1,721,185 research outputs found
Cotelli (M) or Couteau P.
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/342156Reference: P Couteau, 1957, Contribution à la théorie du spectre des naines blanches, Sennac, Paris. Reference note: Supplements aux annale d'astrophysique S.E. 74/53 (2).138608
item: [2014.0039.00319] "Cotelli (M) or Couteau P.
Transcranial stimulation in frontotemporal dementia: a randomized, double-blind, sham-controlled trial
No full textIntroduction: Frontotemporal dementia (FTD) is a progressive disease for which no curative treatment is currently available. We aimed to determine whether transcranial direct current stimulation (tDCS) can modulate intracortical connectivity and improve cognition in symptomatic FTD patients and presymptomatic FTD subjects. Methods: We performed a double-blind, randomized, sham-controlled trial with anodal tDCS or sham stimulation over the left prefrontal cortex in 70 participants (15 presymptomatic and 55 symptomatic FTD). Results: We observed a significant increase of intracortical connectivity (short interval intracortical inhibition and facilitation) and improvement in clinical scores and behavioral disturbances in both symptomatic FTD patients and presymptomatic carriers after real tDCS but not after sham stimulation. Discussion: A 2-weeks’ treatment with anodal left prefrontal tDCS improves symptoms and restores intracortical inhibitory and excitatory circuits in both symptomatic FTD patients and presymptomatic carriers. tDCS might represent a promising future therapeutic and rehabilitative approach in patients with FTD
Effortful speech with distortion of prosody following SARS-CoV-2 infection
No full textCoronavirus disease 2019 (COVID-19) infection has the potential for targeting the central nervous system, and several neurological symptoms have been reported in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We describe a 48-year-old Caucasian woman with SARS-CoV-2 infection followed by the onset of word finding difficulties, effortful speech along with prosody distortion, in the context of spared semantic and syntactic abilities. The clinical picture, perceived as foreign accent syndrome (FAS), was not associated with structural and functional imaging changes or neurophysiological assessment abnormalities. We suggest that FAS, herein perceived as a regional accent syndrome, should be considered a possible additional neurological manifestation of SARS-CoV-2
Alpha tACS Improves Cognition and Modulates Neurotransmission in Dementia with Lewy Bodies
No full textBackground: Dementia with Lewy bodies (DLB) is characterized by a marked shift of electroencephalographic (EEG) power and dominant rhythm, from the α toward the θ frequency range. Transcranial alternate current stimulation (tACS) is a non-invasive brain stimulation technique that allows entrainment of cerebral oscillations at desired frequencies. Objectives: Our goal is to evaluate the effects of occipital α-tACS on cognitive functions and neurophysiological measures in patients with DLB. Methods: We conducted a double-blind, randomized, sham-controlled, cross-over clinical trial in 14 participants with DLB. Participants were randomized to receive either α-tACS (60 minutes of 3 mA peak-to-peak stimulation at 12 Hz) or sham stimulation applied over the occipital cortex. Clinical evaluations were performed to assess visuospatial and executive functions, as well as verbal episodic memory. Neurophysiological assessments and EEG recordings were conducted at baseline and following both α-tACS and sham stimulations. Results: Occipital α-tACS was safe and well-tolerated. We observed a significant enhancement in visuospatial abilities and executive functions, but no improvement in verbal episodic memory. We observed an increase in short latency afferent inhibition, a neurophysiological marker indirectly and partially dependent on cholinergic transmission, coinciding with an increase in α power and a decrease in Δ power following α-tACS stimulation, effects not seen with sham stimulation. Conclusions: This study demonstrates that occipital α-tACS is safe and enhances visuospatial and executive functions in patients with DLB. Improvements in indirect markers of cholinergic transmission and EEG changes indicate significant neurophysiological engagement. These findings justify further exploration of α-tACS as a therapeutic option for DLB patients. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
Effortful speech with distortion of prosody following SARS-CoV-2 infection
No full textCoronavirus disease 2019 (COVID-19) infection has the potential for targeting the central nervous system, and several neurological symptoms have been reported in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We describe a 48-year-old Caucasian woman with SARS-CoV-2 infection followed by the onset of word finding difficulties, effortful speech along with prosody distortion, in the context of spared semantic and syntactic abilities. The clinical picture, perceived as foreign accent syndrome (FAS), was not associated with structural and functional imaging changes or neurophysiological assessment abnormalities. We suggest that FAS, herein perceived as a regional accent syndrome, should be considered a possible additional neurological manifestation of SARS-CoV-2
Social cognition in patients with frontotemporal dementia and Alzheimer's disease: Preliminary results of an experimental study
No full textPLANNING TIMES DURING TRAVELING SALESMAN'S PROBLEM : DIFFERENCES BETWEEN CLOSED HEAD INJURY AND NORMAL SUBJECTS
No full textAutonomic measures and explicit evaluation of emotional cues in behavioral variant and agrammatic variant of frontotemporal dementia
No full textPrevious studies reported significant deficits on emotion recognition over the Frontotemporal Dementia (FTD) spectrum. However, the basis of emotional impairment is still poorly understood, and previously tested only by face recognition approach. In order to assess the status of emotional skills in a group of patients with FTD, we investigated both conscious and explicit evaluation of emotions, by testing valence and arousal self-report measures, and the automatic and unconscious responsiveness to emotional cues, by autonomic measures (Skin Conductance Response, SCR; Heart Rate, HR). Sixteen behavioural variant of FTD patients (bvFTD) and 12 agrammatic variant Primary and Progresive Aphasia (avPPA) patients were tested. Their performance was compared to a group of 14 patients with mild probable Alzheimer’s Disease (AD) and to 20 healthy controls (HC). Patients and HC were required to observe and evaluate affective pictures (IAPS) during autonomic parameters recording (Biofeedback recorder). Whereas a significant partially preserved competence in FTD groups in term of emotion rating and classification was observed, FTD patients showed significant changes in autonomic implicit response. BvFTD and avPPA patients showed lower values of SCR compared with control subjects and patients with AD. The present findings indicate that, within the FTD spectrum, an impairment of emotional recognition can be detected using autonomic measures. In particular, bvFTD showed a nonspecific and generic responsiveness to the emotional cues taking into account the autonomic measures
Vowels in the buffer: A case study of acquired dysgraphia with selective vowel substitutions
No full textThe role of the motor system in action naming in patients with neurodegenerative extrapyramidal syndromes.
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