130,489 research outputs found
Carta de J. Cosentini a Pedro Dorado Montero
No full textCarta de D. J. Cosentini, director del Laboratorio di Sociologia e Scienze Economico-Sociali di Palermo, a D. Pedro Dorado Montero, comunicándole su nombramiento como miembro del Laboratorio y pidiéndole una memoria o una comunicación
3D-electrical resistivity tomography monitoring of salt transport in homogeneous and layered soil samples
No full textMonitoring transport of dissolved substances in soil deposits is particularly relevant where safety is concerned, as in the case of geo-environmental barriers. Geophysical methods are very appealing, since they cover a wide domain, localising possible preferential flow paths and providing reliable links between geophysical quantities and hydrological variables. This paper describes a 3D laboratory application of Electrical Resistivity Tomography (ERT) used to monitor solute transport processes. Dissolution and transport tests on both homogeneous and heterogeneous samples were conducted in an instrumented oedometer cell. ERT was used to create maps of electrical conductivity of the monitored domain at different time intervals and to estimate concentration variations within the interstitial fluid. Comparisons with finite element simulations of the transport processes were performed to check the consistency of the results. Tests confirmed that the technique can monitor salt transport, infer the hydro-chemical behaviour of heterogeneous geomaterials and evaluate the performances of clay barrier
Estimation of the hydraulic parameters of unsaturated samples by electrical resistivity tomography
No full textIn situ and laboratory experiments have shown that electrical resistivity tomography (ERT) is an effective tool to image transient phenomena in soils. However, its application in quantifying soil hydraulic parameters has been limited. In this study, experiments of water inflow in unsaturated soil samples were conducted in an oedometer equipped to perform three-dimensional electrical measurements. Reconstructions of the electrical conductivity at different times confirmed the usefulness of ERT for monitoring the evolution of water content. The tomographic reconstructions were subsequently used in conjunction with a finite-element simulation to infer the water retention curve and the unsaturated hydraulic conductivity. The parameters estimated with ERT agree satisfactorily with those determined using established techniques, hence the proposed approach shows good potential for relatively fast characterisations. Similar experiments could be carried out on site to study the hydraulic behaviour of the entire soil deposi
Molecular genotyping of adrenocortical carcinoma: a systematic analysis of published literature 2019–2021
No full textPurpose of review comprehensive molecular characterization of adrenocortical carcinoma (ACC) through next-generation sequencing and bioinformatics analyses is expanding the number of targets with potential prognostic and therapeutic value. We performed a critical review of recent published literature on genotyping of ACC. Recent findings 423 studies were published between 2019 and 2021. After manual curation we summarized selected evidence in two thematic areas: Germline deoxyribonucleic acid (DNA) variations, genomic alterations and prognosis. Summary the evolving genomic landscape of ACC requires target validation in terms of prognostic and predictive value within scientific consortia. Although the existing multiple driver genes are difficult targets in the perspective of precision oncology, alterations in DNA damage repair genes or in promoter hypermethylation could open new venues for repurposing of existing drugs in ACC
Incidence of community-acquired pneumonia caused by Chlamydia pneumoniae in Italian patients
No full textThe incidence of Chlamydia pneumoniae as a cause of community-acquired pneumonia was evaluated in a one-year prospective study in 108 patients with community-acquired pneumonia. The bacteriological diagnosis was based on culture of sputum or bronchial aspirate and examination of acute and convalescent phase sera for Mycoplasma pneumoniae, Legionella pneumophila and Chlamydia pneumoniae. A definitive microbiological diagnosis was obtained in 58 (54 %) patients. Chlamydia pneumoniae was the causative agent in 14 patients (13 %) on the basis of positive serological tests; in 10 of the 14 patients Chlamydia pneumoniae was also detected by means of an indirect immunofluorescence test using pharyngeal swab specimens. In conclusion, Chlamydia pneumoniae seems to be a common etiological agent of community-acquired pneumonia, as increasingly reported in the last six to seven years
Different management of adrenocortical carcinoma in children compared to adults: is it time to share guidelines?
No full textPediatric and adult adrenocortical carcinomas differ in many respects but treatment is often similar in both age groups. The Journal of Clinical Oncology recently published the results of a risk-stratified single-arm interventional trial conducted by the Children’s Oncology Group in which 77 patients were treated in three different interventional cohorts. In this Point of View paper we comment on the treatment strategies adopted within the ARAR0332 trial in terms of surgery approach, duration of adjuvant therapies, and palliative chemotherapy. We focus on the differences in the treatment of pediatric ACC patients compared to the ESE/ENSAT and ESMO guidelines released in 2018 for adult patients. For example, patients in stratum 3 and 4 received 8 (instead of 6) cycles of EDP chemotherapy but 8 months (instead of 24) of mitotane adjuvant therapy. Bearing clearly in the mind that pediatric and adult ACC patients represent different settings, we wonder whether there could be some areas of intervention overlapping to constitute a continuum of disease across ages. Thus, pediatric and adult cohoperative groups should be encouraged to collaborate in order to reach common guidelines for the treatment of such a rare disease
The guanine nucleotide exchange factor VAV2 as a new prognostic parameter in adrenocortical carcinoma
No full textEffects of 2012 Earthquake on the behavior of Ghirlandina tower in Modena
No full textCollapse events, that occurred in the past (such as the Venice Bell Tower in 1902 and the Civic Tower in Pavia in 1989) claimed for the need to assess the long-term behavior of such monuments. A significant effort has been therefore devoted to clarify the reasons for these collapses after many centuries from the construction date. In addition, recent earthquakes in Italy have once again put into evidence the seismic vulnerability of the cultural heritage. To assess this aspect, in many cases the soil-structure interaction cannot be neglected. In this context, a simple but consistent framework for soil-structure interaction analysis is here presented with reference to a case history. It is discussed how the difference in the fundamental frequency observed during seismic events can be associated to non-linearity in soil response, leading to a rotational stiffness of the soil-foundation system consistent with the shear strain level derived from the seismic ground response analysis. Thereafter, the validated soil-structure interaction model has been used to define an equivalent SDOF model of the structure that explains the differential settlements suffered by the Ghirlandina tower in Modena during the 2012 seismic events as well as its behavior since those
events
Erratum: Dynamic behavior of shallow founded historic towers: Validation of simplified approaches for seismic analyses (International Journal of Geotechnical Engineering 9:1 (13-29) DOI: 10.1179/1939787914Y.0000000066)
No full textMeSH term explosion and author rank improve expert recommendations
No full textInformation overload is an often-cited phenomenon that reduces the productivity, efficiency and efficacy of scientists. One challenge for scientists is to find appropriate collaborators in their research. The literature describes various solutions to the problem of expertise location, but most current approaches do not appear to be very suitable for expert recommendations in biomedical research. In this study, we present the development and initial evaluation of a vector space model-based algorithm to calculate researcher similarity using four inputs: 1) MeSH terms of publications; 2) MeSH terms and author rank; 3) exploded MeSH terms; and 4) exploded MeSH terms and author rank. We developed and evaluated the algorithm using a data set of 17,525 authors and their 22,542 papers. On average, our algorithms correctly predicted 2.5 of the top 5/10 coauthors of individual scientists. Exploded MeSH and author rank outperformed all other algorithms in accuracy, followed closely by MeSH and author rank. Our results show that the accuracy of MeSH term-based matching can be enhanced with other metadata such as author rank
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