183,789 research outputs found

    Folder 8: Schwiderski, Richard Craig v. State of Texas 1, 1979-1984

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    A notarized affidavit dated December 22, 1980 from Sharon L. Cox stating that she will not be able to finish a transcript in time for a deadline

    Folder 2: Court Documents 1, 1980-1981

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    A transcript of a trial written by Sharon L. Cox July 29, 1980 before the court in the State of Texas v. Orval David Austin

    Folder 8: Schwiderski, Richard Craig v. State of Texas 1, 1979-1984

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    A notarized affidavit dated February 6, 1981 from Sharon L. Cox stating that she needs an extension of time to create a transcript

    Folder 8: Schwiderski, Richard Craig v. State of Texas 1, 1979-1984

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    A carbon copy and a copy of a bill dated March 10, 1981 to Donald J. Maison for transcription services by Sharon L. Cox in the State of Texas v. Richard Craig Schwiderski case

    A very high density microsatellite map (1 STR/41kb) of 1.7 Mb on Xp22 spanning the microphthalmia with linear skin defects (MLS) syndrome critical region

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    Microphthalmia with linear skin defects (MLS) syndrome is an X-linked disorder presenting only in XX individuals. It is characterised by dysmorphic features such as microphthalmia, sclerocornea, and linear streaks of erythematous and hypoplastic skin restricted to the head and neck. Karyotype analyses have so far revealed a terminal deletion or translocation causing monosomy for the distal Xp region (Xp22.3) in all patients. We have used existing cosmid clones from the region to perform a saturation screen for AC-type microsatellites with the goal of facilitating analysis of five novel patients with features of MLS. Three of these cases had an Xp22.3 abnormality, while the other two showed some characteristic features of MLS but had apparently normal karyotypes. Forty-two novel microsatellite markers have now been developed from the 1.7 Mb cloned interval. Ninety-three percent of the novel markers exhibited allelic variation, representing an average of one polymorphic PCR-based marker (STR) every 41 kb.Timothy C Cox, Liza L Cox & Andrea Ballabi

    Giants of Cardiothoracic Surgery: An Interview With James L. Cox

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    In this Giants of Cardiothoracic Surgery interview, Joel Dunning speaks with James L. Cox, creator of the Cox maze procedure for the treatment of atrial fibrillation. Dr. Cox recounts the creation of the Cox maze operation and the evolution to modern atrial fibrillation surgery, as well as the future of this treatment. He also calls for a new categorization system for atrial fibrillation, calling the current system “not fit for purpose.”</p

    Joseph L. Cox IV, Salt Lake City, Utah: an interview by Landon Troester, 3 December 2014

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    Transcript (25 pages) of an interview by Landon Troester with Joseph L. Cox IV on December 3, 2014, in Salt Lake City, Utah

    Brian Cox

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    Six men, two holding dead kangagaroo. Back of photo: "Tip to Hamilton Downs. R to L Fritz Vose, Doug Boerner, ?. Allied Council men, Alice Springs NT 1944. Photo taken by Brian Cox 1944."Date:194

    Selective COX-2 inhibitors and risk of myocardial infarction

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    Selective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids. Recently some coxibs, which were designed to exploit the advantageous effects of non- steroidal anti-inflammatory drugs while evading their side effects, have been reported to increase the risk of myocardial infarction and atherothrombotic events. This has led to the withdrawal of rofecoxib from global markets, and warnings have been issued by drug authorities about similar events during the use of celecoxib or valdecoxib/ parecoxib, bringing about questions of an inherent atherothrombotic risk of all coxibs and consequences that should be drawn by health care professionals. These questions need to be addressed in light of the known effects of selective inhibition of COX- 2 on the cardiovascular system. Although COX- 2, in contrast to the cyclooxygenase-1 ( COX- 1) isoform, is regarded as an inducible enzyme that only has a role in pathophysiological processes like pain and inflammation, experimental and clinical studies have shown that COX- 2 is constitutively expressed in tissues like the kidney or vascular endothelium, where it executes important physiological functions. COX- 2- dependent formation of prostanoids not only results in the mediation of pain or inflammatory signals but also in the maintenance of vascular integrity. Especially prostacyclin ( PGI(2)), which exerts vasodilatory and antiplatelet properties, is formed to a significant extent by COX- 2, and its levels are reduced to less than half of normal when COX- 2 is inhibited. This review outlines the rationale for the development of selective COX- 2 inhibitors and the pathophysiological consequences of selective inhibition of COX- 2 with special regard to vasoactive prostaglandins. It describes coxibs that are currently available, evaluates the current knowledge on the risk of atherothrombotic events associated with their intake and critically discusses the consequences that should be drawn from these insights. Copyright (C) 2005 S. Karger AG, Basel

    Concentration in Knowledge Output: A case of Economics Journals

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    This paper assesses the degree of author concentration in seven economics journals, which were published in India during 1990-2002. To measure the degree of author concentration, Lotka's Law was used. Moreover, we also make an exploratory analysis of the geographic, economics subfield and institutional concentration in 704 economics journals. An important finding of this paper is that specialized journals in the sample report the highest degree of author concentration. This result is quite similar to the findings by Cox and Chung (1991). Furthermore, there are several instances showing that the journals lean towards certain norms; this may affect the flow of innovative ideas into economics. We conclude that a knowledge activity, involving the high degree of concentration and a biased publication process, may affect the flow of new ideas into the discipline.Concentration, Lotka's Law
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