1,925 research outputs found
Selective COX-2 inhibitors and risk of myocardial infarction
No full textSelective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids. Recently some coxibs, which were designed to exploit the advantageous effects of non- steroidal anti-inflammatory drugs while evading their side effects, have been reported to increase the risk of myocardial infarction and atherothrombotic events. This has led to the withdrawal of rofecoxib from global markets, and warnings have been issued by drug authorities about similar events during the use of celecoxib or valdecoxib/ parecoxib, bringing about questions of an inherent atherothrombotic risk of all coxibs and consequences that should be drawn by health care professionals. These questions need to be addressed in light of the known effects of selective inhibition of COX- 2 on the cardiovascular system. Although COX- 2, in contrast to the cyclooxygenase-1 ( COX- 1) isoform, is regarded as an inducible enzyme that only has a role in pathophysiological processes like pain and inflammation, experimental and clinical studies have shown that COX- 2 is constitutively expressed in tissues like the kidney or vascular endothelium, where it executes important physiological functions. COX- 2- dependent formation of prostanoids not only results in the mediation of pain or inflammatory signals but also in the maintenance of vascular integrity. Especially prostacyclin ( PGI(2)), which exerts vasodilatory and antiplatelet properties, is formed to a significant extent by COX- 2, and its levels are reduced to less than half of normal when COX- 2 is inhibited. This review outlines the rationale for the development of selective COX- 2 inhibitors and the pathophysiological consequences of selective inhibition of COX- 2 with special regard to vasoactive prostaglandins. It describes coxibs that are currently available, evaluates the current knowledge on the risk of atherothrombotic events associated with their intake and critically discusses the consequences that should be drawn from these insights. Copyright (C) 2005 S. Karger AG, Basel
IGF-II-Mediated COX-2 Gene Expression in Human Keratinocytes Through Extracellular Signal-Regulated Kinase Pathway
No full textWe monitored cyclooxygenase-2 (COX-2) expression in the insulin-like growth factor-II (IGF-II) treated human keratinocytes and explored the IGF-II signaling pathways with respect to the expression of COX-2. IGF-II induced COX-2 mRNA and protein levels, and the up-regulation of COX-2 expression by IGF-II was reduced by pretreatment with inhibitors of tyrosine kinase, Src and PI3-kinase. The inhibition of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) 1 also reduced the increased expression of COX-2 by IGF-II, but the inhibition of p38 did not. To further examine the roles of these mitogen-activated protein kinases (MAPKs) in IGF-II-induced COX-2 expression, we performed COX-2 promoter analysis using dominant negative plasmids of MEK1 (DN-MEK1), p38 (DN-p38) and JNK1 (DN-JNK1). Although IGF-II increased COX-2 promoter activity approximately 2.5-fold, this increase was blocked by cotransfection with DN-MEK1 or DN-JNK1. However, DN-p38 did not block the IGF-II-induced COX-2 promoter activity. In addition, inhibition of ERK or JNK1 reduced the increase of IGF-II-induced prostaglandin E2 synthesis or cell proliferation. These results suggest that IGF-II induces COX-2 expression through the tyrosine kinase-Src-ERK and tyrosine kinase-PI3-kinase pathways, but not via p38 MAPK pathway, and that the basal JNK activity is required for the upregulation of COX-2 by IGF-II, as well
Cox rings of du Val singularities
No full textIn this note we introduce Cox rings of singularities and explicitly compute them in the case of du Val singularities Dn , E6 , E7 and E8 .<br /
Disputatio Medica De Generatione Hominis In Ovo / Quam, ... Sub Praesidio ... Dn. Johannis Jacobi Waldschmied/ Medicinae Doctoris ... exhibet Author Dominicus Beddevole, Genevensis, In Auditorio Medico d. 3. Septemb. ...
No full textDISPUTATIO MEDICA DE GENERATIONE HOMINIS IN OVO / QUAM, ... SUB PRAESIDIO ... DN. JOHANNIS JACOBI WALDSCHMIED/ MEDICINAE DOCTORIS ... EXHIBET AUTHOR DOMINICUS BEDDEVOLE, GENEVENSIS, IN AUDITORIO MEDICO D. 3. SEPTEMB. ...
Disputatio Medica De Generatione Hominis In Ovo / Quam, ... Sub Praesidio ... Dn. Johannis Jacobi Waldschmied/ Medicinae Doctoris ... exhibet Author Dominicus Beddevole, Genevensis, In Auditorio Medico d. 3. Septemb. ... (1)
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DN-Rab10 inhibits methamphetamine-induced mortality.
No full text<p>Methamphetamine was added to the food at 3 or 6 mg/ml and the number of flies surviving over the next 8 days was determined. Death was recorded at the time activity was no longer detected. (A) The median survival time was 2.8 days for control (Appl-GAL4) flies fed 6 mg/ml methamphetamine and 4.1 days for flies expressing DN-Rab10 in all neurons (Appl>DN-Rab10). p = 0.0012 for comparison of the curves (Mantel-Cox log-rank test). The typical % survival over the same time period in flies not fed methamphetamine is greater than 90% (not shown). (B) The median survival time was 2.9 days for control flies (UAS-DN-Rab10), 6.5 days for flies expressing DN-Rab10 in all neurons (Appl>DN-Rab10) and 3.6 days for flies expressing DN-Rab10 in cholinergic neurons (Cha>DN-Rab10) and fed 3 mg/ml methamphetamine. P < 0.0001 for the comparison of the control and Appl>DN-Rab10 curves and p = 0.49 for the comparison of the control and Cha>DN-Rab10 curves.</p
Consensu Et Author. Magnifici Ictorum Ordinis In Illustri Ad Salam Academia, Sub Praesidio ... Dn. Joh. Volk. Bechmanns ... Dissertationem Iuridicam De Iure Braxandi in Ictorum Auditorio ad diem Octobr. h.c. Publicae Eruditorum Censurae Subiiciet Paul. Christianus Arnoldus, Olsnen. Siles. Author & Respondens
No full textCONSENSU ET AUTHOR. MAGNIFICI ICTORUM ORDINIS IN ILLUSTRI AD SALAM ACADEMIA, SUB PRAESIDIO ... DN. JOH. VOLK. BECHMANNS ... DISSERTATIONEM IURIDICAM DE IURE BRAXANDI IN ICTORUM AUDITORIO AD DIEM OCTOBR. H.C. PUBLICAE ERUDITORUM CENSURAE SUBIICIET PAUL. CHRISTIANUS ARNOLDUS, OLSNEN. SILES. AUTHOR & RESPONDENS
Consensu Et Author. Magnifici Ictorum Ordinis In Illustri Ad Salam Academia, Sub Praesidio ... Dn. Joh. Volk. Bechmanns ... Dissertationem Iuridicam De Iure Braxandi in Ictorum Auditorio ad diem Octobr. h.c. Publicae Eruditorum Censurae Subiiciet Paul. Christianus Arnoldus, Olsnen. Siles. Author & Respondens ([1])
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De. Condictione L. Si quis Conductionis. 25. C. de locato conducto. Sub Praesidio Dn. Andreae Mylii ... Publice disputabit. Author. Johann Gottfried Schönfeld/ Zitt. Lus. die 11. Iunii. M.DC.XCVI.
No full textDE. CONDICTIONE L. SI QUIS CONDUCTIONIS. 25. C. DE LOCATO CONDUCTO. SUB PRAESIDIO DN. ANDREAE MYLII ... PUBLICE DISPUTABIT. AUTHOR. JOHANN GOTTFRIED SCHÖNFELD/ ZITT. LUS. DIE 11. IUNII. M.DC.XCVI.
De. Condictione L. Si quis Conductionis. 25. C. de locato conducto. Sub Praesidio Dn. Andreae Mylii ... Publice disputabit. Author. Johann Gottfried Schönfeld/ Zitt. Lus. die 11. Iunii. M.DC.XCVI. (1)
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Time to initiate postpartum modern contraceptives among pregnant women in Ambo Town, Central Ethiopia; Cox-proportional hazard regression analysis
No full textBACKGROUND: Timing of postpartum family planning is crucial for maternal and child wellbeing by preventing unintended and closely spaced pregnancies. However, studies are limited on the time to use modern contraceptives in Ethiopia. Therefore, this study aimed to fill these gaps by assessing the time to initiate postpartum modern contraceptive and identifying its predictors among pregnant women in Ambo town, central Ethiopia. METHODS: An institution based cross-sectional study was conducted among 356 pregnant women in Ambo town, Central Ethiopia. The data were analysed using STATA-16 software. Kaplan–Meier estimates were performed to explain time-to- modern contraceptive use. A Cox-proportional hazard regression analysis was conducted to identify predictors. The adjusted hazard ratio (AHR) with a 95% confidence interval was considered to declare a statistically significant association. RESULTS: This study showed that the median survival time to initiate postpartum modern contraceptives was 6 months. In this study, the risk of modern contraceptive use was 2.13 times higher (AHR = 2.13; 95% CI: 1.02–4.45) among younger women, 1.44 times higher (AHR = 1.44; 95% CI: 1.09–2.66) among women with no desire for more children, and 2.25 times higher (AHR = 2.25; 95% CI: 1.02–4.95) among nulliparous women. However, it is 57% times lower (AHR = 0.57; 95% CI: 0.32–0.94) among pregnant women with current unintended pregnancy. CONCLUSION AND RECOMMENDATION: The median survival time to initiate postpartum modern contraceptive was 6 months. Age of the women, desire for more children, parity and pregnancy status were found to be the significant predictors of time to initiate postpartum modern contraceptive. Therefore health care providers and concerned stakeholders should consider these factors to increase the uptake of the postpartum contraceptive methods
The Scoop on SCOBY (Symbiotic Culture of Bacteria and Yeast): Exploring Consumer Behaviours towards a Novel Ice Cream
No full textWith the growing demand for sustainable practises, the food industry is increasingly adopting circular economy approaches. One example is recycling the symbiotic culture of bacteria and yeast (SCOBY) used in kombucha fermentation to create value-added products. However, consumer acceptance of such novel products remains unclear. To address this, the present study examined consumer attitudes towards ice cream made with SCOBY as an ingredient and how this affected their intention to consume it. Drawing on the theory of planned behaviour (TPB) and additional constructs such as emotions and food neophobia, an online survey was conducted with New Zealand consumers (N = 170). Results showed that the TPB constructs significantly predicted the intention to consume SCOBY ice cream. Moreover, by adding emotions to the constructs, the model's explanatory power was enhanced. Attitudes, subjective norms, and emotions were the main predictors of intention, which in turn was found to be the main predictor of behaviour. Participants' beliefs about the safety and taste of SCOBY ice cream were significantly correlated with their intention and behaviour, as were the opinions of nutritionists/dietitians, friends, and family. The model accounted for 21.7% of the variance in behaviour and 57.4% of the variance in intention. These findings can be used to plan marketing strategies related to waste-to-value-added products such as SCOBY ice cream.fals
Dissertatio De Censu Augusti / Quam Sub Praesidio ... Dn. Ulrici Obrechti, In Alma Argentinensium Universitate Professoris Histor. ... Ad Examen Solenne Proponit Michael Förtsch/ Wertheimio-Francus Author. A. D. [...] Maii MDCLXXV.
No full textDISSERTATIO DE CENSU AUGUSTI / QUAM SUB PRAESIDIO ... DN. ULRICI OBRECHTI, IN ALMA ARGENTINENSIUM UNIVERSITATE PROFESSORIS HISTOR. ... AD EXAMEN SOLENNE PROPONIT MICHAEL FÖRTSCH/ WERTHEIMIO-FRANCUS AUTHOR. A. D. [...] MAII MDCLXXV.
Dissertatio De Censu Augusti / Quam Sub Praesidio ... Dn. Ulrici Obrechti, In Alma Argentinensium Universitate Professoris Histor. ... Ad Examen Solenne Proponit Michael Förtsch/ Wertheimio-Francus Author. A. D. [...] Maii MDCLXXV. (1)
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