43 research outputs found
The effect of vascular graft and human umbilical cord blood-derived CD34+ stem cell on peripheral nerve healing
No full textAIM: There are many trials concerning peripheral nerve damage causes and treatment options. Unfortunately, nerve damage is still a major problem regarding health, social and economic issues. On this study, we used vascular graft and human cord blood derived stem cells to find an alternative treatment solution to this problem. MATERIAL AND METHODS: We used 21 female Wistar rats on our study. They were anesthetized with ketamine and we studied right hind limbs. On Group 1, we did a full layer cut on the right sciatic nerve. On Group 2, we did a full layer cut on the right sciatic nerve, and we covered synthetic vascular graft on cut area. On Group 3, we did a full layer cut on right sciatic nerve, and we covered the area with stem cell applied vascular graft. RESULTS: At the end of postoperative 8. weeks, we performed EMG on the rats. When we compared healthy and degenerated areas as a result of EMG, we found significant amplitude differences between the groups on healthy areas whereas there was no significant difference on degenerated areas between the groups. Then we re-opened the operated area again to reveal the sciatic nerve cut area, and we performed electron microscope evaluation. On the stem cell group, we observed that both the axon and the myelin sheet prevented degeneration. CONCLUSION: This study is a first on using synthetic vascular graft and cord blood derived CD34+ cells in peripheral nerve degeneration. On the tissues that were examined with electron microscope, we observed that CD34+ cells prevented both axonal and myelin sheath degeneration. Nerve tissue showed similar results to the control group, and the damage was minimal. © 2018 Ali Yilmaz, Abdullah Topcu, Cagdas Erdogan, Levent Sinan Bir, Barbaros Sahin, Gulcin Abban, Erdal Coskun, Ayca Ozkul
Evaluation of Atrial Conduction Times and Epicardial Adipose Tissue Thickness in Patients with Ankylosing Spondylitis
No full textIntroduction: In this study, we aimed to evaluate whether atrial electromechanical delay (EMD) and epicardial adipose tissue (EAT) thickness differed between ankylosing spondylitis (AS) patients and healthy subjects. Methods: This prospective, cross-sectional study included 43 consecutive AS patients followed up in the Physical Medicine and Rehabilitation Department of the University of Health Sciences Turkey, Istanbul Training and Research Hospital, between June 2019 and January 2020. The control group consisted of 42 age-and gender-matched healthy participants. The PA atrial EMD was accepted as the beginning of the P wave on the electrocardiograph and the begining of late diastolic wave (Am wave) on the tissue Doppler obtained by transthoracic echocardiography, and all EMD parameters, including lateral mitral annulus (lateral PA), septa! mitral annulus (septa) PA) and right ventricular tricuspid annulus (tricuspid PA), were calculated. The thickness of EAT was obtained from the thickest part of the right ventricular free wall at the end of diastole in the parasternal long axis window. Results: In AS patients, tissue Doppler measurements of PA lateral, PA septal and PA tricuspid were longer than the measurements in the control group. In addition, EAT thickness was significantly higher in AS patients than in the control group. There was a moderate correlation between interatrial EMD and C-reactive protein (r=0.445, p<0.001) and EAT thickness (r=0.451, p<0.001). Conclusion: In this study, interatrial EMD and intraatrial EMD were significantly higher in AS patients. In addition, the thickness of EAD was significantly greater in patients with AS. These findings suggest a higher tendency toward coronary artery disease and atrial fibrillation in patients with AS
Pros and cons of botulinum toxin injection therapy in cerebral palsy: A qualitative study exploring caregivers' perspective
No full textBackground To describe and understand the experiences and beliefs of caregivers of children with cerebral palsy following botulinum toxin injection. Methods A descriptive case study approach with focus group interviews was employed. A semi-structured questionnaire was conducted to collect data. Twenty-one caregivers of children (3-13 years old) with cerebral palsy were recruited with a maximum variation sampling strategy to gain insight through different perspectives. Qualitative analysis with verbatim transcripts was analysed using a thematic approach. Findings Four themes emerged from qualitative analyses: acceptance of diagnosis, perceptions about treatment, caregivers' experiences with the health environment, and feelings and thoughts after the treatment. Conclusions This study highlights caregivers' requests for information about the possible long-term effect of botulinum toxin, as well as information and support to provide the best rehabilitation programme immediately after injection
Evolutionary Algorithms for Designing Self-sufficient Floating Neighborhoods
No full textFloating neighborhoods are innovative and promising urban areas for challenges in the development of cities and settlements. However, this design task requires a lot of considerations and technical challenges. Computational tools and methods can be beneficial to tackle the complexity of floating neighborhood design. This paper considers the design of a self-sufficient floating neighborhood by using computational intelligence techniques. In this respect, we consider a design problem for locating each neighborhood function in each cluster with a certain density within a floating neighborhood. In order to develop a self-sufficient floating neighborhood, we propose multi-objective evolutionary algorithms, namely, a self-adaptive real-coded genetic algorithm (CGA) as well as a self-adaptive real-coded genetic algorithm (CGA_DE) employing mutation operator of differential evolution algorithm. The only difference between CGA and CGA_DE is the fact that CGA uses random immigration of certain individuals into the population as a mutation operator whereas in the mutation phase of CGA_DE algorithm, the traditional mutation operator DE/rand/1/bin of DE algorithms. The arrangement of individual functions to develop each neighborhood function is further elaborated and formed by using Voronoi diagram algorithm. An application to design a self-sufficient floating neighborhood in Urla district, which is on the west coast of Turkey, İzmir, is presented.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Design Informatic
Vectorial bent functions and their duals
No full textCesmelioglu, Ayca/0000-0001-5049-9135Motivated by the observation that for two (weakly regular) bent functions f, g for which also f + g is bent, the sum f* + g* of their duals f and g* is sometimes but not always bent, we initiate the study of duality for vectorial bent functions. We propose and investigate two concepts of self-duality for vectorial bent functions, self-duality and weak self-duality. (C) 2018 Elsevier Inc. All rights reserved.Austrian Science Fund (FWF)Austrian Science Fund (FWF) [M 1767-N26]The second author is supported by the Austrian Science Fund (FWF) Project no. M 1767-N26
Effects of various preprocessing techniques to Turkish text categorization using n-gram features
No full textNatural Language Processing (NLP) is a prominent subject which includes various subcategories such as text classification, error correction, machine translation, etc. Unlike other languages, there are limited number of Turkish NLP studies in literature. In this study, we apply text classification on Turkish documents by using n-gram features. Our algorithm applies different preprocessing techniques, namely, n-gram choice (character level or word level, bigram or trigram models), stemming, and use of punctuation, and then determines the Turkish document's author and genre, and the gender of the author. For this purpose, Naive Bayes, Support Vector Machines and Random Forest are used as classification techniques. Finally, we discuss the effects of above mentioned preprocessing techniques to the performance of Turkish text classification
Effects of Various Preprocessing Techniques to Turkish Text Categorization Using N-Gram Features
No full textNatural Language Processing (NLP) is a prominent subject which includes various subcategories such as text classification, error correction, machine translation, etc. Unlike other languages, there are limited number of Turkish NLP studies in literature. In this study, we apply text classification on Turkish documents by using n-gram features. Our algorithm applies different preprocessing techniques, namely, n-gram choice (character level or word level, bigram or trigram models), stemming, and use of punctuation, and then determines the Turkish document's author and genre, and the gender of the author. For this purpose, Naive Bayes, Support Vector Machines and Random Forest are used as classification techniques. Finally, we discuss the effects of above mentioned preprocessing techniques to the performance of Turkish text classification
Efficacy of Sinapic Acid Administration in a Model of PenicillinInduced Epilepsy
No full text[No abstract available]Duzce University Research Fund [BAP-2021.04.01.1233]This study was supported by the Duzce University Research Fund (BAP-2021.04.01.1233)
Bringing ideas back to the evolution of design
No full textThis thesis is an exploration into the evolution of design. It attempts to develop an awareness of the effectiveness of what we do as designers and users to improve design. To achieve this purpose, it elaborates on some of the implications of paradigms which have emerged in design evolution. It presents some of the evolutionary theories and their analogies. These theories and analogies develop a view of design evolution - a conception of design as a process which moves from a lower to a higher state. With this conception, concern is directed at the identification of past and current design processes. An attempt is made to elaborate prescriptive and descriptive theories of design studies. For the identification of the higher state of design the characteristics of an ideal design are elucidated.
The broader aim, to which the author hopes this thesis will contribute, is to design a process (the order of actions) which helps achieve the ideals of design. This study brings in ideas on how to achieve the ideals of design. The purpose is to inquire into the essence of the ideals behind the process which plays out the ultimate freedom in design inquiry through design education, practice and theory
A comparison of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion for oocyte retrieval
No full textOBJECTIVE: To evaluate the effects of three different target-controlled remifentanil infusion rates during target-controlled propofol infusion on hemodynamic parameters, pain, sedation, and recovery score during oocyte retrieval. METHODS: Sixty-nine women were scheduled for oocyte retrieval. Target-controlled propofol infusion at an effectsite concentration of 1.5 μg/mL was instituted. The patients were randomly allocated to receive remifentanil at an effect-site concentration of either 1.5 (group I, n = 23), 2 (group II, n = 23) or 2.5 ng/mL (group III, n = 23). Hemodynamic variables, sedation, pain, the Aldrete recovery score, and side effects were recorded. RESULTS: Hemodynamic variables, sedation and pain scores and the number of patients with the maximum Aldrete recovery score 10 min after the procedure were comparable among the groups. The number of patients in group III with the maximum Aldrete recovery score 5 min after the procedure was significantly lower than that in groups I and II. One patient in group II and one patient in group III suffered from nausea. CONCLUSION: Similar pain-free conscious sedation conditions without significant changes in hemodynamic parameters were provided by all three protocols. However, target controlled infusion of remifentanil at 1.5 or 2 ng/mL proved superior at providing early recovery compared to 2.5 ng/mL
