1,721,009 research outputs found
Optical Coherence Tomographic Angiography in Diabetic Macular Ischemia A New Step Forward
No full text
New insight on choroidal vasculature: multimodal morphofunctional approach
No full textmaging the choroid in vivo using standard modalities is difficult because of light scattering within overlying tissue, particularly the retinal pigment epithelium (RPE). Although the choriocapillaris is composed of relatively large-diameter capillaries, they are interconnected in a dense arrangement. The flow in the choriocapillaris is fast and because of the prominent fluorescein leakage vascular structure is obscured. Indocyanine green dye shows less leakage than fluorescein, but it still leaks from the choriocapillaris and stains Bruch’s membrane and the choroidal stroma. Optical coherence tomography angiography has high axial resolution, but the lateral resolution is insufficient to visualize the choriocapillaris clearly in the posterior pole. Nevertheless, it can detect choriocapillaris blood flow, producing contrast between the RPE and choriocapillaris. However, because of signal loss, fringe
wash-out, and thresholding used in signal processing, the vessels in Sattler’s layer and certainly in Haller’s layer appear dark in normal eyes. Purpose of the lecture is to evaluate various choroidal multimodal imaging findings and to allocate them in the context of different macular diseases
Choroidal neovascularisation complicating geographic atrophy in age-related macular degeneration.
No full textAbstract
OBJECTIVE:
To investigate the morphological and functional outcomes after intravitreal ranibizumab injections for choroidal neovascularisation (CNV) complicating geographic atrophy (GA).
DESIGN:
Retrospective, interventional, consecutive case series.
METHODS:
We reviewed the charts of all consecutive patients with GA due to age-related macular degeneration (AMD), who received intravitreal ranibizumab injections for the development of CNV at least 24 months earlier.
RESULTS:
21 treatment-naive eyes of 21 consecutive patients (4 men, 17 women, mean age 86.9±1.6 years) were included. In 95.2% of eyes a type 2 CNV was present, extrafoveal in 42.8% of cases. After a mean of 5.0±0.87 (range 1-20) intravitreal ranibizumab injections, best-corrected visual acuity (BCVA) significantly worsened at the 24-month follow-up visit (0.73±0.05 vs 0.88±0.08 logMAR, respectively; p=0.01). A significant reduction of intraretinal cystic lesions, subretinal fluid and pigment epithelium detachment (p<0.001) and a significant increase of GA area (p=0.003) were present at last visit.
CONCLUSIONS:
Ranibizumab treatment of GA-associated CNVs provides no BCVA improvement at 24 months follow-up despite an anatomic response of CNV. Low effectiveness of ranibizumab in these cases is likely due to GA progression
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY VERSUS TRADITIONAL MULTIMODAL IMAGING IN ASSESSING THE ACTIVITY OF EXUDATIVE AGE-RELATED MACULAR DEGENERATION A New Diagnostic Challenge
No full textChoroidal neovascularisation complicating geographic atrophy in age-related macular degeneration
No full textObjective To investigate the morphological and functional outcomes after intravitreal ranibizumab injections for choroidal neovascularisation (CNV) complicating geographic atrophy (GA). Design Retrospective, interventional, consecutive case series. Methods We reviewed the charts of all consecutive patients with GA due to age-related macular degeneration (AMD), who received intravitreal ranibizumab injections for the development of CNV at least 24 months earlier. Results 21 treatment-naive eyes of 21 consecutive patients (4 men, 17 women, mean age 86.9 +/- 1.6 years) were included. In 95.2% of eyes a type 2 CNV was present, extrafoveal in 42.8% of cases. After a mean of 5.0 +/- 0.87 (range 1-20) intravitreal ranibizumab injections, best-corrected visual acuity (BCVA) significantly worsened at the 24-month follow-up visit (0.73 +/- 0.05 vs 0.88 +/- 0.08 logMAR, respectively; p=0.01). A significant reduction of intraretinal cystic lesions, subretinal fluid and pigment epithelium detachment (p<0.001) and a significant increase of GA area (p=0.003) were present at last visit. Conclusions Ranibizumab treatment of GA-associated CNVs provides no BCVA improvement at 24 months follow-up despite an anatomic response of CNV. Low effectiveness of ranibizumab in these cases is likely due to GA progression
New insight on choroidal vasculature: multimodal morphofunctional approach
No full textmaging the choroid in vivo using standard modalities is difficult because of light scattering within overlying tissue, particularly the retinal pigment epithelium (RPE). Although the choriocapillaris is composed of relatively large-diameter capillaries, they are interconnected in a dense arrangement. The flow in the choriocapillaris is fast and because of the prominent fluorescein leakage vascular structure is obscured. Indocyanine green dye shows less leakage than fluorescein, but it still leaks from the choriocapillaris and stains Bruch’s membrane and the choroidal stroma. Optical coherence tomography angiography has high axial resolution, but the lateral resolution is insufficient to visualize the choriocapillaris clearly in the posterior pole. Nevertheless, it can detect choriocapillaris blood flow, producing contrast between the RPE and choriocapillaris. However, because of signal loss, fringe
wash-out, and thresholding used in signal processing, the vessels in Sattler’s layer and certainly in Haller’s layer appear dark in normal eyes. Purpose of the lecture is to evaluate various choroidal multimodal imaging findings and to allocate them in the context of different macular diseases
Choroidal Neovascularization in Malattia Leventinese Diagnosed Using Optical Coherence Tomography Angiography
No full textPURPOSE: To compare optical coherence tomography angiography (OCT-A) with traditional multimodal imaging in patients with Malattia Leventinese.DESIGN: Retrospective case series.METHODS: Eight eyes of 4 consecutive patients with Malattia Leventinese were retrospectively studied. All patients underwent a complete ophthalmologic examination including color fundus photography, fluorescein and indocyanine green angiographies, spectral-domain optical coherence tomography, and optical coherence tomography angiography.RESULTS: The choriocapillaris segmentation of OCTA revealed the presence of a hyperflow signal corresponding to active choroidal neovascularization in 3 eyes and inactive choroidal neovascularization in 1 eye. Traditional multimodal imaging did not show each vascular layer and any leakage in these cases.CONCLUSION: OCT-A, unlike traditional multimodal imaging, helps diagnose choroidal neovascularization in patients with Malattia Leventinese suffering from metamorphopsia and reduced visual acuity. (C) 2017 Elsevier Inc. All rights reserved
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