157,143 research outputs found
An universal system of water and water works philosophical and practical : in four books
No full textConsta en port. del vol. II.: "An introduction to a general system of hydrostaticks and hydraulicks ..."Vol. II con pie de imp.: "printed for T. Astley at the Rose, S. Austen at the Angel, in St. Paul's Church-Yard, and L. Gilliver, at Homer's Head against St.Dunkan's Church, Fleetstreet, MCCXXIX"Sign.: A\p3\s, a-e\p4\s, f\p2\s, B-Z\p4\s, 2A-2M\p4\s, 2N\p1\s, A\p4\s, B\p1\s ; A\p4\s, 2N\b2-4\s, 2O-2Y\p4\s, 2Z*\p2\s, 2Z\p4\s, 2A-2F\p4\s, 2G\p2\s, 2H\p1\s, 2G\p4\s, 2H\p3\sLa h. de grab. es port. front. calc.: " J. Devoto inv\pt\s. Toms Sculp."Las h. de grab calc. pleg. son calc. : "Toms delint. et Sculp\pt\"Contiene, según consta en port.: "I. An historical account of the chief water works that were and are remarkable in ancient and modern times, more particularly the roman aqueducts, etc., and the honour they have contributed to the perspective places where they have been used ; II. The different hypotheses which have been laid down concerning the original and rise of springs of the good and bad properties of water, the best manner of discovering and searching for springs, and the taking of true levels in order for the conducting to its several intended uses ; III.Hydrostatical experiments (relating to the motion of water) selected from the most -celebrated foreing and english authors, more particularly Boyle, Hooke, Wallis, Lowthorpe, etc., also the full description and uses of mechanical engines for the forcing water to great heights and applying the same to the watering gentlemens seats and gardens, in a better manner than any hitherto extant ; IV. Some curious disquisitions concerning the vacuum of the ancients the gravitation of fluids , the elasticity, dilatation, and compression of air the best methods of conveying water and for making reservoirs, basons , cascades, cataracts, rural grotesque canals, fountains and all kinds of ornamental water-works ; V. A collection of designs for this purpose from the most eminen masters, finely engraven on sixty copper plate
Interview with Tyrus T. Cox, 1987
No full textFredericksburg, Texas
Architectural restoration specialist and longtime Fredericksburg resident Tyrus T. Cox explains his work on Texas’ frontier forts and many of the historic structures in Fredericksburg. His recollections about authentic building techniques are mixed with historic facts about the areas in which he had worked
Mrs. T. W. Cox letter to Franklin County Woman Suffrage Association, October 23, 1914
No full textMrs. T. W. Cox sent this letter to the Franklin County Woman Suffrage Association on October 23, 1914. She wrote the letter to inform the women of Franklin County that she was sending posters on women's suffrage. She also requested they send her the leaflet "Justice and Equality."
The Franklin County Woman Suffrage Association was formed in 1912, after the Ohio Constitutional Convention elected to bring to a vote the question of removing the words "white male" from the state constitution with regard to voting rights. Headquartered in the Chamber of Commerce building in Columbus, Ohio, the organization put out regular publications, organized public speeches and meetings, distributed literature and held parades in support of the suffrage movement. Women's suffrage in Ohio was defeated in a special election in 1912 and again in 1914 and 1916 before a resolution narrowly passed in 1917 allowing municipal voting by women in Columbus. In 1920, the 19th Amendment passed, extending the vote to women and prohibiting state and federal government from denying suffrage on the basis of sex
Selective COX-2 inhibitors and risk of myocardial infarction
No full textSelective inhibitors of cyclooxygenase- 2 ( COX- 2, ` coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the formation of prostanoids. Recently some coxibs, which were designed to exploit the advantageous effects of non- steroidal anti-inflammatory drugs while evading their side effects, have been reported to increase the risk of myocardial infarction and atherothrombotic events. This has led to the withdrawal of rofecoxib from global markets, and warnings have been issued by drug authorities about similar events during the use of celecoxib or valdecoxib/ parecoxib, bringing about questions of an inherent atherothrombotic risk of all coxibs and consequences that should be drawn by health care professionals. These questions need to be addressed in light of the known effects of selective inhibition of COX- 2 on the cardiovascular system. Although COX- 2, in contrast to the cyclooxygenase-1 ( COX- 1) isoform, is regarded as an inducible enzyme that only has a role in pathophysiological processes like pain and inflammation, experimental and clinical studies have shown that COX- 2 is constitutively expressed in tissues like the kidney or vascular endothelium, where it executes important physiological functions. COX- 2- dependent formation of prostanoids not only results in the mediation of pain or inflammatory signals but also in the maintenance of vascular integrity. Especially prostacyclin ( PGI(2)), which exerts vasodilatory and antiplatelet properties, is formed to a significant extent by COX- 2, and its levels are reduced to less than half of normal when COX- 2 is inhibited. This review outlines the rationale for the development of selective COX- 2 inhibitors and the pathophysiological consequences of selective inhibition of COX- 2 with special regard to vasoactive prostaglandins. It describes coxibs that are currently available, evaluates the current knowledge on the risk of atherothrombotic events associated with their intake and critically discusses the consequences that should be drawn from these insights. Copyright (C) 2005 S. Karger AG, Basel
A very high density microsatellite map (1 STR/41kb) of 1.7 Mb on Xp22 spanning the microphthalmia with linear skin defects (MLS) syndrome critical region
No full textMicrophthalmia with linear skin defects (MLS) syndrome is an X-linked disorder presenting only in XX individuals. It is characterised by dysmorphic features such as microphthalmia, sclerocornea, and linear streaks of erythematous and hypoplastic skin restricted to the head and neck. Karyotype analyses have so far revealed a terminal deletion or translocation causing monosomy for the distal Xp region (Xp22.3) in all patients. We have used existing cosmid clones from the region to perform a saturation screen for AC-type microsatellites with the goal of facilitating analysis of five novel patients with features of MLS. Three of these cases had an Xp22.3 abnormality, while the other two showed some characteristic features of MLS but had apparently normal karyotypes. Forty-two novel microsatellite markers have now been developed from the 1.7 Mb cloned interval. Ninety-three percent of the novel markers exhibited allelic variation, representing an average of one polymorphic PCR-based marker (STR) every 41 kb.Timothy C Cox, Liza L Cox & Andrea Ballabi
J. Cox
No full text"Cpl. J. Cox R.A.A.F. 16514 No 18 Replenishmen[t] Centre Larrimah and Fenton Aug 1943 to Dec. 1944."Corporal J. Cox, Royal Australian Air Force 16514. Number 18 Replenishment Centre. Larrimah and Fenton, August 1943 to December 1944
COX-2 induces T cell accumulation and IFN-γ production during the development of chromium allergy
No full textChromium (Cr) is commonly added into various metal alloys to improve some mechanical properties such as corrosion resistance, strength, and workability. However, Cr is also known to be a metal allergen for some individuals. Metal allergy is a T cell-mediated disease with symptoms of inflammation and swelling that involve inflammatory cytokines and prostaglandins. Hence, suppressing these inflammation paths by using COX-2 inhibitor might be useful in treating Cr allergy. In this study, mice were used with Cr-induced allergy challenge model. The mice were injected with celecoxib once per day for 7 days one hour after the challenge. Footpad samples were stained with haematoxylin and eosin (H&E), and lymphocytes were isolated from popliteal lymph nodes for the flow cytometric analysis. The results show that both prostaglandin E2 (PGE2), a known mediator of inflammation, and cyclooxygenases (COX)-2 have important roles in the development of Cr allergy. Further, COX-2 inhibitor, celecoxib, was effective in relieving swelling and inflammation in Cr-allergic mice concordant with suppression of IFN-γ production by CD8+ T cells and T cell accumulation in the lymph nodes. Therefore, the inhibition of COX-2 may be a therapeutic target for Cr allergy, and additional molecules in the PGE2 signalling pathway may also be an effective therapeutic target for the treatment of metal allergy.</p
Letter from W. T. Johnson to Miss Bessie M. Cox
No full textLetter from W. T. Johnson to Miss Bessie M. Cox, concerning Jamison Federation meeting
[Letter from George M. Cox to T. N. Carswell - November 27, 1941]
No full textA letter written to Mr. T. N. Carswell, Parramore Post No. 57, American Legion, Abilene, Texas, from George M. Cox, Executive Editor, The Mobile Press Register, Mobile, Alabama, dated November 27, 1941. George M. Cox defines Americanism
Concentration in Knowledge Output: A case of Economics Journals
No full textThis paper assesses the degree of author concentration in seven economics journals, which were published in India during 1990-2002. To measure the degree of author concentration, Lotka's Law was used. Moreover, we also make an exploratory analysis of the geographic, economics subfield and institutional concentration in 704 economics journals. An important finding of this paper is that specialized journals in the sample report the highest degree of author concentration. This result is quite similar to the findings by Cox and Chung (1991). Furthermore, there are several instances showing that the journals lean towards certain norms; this may affect the flow of innovative ideas into economics. We conclude that a knowledge activity, involving the high degree of concentration and a biased publication process, may affect the flow of new ideas into the discipline.Concentration, Lotka's Law
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