on the function biblical quotations have in some of the most representative literary forms of Slavia orthodoxa. M. Garzaniti analy - ses hagiographic texts, pilgrimage tales and chronicles; F. Romoli sermons and spiritual teachings

    Solid supported 9-amino-9-deoxy-epi-quinine as efficient organocatalyst for stereoselective reactions in batch and under continuous flow conditions

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    Polystyrene-supported 9-amino-9-deoxy-epi-quinine was synthesized through co-polymerization of an ad hoc-designed chiral monomer with divinylbenzene, in the presence of azobis(isobutyronitile) (AIBN) as radical initiator and toluene and 1-dodecanol as porogenic solvents. The heterogenized catalyst efficiently promoted the reaction of isobutyric aldehyde with b-nitrostyrene, in very high yield and enantioselectivity, comparable or even higher than that of the homogeneous counterpart (up to 95% ee). The recyclability of the catalyst, its general applicability and its successful application to other reactions was also demonstrated. Finally, for the first time, a 9-amino- epi-quinine derivative was employed to perform an enantioselective Michael reaction under continuous-flow conditions; by using a home-made, packed-bed catalytic reactor, the aldehyde addition to nitrostyrene was successfully realized in flow mode, leading to the product in up to 93% ee

    A hyphenated microLC-Q-TOF-MS platform for exosomal lipidomics investigations: application to RCC urinary exosomes

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    Urinary exosomes are released from every renal epithelial cell type facing the urinary space and therefore, they may carry molecular markers of renal dysfunction and structural injury. Here, we present a hyphenated microLC-Q-TOF-MS platform for lipidomics studies applied to investigate the urinary exosome lipid repertoire. Lipids were separated by reversed-phase chromatography using a linear gradient of formic acid 0.2% and tetrahydrofuran, in 40 min of analysis. Features (m/z with associated own retention time) were extracted by MarkerLynx(TM) (Waters) and processed, demonstrating good analytical performance in terms of repeatability and mass accuracy of the microLC Q-TOF MS platform. In particular, a stable retention time (RSD less than 4%) and relative intensity (RSD from 2.9% to 11%) were observed. Moreover, the method takes advantages by the use of a lock spray interface (Waters) that allows readjusting the m/z data after acquisition, obtaining inaccuracy below 6 ppm in measuring the m/z value of the reference compound during chromatographic run. The method was employed in a preliminary application to perform comparative analysis from healthy control subjects and renal cell carcinoma (RCC) patients, in order to possibly highlight differences in lipid composition to be exploited as potential tumor biomarker. Differential lipid composition in RCC urinary exosomes was achieved and tentatively identified by accurate mass, providing a preliminary indication of a relationship between lipid composition of urinary exosomes and RCC disease. Among the total features significantly different in RCC exosomes, the ion at m/z 502.3 was taken as an example for molecular confirmation by MS/MS fragmentation analysis
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