1,184 research outputs found
Liam Rector, 14th Annual ODU Literary Festival
No full textLiam Rector is the author of The Sorrow of Architecture, a book of poems. He\u27s also the editor of The Day I Was Older: On the Poetry of Donald Hall. He has taught at Old Dominion University, George Mason, Goucher College, and Phillips Academy at Andover. In addition, he has administered literary programs at the Folger Academy of American Poets. Currently, Liam Rector is executive director of Associated Writing Programs, which has lately taken a leading role in defending the 1st amendment. Rector has been awarded both NEA and Guggenheim fellowships for poetry
Liam Rector, 12th Annual ODU Literary Festival
No full textLiam Rector is the author of a book of poetry, The Sorrow of Architecture, 1984, and editor of The Day I Was Older: On the Poetry of Donald Hall, 1989, and is currently working on a second book of poems, tentatively titled The Persistence of Virginia. He is executive director of the Associated Writing Programs, located at Old Dominion University
Measuring performance and missing the point?
Full text linkTargets do not necessarily translate into improvements for service users. Iona Heath, Julia Hippisley-Cox, and Liam Smeeth argue that performance measurement in the UK is shifting focus from what each patient needs and those who need it mos
M3D-BIO - Microfluidics-Enabled 3D Printing for Biofabrication
Full text linkMicrofluidics market is the fastest growing research area in the world, and they have shown much promise in biofabrication and 3D bioprinting of tissues and organs. However, microfluidics is conventionally produced using drawn-out and expensive lithographic methods, hindering their wider uptake. To this end, we have established a streamlined pipeline which incorporates simulation, design, fabrication and validation processes to produce versatile microfluidic chip nozzles for a range of applications in biofabrication. The microfluidic devices are produced by combining material extrusion additive manufacturing (MEAM) with innovative design approaches to achieve leak-free and low-surface roughness channels without any need of special tubing. These microfluidic chip nozzles create complex anisotropic fibrous core-shell structures matching blood vessels at resolutions not reported previously. The results of this study show that the novel microfluidics system can be adopted in a wide range of applications from tissue scaffolds, cell culture systems, biochemical sensors and lab-on-a-chips, paving ways for next generation of 3D-printed microfluidics in biofabrication.</p
Agallamh na Míosa: Liam Ó Muirthile ag caint le: Pat Cox: Ard-rúnaí, an páirtí daonlathach
No full textFocussing on appetite decline to optimise management of undernutrition in later life - a geriatric medicine perspective
No full textUndernutrition is common amongst older people and can lead to adverse health outcomes and increased dependence. This review focuses on an aspect of undernutrition that is often overlooked, namely loss of appetite, and will discuss the challenges in this under-researched field from the perspective of geriatric medicine. Appetite decline is common in later life and predicts undernutrition in older populations. As such, timely identification and intervention on poor appetite could delay onset or progression of undernutrition to optimise healthy ageing and maintain independence. In addition, management of undernutrition ultimately requires the individual to meet their nutritional requirements. However, unless attention is paid to mitigating appetite decline, strategies to improve intake are likely to be ineffective. Treatment for appetite decline is challenging due to the multiple and complex underlying mechanisms. Current evidence is limited to a few trials targeting older people including flavour enhancement and fortification or supplementation, lifestyle measures such as increasing physical activity and social interaction, and medications, all with mixed results. Progress on treatments for appetite decline has been hampered by a lack of distinction from undernutrition, but also perhaps the approach to it as a concept. Categorising appetite decline in ageing as a geriatric syndrome could aid progress in the unification of approaches to mechanistic research, assessment and management strategies, which are likely to be most effective when in multi-component form and underpinned by the principles of Comprehensive Geriatric Assessment (CGA)
Project Triton : A study into delivering targeted information to an individual based on implicit and explicit data.
No full textThe World Wide Web is frequently seen as a source of knowledge, however much of this remains undiscovered by its users. In recent times, recommender systems (e.g. Digg and Last.fm) have attempted to bridge this gap, alerting users to previously untapped knowledge. As more socially oriented services appear on the Web (e.g. Facebook and MySpace), it has never been easier to obtain information pertaining to an individual’s interests. At present, solutions for automated data recommendation tend to be highly topic specific (recommending only a certain topic such as news) and often only allow access to the system using monolithic interfaces. This report hopes to detail the stages from research to evaluation involved in creating an extensible framework, which will operate without the need for human intervention. The framework will feature several proof-of-concept plugins residing in a custom workflow, which target information that is useful to the user. Information will be retrieved automatically through plugins involved with data gathering (such as feed processing and page scraping), while users’ interests will be obtained implicitly (for example, using header information to derive location) or explicitly (taking advantage of Social Network APIs such as Facebook Connect). Finally, Third Parties will be able to integrate the framework into their own solutions using the customisable XML API (written in PHP), so that their products can provide custom user interfaces without style constraints
Versatile Microfluidics for Biofabrication Platforms Enabled by an Agile and Inexpensive Fabrication Pipeline
Full text linkMicrofluidics have transformed diagnosis and screening in regenerative medicine. Recently, they are showing much promise in biofabrication. However, their adoption is inhibited by costly and drawn‐out lithographic processes thus limiting progress. Here, multi‐material fibers with complex core‐shell geometries with sizes matching those of human arteries and arterioles are fabricated employing versatile microfluidic devices produced using an agile and inexpensive manufacturing pipeline. The pipeline consists of material extrusion additive manufacturing with an innovative continuously varied extrusion (CONVEX) approach to produce microfluidics with complex seamless geometries including, novel variable‐width zigzag (V‐zigzag) mixers with channel widths ranging from 100–400 µm and hydrodynamic flow‐focusing components. The microfluidic systems facilitated rapid mixing of fluids by decelerating the fluids at specific zones to allow for increased diffusion across the interfaces. Better mixing even at high flow rates (100−1000 µL min−1) whilst avoiding turbulence led to high cell cytocompatibility (>86%) even when 100 µm nozzles are used. The presented 3D‐printed microfluidic system is versatile, simple and efficient, offering a great potential to significantly advance the microfluidic platform in regenerative medicine
The COX-2 inhibitor NS398 selectively sensitizes hypoxic HeLa cells to ionising radiation by mechanisms both dependent and independent of COX-2
No full textIt is widely accepted that the hypoxic nature of solid tumors contribute to their resistance to radiation therapy. There is increasing evidence that cyclooxygenase-2 (COX-2) contributes to increased resistance of tumors to radiation therapy. Several studies demonstrate that combination of COX-2 selective inhibitors with radiation therapy selectively enhances radioresponsiveness of tumor cells. However, the majority of these studies utilised suprapharmacological concentrations under normoxic conditions only. Furthermore, the mechanism by which these agents act remain largely unclear. Therefore, the aim of this study was to determine the impact of COX-2 selective inhibitors on both normoxic and hypoxic radiosensitivity in vitro and the mechanisms underlying this. Because of the close, reciprocal relationship between COX-2 and p53 we investigated their contribution to radioresistance. To achieve this we exposed HeLa, MCF-7 and MeWo cells to the COX-2 selective inhibitor, NS398 (10µM). NS398 (10µM) selectively sensitized hypoxic HeLa and MCF-7 but not MeWo cells to ionising radiation (5 Gy). Furthermore, while knockdown of COX-2 with siRNA did not affect either normoxic radiosensitivity in HeLa cells, the radiosensitisation observed with NS398 was lost suggesting both COX-2 dependent and independent mechanisms. We also show that ionising radiation at 5 Gy results in phosphorylation of p53 at serine 15, a key phosphorylation site for p53-mediated apoptosis, and that hypoxia attenuates this phosphorylation. Attenuated phosphorylation of p53 under hypoxic conditions may therefore contribute to hypoxic radioresistance. We also show that NS398 selectively phosphorylates p53 under hypoxic conditions following irradiation at 5 Gy. p53 phosphorylation could be an underlying mechanism by which this agent and other COX-2 inhibitors sensitize tumors to radiation therapy.</p
sj-xlsx-1-eqs-10.1177_87552930221130762 – Research Data for The influence of multiple impedance contrasts on mHVSR site period estimates in the Canterbury Plains of New Zealand and implications for site classification
No full textResearch Data, sj-xlsx-1-eqs-10.1177_87552930221130762 for The influence of multiple impedance contrasts on mHVSR site period estimates in the Canterbury Plains of New Zealand and implications for site classification by Andrew Stolte, Liam Wotherspoon, Brady Cox, Clinton Wood, Seokho Jeong and James Munro in Earthquake Spectra</p
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