1,914,031 research outputs found
Corsello et al. example
No full textData corresponding to the Corsello et al. drug repurposing example
Cell line feature sets used in Corsello et al., 2020
No full textThe cancer cell line characteristics used in the biomarker analysis presented in Corsello et al., 2020 (doi.org/10.1101/730119). Please see Supplementary Table 9 for the original sources of each dataset and the complete output of the analysis is available at https://depmap.org/repurposing/. For updated versions of the datasets, we refer the user to the depmap.org.</div
Hypophysitis induced by monoclonal antibodies to cytotoxic T lymphocyte antigen 4: challenges from a new cause of a rare disease
No full textSpecific human monoclonal antibodies antagonize cytotoxic T-lymphocyte antigen 4 (anti-CTLA-4 mAbs), a negative regulator of the immune system, inducing unrestrained T-cell activation. In patients with advanced or metastatic melanoma, one of these agents, ipilimumab, produced considerable disease control rates and, for the first time, a clear improvement in overall survival outcomes. However, accumulating clinical experience with anti-CTLA-4 mAbs identified a novel syndrome of autoimmune and autoinflammatory side effects, designated as "immune-related adverse events," including mainly rash, colitis, and hepatitis. Autoimmune hypophysitis has emerged as a distinctive side effect induced by anti-CTLA-4 mAbs. This condition may be life threatening because of adrenal insufficiency if not promptly recognized, but it may easily be diagnosed and treated if clinically suspected. Hypopituitarism caused by these agents is rarely reversible and prolonged or life-long substitutive hormonal treatment is often required. The precise mechanism of injury to the pituitary triggered by anti-CTLA-4 mAbs is yet to be fully elucidated
Le problematiche IUGR nei gemelli
No full textIntrauterin Growth Retardation is more common
among twins than singleton. The reduction of intrauterine enviroment and level of transplacental diffusion of
nutrients are main responsible factors. Moreover, anastomosis of vessels between the arterial and venous systems of twins may induce a different irroration and a discordance of growth. Levels of discordane greater than 25% between twin may be associated with a twin¬twin transfusion syndrome, in which the donor is pale and ischemic and the recipient shows hemodynamic troubles within the spectrum of a hyperviscosity syn¬drome. These twins show an additional risk of morta¬lity and morbidity with respect to singleton and con¬cordant twins. The overall number of twins is nowa¬days increased up to 2.5 per thousands livebirths in relation to the diffusion of the pregnancies due to assisted technologies (ART). In faci, both the pharmacological induction of the ovulation and the implantation of in vitro fertilized embryos increase the probability of twinning, dyzygotic as well as monozygotic ones
A case of Kawasaki disease mimicking acute appendicitis
No full textKawasaki disease (KD) is an acute vasculitis of unknown aetiology occurring mostly in infants and young children. KD is characterized by fever (≥5 days), conjunctivitis, rash, cervical lymphadenopathy, lips, oral mucosa, palms and soles erythema, hands and feet oedema [1].
Coronary artery aneurysms develop in 15-25% of untreated children [2] with risk of ischemic heart disease, myocardial infarction, sudden death [3;4]. Treatment with intravenous gamma globulins (IVIG) within the first 10 days reduces the incidence of aneurysms to <5% [4]. The KD diagnosis is clinical, based on the recognition of a characteristic set of signs and symptoms [4]. Children not meeting traditional criteria are considered as “atypical” or “incomplete” KD (10-45%) possessing higher risk of coronary artery aneurysms [4]. Abdominal symptoms, including acute appendicitis and appendicular vasculitis, can occur before the development of classical features [4;5]. A 50% coronary artery aneurysm rate is reported in KD children with a surgical abdomen. It is still unclear if it reflects the delay in diagnosis and treatment or it is a marker of a more severe vasculitis, involving intestinal tract.
Our clinical case is a 3 years-old child with fever (remittent, high-spiking 37.5÷39 °C, 2-3 spikes/day, persisting for two weeks), right lower quadrant abdominal pain, McBurney’s sign, rebound tenderness. Abdominal echography confirmed acute appendicitis with peritonitis diagnosis. Appendicular vasculitis with peritoneal inflammation and serous secretion was postoperative diagnosis. After intervention and cephalosporin injection fever persisted; some days later, he presented conjunctivitis, lips cracking, elevation of the erythrocyte sedimentation rate and C-reactive protein, thrombocytosis (715.000); KD was suspected and echocardiogram revealed two sacciform coronary artery aneurysms in the common trunk proximal part (diameter: 3.1, 2.9 mm). He received IVIG (2 g/kg) and acetylsalicylic acid (100 mg/kg/day in four doses). He failed to defervesce and received a second IVIG dose [4], with a dramatic clinical improvement. Five days later he developed hands oedema and periungueal fingers peeling; he was kept on Aspirin at 5 mg/kg/day. On follow-up echocardiograms demonstrated persistent coronary artery dilatation.
Persistent fever with conjunctivitis and lips cracking is very important marker for KD suspicion. At our patient’s age acute appendicitis is rare; on the contrary medical aetiology of abdominal pain must be excluded. The unusual post-operative course with persistent fever, also after antibiotics administration, is another marker for correct diagnosis.
We suggest to extend differential diagnosis of abdominal pain and fever also to KD and to evaluate by echocardiogram all suspected KD
Reversible dilated cardiomyopathy due to growth hormone deficiency
No full textWe describe the role of reversible dilated cardiomyopathy due to growth hormone deficienc
HAXPES spectra for Sm
No full textHAXPES spectra for Sm measured at BL15XU of SPring-8. This dataset is a part of "HAXPES spectra for elemental solids" MDR collection https://doi.org/10.48505/nims.370
Sclerosis Multiplexben szenvedő betegek életminőségének felmérése, és az SM nővér szerepének vizsgálata az életminőség javításában
No full textA kutatásom célja az volt, hogy munkahelyemen, a Kenézy Gyula Kórház és Rendelőintézet Neurológiai Osztály SM centrumában gondozott betegek életminőségét felmérjem, és összehasonlítsam a DE KK Neurológiai Klinika által gondozott SM betegek eredményeivel. A vizsgálatomban arra is választ szerettem volna kapni, hogy milyen eszközökkel képes az SM nővér a betegek életminőségét pozitívan befolyásolni, ezen kívül, hogy van-e igény az adott területen mesterképzésben részesülő SM nővér tudására. A vizsgálat során az SM betegek szubjektív életminőségének felmérésére került sor.VTápoláslevelezőmagyarMSc/M
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